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The map label for this gene is zraR [H]

Identifier: 124266108

GI number: 124266108

Start: 970557

End: 972005

Strand: Direct

Name: zraR [H]

Synonym: Mpe_A0915

Alternate gene names: 124266108

Gene position: 970557-972005 (Clockwise)

Preceding gene: 124266107

Following gene: 124266109

Centisome position: 24.0

GC content: 69.01

Gene sequence:

>1449_bases
ATGAGCAGCCAGCCCCGCAGGGAAGCACCGGCCGAGGCACGGCGGCCGTCGGAACAGGTGCTCGTGATCGACGACGACCA
CGGCATCGGCGACTGCGTCGAGATGCTGCTGCAGCGCGCCGGCTACACCTGCGTGATCACGCGCACCGGCGGCGAGGGCC
TGGCGCAGCTCCGCAGCCGCGAGTTCGACATGGTCATCACCGACCTGCGCCTGCCCGACGCCAGCGGGCTGGACATCGTG
GCGGCCAGCAAGGCGGCCAACCCCGAGACGCAGGTGATCCTGATGACCAGCTTCTCGTCGGTCGAGAGCGCGATCGAGGC
GCTGCGCCTGGGCGCCAACGACTACGTGATCAAGCCCTTCGACAACGATGACTTCCTGTTCTCGGTGGAGCGGGCGCTCG
GCGAGCGCCGCACCCGCATGGAGAACGTGGCCCTCAAGCGCAGCCTGCGCAAGGCCTATTCCCAGAACGCCATCATCGGC
GAGAGCGACGGCGTCAAGCGCCTGCTGGGCATGATCCAGCGCGTGGCCGCCACCGAGGCCAACGTGCTGATCCAGGGCGA
GAGCGGCACCGGCAAGGAACTGGTGGCCCAGGCCATCCACTTCGGCGGCAATCGGGCGCACCGGCCGTTCGTCGCGGTGA
ACTGCGGGGCCATTCCGGCCGAGCTGATCGAGTCCGAGCTGTTCGGCCACGTCAAGGGCGCCTACACGGGCGCGGCCTCG
GCCAGCGAGGGCCTGATCCGCGAAGCCAGCGGCGGGACGCTGTTCCTCGACGAGATCTCGGAGATGCCGCTCAACGTGCA
GGTGAAGCTGCTGCGGGTGCTGCAGGAGCGCCAGGTGCGACCGCTCGGTTCGGGACAGAGCTACATCACCGACACGCGCT
TCCTCGCGGCGAGCAACCGCAACCTGAAGGAGAGCGCCGAGAGCGGCAGCTTCCGCGCCGACCTCTACTACCGCCTGAAC
GTCATCACGATCCACGTGCCGCCACTGCGCGAGCGCGGGGCCGACATCGAGCTGCTCGCGCGCCACTTCATGCAGTTGTT
CAGCCGCAAGTTCGGCAGCCGGGTCAGCGGCATGGACCGGGACTTCATCGACTTCCTGCACCGCCACTCCTGGCCCGGCA
ACGTGCGCGAGCTCCAGAACGTGATCGAGCGCGCGGTGATCCTGGCCGATGCCGACATCCTGAGCGCCGCCGACCTGGAG
GAAACGCTCGCGCTGCCGGCCAAGGAGACTCACCTGCCGCTGGGCAGCGGGTTGCCCCTGTCGGTGGAGGAGTACATCAA
GGAAGTCGTGCTGCTCTACCAGGACCGGCACGGCGAGGCCGAGCTTGCGGCGATGCTCGGCATCGGCCGCAAGGCGCTCT
GGATGCGGCGCCGCAACTGGGGCCTGCACCGGCAGCGCGAGCGCGCACCGGCCGGCGACGAGCTAGACCACCTCCACCGC
GTTCAGTGA

Upstream 100 bases:

>100_bases
TCAGCACCGAGATCGCCCACGAGCACGGCGGCAGCCTCTCGCTGCGACACACCGGCAGCGAGGGCGCCACGTTCTGCGTC
GCGCTGCCCAGGGAACGCGC

Downstream 100 bases:

>100_bases
ACCGCACGGAAAGCAGCCATGTCGAACGAATCCGCCGAACTGCTGACACCGAACCTGATCCTCGCGCAGACGGGTTTCTT
CCAGGACCTGACCGCGCGCC

Product: two-component response regulator CbrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSSQPRREAPAEARRPSEQVLVIDDDHGIGDCVEMLLQRAGYTCVITRTGGEGLAQLRSREFDMVITDLRLPDASGLDIV
AASKAANPETQVILMTSFSSVESAIEALRLGANDYVIKPFDNDDFLFSVERALGERRTRMENVALKRSLRKAYSQNAIIG
ESDGVKRLLGMIQRVAATEANVLIQGESGTGKELVAQAIHFGGNRAHRPFVAVNCGAIPAELIESELFGHVKGAYTGAAS
ASEGLIREASGGTLFLDEISEMPLNVQVKLLRVLQERQVRPLGSGQSYITDTRFLAASNRNLKESAESGSFRADLYYRLN
VITIHVPPLRERGADIELLARHFMQLFSRKFGSRVSGMDRDFIDFLHRHSWPGNVRELQNVIERAVILADADILSAADLE
ETLALPAKETHLPLGSGLPLSVEEYIKEVVLLYQDRHGEAELAAMLGIGRKALWMRRRNWGLHRQRERAPAGDELDHLHR
VQ

Sequences:

>Translated_482_residues
MSSQPRREAPAEARRPSEQVLVIDDDHGIGDCVEMLLQRAGYTCVITRTGGEGLAQLRSREFDMVITDLRLPDASGLDIV
AASKAANPETQVILMTSFSSVESAIEALRLGANDYVIKPFDNDDFLFSVERALGERRTRMENVALKRSLRKAYSQNAIIG
ESDGVKRLLGMIQRVAATEANVLIQGESGTGKELVAQAIHFGGNRAHRPFVAVNCGAIPAELIESELFGHVKGAYTGAAS
ASEGLIREASGGTLFLDEISEMPLNVQVKLLRVLQERQVRPLGSGQSYITDTRFLAASNRNLKESAESGSFRADLYYRLN
VITIHVPPLRERGADIELLARHFMQLFSRKFGSRVSGMDRDFIDFLHRHSWPGNVRELQNVIERAVILADADILSAADLE
ETLALPAKETHLPLGSGLPLSVEEYIKEVVLLYQDRHGEAELAAMLGIGRKALWMRRRNWGLHRQRERAPAGDELDHLHR
VQ
>Mature_481_residues
SSQPRREAPAEARRPSEQVLVIDDDHGIGDCVEMLLQRAGYTCVITRTGGEGLAQLRSREFDMVITDLRLPDASGLDIVA
ASKAANPETQVILMTSFSSVESAIEALRLGANDYVIKPFDNDDFLFSVERALGERRTRMENVALKRSLRKAYSQNAIIGE
SDGVKRLLGMIQRVAATEANVLIQGESGTGKELVAQAIHFGGNRAHRPFVAVNCGAIPAELIESELFGHVKGAYTGAASA
SEGLIREASGGTLFLDEISEMPLNVQVKLLRVLQERQVRPLGSGQSYITDTRFLAASNRNLKESAESGSFRADLYYRLNV
ITIHVPPLRERGADIELLARHFMQLFSRKFGSRVSGMDRDFIDFLHRHSWPGNVRELQNVIERAVILADADILSAADLEE
TLALPAKETHLPLGSGLPLSVEEYIKEVVLLYQDRHGEAELAAMLGIGRKALWMRRRNWGLHRQRERAPAGDELDHLHRV
Q

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=43.3106575963719, Blast_Score=341, Evalue=7e-95,
Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=40.3547671840355, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1788905, Length=395, Percent_Identity=41.5189873417722, Blast_Score=301, Evalue=9e-83,
Organism=Escherichia coli, GI1790299, Length=370, Percent_Identity=42.972972972973, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1789233, Length=318, Percent_Identity=42.1383647798742, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1789087, Length=399, Percent_Identity=38.3458646616541, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87082117, Length=257, Percent_Identity=47.0817120622568, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87082152, Length=307, Percent_Identity=44.6254071661238, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1786524, Length=260, Percent_Identity=44.2307692307692, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1787583, Length=341, Percent_Identity=34.6041055718475, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI87081872, Length=236, Percent_Identity=39.8305084745763, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1789828, Length=248, Percent_Identity=33.8709677419355, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081858, Length=301, Percent_Identity=30.5647840531561, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1786784, Length=102, Percent_Identity=31.3725490196078, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789402, Length=102, Percent_Identity=35.2941176470588, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790860, Length=103, Percent_Identity=33.0097087378641, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53391; Mature: 53259

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQPRREAPAEARRPSEQVLVIDDDHGIGDCVEMLLQRAGYTCVITRTGGEGLAQLRSR
CCCCCCCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCC
EFDMVITDLRLPDASGLDIVAASKAANPETQVILMTSFSSVESAIEALRLGANDYVIKPF
CCCEEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCEEECC
DNDDFLFSVERALGERRTRMENVALKRSLRKAYSQNAIIGESDGVKRLLGMIQRVAATEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
NVLIQGESGTGKELVAQAIHFGGNRAHRPFVAVNCGAIPAELIESELFGHVKGAYTGAAS
CEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCC
ASEGLIREASGGTLFLDEISEMPLNVQVKLLRVLQERQVRPLGSGQSYITDTRFLAASNR
CCCCCEEECCCCEEEEEHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEEECCC
NLKESAESGSFRADLYYRLNVITIHVPPLRERGADIELLARHFMQLFSRKFGSRVSGMDR
CHHHHHCCCCEEEEEEEEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
DFIDFLHRHSWPGNVRELQNVIERAVILADADILSAADLEETLALPAKETHLPLGSGLPL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCHHHHHCCCCHHCCCCCCCCCCC
SVEEYIKEVVLLYQDRHGEAELAAMLGIGRKALWMRRRNWGLHRQRERAPAGDELDHLHR
CHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHC
VQ
CC
>Mature Secondary Structure 
SSQPRREAPAEARRPSEQVLVIDDDHGIGDCVEMLLQRAGYTCVITRTGGEGLAQLRSR
CCCCCCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCC
EFDMVITDLRLPDASGLDIVAASKAANPETQVILMTSFSSVESAIEALRLGANDYVIKPF
CCCEEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCEEECC
DNDDFLFSVERALGERRTRMENVALKRSLRKAYSQNAIIGESDGVKRLLGMIQRVAATEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
NVLIQGESGTGKELVAQAIHFGGNRAHRPFVAVNCGAIPAELIESELFGHVKGAYTGAAS
CEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCC
ASEGLIREASGGTLFLDEISEMPLNVQVKLLRVLQERQVRPLGSGQSYITDTRFLAASNR
CCCCCEEECCCCEEEEEHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEEECCC
NLKESAESGSFRADLYYRLNVITIHVPPLRERGADIELLARHFMQLFSRKFGSRVSGMDR
CHHHHHCCCCEEEEEEEEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
DFIDFLHRHSWPGNVRELQNVIERAVILADADILSAADLEETLALPAKETHLPLGSGLPL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCHHHHHCCCCHHCCCCCCCCCCC
SVEEYIKEVVLLYQDRHGEAELAAMLGIGRKALWMRRRNWGLHRQRERAPAGDELDHLHR
CHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHC
VQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]