Click here to switch to the map view.

The map label for this gene is copA2 [H]

Identifier: 124265688

GI number: 124265688

Start: 535990

End: 537402

Strand: Reverse

Name: copA2 [H]

Synonym: Mpe_A0495

Alternate gene names: 124265688

Gene position: 537402-535990 (Counterclockwise)

Preceding gene: 124265689

Following gene: 124265687

Centisome position: 13.29

GC content: 67.94

Gene sequence:

>1413_bases
ATGGTTTCCCGACGCAACTTCCTCGGCCGTGCCGGCGCGGTCACTGCGGCCGTCAGCGCCGCCGCCGTCAGCAAGGTCGC
GATGGCCGCGCTGCCCGAACCGGTGACGCAGCACTCGCCCGACACGATGCCTCCACTGGTGCCCGAGCGCGGCCGGCCCT
ACAACCCGGTCGTCACCCTGAATGGCTGGACGCTGCCCTGGCGCATGAACAACGGCGTCAAGGAGTTCCACCTGGTCGCC
GAACCGGTGGTGCGGGAGATGGCCCCCGGCTTCAAGGCGCATCTTTGGGGCTACAACGGCCAGAGCCCGGGGCCGACCAT
CGAGGTGGTGGAAGGCGACCGCGTGCGCGTCTTCGTCACCAACAAGCTGCCCGAGCACACCACCGTCCACTGGCACGGCC
AGCGCCTGCCCAACGGCATGGACGGCGTCGGCGGGCTCACGCAACCCGCCATACAACCCGGCAAGACCTTCGTCTACGAA
TTCGTCGCGCGCCGCCCCGGCACCTTCATGTACCACCCGCATGCCGACGAGATGGTGCAGATGGCGATGGGCATGATGGG
CTTCTGGATCACGCACCCGAAACAGAAGCACCCTCTGATCGACGAGGTCGATCGCGACTTCGTGTTCCTGCTCAACGCCT
ACGACATCGATCCCGGTGCCTACACGCCGAAGGTCATGACGATGCTCGACTTCAACCTGTGGAGCTGGAACAGCCGCGTG
TTCCCGGGCATCGACACGCTCAACGTCCGCAAGAACGACAAGGTGCGCATCCGCATCGGCAACCTGACGATGACCAACCA
CCCGATCCACCTGCACGGCCACGAGTTCGCGGTCACCGGCACCGACGGCGGGCCGACGCCGAAGGGCACGCGCTGGCTTG
AGGTGACCACCGACGTGGCGGTGGGCCAGATGCGCCAGATCGAGTTCCGGGCCGACGAGGAAGGCGACTGGGCCTTCCAC
TGCCACAAGAGCCACCACACGATGAATGCCATGGGGCACGGTGTGCCGACGATGATCGGCGTCGACCACCGCGAGGTGGT
CTCGAAGATCACGCAGCTCGTGCCCGACTACATGGTGATGGGCGAGCGCGGCATGGCCGACATGGCCGAGATGCCGATGC
CCCTGCCCGACAACACCGTGCCGATGATGAGCGGCGCCGGCCCGTTCGGCTCGGTCGAGATGGGCGGCATGTTCACCGTG
CTGAAGGTGCGCCGGGATCAGAAGCCGGGCGACTACGGTGACCCCGGCTGGTTCGACCACCCCGCCGGCACCGTGGCCTA
CGAATGGACCGGTGCGCTGGCCACGCCCGCGCGCGATCGGGACCCGGGTCGCTCGGCGATGCCGGCGCGCAACCGTCCGG
CCCGCGAGATCGAGGTCCAGGTCCGCAAGCCCGACCGGCACGGCCCGCACTGA

Upstream 100 bases:

>100_bases
ATCGGAAAACCCGGACTGTCGGGCGCGGCCTTGGCGCTCGGCAGCAGCCCGGCTGCCGGCGATGTCGGCGCCGACCACTG
AACGCCAGGAAGGACCTCCG

Downstream 100 bases:

>100_bases
CGCAGGCCCGGCCTGCCCCGACCACCACTTCAGCGATCAGAACCAACCATGCAACACCCCCCGAAAGCCGACCGCCGCCG
CACCCTGACCCGCCTGTGTG

Product: multi-Cu oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MVSRRNFLGRAGAVTAAVSAAAVSKVAMAALPEPVTQHSPDTMPPLVPERGRPYNPVVTLNGWTLPWRMNNGVKEFHLVA
EPVVREMAPGFKAHLWGYNGQSPGPTIEVVEGDRVRVFVTNKLPEHTTVHWHGQRLPNGMDGVGGLTQPAIQPGKTFVYE
FVARRPGTFMYHPHADEMVQMAMGMMGFWITHPKQKHPLIDEVDRDFVFLLNAYDIDPGAYTPKVMTMLDFNLWSWNSRV
FPGIDTLNVRKNDKVRIRIGNLTMTNHPIHLHGHEFAVTGTDGGPTPKGTRWLEVTTDVAVGQMRQIEFRADEEGDWAFH
CHKSHHTMNAMGHGVPTMIGVDHREVVSKITQLVPDYMVMGERGMADMAEMPMPLPDNTVPMMSGAGPFGSVEMGGMFTV
LKVRRDQKPGDYGDPGWFDHPAGTVAYEWTGALATPARDRDPGRSAMPARNRPAREIEVQVRKPDRHGPH

Sequences:

>Translated_470_residues
MVSRRNFLGRAGAVTAAVSAAAVSKVAMAALPEPVTQHSPDTMPPLVPERGRPYNPVVTLNGWTLPWRMNNGVKEFHLVA
EPVVREMAPGFKAHLWGYNGQSPGPTIEVVEGDRVRVFVTNKLPEHTTVHWHGQRLPNGMDGVGGLTQPAIQPGKTFVYE
FVARRPGTFMYHPHADEMVQMAMGMMGFWITHPKQKHPLIDEVDRDFVFLLNAYDIDPGAYTPKVMTMLDFNLWSWNSRV
FPGIDTLNVRKNDKVRIRIGNLTMTNHPIHLHGHEFAVTGTDGGPTPKGTRWLEVTTDVAVGQMRQIEFRADEEGDWAFH
CHKSHHTMNAMGHGVPTMIGVDHREVVSKITQLVPDYMVMGERGMADMAEMPMPLPDNTVPMMSGAGPFGSVEMGGMFTV
LKVRRDQKPGDYGDPGWFDHPAGTVAYEWTGALATPARDRDPGRSAMPARNRPAREIEVQVRKPDRHGPH
>Mature_470_residues
MVSRRNFLGRAGAVTAAVSAAAVSKVAMAALPEPVTQHSPDTMPPLVPERGRPYNPVVTLNGWTLPWRMNNGVKEFHLVA
EPVVREMAPGFKAHLWGYNGQSPGPTIEVVEGDRVRVFVTNKLPEHTTVHWHGQRLPNGMDGVGGLTQPAIQPGKTFVYE
FVARRPGTFMYHPHADEMVQMAMGMMGFWITHPKQKHPLIDEVDRDFVFLLNAYDIDPGAYTPKVMTMLDFNLWSWNSRV
FPGIDTLNVRKNDKVRIRIGNLTMTNHPIHLHGHEFAVTGTDGGPTPKGTRWLEVTTDVAVGQMRQIEFRADEEGDWAFH
CHKSHHTMNAMGHGVPTMIGVDHREVVSKITQLVPDYMVMGERGMADMAEMPMPLPDNTVPMMSGAGPFGSVEMGGMFTV
LKVRRDQKPGDYGDPGWFDHPAGTVAYEWTGALATPARDRDPGRSAMPARNRPAREIEVQVRKPDRHGPH

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323703, Length=96, Percent_Identity=44.7916666666667, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321067, Length=105, Percent_Identity=40.9523809523809, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18859919, Length=104, Percent_Identity=42.3076923076923, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28574104, Length=116, Percent_Identity=40.5172413793103, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650186, Length=114, Percent_Identity=39.4736842105263, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 52298; Mature: 52298

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRRNFLGRAGAVTAAVSAAAVSKVAMAALPEPVTQHSPDTMPPLVPERGRPYNPVVTL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCEEEE
NGWTLPWRMNNGVKEFHLVAEPVVREMAPGFKAHLWGYNGQSPGPTIEVVEGDRVRVFVT
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCEEEEEEE
NKLPEHTTVHWHGQRLPNGMDGVGGLTQPAIQPGKTFVYEFVARRPGTFMYHPHADEMVQ
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHHH
MAMGMMGFWITHPKQKHPLIDEVDRDFVFLLNAYDIDPGAYTPKVMTMLDFNLWSWNSRV
HHHHHHHHEECCCCCCCCCHHHCCCCEEEEEEEEECCCCCCCCEEEEEEEEEEECCCCEE
FPGIDTLNVRKNDKVRIRIGNLTMTNHPIHLHGHEFAVTGTDGGPTPKGTRWLEVTTDVA
CCCCCEEEECCCCEEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCCCEEEEEECCHH
VGQMRQIEFRADEEGDWAFHCHKSHHTMNAMGHGVPTMIGVDHREVVSKITQLVPDYMVM
HCCEEEEEEECCCCCCEEEEEECCCCCHHHHCCCCCEEECCCHHHHHHHHHHHCCHHEEE
GERGMADMAEMPMPLPDNTVPMMSGAGPFGSVEMGGMFTVLKVRRDQKPGDYGDPGWFDH
CCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCCCCCCCCCC
PAGTVAYEWTGALATPARDRDPGRSAMPARNRPAREIEVQVRKPDRHGPH
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MVSRRNFLGRAGAVTAAVSAAAVSKVAMAALPEPVTQHSPDTMPPLVPERGRPYNPVVTL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCEEEE
NGWTLPWRMNNGVKEFHLVAEPVVREMAPGFKAHLWGYNGQSPGPTIEVVEGDRVRVFVT
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCEEEEEEE
NKLPEHTTVHWHGQRLPNGMDGVGGLTQPAIQPGKTFVYEFVARRPGTFMYHPHADEMVQ
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHHH
MAMGMMGFWITHPKQKHPLIDEVDRDFVFLLNAYDIDPGAYTPKVMTMLDFNLWSWNSRV
HHHHHHHHEECCCCCCCCCHHHCCCCEEEEEEEEECCCCCCCCEEEEEEEEEEECCCCEE
FPGIDTLNVRKNDKVRIRIGNLTMTNHPIHLHGHEFAVTGTDGGPTPKGTRWLEVTTDVA
CCCCCEEEECCCCEEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCCCEEEEEECCHH
VGQMRQIEFRADEEGDWAFHCHKSHHTMNAMGHGVPTMIGVDHREVVSKITQLVPDYMVM
HCCEEEEEEECCCCCCEEEEEECCCCCHHHHCCCCCEEECCCHHHHHHHHHHHCCHHEEE
GERGMADMAEMPMPLPDNTVPMMSGAGPFGSVEMGGMFTVLKVRRDQKPGDYGDPGWFDH
CCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCCCCCCCCCC
PAGTVAYEWTGALATPARDRDPGRSAMPARNRPAREIEVQVRKPDRHGPH
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]