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The map label for this gene is zraS [H]

Identifier: 124266107

GI number: 124266107

Start: 969529

End: 970560

Strand: Direct

Name: zraS [H]

Synonym: Mpe_A0914

Alternate gene names: 124266107

Gene position: 969529-970560 (Clockwise)

Preceding gene: 124266105

Following gene: 124266108

Centisome position: 23.97

GC content: 70.16

Gene sequence:

>1032_bases
ATGAGAGCCCAGCGCCATACGTACGATCTTGCCGAGGTGTTCGAACAGATCTTCTCGGCCGCGCCGTGGCCGATGCTGAT
GCTGGGTGAGGACGCCGCGGTGCTGGGTGCGAGCGACGAATACGGCCACGGTGAGGCCGACTCCGACCTGCCGCTGCGCG
CGCGTGCGCCGCACTACCTGGCGTCGTTGCGCGGCGGCCCGCCGTGGTCGGCCGCGCAGGAGGCCGACAGCGTGCGGACG
CTGCCCTCGGGGGCGCAGGTGCACGAGCGGCTCTTCCTGCGCCGCACGCCCTGGGGGGCCAGCCTCGTGATCGTCGACCA
GACCGACCTGCGCCAGCTCCAGACCTCCGACCTGCAGACGGCACGGCTCGCGGCGCTGGGCTTCATGGTGGCGGGCGTCT
GCCACGAGATCACGAACCCGCTCACCTCGCTGCACTCCATCGTGCAGATCCTGCGGTCCGAGAAGCAGCCGAGCCCGGCG
CTGCTGGACAAGGGCTTCGACAACATCGCGGTCAACGTCAAGCGCATCCTCGACATCTCGCGGCGGCTGGTGAAGTTCTC
GCGCGTCGGTGACGAGCCGCGCTACGGCTTCGCGGTCGACGAGGCCATCGAGGAGGCGCTCTACGTGCTGCGCCAGGACG
ACCTGCTGCGCGACGTGGAGCTGCAGTACCTGCGCCGCGACGCGGGCCTGAAGGTGTTCGGCAACACGGGGCAGATCCGC
GAGATCTTCCTGAACCTGTTCGTCAATGCCGCTCAGGCGATGGCCGGCCGCGGCACGCTGCGCATCGAGACCCGCGAGGC
CGGCCCGATGGTCGAAGTGCTGGTCGGTGACACCGGCCCGGGCGTGCCGGCCGAGGCCGTGGGCCGCATCTTCGAACCCT
TCTTCACCACCAAGTCCAGCATGCACGGCACCGGGCTCGGGCTGGCGATCAGCACCGAGATCGCCCACGAGCACGGCGGC
AGCCTCTCGCTGCGACACACCGGCAGCGAGGGCGCCACGTTCTGCGTCGCGCTGCCCAGGGAACGCGCATGA

Upstream 100 bases:

>100_bases
GCCGATCGGTGCGTGGGGGTCGCTCTCTATTGCTGCGTGCACTGCGTGCCCATACGCTCTGTTCTGCCCCCGCCATCATC
TGTTCCATTGACCGATACCG

Downstream 100 bases:

>100_bases
GCAGCCAGCCCCGCAGGGAAGCACCGGCCGAGGCACGGCGGCCGTCGGAACAGGTGCTCGTGATCGACGACGACCACGGC
ATCGGCGACTGCGTCGAGAT

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRAQRHTYDLAEVFEQIFSAAPWPMLMLGEDAAVLGASDEYGHGEADSDLPLRARAPHYLASLRGGPPWSAAQEADSVRT
LPSGAQVHERLFLRRTPWGASLVIVDQTDLRQLQTSDLQTARLAALGFMVAGVCHEITNPLTSLHSIVQILRSEKQPSPA
LLDKGFDNIAVNVKRILDISRRLVKFSRVGDEPRYGFAVDEAIEEALYVLRQDDLLRDVELQYLRRDAGLKVFGNTGQIR
EIFLNLFVNAAQAMAGRGTLRIETREAGPMVEVLVGDTGPGVPAEAVGRIFEPFFTTKSSMHGTGLGLAISTEIAHEHGG
SLSLRHTGSEGATFCVALPRERA

Sequences:

>Translated_343_residues
MRAQRHTYDLAEVFEQIFSAAPWPMLMLGEDAAVLGASDEYGHGEADSDLPLRARAPHYLASLRGGPPWSAAQEADSVRT
LPSGAQVHERLFLRRTPWGASLVIVDQTDLRQLQTSDLQTARLAALGFMVAGVCHEITNPLTSLHSIVQILRSEKQPSPA
LLDKGFDNIAVNVKRILDISRRLVKFSRVGDEPRYGFAVDEAIEEALYVLRQDDLLRDVELQYLRRDAGLKVFGNTGQIR
EIFLNLFVNAAQAMAGRGTLRIETREAGPMVEVLVGDTGPGVPAEAVGRIFEPFFTTKSSMHGTGLGLAISTEIAHEHGG
SLSLRHTGSEGATFCVALPRERA
>Mature_343_residues
MRAQRHTYDLAEVFEQIFSAAPWPMLMLGEDAAVLGASDEYGHGEADSDLPLRARAPHYLASLRGGPPWSAAQEADSVRT
LPSGAQVHERLFLRRTPWGASLVIVDQTDLRQLQTSDLQTARLAALGFMVAGVCHEITNPLTSLHSIVQILRSEKQPSPA
LLDKGFDNIAVNVKRILDISRRLVKFSRVGDEPRYGFAVDEAIEEALYVLRQDDLLRDVELQYLRRDAGLKVFGNTGQIR
EIFLNLFVNAAQAMAGRGTLRIETREAGPMVEVLVGDTGPGVPAEAVGRIFEPFFTTKSSMHGTGLGLAISTEIAHEHGG
SLSLRHTGSEGATFCVALPRERA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=31.404958677686, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=29.5652173913043, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI87081816, Length=219, Percent_Identity=29.2237442922374, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=280, Percent_Identity=25.3571428571429, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786600, Length=215, Percent_Identity=25.1162790697674, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788393, Length=130, Percent_Identity=31.5384615384615, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790300, Length=263, Percent_Identity=28.8973384030418, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=24.6636771300448, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37490; Mature: 37490

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAQRHTYDLAEVFEQIFSAAPWPMLMLGEDAAVLGASDEYGHGEADSDLPLRARAPHYL
CCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHH
ASLRGGPPWSAAQEADSVRTLPSGAQVHERLFLRRTPWGASLVIVDQTDLRQLQTSDLQT
HHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHEECCCCCEEEEECCHHHHHHHHCCHHH
ARLAALGFMVAGVCHEITNPLTSLHSIVQILRSEKQPSPALLDKGFDNIAVNVKRILDIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHH
RRLVKFSRVGDEPRYGFAVDEAIEEALYVLRQDDLLRDVELQYLRRDAGLKVFGNTGQIR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHH
EIFLNLFVNAAQAMAGRGTLRIETREAGPMVEVLVGDTGPGVPAEAVGRIFEPFFTTKSS
HHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
MHGTGLGLAISTEIAHEHGGSLSLRHTGSEGATFCVALPRERA
CCCCCCEEEEEHHHHHHCCCEEEEEECCCCCCEEEEECCCCCC
>Mature Secondary Structure
MRAQRHTYDLAEVFEQIFSAAPWPMLMLGEDAAVLGASDEYGHGEADSDLPLRARAPHYL
CCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHH
ASLRGGPPWSAAQEADSVRTLPSGAQVHERLFLRRTPWGASLVIVDQTDLRQLQTSDLQT
HHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHEECCCCCEEEEECCHHHHHHHHCCHHH
ARLAALGFMVAGVCHEITNPLTSLHSIVQILRSEKQPSPALLDKGFDNIAVNVKRILDIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHH
RRLVKFSRVGDEPRYGFAVDEAIEEALYVLRQDDLLRDVELQYLRRDAGLKVFGNTGQIR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHH
EIFLNLFVNAAQAMAGRGTLRIETREAGPMVEVLVGDTGPGVPAEAVGRIFEPFFTTKSS
HHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
MHGTGLGLAISTEIAHEHGGSLSLRHTGSEGATFCVALPRERA
CCCCCCEEEEEHHHHHHCCCEEEEEECCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]