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The map label for this gene is gdhII [H]

Identifier: 124265606

GI number: 124265606

Start: 446478

End: 447314

Strand: Reverse

Name: gdhII [H]

Synonym: Mpe_A0413

Alternate gene names: 124265606

Gene position: 447314-446478 (Counterclockwise)

Preceding gene: 124265607

Following gene: 124265602

Centisome position: 11.06

GC content: 67.98

Gene sequence:

>837_bases
ATGACGACGACCCTGCGCGACAAGACCCTGTTCATCACCGGCGCCAGCCGCGGCATCGGCCTGGCGATCGCGAAGCGCGC
CGCGGCCGACGGTGCGCGCATCGCGATCGTGGCCAAGACCACCGAGGCCAACCCCAAGCTGCCGGGCACCATCTACAGCG
CGGCGGCGGAAATCGAGGCCGCGGGCGGCCAGGCACTGGCGATCGCCGGCGACATCCGTGACGAGGCCAGCGTGCTGGCC
GCGGTGGCGCAGACCGTCGAGCGCTTCGGCGGCATCGACATCCTGGTCAACAACGCCAGCGCGATCAGCCTCACGCCGAC
GCCGATGACGCCGATGAAGCGCTTCGACCTGATGTTCGGCGTCAACGTGCGCGGCACCTACCTGTGCACCCAGGCCTGCC
TGCCGGAGCTGCTAAAGAGCGCCGCGGCCGGCCGCAACCCGCACGTGCTGAACATGAGCCCCCCGCTGTCGATGAAGCCT
CACTGGTTCAAGAACCACGTGGCATACACGATGGCGAAGTACGGCATGAGCGAATGCACGCTGGGTCACGCAGCCGAGTT
CAGGAGCCATGGCATCGCCGTCAACAGCCTGTGGCCGCGCACTGCCATCGCCACCGCGGCGCTGCAGATGATCCCCGGCA
TCGACATCGCCCGCTGCCGCACGCCGGAGATCCTGGCCGACGCCGCCTGGCTGGTGCTGACCCGCGACGCGAAGACGGTG
ACCGGCAACTTCTTCATCGACGACACGCTGCTCGCGCAGCACGGCATCACCGACCTGGAGAAGTACAGCGTCACGCCCGG
CACGAAGGACTTCGTGCTGGACTTCTTCGTCGACTGA

Upstream 100 bases:

>100_bases
GAGGCGTTCTCGGCCTTCATGGACAAGCGCAAGCCGGACTTCAGCAAGGTCTGAGCCCACGCACTCCCGCCCCTGCCTGC
CCTGCCTCGAGGATGCTGCC

Downstream 100 bases:

>100_bases
GACGCGCGGGCGTTCTTCCGCTCAGGCAGCGGCCCCCGGCGGCGCGGCCGCCTGCAGTGCGGCCAGCGTGCGGTCCAGCT
GCTCGGCGACGCGCTGGTGC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: GLCDH-II [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MTTTLRDKTLFITGASRGIGLAIAKRAAADGARIAIVAKTTEANPKLPGTIYSAAAEIEAAGGQALAIAGDIRDEASVLA
AVAQTVERFGGIDILVNNASAISLTPTPMTPMKRFDLMFGVNVRGTYLCTQACLPELLKSAAAGRNPHVLNMSPPLSMKP
HWFKNHVAYTMAKYGMSECTLGHAAEFRSHGIAVNSLWPRTAIATAALQMIPGIDIARCRTPEILADAAWLVLTRDAKTV
TGNFFIDDTLLAQHGITDLEKYSVTPGTKDFVLDFFVD

Sequences:

>Translated_278_residues
MTTTLRDKTLFITGASRGIGLAIAKRAAADGARIAIVAKTTEANPKLPGTIYSAAAEIEAAGGQALAIAGDIRDEASVLA
AVAQTVERFGGIDILVNNASAISLTPTPMTPMKRFDLMFGVNVRGTYLCTQACLPELLKSAAAGRNPHVLNMSPPLSMKP
HWFKNHVAYTMAKYGMSECTLGHAAEFRSHGIAVNSLWPRTAIATAALQMIPGIDIARCRTPEILADAAWLVLTRDAKTV
TGNFFIDDTLLAQHGITDLEKYSVTPGTKDFVLDFFVD
>Mature_277_residues
TTTLRDKTLFITGASRGIGLAIAKRAAADGARIAIVAKTTEANPKLPGTIYSAAAEIEAAGGQALAIAGDIRDEASVLAA
VAQTVERFGGIDILVNNASAISLTPTPMTPMKRFDLMFGVNVRGTYLCTQACLPELLKSAAAGRNPHVLNMSPPLSMKPH
WFKNHVAYTMAKYGMSECTLGHAAEFRSHGIAVNSLWPRTAIATAALQMIPGIDIARCRTPEILADAAWLVLTRDAKTVT
GNFFIDDTLLAQHGITDLEKYSVTPGTKDFVLDFFVD

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254986, Length=273, Percent_Identity=56.4102564102564, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI10190704, Length=209, Percent_Identity=27.7511961722488, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI209862901, Length=207, Percent_Identity=28.9855072463768, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI19923983, Length=207, Percent_Identity=28.9855072463768, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI87082100, Length=222, Percent_Identity=31.5315315315315, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=29.0322580645161, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790717, Length=260, Percent_Identity=25.3846153846154, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=271, Percent_Identity=58.6715867158672, Blast_Score=317, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI17558628, Length=271, Percent_Identity=59.7785977859779, Blast_Score=308, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17544670, Length=239, Percent_Identity=25.9414225941423, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=200, Percent_Identity=28.5, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=278, Percent_Identity=25.8992805755396, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=196, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=189, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=199, Percent_Identity=29.6482412060301, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=202, Percent_Identity=27.7227722772277, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=204, Percent_Identity=27.9411764705882, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=273, Percent_Identity=24.5421245421245, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=204, Percent_Identity=26.9607843137255, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17542178, Length=206, Percent_Identity=29.6116504854369, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=206, Percent_Identity=26.2135922330097, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=203, Percent_Identity=26.6009852216749, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21357673, Length=279, Percent_Identity=59.8566308243728, Blast_Score=328, Evalue=2e-90,
Organism=Drosophila melanogaster, GI21357041, Length=213, Percent_Identity=31.924882629108, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI23397609, Length=196, Percent_Identity=34.1836734693878, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571526, Length=198, Percent_Identity=32.3232323232323, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24644339, Length=192, Percent_Identity=30.2083333333333, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355319, Length=267, Percent_Identity=26.5917602996255, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24643142, Length=205, Percent_Identity=27.8048780487805, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 29648; Mature: 29516

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTLRDKTLFITGASRGIGLAIAKRAAADGARIAIVAKTTEANPKLPGTIYSAAAEIEA
CCCCCCCCEEEEEECCCCCCCEEHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCC
AGGQALAIAGDIRDEASVLAAVAQTVERFGGIDILVNNASAISLTPTPMTPMKRFDLMFG
CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCHHHHHHEEEC
VNVRGTYLCTQACLPELLKSAAAGRNPHVLNMSPPLSMKPHWFKNHVAYTMAKYGMSECT
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCC
LGHAAEFRSHGIAVNSLWPRTAIATAALQMIPGIDIARCRTPEILADAAWLVLTRDAKTV
CCHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHCCEEEEEECCCCEE
TGNFFIDDTLLAQHGITDLEKYSVTPGTKDFVLDFFVD
ECCEEECCHHHHHCCCCCHHHEECCCCCHHEEEEEECC
>Mature Secondary Structure 
TTTLRDKTLFITGASRGIGLAIAKRAAADGARIAIVAKTTEANPKLPGTIYSAAAEIEA
CCCCCCCEEEEEECCCCCCCEEHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCC
AGGQALAIAGDIRDEASVLAAVAQTVERFGGIDILVNNASAISLTPTPMTPMKRFDLMFG
CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCHHHHHHEEEC
VNVRGTYLCTQACLPELLKSAAAGRNPHVLNMSPPLSMKPHWFKNHVAYTMAKYGMSECT
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCC
LGHAAEFRSHGIAVNSLWPRTAIATAALQMIPGIDIARCRTPEILADAAWLVLTRDAKTV
CCHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHCCEEEEEECCCCEE
TGNFFIDDTLLAQHGITDLEKYSVTPGTKDFVLDFFVD
ECCEEECCHHHHHCCCCCHHHEECCCCCHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA