Click here to switch to the map view.

The map label for this gene is gpwA [H]

Identifier: 124265430

GI number: 124265430

Start: 253458

End: 254075

Strand: Reverse

Name: gpwA [H]

Synonym: Mpe_A0237

Alternate gene names: 124265430

Gene position: 254075-253458 (Counterclockwise)

Preceding gene: 124265434

Following gene: 124265429

Centisome position: 6.28

GC content: 64.24

Gene sequence:

>618_bases
ATGCCCACTCTTGCCACGAGATCAGCCAGCGCCACCCTCTCGCCACGGCGCCGTCCGTGGCTCGGTCGCTCGGCGTTGCG
ACGCCTCGCGATCGCCGCGCTACTGTGCATCGTGGGCAGCGGCGCACAGGCCGCGTGCCCGCCGTTGCTGGACCGCAGCT
TCCCCCGCCTGCAAGACGAGAAGCCGCAGAACCTCTGCCAGTACGCCGGCAAGGTGGTGGTGGTGGTCAACACCGCCAGT
TATTGCGGCTTCACCTCCCAGTACAAGGGGCTCGAGGCGCTGCACGCCCGGTACCAGTCGAGAGGCCTGGTCGTGCTCGG
CTTCCCGTCCAATGACTTCGGCTCGCAGGAACCCGGCAGCAACCAGGACATCGCCGCATTCTGCGAGAACACCTTCGGCG
TCAGGTTTCCGATGTTCGCGAAGTCCAGCGTGAAGGGCAGCGCCCGCAACCCGTTGTACGCAGACCTCGCGCAGCGCACC
GGGAAGACGCCCGCATGGAATTTCCACAAGTACCTGATCGGCCGCGACGGGCAGGTCGTGCTCAGCTTCTCGAGTCAGAC
CGACCCGCAAGACCCTGTGTTTGTCCAAGAGATTGAAAAACTTGTGGATTCACAATAA

Upstream 100 bases:

>100_bases
ATACACGTTTCATTGCGGGTCGACCAGCATTTGACGGGGGCATGGGCGCTCGTAATATAGATCAGTTCCAGCGTTTGACC
AGGACAAACAGGAGATCCTC

Downstream 100 bases:

>100_bases
GACTGAACAGTAATATATAGACCATGCAGTTCAATAAGTTACAGCCCGAGAGCGGCAACGCCAATGCCAGAGACGGGCAT
CCATGGAGCTGCTTGCAAGT

Product: putative glutathione peroxidase transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MPTLATRSASATLSPRRRPWLGRSALRRLAIAALLCIVGSGAQAACPPLLDRSFPRLQDEKPQNLCQYAGKVVVVVNTAS
YCGFTSQYKGLEALHARYQSRGLVVLGFPSNDFGSQEPGSNQDIAAFCENTFGVRFPMFAKSSVKGSARNPLYADLAQRT
GKTPAWNFHKYLIGRDGQVVLSFSSQTDPQDPVFVQEIEKLVDSQ

Sequences:

>Translated_205_residues
MPTLATRSASATLSPRRRPWLGRSALRRLAIAALLCIVGSGAQAACPPLLDRSFPRLQDEKPQNLCQYAGKVVVVVNTAS
YCGFTSQYKGLEALHARYQSRGLVVLGFPSNDFGSQEPGSNQDIAAFCENTFGVRFPMFAKSSVKGSARNPLYADLAQRT
GKTPAWNFHKYLIGRDGQVVLSFSSQTDPQDPVFVQEIEKLVDSQ
>Mature_204_residues
PTLATRSASATLSPRRRPWLGRSALRRLAIAALLCIVGSGAQAACPPLLDRSFPRLQDEKPQNLCQYAGKVVVVVNTASY
CGFTSQYKGLEALHARYQSRGLVVLGFPSNDFGSQEPGSNQDIAAFCENTFGVRFPMFAKSSVKGSARNPLYADLAQRTG
KTPAWNFHKYLIGRDGQVVLSFSSQTDPQDPVFVQEIEKLVDSQ

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=118, Percent_Identity=48.3050847457627, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI192455698, Length=133, Percent_Identity=39.0977443609023, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI75709200, Length=133, Percent_Identity=40.6015037593985, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI90903240, Length=133, Percent_Identity=40.6015037593985, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI4557629, Length=144, Percent_Identity=36.1111111111111, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI6006001, Length=145, Percent_Identity=35.8620689655172, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI90903238, Length=115, Percent_Identity=41.7391304347826, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI33186887, Length=154, Percent_Identity=32.4675324675325, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI41406084, Length=146, Percent_Identity=34.2465753424658, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1788003, Length=165, Percent_Identity=39.3939393939394, Blast_Score=133, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17535473, Length=132, Percent_Identity=44.6969696969697, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI193210707, Length=150, Percent_Identity=40.6666666666667, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506887, Length=132, Percent_Identity=40.9090909090909, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71993584, Length=151, Percent_Identity=33.7748344370861, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17550320, Length=180, Percent_Identity=29.4444444444444, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193209493, Length=165, Percent_Identity=28.4848484848485, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319721, Length=141, Percent_Identity=48.2269503546099, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322228, Length=128, Percent_Identity=47.65625, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322826, Length=125, Percent_Identity=41.6, Blast_Score=113, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656772, Length=145, Percent_Identity=40.6896551724138, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24656777, Length=145, Percent_Identity=40.6896551724138, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656767, Length=145, Percent_Identity=40.6896551724138, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI85726443, Length=130, Percent_Identity=38.4615384615385, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 22401; Mature: 22270

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLATRSASATLSPRRRPWLGRSALRRLAIAALLCIVGSGAQAACPPLLDRSFPRLQDE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCC
KPQNLCQYAGKVVVVVNTASYCGFTSQYKGLEALHARYQSRGLVVLGFPSNDFGSQEPGS
CHHHHHHHCCCEEEEEECCHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC
NQDIAAFCENTFGVRFPMFAKSSVKGSARNPLYADLAQRTGKTPAWNFHKYLIGRDGQVV
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHEECCCCEEE
LSFSSQTDPQDPVFVQEIEKLVDSQ
EEECCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PTLATRSASATLSPRRRPWLGRSALRRLAIAALLCIVGSGAQAACPPLLDRSFPRLQDE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCC
KPQNLCQYAGKVVVVVNTASYCGFTSQYKGLEALHARYQSRGLVVLGFPSNDFGSQEPGS
CHHHHHHHCCCEEEEEECCHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC
NQDIAAFCENTFGVRFPMFAKSSVKGSARNPLYADLAQRTGKTPAWNFHKYLIGRDGQVV
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHEECCCCEEE
LSFSSQTDPQDPVFVQEIEKLVDSQ
EEECCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA