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The map label for this gene is paaF [H]

Identifier: 124265607

GI number: 124265607

Start: 447361

End: 448131

Strand: Reverse

Name: paaF [H]

Synonym: Mpe_A0414

Alternate gene names: 124265607

Gene position: 448131-447361 (Counterclockwise)

Preceding gene: 124265608

Following gene: 124265606

Centisome position: 11.08

GC content: 71.98

Gene sequence:

>771_bases
ATGAGCCACGACGACCTCCTGAGCCACGCCGAAGCCGGCGTGCTGACGCTGACCTTCAACCGCCTCGACAAGAAGAACTC
GATCACCGCAGCGATGTACGCGGCGCTCGCCGACGCACTGGCCGCGGCCCGCGACGACGCCGCGGTGCGCGCCGTGGTGA
TCCAGGGCCACGAGCTGATCTTCAGCGCCGGCAACGACCTCGCCGACTTCCTGAACGATCCGCCGGCCAGCGCCGATGCG
CCGGTGTGGCGCTTCCTGCACGGCCTGCGCAGCTTCCCGAAGCCGCTGGTGGCCGGCGTCTGCGGCGCAGCGGTCGGCAT
CGGCACCACGCTGCTGCTGCATTGCGACCTGGTCTACGCCGGCGACAACGCGAAGTTCAGCCTGCCCTTCGTGAACCTGG
GCCTGTGCCCCGAGGCGGCGTCGAGCCTGCTGCTGCCGGCGCGCCTCGGCCATGTGCGCGCCGCCGAGGCGCTGCTGCTC
GGCGAGCCCTTCGGCGCCGAGCAGGCGGCGGAGTGGGGGTTGGTGAACCGCATCCTGCCGCCCGGCGAGGTGAACAGCTT
CGCGCAGGCGCAGGCGCGCCGGCTGGCCGACAAGCCGCAGAGCGCGCTGGTCGCGACCAAGCGCCTGATGAAGGCCGCAT
CGGCCGACGCGGTGGCCACGGCGATGGCCGCCGAAGGCGAGGTGTTCGGTCCGCTGCTGCGCGGGCCGGCGGCACGCGAG
GCGTTCTCGGCCTTCATGGACAAGCGCAAGCCGGACTTCAGCAAGGTCTGA

Upstream 100 bases:

>100_bases
CTGGCCGCACACTGGCAGCAGTTCGAGGAAACCCGGCTCGCCTGAGGCGCCGCACCGGATCGACACCCCTCGCCCTCGCA
CAACCCCTCGGAGCCCCGAC

Downstream 100 bases:

>100_bases
GCCCACGCACTCCCGCCCCTGCCTGCCCTGCCTCGAGGATGCTGCCATGACGACGACCCTGCGCGACAAGACCCTGTTCA
TCACCGGCGCCAGCCGCGGC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSHDDLLSHAEAGVLTLTFNRLDKKNSITAAMYAALADALAAARDDAAVRAVVIQGHELIFSAGNDLADFLNDPPASADA
PVWRFLHGLRSFPKPLVAGVCGAAVGIGTTLLLHCDLVYAGDNAKFSLPFVNLGLCPEAASSLLLPARLGHVRAAEALLL
GEPFGAEQAAEWGLVNRILPPGEVNSFAQAQARRLADKPQSALVATKRLMKAASADAVATAMAAEGEVFGPLLRGPAARE
AFSAFMDKRKPDFSKV

Sequences:

>Translated_256_residues
MSHDDLLSHAEAGVLTLTFNRLDKKNSITAAMYAALADALAAARDDAAVRAVVIQGHELIFSAGNDLADFLNDPPASADA
PVWRFLHGLRSFPKPLVAGVCGAAVGIGTTLLLHCDLVYAGDNAKFSLPFVNLGLCPEAASSLLLPARLGHVRAAEALLL
GEPFGAEQAAEWGLVNRILPPGEVNSFAQAQARRLADKPQSALVATKRLMKAASADAVATAMAAEGEVFGPLLRGPAARE
AFSAFMDKRKPDFSKV
>Mature_255_residues
SHDDLLSHAEAGVLTLTFNRLDKKNSITAAMYAALADALAAARDDAAVRAVVIQGHELIFSAGNDLADFLNDPPASADAP
VWRFLHGLRSFPKPLVAGVCGAAVGIGTTLLLHCDLVYAGDNAKFSLPFVNLGLCPEAASSLLLPARLGHVRAAEALLLG
EPFGAEQAAEWGLVNRILPPGEVNSFAQAQARRLADKPQSALVATKRLMKAASADAVATAMAAEGEVFGPLLRGPAAREA
FSAFMDKRKPDFSKV

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI260274832, Length=234, Percent_Identity=34.6153846153846, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI45643119, Length=234, Percent_Identity=34.6153846153846, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI260275230, Length=234, Percent_Identity=34.6153846153846, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI194097323, Length=242, Percent_Identity=28.5123966942149, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI4757968, Length=262, Percent_Identity=25.9541984732824, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI49355787, Length=262, Percent_Identity=25.9541984732824, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI25453481, Length=261, Percent_Identity=25.6704980842912, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI51538573, Length=261, Percent_Identity=25.6704980842912, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=25.7028112449799, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI4757966, Length=237, Percent_Identity=27.4261603375527, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI51538581, Length=237, Percent_Identity=27.4261603375527, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI221136756, Length=259, Percent_Identity=24.3243243243243, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI221136753, Length=259, Percent_Identity=24.3243243243243, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI221307494, Length=259, Percent_Identity=24.3243243243243, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI70995211, Length=193, Percent_Identity=29.0155440414508, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI68989263, Length=258, Percent_Identity=29.4573643410853, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI116235487, Length=216, Percent_Identity=26.8518518518519, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI62530384, Length=250, Percent_Identity=25.2, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787659, Length=250, Percent_Identity=34, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=36.71875, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI221142681, Length=250, Percent_Identity=31.2, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=28.2868525896414, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082183, Length=248, Percent_Identity=24.1935483870968, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790281, Length=195, Percent_Identity=26.1538461538462, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17535521, Length=255, Percent_Identity=30.1960784313725, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17554946, Length=244, Percent_Identity=29.9180327868852, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25145438, Length=247, Percent_Identity=29.1497975708502, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17549921, Length=216, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560910, Length=261, Percent_Identity=27.2030651340996, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540306, Length=239, Percent_Identity=27.6150627615063, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540714, Length=234, Percent_Identity=24.7863247863248, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=221, Percent_Identity=26.2443438914027, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323314, Length=224, Percent_Identity=25.4464285714286, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24654903, Length=256, Percent_Identity=31.25, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI20129971, Length=245, Percent_Identity=27.3469387755102, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24653477, Length=245, Percent_Identity=27.3469387755102, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19922422, Length=254, Percent_Identity=26.7716535433071, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653139, Length=257, Percent_Identity=28.7937743190661, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357171, Length=237, Percent_Identity=26.5822784810127, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19920382, Length=212, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 26836; Mature: 26705

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDDLLSHAEAGVLTLTFNRLDKKNSITAAMYAALADALAAARDDAAVRAVVIQGHELI
CCHHHHHHHHCCCEEEEEECHHCCCCHHHHHHHHHHHHHHHHHCCCHHEEEEEEECCEEE
FSAGNDLADFLNDPPASADAPVWRFLHGLRSFPKPLVAGVCGAAVGIGTTLLLHCDLVYA
EECCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEEE
GDNAKFSLPFVNLGLCPEAASSLLLPARLGHVRAAEALLLGEPFGAEQAAEWGLVNRILP
CCCCEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
PGEVNSFAQAQARRLADKPQSALVATKRLMKAASADAVATAMAAEGEVFGPLLRGPAARE
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCCHHHH
AFSAFMDKRKPDFSKV
HHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SHDDLLSHAEAGVLTLTFNRLDKKNSITAAMYAALADALAAARDDAAVRAVVIQGHELI
CHHHHHHHHCCCEEEEEECHHCCCCHHHHHHHHHHHHHHHHHCCCHHEEEEEEECCEEE
FSAGNDLADFLNDPPASADAPVWRFLHGLRSFPKPLVAGVCGAAVGIGTTLLLHCDLVYA
EECCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEEE
GDNAKFSLPFVNLGLCPEAASSLLLPARLGHVRAAEALLLGEPFGAEQAAEWGLVNRILP
CCCCEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
PGEVNSFAQAQARRLADKPQSALVATKRLMKAASADAVATAMAAEGEVFGPLLRGPAARE
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCCHHHH
AFSAFMDKRKPDFSKV
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]