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The map label for this gene is fabF [H]

Identifier: 124265833

GI number: 124265833

Start: 674280

End: 675524

Strand: Direct

Name: fabF [H]

Synonym: Mpe_A0640

Alternate gene names: 124265833

Gene position: 674280-675524 (Clockwise)

Preceding gene: 124265832

Following gene: 124265834

Centisome position: 16.67

GC content: 67.15

Gene sequence:

>1245_bases
ATGAGCCGTCGTCGCGTCGTGGTGACCGGGCTCGGTCTCGTCACCCCCCTGGGCAACACGGTGGACGAGTCCTGGTCGCG
GCTCGTGGCTGGCCAGTCCGGCATCGCCACCGTCACCAAGTTCGATGCCACCAAGCTGGCCTGCCACATCGCCGGCGAGG
TGAAGGGTTTCCAGATCGAGGATTACATCCCCGCCAAGGAAGCCCGGCACATGGACACCTTCATCCACTACGGCCTCGCA
GCGTCGCTGCAGGCAGTGAAGGATGCCGGGCTGCCCACGGGCGATGCGCTGAACGAGGAGCAGGCCGAGCGCATCGGTTG
CCTCGTCGGCTCGGGCATCGGCGGCCTGCCGCTGATCGAGGAGACCCACGCGGAGTACGCGGCACGCGGGGCGCGGCGGA
TCTCGCCGTTCTTCGTGCCGGCCTCGATCATCAACATGATCTCGGGGCATCTGTCGATCCAGTGCGGCTTCACGGGGCCG
AACCTCGCGATCGTGACTGCCTGCACCACCGGCCTGCACTGCATCGGACAGTCGGCCCGCATGATCGAGGCCGGCGATGC
TGACGCGATGATCGCTGGCGGTGCCGAGTCGACCGTCTCGCCGCTCGGCATCGGTGGCTTCGCCGCGGCACGTGCGCTGT
CGACCCGCAACGACGATCCGGCCACCGCCTCGCGCCCCTGGGATCGCGACCGCGACGGCTTCGTGCTCGGCGAAGGGGCC
GGCGTGATGGTGCTCGAGGAGTACGAGCACGCCAAGGCCCGCGGCGCACGGATCTATGCGGAGCTGGCCGGCTTCGGCAT
GGGCGCGGACGCCTTCCACATGACGGCGCCCAACGTGGACGGCCCGAAGCGTGCGATGAAGGCCGCGTTGCGCAGCGCGG
GAATCGAAGCGGGTCAGGTGCAGTACCTGAACGCGCACGGCACCTCGACGCCGCTGGGCGATCTGAACGAGAGTAACGCG
ATCAAGCTGGCCTTCGGCGATCACGCGAAGAAGCTGGTGGTCAATTCCACCAAGTCGATGACCGGTCACCTGCTTGGCGG
CGCAGGCGGCATCGAATCGGTGTTCACCGTGCTCGCGATCCGCGACCAGGTGTCGCCGCCCACGATCAACATCTTCAACC
AGGATCCCGAGTGCGACCTGGACTACTGCGCGAACACTGCGCGCGAGATGAAGATCGAGCACGCCGTGAAGAACAACTTC
GGTTTCGGCGGCACCAACGGCACGCTGGTGTTCAAGCGCGTCTGA

Upstream 100 bases:

>100_bases
CGGAGAAGATCACGACTGTGCAGCTCGCGATCGACTACGCCAAGAGTCACGCCAAGGCCTGACGGCCGCGGTTTCCGTTT
CATTCGTTTCTCTACAGCGC

Downstream 100 bases:

>100_bases
CGCGCGTGCCGGCCCTGAGCATTTCCCTGAACGATGCGTGCGGCTCCCGCCGTGGCGGTGACGGCGTGTCCGGGGCTGGC
GCGAGCGGTGCTGCGACTCC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSRRRVVVTGLGLVTPLGNTVDESWSRLVAGQSGIATVTKFDATKLACHIAGEVKGFQIEDYIPAKEARHMDTFIHYGLA
ASLQAVKDAGLPTGDALNEEQAERIGCLVGSGIGGLPLIEETHAEYAARGARRISPFFVPASIINMISGHLSIQCGFTGP
NLAIVTACTTGLHCIGQSARMIEAGDADAMIAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDRDRDGFVLGEGA
GVMVLEEYEHAKARGARIYAELAGFGMGADAFHMTAPNVDGPKRAMKAALRSAGIEAGQVQYLNAHGTSTPLGDLNESNA
IKLAFGDHAKKLVVNSTKSMTGHLLGGAGGIESVFTVLAIRDQVSPPTINIFNQDPECDLDYCANTAREMKIEHAVKNNF
GFGGTNGTLVFKRV

Sequences:

>Translated_414_residues
MSRRRVVVTGLGLVTPLGNTVDESWSRLVAGQSGIATVTKFDATKLACHIAGEVKGFQIEDYIPAKEARHMDTFIHYGLA
ASLQAVKDAGLPTGDALNEEQAERIGCLVGSGIGGLPLIEETHAEYAARGARRISPFFVPASIINMISGHLSIQCGFTGP
NLAIVTACTTGLHCIGQSARMIEAGDADAMIAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDRDRDGFVLGEGA
GVMVLEEYEHAKARGARIYAELAGFGMGADAFHMTAPNVDGPKRAMKAALRSAGIEAGQVQYLNAHGTSTPLGDLNESNA
IKLAFGDHAKKLVVNSTKSMTGHLLGGAGGIESVFTVLAIRDQVSPPTINIFNQDPECDLDYCANTAREMKIEHAVKNNF
GFGGTNGTLVFKRV
>Mature_413_residues
SRRRVVVTGLGLVTPLGNTVDESWSRLVAGQSGIATVTKFDATKLACHIAGEVKGFQIEDYIPAKEARHMDTFIHYGLAA
SLQAVKDAGLPTGDALNEEQAERIGCLVGSGIGGLPLIEETHAEYAARGARRISPFFVPASIINMISGHLSIQCGFTGPN
LAIVTACTTGLHCIGQSARMIEAGDADAMIAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDRDRDGFVLGEGAG
VMVLEEYEHAKARGARIYAELAGFGMGADAFHMTAPNVDGPKRAMKAALRSAGIEAGQVQYLNAHGTSTPLGDLNESNAI
KLAFGDHAKKLVVNSTKSMTGHLLGGAGGIESVFTVLAIRDQVSPPTINIFNQDPECDLDYCANTAREMKIEHAVKNNFG
FGGTNGTLVFKRV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=46.0620525059666, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI223972627, Length=145, Percent_Identity=51.7241379310345, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI41872631, Length=437, Percent_Identity=23.3409610983982, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1787337, Length=417, Percent_Identity=58.9928057553957, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=37.43961352657, Blast_Score=244, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=35.5769230769231, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=39.2156862745098, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=361, Percent_Identity=25.7617728531856, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=285, Percent_Identity=24.9122807017544, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=36.7713004484305, Blast_Score=270, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=44.1527446300716, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI221330659, Length=379, Percent_Identity=25.065963060686, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19920632, Length=379, Percent_Identity=25.065963060686, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24581345, Length=432, Percent_Identity=21.9907407407407, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43439; Mature: 43308

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRVVVTGLGLVTPLGNTVDESWSRLVAGQSGIATVTKFDATKLACHIAGEVKGFQIE
CCCCEEEEEECHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCCCEEEE
DYIPAKEARHMDTFIHYGLAASLQAVKDAGLPTGDALNEEQAERIGCLVGSGIGGLPLIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEECCCCCCCCHH
ETHAEYAARGARRISPFFVPASIINMISGHLSIQCGFTGPNLAIVTACTTGLHCIGQSAR
HHHHHHHHCCHHHCCCEEEHHHHHHHHCCCEEEEECCCCCCEEEEEEHHHHHHHHCCCCE
MIEAGDADAMIAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDRDRDGFVLGEGA
EEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCC
GVMVLEEYEHAKARGARIYAELAGFGMGADAFHMTAPNVDGPKRAMKAALRSAGIEAGQV
CEEEEECHHHHHHCCCEEEEEHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
QYLNAHGTSTPLGDLNESNAIKLAFGDHAKKLVVNSTKSMTGHLLGGAGGIESVFTVLAI
EEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHCCEEECCCCCHHHHHHHHHH
RDQVSPPTINIFNQDPECDLDYCANTAREMKIEHAVKNNFGFGGTNGTLVFKRV
HCCCCCCEEEEECCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SRRRVVVTGLGLVTPLGNTVDESWSRLVAGQSGIATVTKFDATKLACHIAGEVKGFQIE
CCCEEEEEECHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCCCEEEE
DYIPAKEARHMDTFIHYGLAASLQAVKDAGLPTGDALNEEQAERIGCLVGSGIGGLPLIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEECCCCCCCCHH
ETHAEYAARGARRISPFFVPASIINMISGHLSIQCGFTGPNLAIVTACTTGLHCIGQSAR
HHHHHHHHCCHHHCCCEEEHHHHHHHHCCCEEEEECCCCCCEEEEEEHHHHHHHHCCCCE
MIEAGDADAMIAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDRDRDGFVLGEGA
EEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCC
GVMVLEEYEHAKARGARIYAELAGFGMGADAFHMTAPNVDGPKRAMKAALRSAGIEAGQV
CEEEEECHHHHHHCCCEEEEEHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
QYLNAHGTSTPLGDLNESNAIKLAFGDHAKKLVVNSTKSMTGHLLGGAGGIESVFTVLAI
EEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHCCEEECCCCCHHHHHHHHHH
RDQVSPPTINIFNQDPECDLDYCANTAREMKIEHAVKNNFGFGGTNGTLVFKRV
HCCCCCCEEEEECCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]