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The map label for this gene is atzB [H]

Identifier: 124265975

GI number: 124265975

Start: 817660

End: 819042

Strand: Direct

Name: atzB [H]

Synonym: Mpe_A0782

Alternate gene names: 124265975

Gene position: 817660-819042 (Clockwise)

Preceding gene: 124265974

Following gene: 124265976

Centisome position: 20.22

GC content: 72.38

Gene sequence:

>1383_bases
ATGCCCACGCTGCTGATCCACAACGCCCGCCTCGTCGTCACGATGGACGAGCAGCGCCGCGAGATCGCCGACGGCAGCGT
GTTCATCCGCGACCACGTGATCGAGGCGGTCGGTCCGGCGGCCGAACTGCCAGGCACCGCCGACGAGGTGATCGATGCCC
GTGACCACGTCGTCCTGCCCGGGCTGATCAACACCCACCACCACATGACCCAGTCCTTGACGCGCGTGATCGCGCAGGAC
TGCGAGCTGTTCGACTGGCTGGGGACGCTCTACCCGATCTGGGCCGGGCTCACGCCCGAGATGGTGCGGGTGTCGACGCA
GACCGCGATGGCCGAGCTGCTGCTGGCGGGCTGCACGACCAGCAGCGACCATCTCTATCTCTACCCCAACGGGGTGATGC
TCGACGACAGCATCGAGGCGGCCACGGAGATCGGCATGCGCTTCCACGCGGCGCGCGGCTCGATGAGCGTGGGCCAGAGC
CAGGGCGGCCTGCCACCCGACCGCGTGGTGGAGGCCGAGCCGGCGATCCTGAAGGAGACGCAGCGGCTGATCGAGCGCTG
GCACGACCCGGCGCGCTTCGCGATGCGGCGCATCGTCGTCGCGCCGTGCTCGCCGTTCTCGGTGAGCCGCACGCTGATGC
GCGAGTCGGCGGCGCTGGCACGCAGCTTCGGCGCGGACCACCGCGTCTCGCTGCACACCCACCTGGCCGAGAACGACAAG
GACATCGACTACTCGCGCGAGAAGTTCGGCATGACGCCGGCCGAGTACGCCGAGGACCTGGGCTGGGTCGGCCGCGACGT
GTGGCATGCGCACTGCGTCAAACTCGACGCGCCCGGCATCGGCCTGTTCGCGCGCACCGGCACCGGCGTGGCGCATTGCC
CCTGCTCGAACATGCGGCTGGCCTCCGGCATCGCACCGGTGCGCGCGATGCGCGACGCCGGCGTGCCGGTGGGCCTGGGC
GTGGATGGCTCGGCCTCGAACGACGGCGGCCACCTGCTGGCCGAGGCGCGCATGGCGATGCTGCTGCAGCGCGTGGCGCA
CGGCCCCGAGCGCGGGCCATCGGCGATGGGCGCGCGCGAGGCTCTCGAGCTGGCCACGCGCGGCGGCGCCGCGGTGCTGA
ACCGCGACGACATCGGCGTGCTCGCACCCGGCATGGCGGCCGACCTGGCGATCTTCGGGCTCGACGACGTGGGCCTGGCC
GGCGCGCTGCACGACCCGCTGGCCGCGTTGCTGTTCTGCCAGCCGCCGCGCGCTCGCCACACCCTCGTGCACGGCCGCGT
GGTGGTGCGCGACTGCGAGCTGACCACGCTGGAACTGCCGGCCCTGGTGCGGCGGCACAACCGGCTGGCGCGGCAACTCG
TCGATGGAGCCGGCCGCGCCTGA

Upstream 100 bases:

>100_bases
CAAGCTCGTGGTGCTCCGCCAGCCCCAACTGTCTCTGCCTCGTCGGCCGCTCGCCGCCCCGCATGAACCTCTCGCGCACG
CGACCTACGAAAGCAAGCCC

Downstream 100 bases:

>100_bases
GCGGCTCGGCCGCCGACCGCCGCGCAGCGCGGCGTTTCCCCGCATTGGCGCCCTGTCGAACATTGATATGCTAGTGACAT
ATCAAACGCTCGAAGGAGAC

Product: hydroxydechloroatrazine ethylaminohydrolase

Products: NA

Alternate protein names: Hydroxyatrazine hydrolase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MPTLLIHNARLVVTMDEQRREIADGSVFIRDHVIEAVGPAAELPGTADEVIDARDHVVLPGLINTHHHMTQSLTRVIAQD
CELFDWLGTLYPIWAGLTPEMVRVSTQTAMAELLLAGCTTSSDHLYLYPNGVMLDDSIEAATEIGMRFHAARGSMSVGQS
QGGLPPDRVVEAEPAILKETQRLIERWHDPARFAMRRIVVAPCSPFSVSRTLMRESAALARSFGADHRVSLHTHLAENDK
DIDYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAPGIGLFARTGTGVAHCPCSNMRLASGIAPVRAMRDAGVPVGLG
VDGSASNDGGHLLAEARMAMLLQRVAHGPERGPSAMGAREALELATRGGAAVLNRDDIGVLAPGMAADLAIFGLDDVGLA
GALHDPLAALLFCQPPRARHTLVHGRVVVRDCELTTLELPALVRRHNRLARQLVDGAGRA

Sequences:

>Translated_460_residues
MPTLLIHNARLVVTMDEQRREIADGSVFIRDHVIEAVGPAAELPGTADEVIDARDHVVLPGLINTHHHMTQSLTRVIAQD
CELFDWLGTLYPIWAGLTPEMVRVSTQTAMAELLLAGCTTSSDHLYLYPNGVMLDDSIEAATEIGMRFHAARGSMSVGQS
QGGLPPDRVVEAEPAILKETQRLIERWHDPARFAMRRIVVAPCSPFSVSRTLMRESAALARSFGADHRVSLHTHLAENDK
DIDYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAPGIGLFARTGTGVAHCPCSNMRLASGIAPVRAMRDAGVPVGLG
VDGSASNDGGHLLAEARMAMLLQRVAHGPERGPSAMGAREALELATRGGAAVLNRDDIGVLAPGMAADLAIFGLDDVGLA
GALHDPLAALLFCQPPRARHTLVHGRVVVRDCELTTLELPALVRRHNRLARQLVDGAGRA
>Mature_459_residues
PTLLIHNARLVVTMDEQRREIADGSVFIRDHVIEAVGPAAELPGTADEVIDARDHVVLPGLINTHHHMTQSLTRVIAQDC
ELFDWLGTLYPIWAGLTPEMVRVSTQTAMAELLLAGCTTSSDHLYLYPNGVMLDDSIEAATEIGMRFHAARGSMSVGQSQ
GGLPPDRVVEAEPAILKETQRLIERWHDPARFAMRRIVVAPCSPFSVSRTLMRESAALARSFGADHRVSLHTHLAENDKD
IDYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAPGIGLFARTGTGVAHCPCSNMRLASGIAPVRAMRDAGVPVGLGV
DGSASNDGGHLLAEARMAMLLQRVAHGPERGPSAMGAREALELATRGGAAVLNRDDIGVLAPGMAADLAIFGLDDVGLAG
ALHDPLAALLFCQPPRARHTLVHGRVVVRDCELTTLELPALVRRHNRLARQLVDGAGRA

Specific function: Catalyzes the deamination reaction of hydroxyatrazine to N-isopropylammelide (dihydroxy-isopropyl-atrazine). The enzyme is also capable of catalyzing some dechlorinating reactions [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=342, Percent_Identity=23.9766081871345, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1789249, Length=388, Percent_Identity=28.8659793814433, Blast_Score=118, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6319963, Length=346, Percent_Identity=26.3005780346821, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24643849, Length=361, Percent_Identity=24.9307479224377, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.99.3 [H]

Molecular weight: Translated: 49584; Mature: 49453

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLLIHNARLVVTMDEQRREIADGSVFIRDHVIEAVGPAAELPGTADEVIDARDHVVLP
CCCEEEECCEEEEEECHHHHHHCCCCEEHHHHHHHHHCCHHHCCCCHHHHHCCCCCEEEC
GLINTHHHMTQSLTRVIAQDCELFDWLGTLYPIWAGLTPEMVRVSTQTAMAELLLAGCTT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
SSDHLYLYPNGVMLDDSIEAATEIGMRFHAARGSMSVGQSQGGLPPDRVVEAEPAILKET
CCCEEEECCCCEEECCHHHHHHHHHHHHEECCCCCCCCCCCCCCCHHHEECCCCHHHHHH
QRLIERWHDPARFAMRRIVVAPCSPFSVSRTLMRESAALARSFGADHRVSLHTHLAENDK
HHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCC
DIDYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAPGIGLFARTGTGVAHCPCSNMRL
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCEEECCCCCCCH
ASGIAPVRAMRDAGVPVGLGVDGSASNDGGHLLAEARMAMLLQRVAHGPERGPSAMGARE
HHCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ALELATRGGAAVLNRDDIGVLAPGMAADLAIFGLDDVGLAGALHDPLAALLFCQPPRARH
HHHHHHCCCCEEECCCCCCEECCCHHHCEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHH
TLVHGRVVVRDCELTTLELPALVRRHNRLARQLVDGAGRA
EEEECEEEEEECCEEEEHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PTLLIHNARLVVTMDEQRREIADGSVFIRDHVIEAVGPAAELPGTADEVIDARDHVVLP
CCEEEECCEEEEEECHHHHHHCCCCEEHHHHHHHHHCCHHHCCCCHHHHHCCCCCEEEC
GLINTHHHMTQSLTRVIAQDCELFDWLGTLYPIWAGLTPEMVRVSTQTAMAELLLAGCTT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
SSDHLYLYPNGVMLDDSIEAATEIGMRFHAARGSMSVGQSQGGLPPDRVVEAEPAILKET
CCCEEEECCCCEEECCHHHHHHHHHHHHEECCCCCCCCCCCCCCCHHHEECCCCHHHHHH
QRLIERWHDPARFAMRRIVVAPCSPFSVSRTLMRESAALARSFGADHRVSLHTHLAENDK
HHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCC
DIDYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAPGIGLFARTGTGVAHCPCSNMRL
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCEEECCCCCCCH
ASGIAPVRAMRDAGVPVGLGVDGSASNDGGHLLAEARMAMLLQRVAHGPERGPSAMGARE
HHCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ALELATRGGAAVLNRDDIGVLAPGMAADLAIFGLDDVGLAGALHDPLAALLFCQPPRARH
HHHHHHCCCCEEECCCCCCEECCCHHHCEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHH
TLVHGRVVVRDCELTTLELPALVRRHNRLARQLVDGAGRA
EEEECEEEEEECCEEEEHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9055410 [H]