Click here to switch to the map view.

The map label for this gene is hisA

Identifier: 124266028

GI number: 124266028

Start: 874819

End: 875565

Strand: Direct

Name: hisA

Synonym: Mpe_A0835

Alternate gene names: 124266028

Gene position: 874819-875565 (Clockwise)

Preceding gene: 124266027

Following gene: 124266029

Centisome position: 21.63

GC content: 68.14

Gene sequence:

>747_bases
ATGTTGCTGATCCCTGCCATCGACCTGAAAGACGGCCGCTGCGTGCGCCTGAAGCAAGGCGACATGAATGTGTCCACCAC
CTTCGGTGAGGACCCCGTCGCGATGGCCCGGCGCTGGCTCGACGCCGGGGCGCGCCGCCTGCACCTGGTCGACCTGAACG
GCGCCTTCGCCGGCAAGCCGGTCAACGAGCCGGCGATCAAGGCCATCCTGAAGGAAGTGGGCGACGAGATCCCGGTGCAA
CTGGGCGGCGGCATCCGTGACCTCGACACCATCGAGCGCTACCTCGACGACGGCCTGTCCTACGTGATCATCGGCACCGC
CGCGGTCAAGAACCCGGGCTTCCTGCGCGATGCCTGCACGGCCTTCGGCGGCCACATCATCGTGGGGCTCGATGCCAAGG
ACGGCAAGGTCGCGACCGACGGCTGGAGCAAGCTGACCGGCCACGAGGTGGTGGACCTGGCGAAGAAGTTCGAGGACTAC
GGCGTCGAGGGCGTGATCTACACCGACATCGGCCGCGACGGCATGCTGAGCGGCATCAACATCGACGCCACCGTCAAGCT
GGCGCAGGCACTCACCATCCCGGTGATCGCCTCGGGGGGCCTCAGCGACATCGCCGACATCGAGCGCCTGTGCGCCGTCG
AAGGCGAGGGCATCGAGGGTGTGATCTGCGGTCGGGCGATCTACACCGGCGACCTCGACTTCGCCGCGGCGCAGGCGCGG
GCCGACGCGCTGAACGGCGACGCCTGA

Upstream 100 bases:

>100_bases
TGCCACCCAGTTCCACCCCGAGAAGAGCGCTGCACACGGCCTGGCCCTGTACCGCAACTTCCTCGGCTGGTGCCCCTGAC
CCCCCATCCCCCTGACAGCC

Downstream 100 bases:

>100_bases
GCGGCGCCCCCGCATGCTCGCCAAGCGCATCATCCCCTGCCTCGACGTCACCGGCGGCCGCGTCGTCAAGGGCGTCAACT
TCGTCGAGTTGCGTGATGCC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLLIPAIDLKDGRCVRLKQGDMNVSTTFGEDPVAMARRWLDAGARRLHLVDLNGAFAGKPVNEPAIKAILKEVGDEIPVQ
LGGGIRDLDTIERYLDDGLSYVIIGTAAVKNPGFLRDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKKFEDY
GVEGVIYTDIGRDGMLSGINIDATVKLAQALTIPVIASGGLSDIADIERLCAVEGEGIEGVICGRAIYTGDLDFAAAQAR
ADALNGDA

Sequences:

>Translated_248_residues
MLLIPAIDLKDGRCVRLKQGDMNVSTTFGEDPVAMARRWLDAGARRLHLVDLNGAFAGKPVNEPAIKAILKEVGDEIPVQ
LGGGIRDLDTIERYLDDGLSYVIIGTAAVKNPGFLRDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKKFEDY
GVEGVIYTDIGRDGMLSGINIDATVKLAQALTIPVIASGGLSDIADIERLCAVEGEGIEGVICGRAIYTGDLDFAAAQAR
ADALNGDA
>Mature_248_residues
MLLIPAIDLKDGRCVRLKQGDMNVSTTFGEDPVAMARRWLDAGARRLHLVDLNGAFAGKPVNEPAIKAILKEVGDEIPVQ
LGGGIRDLDTIERYLDDGLSYVIIGTAAVKNPGFLRDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKKFEDY
GVEGVIYTDIGRDGMLSGINIDATVKLAQALTIPVIASGGLSDIADIERLCAVEGEGIEGVICGRAIYTGDLDFAAAQAR
ADALNGDA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=34.2857142857143, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1788336, Length=209, Percent_Identity=24.8803827751196, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_METPP (A2SE08)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001020032.1
- ProteinModelPortal:   A2SE08
- STRING:   A2SE08
- GeneID:   4786970
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0835
- NMPDR:   fig|279263.3.peg.2040
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   A2SE08
- ProtClustDB:   PRK00748
- BioCyc:   MPET420662:MPE_A0835-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26107; Mature: 26107

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGRCVRLKQGDMNVSTTFGEDPVAMARRWLDAGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
VNEPAIKAILKEVGDEIPVQLGGGIRDLDTIERYLDDGLSYVIIGTAAVKNPGFLRDACT
CCCHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKKFEDYGVEGVIYTDIGRDGMLSGIN
HCCCEEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
IDATVKLAQALTIPVIASGGLSDIADIERLCAVEGEGIEGVICGRAIYTGDLDFAAAQAR
CCHHEEEHHHEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCHHHHHHH
ADALNGDA
HHCCCCCC
>Mature Secondary Structure
MLLIPAIDLKDGRCVRLKQGDMNVSTTFGEDPVAMARRWLDAGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
VNEPAIKAILKEVGDEIPVQLGGGIRDLDTIERYLDDGLSYVIIGTAAVKNPGFLRDACT
CCCHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKKFEDYGVEGVIYTDIGRDGMLSGIN
HCCCEEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
IDATVKLAQALTIPVIASGGLSDIADIERLCAVEGEGIEGVICGRAIYTGDLDFAAAQAR
CCHHEEEHHHEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCHHHHHHH
ADALNGDA
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA