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The map label for this gene is xdhB [H]

Identifier: 124265992

GI number: 124265992

Start: 835862

End: 837409

Strand: Reverse

Name: xdhB [H]

Synonym: Mpe_A0799

Alternate gene names: 124265992

Gene position: 837409-835862 (Counterclockwise)

Preceding gene: 124266004

Following gene: 124265991

Centisome position: 20.71

GC content: 73.84

Gene sequence:

>1548_bases
ATGAGCCTGCCAGCCGTTCGCTTCTTCCACCGAGGCCGCGTCGTCGCGGTCGAGGGCGCATCGCCGACACGCAGCGTGCT
GAACTGGCTGCGCGAGGACGCCCGCTGCACCGGCAGCAAGGAGGGCTGCAACGAGGGCGACTGCGGCGCCTGCACCGTGG
TCGTCGCCGAGCTGGCCGAGCATGCCGATGCGGTGGGCACGACCTCGGCGCGCGCCACCGTGGTCGGCGGCCTGAGCCTG
CGCACGGTGAACAGCTGCATCCAGTTCCTGCCCACGCTGCACGGCAAGGCGCTGCTGACGGTGGAGGATCTGCAGGCGAT
CGCCCAGGGCATGGCCGTCGCGGACCCCGGCGTGGGCACGCTGCACCCGGTGCAGCAGGCGCTGGTCGACTGCCACGGCT
CGCAGTGCGGCTTCTGCACGCCGGGCTTCGCGATGTCGCTCGCGGCCTGCTACGAGCGCCACTGCGAGGCCGGCTCGCAG
CCGACGCGCGCCGAGCTGGCCGACGAGCTGTCGGGCAACCTGTGCCGCTGCACCGGCTACCGCCCCATCCTCGACGCCGG
CGAGCGCATGTTCACGCTGCCGCCGAAGCGGCTGGACACCGCGCCCATCGTCGCGGCGCTGCGCTCCCTGCAAGGGCAGC
AGCCCGGCGACGCCACCGCCGAGCCGGCCGCCGGCTTCCACACCCCGCGCACACTGGCCGCGCTGGCGGCGCTGGTCGAG
AGCCGCCCGCAGGCACGGCTGCTGGCCGGCAGCACCGACATCGGGCTGTGGGTCAACAAGCAGTTCCGTGCGCTCGGCGA
GATCGTCTACCTCGGCGACGTCGACGAGCTCAAGCGCATCGAGTGGCAGGGCGACACGCTGCGCATCGGCGCCGGCGCGC
CGCTCGAGGACGCGTGGCGCGCGCTGGTCGGCGTCGCGCCGGCACTCGCCGAGGTGTGGCGCCGCTTCGCGTCGCTGCCG
GTGCGCAACGCCGGCACGATGGGCGGCAACGTCGCCAACGGCTCGCCGATCGGCGACAGCGCACCGGTGCTGCTGGCGCT
CGATGCCGCACTGCTGCTGCGCCGCGGCGCGCAGCAGCGCCGCCTGCCACTCGCCGATTTCTACGTCGACTACATGAAGA
ACCGGCTCGCGCCGGGCGAGTTCATCGAGGCGATCGAGCTGCCGCGCCCGGCCGCCTCGACGCAGGTACGGGCCTACAAG
CTCAGCAAGCGCTTCGACTGCGACATCTCGGCGGTGTGCGCCGGCCTCGCCCTCACGCTCGACGGCGAGACGGTGGTGCA
GGCGCGCTTCGCGTTCGGCGGCATGGCGGCCATCGTCAAGCGGGCCGCGGCGGCGGAGGCCGCTGTCGTCGGCCAGCCCT
GGACCGAGGCCACGGTGCAGGCGGCGATGGCCGCGCTCGCCACCGACTACGCGCCGCTGACCGACATGCGGGCGTCGGCC
GGCTACCGCCTGCGCGCGTCGCAGAACCTGCTGATGCGGCTGTGGCTGGAGACGCGGCCGGTTGCGCCGCTGCCGACCTC
GCAGACCAACGTGTGGGCGGCCGCTTGA

Upstream 100 bases:

>100_bases
CTGGCATCGTATTCGCATGGGGTCGGCGTGGAGTACCTTCGGCCCGAACCGCAAGATTCGTCAGACCGCGCCCCGCCCGC
CGCTCCCCCAACGCCACGCA

Downstream 100 bases:

>100_bases
GTCGGACCGTACTGCGTCCATGAGCCTTTTTTCGATGCCTGATCCTGTCGTTCCTGTCGGGCGCGCGCGGGGCCATGGGC
GGGTGAGCGTCATCGCTTGG

Product: putative xanthine dehydrogenase (subunit A) oxidoreductase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MSLPAVRFFHRGRVVAVEGASPTRSVLNWLREDARCTGSKEGCNEGDCGACTVVVAELAEHADAVGTTSARATVVGGLSL
RTVNSCIQFLPTLHGKALLTVEDLQAIAQGMAVADPGVGTLHPVQQALVDCHGSQCGFCTPGFAMSLAACYERHCEAGSQ
PTRAELADELSGNLCRCTGYRPILDAGERMFTLPPKRLDTAPIVAALRSLQGQQPGDATAEPAAGFHTPRTLAALAALVE
SRPQARLLAGSTDIGLWVNKQFRALGEIVYLGDVDELKRIEWQGDTLRIGAGAPLEDAWRALVGVAPALAEVWRRFASLP
VRNAGTMGGNVANGSPIGDSAPVLLALDAALLLRRGAQQRRLPLADFYVDYMKNRLAPGEFIEAIELPRPAASTQVRAYK
LSKRFDCDISAVCAGLALTLDGETVVQARFAFGGMAAIVKRAAAAEAAVVGQPWTEATVQAAMAALATDYAPLTDMRASA
GYRLRASQNLLMRLWLETRPVAPLPTSQTNVWAAA

Sequences:

>Translated_515_residues
MSLPAVRFFHRGRVVAVEGASPTRSVLNWLREDARCTGSKEGCNEGDCGACTVVVAELAEHADAVGTTSARATVVGGLSL
RTVNSCIQFLPTLHGKALLTVEDLQAIAQGMAVADPGVGTLHPVQQALVDCHGSQCGFCTPGFAMSLAACYERHCEAGSQ
PTRAELADELSGNLCRCTGYRPILDAGERMFTLPPKRLDTAPIVAALRSLQGQQPGDATAEPAAGFHTPRTLAALAALVE
SRPQARLLAGSTDIGLWVNKQFRALGEIVYLGDVDELKRIEWQGDTLRIGAGAPLEDAWRALVGVAPALAEVWRRFASLP
VRNAGTMGGNVANGSPIGDSAPVLLALDAALLLRRGAQQRRLPLADFYVDYMKNRLAPGEFIEAIELPRPAASTQVRAYK
LSKRFDCDISAVCAGLALTLDGETVVQARFAFGGMAAIVKRAAAAEAAVVGQPWTEATVQAAMAALATDYAPLTDMRASA
GYRLRASQNLLMRLWLETRPVAPLPTSQTNVWAAA
>Mature_514_residues
SLPAVRFFHRGRVVAVEGASPTRSVLNWLREDARCTGSKEGCNEGDCGACTVVVAELAEHADAVGTTSARATVVGGLSLR
TVNSCIQFLPTLHGKALLTVEDLQAIAQGMAVADPGVGTLHPVQQALVDCHGSQCGFCTPGFAMSLAACYERHCEAGSQP
TRAELADELSGNLCRCTGYRPILDAGERMFTLPPKRLDTAPIVAALRSLQGQQPGDATAEPAAGFHTPRTLAALAALVES
RPQARLLAGSTDIGLWVNKQFRALGEIVYLGDVDELKRIEWQGDTLRIGAGAPLEDAWRALVGVAPALAEVWRRFASLPV
RNAGTMGGNVANGSPIGDSAPVLLALDAALLLRRGAQQRRLPLADFYVDYMKNRLAPGEFIEAIELPRPAASTQVRAYKL
SKRFDCDISAVCAGLALTLDGETVVQARFAFGGMAAIVKRAAAAEAAVVGQPWTEATVQAAMAALATDYAPLTDMRASAG
YRLRASQNLLMRLWLETRPVAPLPTSQTNVWAAA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=553, Percent_Identity=29.2947558770344, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI71773480, Length=519, Percent_Identity=26.0115606936416, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI1789231, Length=282, Percent_Identity=30.1418439716312, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786480, Length=175, Percent_Identity=29.7142857142857, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789232, Length=167, Percent_Identity=33.5329341317365, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540638, Length=556, Percent_Identity=25, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566215, Length=189, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17539860, Length=187, Percent_Identity=34.7593582887701, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17737937, Length=526, Percent_Identity=30.0380228136882, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24647201, Length=518, Percent_Identity=26.6409266409266, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24647199, Length=516, Percent_Identity=27.5193798449612, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24647197, Length=529, Percent_Identity=26.8431001890359, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24647195, Length=351, Percent_Identity=29.0598290598291, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24647193, Length=512, Percent_Identity=27.34375, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 54533; Mature: 54402

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPAVRFFHRGRVVAVEGASPTRSVLNWLREDARCTGSKEGCNEGDCGACTVVVAELAE
CCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
HADAVGTTSARATVVGGLSLRTVNSCIQFLPTLHGKALLTVEDLQAIAQGMAVADPGVGT
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCEECCCCCCC
LHPVQQALVDCHGSQCGFCTPGFAMSLAACYERHCEAGSQPTRAELADELSGNLCRCTGY
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCC
RPILDAGERMFTLPPKRLDTAPIVAALRSLQGQQPGDATAEPAAGFHTPRTLAALAALVE
CHHHHCCCEEEECCCHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
SRPQARLLAGSTDIGLWVNKQFRALGEIVYLGDVDELKRIEWQGDTLRIGAGAPLEDAWR
CCCCCEEEECCCCCEEEECHHHHHHCCEEEECCHHHHHHHEECCCEEEECCCCCHHHHHH
ALVGVAPALAEVWRRFASLPVRNAGTMGGNVANGSPIGDSAPVLLALDAALLLRRGAQQR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHH
RLPLADFYVDYMKNRLAPGEFIEAIELPRPAASTQVRAYKLSKRFDCDISAVCAGLALTL
CCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHCCEEEEE
DGETVVQARFAFGGMAAIVKRAAAAEAAVVGQPWTEATVQAAMAALATDYAPLTDMRASA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCC
GYRLRASQNLLMRLWLETRPVAPLPTSQTNVWAAA
CEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEECC
>Mature Secondary Structure 
SLPAVRFFHRGRVVAVEGASPTRSVLNWLREDARCTGSKEGCNEGDCGACTVVVAELAE
CCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
HADAVGTTSARATVVGGLSLRTVNSCIQFLPTLHGKALLTVEDLQAIAQGMAVADPGVGT
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCEECCCCCCC
LHPVQQALVDCHGSQCGFCTPGFAMSLAACYERHCEAGSQPTRAELADELSGNLCRCTGY
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCC
RPILDAGERMFTLPPKRLDTAPIVAALRSLQGQQPGDATAEPAAGFHTPRTLAALAALVE
CHHHHCCCEEEECCCHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
SRPQARLLAGSTDIGLWVNKQFRALGEIVYLGDVDELKRIEWQGDTLRIGAGAPLEDAWR
CCCCCEEEECCCCCEEEECHHHHHHCCEEEECCHHHHHHHEECCCEEEECCCCCHHHHHH
ALVGVAPALAEVWRRFASLPVRNAGTMGGNVANGSPIGDSAPVLLALDAALLLRRGAQQR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHH
RLPLADFYVDYMKNRLAPGEFIEAIELPRPAASTQVRAYKLSKRFDCDISAVCAGLALTL
CCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHCCEEEEE
DGETVVQARFAFGGMAAIVKRAAAAEAAVVGQPWTEATVQAAMAALATDYAPLTDMRASA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCC
GYRLRASQNLLMRLWLETRPVAPLPTSQTNVWAAA
CEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]