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The map label for this gene is paaG [H]

Identifier: 124266086

GI number: 124266086

Start: 940433

End: 941248

Strand: Direct

Name: paaG [H]

Synonym: Mpe_A0893

Alternate gene names: 124266086

Gene position: 940433-941248 (Clockwise)

Preceding gene: 124266084

Following gene: 124266087

Centisome position: 23.25

GC content: 70.47

Gene sequence:

>816_bases
ATGGATGCGTATGTCGGCTCAGTTTCTTCCCGTTCAACCCTCATGAAGGGCCTGCTCGTCAGCCGCGACGGGGGTCTGGT
GCGTCTGCGCCTCGACCGACCGGAGGCGCTCAATGCGCTCGATGTCGATCTGGCCCAGGCGCTGCTCGCCGCCTGCCGTG
ATCTCGCCGACGACGCGTCGGTGCGTGCCGTGCTGCTCAGCGGTTCGGGCCGCGCCTTCGCCGCTGGCGGTGATCTCTCG
CAGATGCGCGCCGCGCCGGTGGCGGCGGCCGACAGCCTGATCACGCCGATGCACCAGGCGCTGCGTCTGTTGGGGAGCAT
CGATGCGCCGGTGCTGGTCGCGCTGCATGGCGCAGTGGCCGGCGCCGGCCTCAGCCTGGCGGCCGCGGCCGATCTGGCCA
TCGCCGCCGAGGGCACGAAGTTCAACCTGGCCTACATCAACATCGCGACCAGTTGCGACCTCGGCGCCTCGTGGTCGCTG
CCGCGACTGGTGGGCTTGCGCCGCGCGCTCGAGATCGCGCTGCTGGGCGAAAGTTTCGATGCGCGCAAGGCGCTGGAGAT
CGGGCTCGTCAACCGCGTGGTCGCCGCCGACGCGCTGGAGGCCGAGGCCGAGGCGCTGGCGCAGCGGCTGGCACGCGGCC
CGACGCTCGCTTATGGCCACATGCGCCGTCTGATGCGCGCCAGCTTCGAGCGAAGTTTCACCGAGCAGCTCGATGCCGAG
CGCGATGCCTTTCTCGCCAGCGCCGCGACCGCCGATTTCGGCGAAGGCCTGGCGGCCTTCTTCGATCGGCGTCCGGCCCG
TTTCCAGGGCCACTGA

Upstream 100 bases:

>100_bases
ATTCCTGCAGGCGGCCGATGCCCTTGCAGAGGCCACCGCGTGGAGGGCAAGCAAGCCCCTGCGTCGCGGGCCCGACATCG
GGCCCGATCGCGGATCGACG

Downstream 100 bases:

>100_bases
GCGCCGCTCTTGTTCTTCTTTCTATCCAGGCCATGAACATCCTCGACAGCGTTGCGCGTCAGACCCTGGGCGACCTGCTG
CGCCGCACCCGCCAGCGCCA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MDAYVGSVSSRSTLMKGLLVSRDGGLVRLRLDRPEALNALDVDLAQALLAACRDLADDASVRAVLLSGSGRAFAAGGDLS
QMRAAPVAAADSLITPMHQALRLLGSIDAPVLVALHGAVAGAGLSLAAAADLAIAAEGTKFNLAYINIATSCDLGASWSL
PRLVGLRRALEIALLGESFDARKALEIGLVNRVVAADALEAEAEALAQRLARGPTLAYGHMRRLMRASFERSFTEQLDAE
RDAFLASAATADFGEGLAAFFDRRPARFQGH

Sequences:

>Translated_271_residues
MDAYVGSVSSRSTLMKGLLVSRDGGLVRLRLDRPEALNALDVDLAQALLAACRDLADDASVRAVLLSGSGRAFAAGGDLS
QMRAAPVAAADSLITPMHQALRLLGSIDAPVLVALHGAVAGAGLSLAAAADLAIAAEGTKFNLAYINIATSCDLGASWSL
PRLVGLRRALEIALLGESFDARKALEIGLVNRVVAADALEAEAEALAQRLARGPTLAYGHMRRLMRASFERSFTEQLDAE
RDAFLASAATADFGEGLAAFFDRRPARFQGH
>Mature_271_residues
MDAYVGSVSSRSTLMKGLLVSRDGGLVRLRLDRPEALNALDVDLAQALLAACRDLADDASVRAVLLSGSGRAFAAGGDLS
QMRAAPVAAADSLITPMHQALRLLGSIDAPVLVALHGAVAGAGLSLAAAADLAIAAEGTKFNLAYINIATSCDLGASWSL
PRLVGLRRALEIALLGESFDARKALEIGLVNRVVAADALEAEAEALAQRLARGPTLAYGHMRRLMRASFERSFTEQLDAE
RDAFLASAATADFGEGLAAFFDRRPARFQGH

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=241, Percent_Identity=31.5352697095436, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI70995211, Length=180, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI45643119, Length=235, Percent_Identity=22.5531914893617, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI260275230, Length=235, Percent_Identity=22.5531914893617, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI260274832, Length=234, Percent_Identity=22.6495726495727, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI31542718, Length=253, Percent_Identity=25.296442687747, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4502327, Length=274, Percent_Identity=26.2773722627737, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI37594469, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI37594471, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI25453481, Length=220, Percent_Identity=23.6363636363636, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI51538573, Length=220, Percent_Identity=23.6363636363636, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4757966, Length=220, Percent_Identity=23.6363636363636, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI51538581, Length=220, Percent_Identity=23.6363636363636, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4757968, Length=220, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI49355787, Length=220, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787660, Length=262, Percent_Identity=35.4961832061069, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787659, Length=256, Percent_Identity=34.375, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI221142681, Length=263, Percent_Identity=29.6577946768061, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082183, Length=243, Percent_Identity=26.3374485596708, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=26.2948207171315, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788682, Length=186, Percent_Identity=29.5698924731183, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790281, Length=194, Percent_Identity=27.319587628866, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=240, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17554946, Length=266, Percent_Identity=31.203007518797, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17535521, Length=254, Percent_Identity=22.0472440944882, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17534483, Length=199, Percent_Identity=29.6482412060301, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=276, Percent_Identity=25.3623188405797, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=250, Percent_Identity=25.6, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540714, Length=213, Percent_Identity=26.7605633802817, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=260, Percent_Identity=21.5384615384615, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=183, Percent_Identity=28.9617486338798, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=216, Percent_Identity=24.0740740740741, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=193, Percent_Identity=26.4248704663212, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129971, Length=242, Percent_Identity=31.8181818181818, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24653477, Length=242, Percent_Identity=31.8181818181818, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24654903, Length=253, Percent_Identity=24.5059288537549, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19920382, Length=260, Percent_Identity=28.4615384615385, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922422, Length=252, Percent_Identity=21.8253968253968, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357171, Length=249, Percent_Identity=28.9156626506024, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653139, Length=267, Percent_Identity=28.8389513108614, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24650670, Length=215, Percent_Identity=28.3720930232558, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR011968 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28339; Mature: 28339

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAYVGSVSSRSTLMKGLLVSRDGGLVRLRLDRPEALNALDVDLAQALLAACRDLADDAS
CCCCCCCCCHHHHHHHHHHEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VRAVLLSGSGRAFAAGGDLSQMRAAPVAAADSLITPMHQALRLLGSIDAPVLVALHGAVA
EEEEEEECCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GAGLSLAAAADLAIAAEGTKFNLAYINIATSCDLGASWSLPRLVGLRRALEIALLGESFD
CCCCHHHHHHCEEEEECCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHEECCCCC
ARKALEIGLVNRVVAADALEAEAEALAQRLARGPTLAYGHMRRLMRASFERSFTEQLDAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
RDAFLASAATADFGEGLAAFFDRRPARFQGH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDAYVGSVSSRSTLMKGLLVSRDGGLVRLRLDRPEALNALDVDLAQALLAACRDLADDAS
CCCCCCCCCHHHHHHHHHHEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VRAVLLSGSGRAFAAGGDLSQMRAAPVAAADSLITPMHQALRLLGSIDAPVLVALHGAVA
EEEEEEECCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GAGLSLAAAADLAIAAEGTKFNLAYINIATSCDLGASWSLPRLVGLRRALEIALLGESFD
CCCCHHHHHHCEEEEECCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHEECCCCC
ARKALEIGLVNRVVAADALEAEAEALAQRLARGPTLAYGHMRRLMRASFERSFTEQLDAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
RDAFLASAATADFGEGLAAFFDRRPARFQGH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]