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The map label for this gene is ureC

Identifier: 124265860

GI number: 124265860

Start: 703369

End: 705096

Strand: Reverse

Name: ureC

Synonym: Mpe_A0667

Alternate gene names: 124265860

Gene position: 705096-703369 (Counterclockwise)

Preceding gene: 124265861

Following gene: 124265858

Centisome position: 17.43

GC content: 69.68

Gene sequence:

>1728_bases
ATGGCCACCATCGGACGCCGCGCCTACGCGGAGATGTACGGACCGACGGTGGGCGACCGCGTGCGGCTGGCCGACACCGA
ACTCGTTATCGAGGTCGAGGCCGACTACACGTTGCGCGCCGGCGGCTACGGAGAAGAAGTGAAGTTCGGTGGCGGCAAGG
TCATCCGCGACGGCATGGGCCAGAGCCAGCGGCCCAACGGCCCCGGGCCGCACGACGCGGTGGACTGCGTGGTGACCAAT
GCGCTGATCCTCGACCACTGGGGCATCGTGAAGGCCGACATCGGCCTGCGCGGCCAGCGCATCGCCGCGATCGGCAAGGC
CGGCAACCCGGACGTGCAGCCGGGCATCGACATCGTCATCGGCCCGGGCACCGAGGTGATCGCAGGCGAGGGCCTGATCG
TGACCGCCGGCGGCATCGACTGCCACATCCACTTCATCTGCCCGCAGCAGATCGAGGAGGCGCTCTCCAGCGGCGTGACC
ACCATGCTCGGCGGCGGCACCGGGCCGGCCACCGGCACCTTCGCGACCACCTGCACGCCGGGGCCGGAGAACATCGCCAA
CATGCTGCGGGCGGCCGACGCCTTCCCGATGAACCTGGGCTTCTTCGGCAAGGGCAACGCGAGCCGCCCCGAGGCACTGC
GCCAGCAGGTCGAGGCCGGTGTGATCGGCCTCAAGCTGCACGAGGACTGGGGCACGACGCCGGCCGCGATCGACTGCTGC
CTGTCGGTGGCCGACGAGGGCGACGTGCAGGTGGCGATCCACAGCGACACGCTGAACGAGTCGGGCTTCGTCGAGGACAC
CATCGGCGCGACCAAGGGCCGCACGCTGTGCGCCTTCCACACCGAGGGCGCCGGCGGCGGCCACGCGCCCGACATCCTGC
GCGTGGTGGGCGAAGCGAACTTCCTGCCGTCCTCCACCAACCCGACGATGCCCTACACCGTCAACACGCTCGACGAGCAT
GTCGACATGCTGATGGTCTGCCACCACCTCGACGCGGCGATCGCCGAGGACCTGGCCTTCGCCGAGAGCCGCATCCGCCG
CGAGACCATCGCGGCCGAGGACATCCTGCACGACCTGGGCGCGATCAGCATGTTCAGCTCGGACTCGCAGGCCATGGGTC
GCGTCGGCGAGGTGGTGCTGCGCTGCTGGCAGACCGCGCACAAGATGAAGGTCCAGCGCGGCAAGCTGCCGGGCGACCCG
GAGCGCCACGACAACGGCCGCGCCAAACGCTACGTGGCCAAGTACACGATCAACCCGGCCATCGCACACGGCGTCAGCCA
CGAGGTCGGCAGCATCGAGGTCGGCAAGTGGGCCGACCTGGTGTTCTGGCGGCCGGCCTTCTTCGGCGTGAAGCCTTCGC
TGGTGATGAAGGGCGGCTTCATCGCGTCGGCGCTGATGGGCGATGCCAACGCCAGCATCCCGACGCCGCAGCCGGTGCAC
TACCGGCCGATGTTCGGTGCCTTCGGTGGCGCGCTCACGCGCGGTTCGCTCAGCTTCGTGAGCCAGGCCGCGCTGGCCTC
GGAGGTGGGCAGCGTGTACGGCCTGCGCAAGCCGCTCTCGGCGGTGAAGCAGTGCCGCACCGTCAAGAAGGGCGACATGG
TGCACAACGCCTACCTGCCGCGCATGGAGGTCGACGCCCAGACCTACCAGGTGCGCGCCGACGGCCAGCTGCTGACCTGC
GAGCCGGCCACCGCCCTGCCGATGACGCAGCGCTATTTCCTCTTCTGA

Upstream 100 bases:

>100_bases
CGCTTCGAGCCCGGCCAGCAGCGCACTGTCGAGCTGGTCGACTACGCCGGCGACCGCACGGTCTACGGCTTCCGCGGCCT
CGTGCAAGGAAAGCTCTGAC

Downstream 100 bases:

>100_bases
TCCGCGGGCCCCGGCGGGGCCCCGGGCGGCAGACCCTCCTGTGTGGCGCGCGCCATCAGGGCCCGGCAGTCGCGGTCCTC
GCCGGGGCCGGTCTCGATCA

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MATIGRRAYAEMYGPTVGDRVRLADTELVIEVEADYTLRAGGYGEEVKFGGGKVIRDGMGQSQRPNGPGPHDAVDCVVTN
ALILDHWGIVKADIGLRGQRIAAIGKAGNPDVQPGIDIVIGPGTEVIAGEGLIVTAGGIDCHIHFICPQQIEEALSSGVT
TMLGGGTGPATGTFATTCTPGPENIANMLRAADAFPMNLGFFGKGNASRPEALRQQVEAGVIGLKLHEDWGTTPAAIDCC
LSVADEGDVQVAIHSDTLNESGFVEDTIGATKGRTLCAFHTEGAGGGHAPDILRVVGEANFLPSSTNPTMPYTVNTLDEH
VDMLMVCHHLDAAIAEDLAFAESRIRRETIAAEDILHDLGAISMFSSDSQAMGRVGEVVLRCWQTAHKMKVQRGKLPGDP
ERHDNGRAKRYVAKYTINPAIAHGVSHEVGSIEVGKWADLVFWRPAFFGVKPSLVMKGGFIASALMGDANASIPTPQPVH
YRPMFGAFGGALTRGSLSFVSQAALASEVGSVYGLRKPLSAVKQCRTVKKGDMVHNAYLPRMEVDAQTYQVRADGQLLTC
EPATALPMTQRYFLF

Sequences:

>Translated_575_residues
MATIGRRAYAEMYGPTVGDRVRLADTELVIEVEADYTLRAGGYGEEVKFGGGKVIRDGMGQSQRPNGPGPHDAVDCVVTN
ALILDHWGIVKADIGLRGQRIAAIGKAGNPDVQPGIDIVIGPGTEVIAGEGLIVTAGGIDCHIHFICPQQIEEALSSGVT
TMLGGGTGPATGTFATTCTPGPENIANMLRAADAFPMNLGFFGKGNASRPEALRQQVEAGVIGLKLHEDWGTTPAAIDCC
LSVADEGDVQVAIHSDTLNESGFVEDTIGATKGRTLCAFHTEGAGGGHAPDILRVVGEANFLPSSTNPTMPYTVNTLDEH
VDMLMVCHHLDAAIAEDLAFAESRIRRETIAAEDILHDLGAISMFSSDSQAMGRVGEVVLRCWQTAHKMKVQRGKLPGDP
ERHDNGRAKRYVAKYTINPAIAHGVSHEVGSIEVGKWADLVFWRPAFFGVKPSLVMKGGFIASALMGDANASIPTPQPVH
YRPMFGAFGGALTRGSLSFVSQAALASEVGSVYGLRKPLSAVKQCRTVKKGDMVHNAYLPRMEVDAQTYQVRADGQLLTC
EPATALPMTQRYFLF
>Mature_574_residues
ATIGRRAYAEMYGPTVGDRVRLADTELVIEVEADYTLRAGGYGEEVKFGGGKVIRDGMGQSQRPNGPGPHDAVDCVVTNA
LILDHWGIVKADIGLRGQRIAAIGKAGNPDVQPGIDIVIGPGTEVIAGEGLIVTAGGIDCHIHFICPQQIEEALSSGVTT
MLGGGTGPATGTFATTCTPGPENIANMLRAADAFPMNLGFFGKGNASRPEALRQQVEAGVIGLKLHEDWGTTPAAIDCCL
SVADEGDVQVAIHSDTLNESGFVEDTIGATKGRTLCAFHTEGAGGGHAPDILRVVGEANFLPSSTNPTMPYTVNTLDEHV
DMLMVCHHLDAAIAEDLAFAESRIRRETIAAEDILHDLGAISMFSSDSQAMGRVGEVVLRCWQTAHKMKVQRGKLPGDPE
RHDNGRAKRYVAKYTINPAIAHGVSHEVGSIEVGKWADLVFWRPAFFGVKPSLVMKGGFIASALMGDANASIPTPQPVHY
RPMFGAFGGALTRGSLSFVSQAALASEVGSVYGLRKPLSAVKQCRTVKKGDMVHNAYLPRMEVDAQTYQVRADGQLLTCE
PATALPMTQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_METPP (A2SDJ0)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019864.1
- ProteinModelPortal:   A2SDJ0
- SMR:   A2SDJ0
- STRING:   A2SDJ0
- MEROPS:   M38.982
- GeneID:   4784794
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0667
- NMPDR:   fig|279263.3.peg.3231
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   MPET420662:MPE_A0667-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61116; Mature: 60985

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 328-328 BINDING 227-227

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIGRRAYAEMYGPTVGDRVRLADTELVIEVEADYTLRAGGYGEEVKFGGGKVIRDGMG
CCCCCHHHHHHHHCCCCCCEEEEECCEEEEEEECCEEEECCCCCCEEEECCCEEEECCCC
QSQRPNGPGPHDAVDCVVTNALILDHWGIVKADIGLRGQRIAAIGKAGNPDVQPGIDIVI
CCCCCCCCCCHHHHHHHHHHHHHEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCEEEE
GPGTEVIAGEGLIVTAGGIDCHIHFICPQQIEEALSSGVTTMLGGGTGPATGTFATTCTP
CCCCCEEECCCEEEEECCCEEEEEEECHHHHHHHHHCCCEEEECCCCCCCCCCEEEECCC
GPENIANMLRAADAFPMNLGFFGKGNASRPEALRQQVEAGVIGLKLHEDWGTTPAAIDCC
CHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHCCEEEEEEECCCCCCHHHHHHH
LSVADEGDVQVAIHSDTLNESGFVEDTIGATKGRTLCAFHTEGAGGGHAPDILRVVGEAN
HHHCCCCCEEEEEECCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCC
FLPSSTNPTMPYTVNTLDEHVDMLMVCHHLDAAIAEDLAFAESRIRRETIAAEDILHDLG
CCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISMFSSDSQAMGRVGEVVLRCWQTAHKMKVQRGKLPGDPERHDNGRAKRYVAKYTINPA
HHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEEECCHH
IAHGVSHEVGSIEVGKWADLVFWRPAFFGVKPSLVMKGGFIASALMGDANASIPTPQPVH
HHHCCCCCCCCEECCCCEEEEEECHHHHCCCHHHEECCCHHHHHHHCCCCCCCCCCCCCE
YRPMFGAFGGALTRGSLSFVSQAALASEVGSVYGLRKPLSAVKQCRTVKKGDMVHNAYLP
ECCHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHCCCC
RMEVDAQTYQVRADGQLLTCEPATALPMTQRYFLF
CEEECCEEEEEEECCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATIGRRAYAEMYGPTVGDRVRLADTELVIEVEADYTLRAGGYGEEVKFGGGKVIRDGMG
CCCCHHHHHHHHCCCCCCEEEEECCEEEEEEECCEEEECCCCCCEEEECCCEEEECCCC
QSQRPNGPGPHDAVDCVVTNALILDHWGIVKADIGLRGQRIAAIGKAGNPDVQPGIDIVI
CCCCCCCCCCHHHHHHHHHHHHHEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCEEEE
GPGTEVIAGEGLIVTAGGIDCHIHFICPQQIEEALSSGVTTMLGGGTGPATGTFATTCTP
CCCCCEEECCCEEEEECCCEEEEEEECHHHHHHHHHCCCEEEECCCCCCCCCCEEEECCC
GPENIANMLRAADAFPMNLGFFGKGNASRPEALRQQVEAGVIGLKLHEDWGTTPAAIDCC
CHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHCCEEEEEEECCCCCCHHHHHHH
LSVADEGDVQVAIHSDTLNESGFVEDTIGATKGRTLCAFHTEGAGGGHAPDILRVVGEAN
HHHCCCCCEEEEEECCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCC
FLPSSTNPTMPYTVNTLDEHVDMLMVCHHLDAAIAEDLAFAESRIRRETIAAEDILHDLG
CCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISMFSSDSQAMGRVGEVVLRCWQTAHKMKVQRGKLPGDPERHDNGRAKRYVAKYTINPA
HHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEEECCHH
IAHGVSHEVGSIEVGKWADLVFWRPAFFGVKPSLVMKGGFIASALMGDANASIPTPQPVH
HHHCCCCCCCCEECCCCEEEEEECHHHHCCCHHHEECCCHHHHHHHCCCCCCCCCCCCCE
YRPMFGAFGGALTRGSLSFVSQAALASEVGSVYGLRKPLSAVKQCRTVKKGDMVHNAYLP
ECCHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHCCCC
RMEVDAQTYQVRADGQLLTCEPATALPMTQRYFLF
CEEECCEEEEEEECCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA