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The map label for this gene is hprK

Identifier: 124265417

GI number: 124265417

Start: 241226

End: 242182

Strand: Reverse

Name: hprK

Synonym: Mpe_A0224

Alternate gene names: 124265417

Gene position: 242182-241226 (Counterclockwise)

Preceding gene: 124265418

Following gene: 124265415

Centisome position: 5.99

GC content: 67.82

Gene sequence:

>957_bases
ATGAAGCCCACCGTCATCAGCGCAGAGGCGCTGTTCGAGGCTCACCGCACCGCGCTGCGCTGGGAATGGCTTGCCGGCCA
CGCCCACCCGGAGCGCCGCTTCGACGAGGTCGCGGTGCGCGATGCCCAGTCGGCCGCCGACCTGGTGGGCTACCTGAACT
ACATCCACCCCTATCGCGTGCAGATCGTCGGGCGACGCGAGGTGCGCTACCTCGTCGACGTTCCCCCGGAAGACCAGGAA
CGTCGCATCTCGCGCATCGTGACGCTGGAACCGCCGGTGGTGATCGTGGCCGACCAGCAGACGCCGCCGGACCGGCTGGT
CGCGATGTGCGAACGCGCCGACATCCCCCTGTTCGTGACCGAGGAATCCGCCGGCCATGTGATCGACGTGCTGCGCGCCC
ACCTGAGCCAGCACTTCGCCGACCGCACCACGCGGCACGGCGTGTTCATGGACATCCTCGGCCTGGGCGTGCTGCTGACC
GGCGAGTCCGGCCTGGGCAAGAGCGAACTCGGCCTGGAACTGATCTCGCGCGGCCACGGCCTCGTGGCGGACGACGCAGT
CGACCTGTACCGGGTGTCGCAGACGGCCCTGGAAGGCCGCTGCCCCGACCTGCTGCTGAACCTGCTCGAGGTGCGCGGGA
TCGGCCTGCTCGACATCAAGGCGATCTTCGGTGAGACCGCGGTGCGTCGCAAGATGCGCCTCAAGCTCATCGTGCACCTG
GTGCGCAAGGAGACGATGGAGCGCGACTTCGAACGGCTGCCCTACGAGCCGCTTTACGAAGACGTCCTCGACGTACCGGT
GCTGAAGGCGGTGATCGCGGTCGACGCCGGCCGCAACCTCGCCGTGCTGGTCGAAGCCGCAGTGCGCAACACCATCCTGA
AGCTGCGCGGCATCGACACCTACCAGGAGTTCATCGCCCGCCATCGCATCGCGATGGAAGGCGACGAACCGATCTGA

Upstream 100 bases:

>100_bases
GCGATCCGAGGCGGTCAATGAAGCCCCAATCCGTTCGTTCTGCAGCACCGCGTCCGCGCGTGCCTTGCTGCGCAACGGCT
GGCGCGATCCGAGGCGGTCA

Downstream 100 bases:

>100_bases
ACGTCGGTCAGCGCGGCGAGTTGCTGCCCTTGCAGCCGTCGCGCCCGCAGATCACGTAGAGCGCGAGCGAGTGGTCCTGC
AGCTCGTAGCCTCGCTCGCG

Product: HPr kinase/phosphorylase

Products: NA

Alternate protein names: HPrK/P; HPr(Ser) kinase/phosphorylase

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKPTVISAEALFEAHRTALRWEWLAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRVQIVGRREVRYLVDVPPEDQE
RRISRIVTLEPPVVIVADQQTPPDRLVAMCERADIPLFVTEESAGHVIDVLRAHLSQHFADRTTRHGVFMDILGLGVLLT
GESGLGKSELGLELISRGHGLVADDAVDLYRVSQTALEGRCPDLLLNLLEVRGIGLLDIKAIFGETAVRRKMRLKLIVHL
VRKETMERDFERLPYEPLYEDVLDVPVLKAVIAVDAGRNLAVLVEAAVRNTILKLRGIDTYQEFIARHRIAMEGDEPI

Sequences:

>Translated_318_residues
MKPTVISAEALFEAHRTALRWEWLAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRVQIVGRREVRYLVDVPPEDQE
RRISRIVTLEPPVVIVADQQTPPDRLVAMCERADIPLFVTEESAGHVIDVLRAHLSQHFADRTTRHGVFMDILGLGVLLT
GESGLGKSELGLELISRGHGLVADDAVDLYRVSQTALEGRCPDLLLNLLEVRGIGLLDIKAIFGETAVRRKMRLKLIVHL
VRKETMERDFERLPYEPLYEDVLDVPVLKAVIAVDAGRNLAVLVEAAVRNTILKLRGIDTYQEFIARHRIAMEGDEPI
>Mature_318_residues
MKPTVISAEALFEAHRTALRWEWLAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRVQIVGRREVRYLVDVPPEDQE
RRISRIVTLEPPVVIVADQQTPPDRLVAMCERADIPLFVTEESAGHVIDVLRAHLSQHFADRTTRHGVFMDILGLGVLLT
GESGLGKSELGLELISRGHGLVADDAVDLYRVSQTALEGRCPDLLLNLLEVRGIGLLDIKAIFGETAVRRKMRLKLIVHL
VRKETMERDFERLPYEPLYEDVLDVPVLKAVIAVDAGRNLAVLVEAAVRNTILKLRGIDTYQEFIARHRIAMEGDEPI

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRK_METPP (A2SC97)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019421.1
- ProteinModelPortal:   A2SC97
- SMR:   A2SC97
- STRING:   A2SC97
- GeneID:   4784009
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0224
- NMPDR:   fig|279263.3.peg.229
- eggNOG:   COG1493
- HOGENOM:   HBG566466
- OMA:   IHGVLVD
- ProtClustDB:   PRK05428
- BioCyc:   MPET420662:MPE_A0224-MONOMER
- HAMAP:   MF_01249
- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N

EC number: NA

Molecular weight: Translated: 35816; Mature: 35816

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: ACT_SITE 146-146 ACT_SITE 167-167 ACT_SITE 185-185 ACT_SITE 252-252

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTVISAEALFEAHRTALRWEWLAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRV
CCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
QIVGRREVRYLVDVPPEDQERRISRIVTLEPPVVIVADQQTPPDRLVAMCERADIPLFVT
EEEECCCEEEEEECCCCHHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHCCCCEEEE
EESAGHVIDVLRAHLSQHFADRTTRHGVFMDILGLGVLLTGESGLGKSELGLELISRGHG
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCC
LVADDAVDLYRVSQTALEGRCPDLLLNLLEVRGIGLLDIKAIFGETAVRRKMRLKLIVHL
CEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
VRKETMERDFERLPYEPLYEDVLDVPVLKAVIAVDAGRNLAVLVEAAVRNTILKLRGIDT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCH
YQEFIARHRIAMEGDEPI
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKPTVISAEALFEAHRTALRWEWLAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRV
CCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
QIVGRREVRYLVDVPPEDQERRISRIVTLEPPVVIVADQQTPPDRLVAMCERADIPLFVT
EEEECCCEEEEEECCCCHHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHCCCCEEEE
EESAGHVIDVLRAHLSQHFADRTTRHGVFMDILGLGVLLTGESGLGKSELGLELISRGHG
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCC
LVADDAVDLYRVSQTALEGRCPDLLLNLLEVRGIGLLDIKAIFGETAVRRKMRLKLIVHL
CEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
VRKETMERDFERLPYEPLYEDVLDVPVLKAVIAVDAGRNLAVLVEAAVRNTILKLRGIDT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCH
YQEFIARHRIAMEGDEPI
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA