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The map label for this gene is lysS

Identifier: 124265793

GI number: 124265793

Start: 631016

End: 632542

Strand: Reverse

Name: lysS

Synonym: Mpe_A0600

Alternate gene names: 124265793

Gene position: 632542-631016 (Counterclockwise)

Preceding gene: 124265804

Following gene: 124265792

Centisome position: 15.64

GC content: 68.96

Gene sequence:

>1527_bases
ATGACCACCACGCCCCCGAACGCCGCCACGCCCGGCACCGACGACAACCAGCTGATCGCCGAACGCCGCGAGAAGCTCGC
TGCACTGCGTGCGCAGGCCCAGGCCACGGGGAGAGCCGCCTTCCCCAATGACTTCAAGCCGGGCGACCATGCCGTCGACC
TGCACCGCCTGCACGAGGGCAAGAGCGCCGAGGAGCTGGAGGCGCTGGCCATCCCGGCCCGCATCGCCGGCCGCATGATG
CTCAAGCGCGTGATGGGCAAGGCCTGCTTCGCGACGCTGCAGGACGGCTCGGGCCGCATCCAGCTCTACATCACGTCCGA
CGCCGTCGGCCCGGAGGCGCTGGCCGCCTTCAAGCACTGGGACCTGGGCGACATCCTCGGCGCCGAGGGCACGCTGTTCA
AGACCCGCACCGGCGAGCTGAGCCTCAAGGTCGGCACGATCCGGCTGCTGACCAAGAGCCTGCGGCCACTGCCCGACAAG
TTCCACGGCATGGCCGACCAGGAGCTCAAGTACCGCCAGCGCGAGGTCGACCTGATCATGGACGAGGCCTCGCGCGAGCG
CTTCCGCGCGCGCAGCAAGGCCGTGAGCTCGATCCGGCAGTTCATGGTCGAGCACGGCTTCCTCGAGGTCGAGACGCCGA
TGCTGCACCCCATCCCCGGCGGCGCGAACGCCAAGCCCTTCGTGACGCACCACAACGCGCTCGACCAGCAGATGTTCCTG
CGCATCGCGCCCGAGCTCTACCTGAAGCGGCTGGTGGTGGGCGGCTTCGAGCGGGTGTTCGAGATCAACCGCAACTTCCG
CAACGAGGGCGTGTCGGTCCGGCACAACCCCGAGTTCACGATGATGGAGTTCTACGCGGCCTACTGGACCCACCACGACC
TGATGGACTTCACCGAGCAGATCCTGCGCCACGCCGCGCGCAAGGCGGTGGGCACGGCGCAGCTCGCCTACGGTGGGCAG
GCCGTCGACCTGGAATCGCCGTTCGCGCGGCTCTCGGTGCGCGACTCGCTGATCGCCCATGCAGGATTGAGCGCGGCGGA
AGCCGCCGACACCACGGTGCTGCGCGCGAAGCTCGAAGCGCATGGCGAGAAGGCTCCGGCGCACTGGTCGCTCGCCGAAC
TGCAGTTCGGCCTGTTCGAGGCGGCCGTCGAGGAAAAGCTGTGGCAGCCGACCTTCATCGTCGACTACCCGGTGGAGGTG
TCGCCGCTGGCCCGCGCCTCCGATGCCGACCCGACGATCACCGAGCGCTTCGAGCTCTTCATCACCGGCCGCGAGTTCGG
CAACGGCTTCTCGGAGCTCAACGACCCCGAGGACCAGGCCGCGCGCTTCGCGGCCCAGGCCTCGAACAAGGACGCCGGTG
ACGAGGAGGCGATGTACTTCGACACCGACTACATCCGCGCGCTCGAGCACGGCCTGCCGCCCACCGGCGGCTGCGGCATC
GGCATCGACCGACTGATGATGCTGTTGACCGACTCGCCGAACATCCGCGACGTGATCCTGTTCCCCGCGCTGCGGCGCGA
GGGCTGA

Upstream 100 bases:

>100_bases
ACCGGTGGCCCCGGCCGGTGGCACGGAGCCAGTCTCTAAAATCCGCCGCTTGCCCGCCGCGTGCGCCCTGCCCGCGTGCC
GCCGCTCCCAGGACCACCCC

Downstream 100 bases:

>100_bases
GCCGAGCCGAACCGCGCACGCCACGGCGTCGCATCGATGCAGGGCGCCGATGCCCGCATCGATGCGGATCTTCGTCGCCT
CATCCTATGCAGTTGATCGC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MTTTPPNAATPGTDDNQLIAERREKLAALRAQAQATGRAAFPNDFKPGDHAVDLHRLHEGKSAEELEALAIPARIAGRMM
LKRVMGKACFATLQDGSGRIQLYITSDAVGPEALAAFKHWDLGDILGAEGTLFKTRTGELSLKVGTIRLLTKSLRPLPDK
FHGMADQELKYRQREVDLIMDEASRERFRARSKAVSSIRQFMVEHGFLEVETPMLHPIPGGANAKPFVTHHNALDQQMFL
RIAPELYLKRLVVGGFERVFEINRNFRNEGVSVRHNPEFTMMEFYAAYWTHHDLMDFTEQILRHAARKAVGTAQLAYGGQ
AVDLESPFARLSVRDSLIAHAGLSAAEAADTTVLRAKLEAHGEKAPAHWSLAELQFGLFEAAVEEKLWQPTFIVDYPVEV
SPLARASDADPTITERFELFITGREFGNGFSELNDPEDQAARFAAQASNKDAGDEEAMYFDTDYIRALEHGLPPTGGCGI
GIDRLMMLLTDSPNIRDVILFPALRREG

Sequences:

>Translated_508_residues
MTTTPPNAATPGTDDNQLIAERREKLAALRAQAQATGRAAFPNDFKPGDHAVDLHRLHEGKSAEELEALAIPARIAGRMM
LKRVMGKACFATLQDGSGRIQLYITSDAVGPEALAAFKHWDLGDILGAEGTLFKTRTGELSLKVGTIRLLTKSLRPLPDK
FHGMADQELKYRQREVDLIMDEASRERFRARSKAVSSIRQFMVEHGFLEVETPMLHPIPGGANAKPFVTHHNALDQQMFL
RIAPELYLKRLVVGGFERVFEINRNFRNEGVSVRHNPEFTMMEFYAAYWTHHDLMDFTEQILRHAARKAVGTAQLAYGGQ
AVDLESPFARLSVRDSLIAHAGLSAAEAADTTVLRAKLEAHGEKAPAHWSLAELQFGLFEAAVEEKLWQPTFIVDYPVEV
SPLARASDADPTITERFELFITGREFGNGFSELNDPEDQAARFAAQASNKDAGDEEAMYFDTDYIRALEHGLPPTGGCGI
GIDRLMMLLTDSPNIRDVILFPALRREG
>Mature_507_residues
TTTPPNAATPGTDDNQLIAERREKLAALRAQAQATGRAAFPNDFKPGDHAVDLHRLHEGKSAEELEALAIPARIAGRMML
KRVMGKACFATLQDGSGRIQLYITSDAVGPEALAAFKHWDLGDILGAEGTLFKTRTGELSLKVGTIRLLTKSLRPLPDKF
HGMADQELKYRQREVDLIMDEASRERFRARSKAVSSIRQFMVEHGFLEVETPMLHPIPGGANAKPFVTHHNALDQQMFLR
IAPELYLKRLVVGGFERVFEINRNFRNEGVSVRHNPEFTMMEFYAAYWTHHDLMDFTEQILRHAARKAVGTAQLAYGGQA
VDLESPFARLSVRDSLIAHAGLSAAEAADTTVLRAKLEAHGEKAPAHWSLAELQFGLFEAAVEEKLWQPTFIVDYPVEVS
PLARASDADPTITERFELFITGREFGNGFSELNDPEDQAARFAAQASNKDAGDEEAMYFDTDYIRALEHGLPPTGGCGIG
IDRLMMLLTDSPNIRDVILFPALRREG

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=530, Percent_Identity=39.811320754717, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI194272210, Length=530, Percent_Identity=39.811320754717, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI45439306, Length=469, Percent_Identity=22.3880597014925, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI40789249, Length=228, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790571, Length=509, Percent_Identity=56.7779960707269, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1789256, Length=509, Percent_Identity=57.3673870333988, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI87082379, Length=337, Percent_Identity=31.1572700296736, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788173, Length=288, Percent_Identity=25.3472222222222, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17535925, Length=494, Percent_Identity=39.0688259109312, Blast_Score=334, Evalue=8e-92,
Organism=Caenorhabditis elegans, GI17535927, Length=494, Percent_Identity=39.0688259109312, Blast_Score=334, Evalue=8e-92,
Organism=Caenorhabditis elegans, GI71994340, Length=494, Percent_Identity=39.0688259109312, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI32566633, Length=300, Percent_Identity=23.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=455, Percent_Identity=43.2967032967033, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6324256, Length=478, Percent_Identity=29.9163179916318, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24640849, Length=499, Percent_Identity=41.2825651302605, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640851, Length=499, Percent_Identity=41.2825651302605, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI17136276, Length=464, Percent_Identity=23.0603448275862, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24584738, Length=277, Percent_Identity=25.9927797833935, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_METPP (A2SDC3)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019797.1
- ProteinModelPortal:   A2SDC3
- SMR:   A2SDC3
- STRING:   A2SDC3
- GeneID:   4785701
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0600
- NMPDR:   fig|279263.3.peg.3166
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   RNEGMDH
- PhylomeDB:   A2SDC3
- ProtClustDB:   PRK00484
- BioCyc:   MPET420662:MPE_A0600-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 56391; Mature: 56260

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTPPNAATPGTDDNQLIAERREKLAALRAQAQATGRAAFPNDFKPGDHAVDLHRLHEG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCC
KSAEELEALAIPARIAGRMMLKRVMGKACFATLQDGSGRIQLYITSDAVGPEALAAFKHW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCC
DLGDILGAEGTLFKTRTGELSLKVGTIRLLTKSLRPLPDKFHGMADQELKYRQREVDLIM
CCHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHH
DEASRERFRARSKAVSSIRQFMVEHGFLEVETPMLHPIPGGANAKPFVTHHNALDQQMFL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEECCCCCCCCCCCEEECCHHHHHHHHH
RIAPELYLKRLVVGGFERVFEINRNFRNEGVSVRHNPEFTMMEFYAAYWTHHDLMDFTEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
ILRHAARKAVGTAQLAYGGQAVDLESPFARLSVRDSLIAHAGLSAAEAADTTVLRAKLEA
HHHHHHHHHHCCHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HGEKAPAHWSLAELQFGLFEAAVEEKLWQPTFIVDYPVEVSPLARASDADPTITERFELF
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHEEEEEE
ITGREFGNGFSELNDPEDQAARFAAQASNKDAGDEEAMYFDTDYIRALEHGLPPTGGCGI
EECHHHCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCC
GIDRLMMLLTDSPNIRDVILFPALRREG
CHHHHHHHHCCCCCCCEEEEECCHHCCC
>Mature Secondary Structure 
TTTPPNAATPGTDDNQLIAERREKLAALRAQAQATGRAAFPNDFKPGDHAVDLHRLHEG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCC
KSAEELEALAIPARIAGRMMLKRVMGKACFATLQDGSGRIQLYITSDAVGPEALAAFKHW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCC
DLGDILGAEGTLFKTRTGELSLKVGTIRLLTKSLRPLPDKFHGMADQELKYRQREVDLIM
CCHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHH
DEASRERFRARSKAVSSIRQFMVEHGFLEVETPMLHPIPGGANAKPFVTHHNALDQQMFL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEECCCCCCCCCCCEEECCHHHHHHHHH
RIAPELYLKRLVVGGFERVFEINRNFRNEGVSVRHNPEFTMMEFYAAYWTHHDLMDFTEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
ILRHAARKAVGTAQLAYGGQAVDLESPFARLSVRDSLIAHAGLSAAEAADTTVLRAKLEA
HHHHHHHHHHCCHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HGEKAPAHWSLAELQFGLFEAAVEEKLWQPTFIVDYPVEVSPLARASDADPTITERFELF
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHEEEEEE
ITGREFGNGFSELNDPEDQAARFAAQASNKDAGDEEAMYFDTDYIRALEHGLPPTGGCGI
EECHHHCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCC
GIDRLMMLLTDSPNIRDVILFPALRREG
CHHHHHHHHCCCCCCCEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA