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The map label for this gene is holA [H]

Identifier: 124265409

GI number: 124265409

Start: 233764

End: 234855

Strand: Reverse

Name: holA [H]

Synonym: Mpe_A0216

Alternate gene names: 124265409

Gene position: 234855-233764 (Counterclockwise)

Preceding gene: 124265410

Following gene: 124265408

Centisome position: 5.81

GC content: 71.43

Gene sequence:

>1092_bases
ATGCAGATCAAGCCCGACCAGCTCGATGCGCATCTGAAGAAGGGCCTGCGTCCGCTGTACACGCTGCACGGCGACGAGCC
GCTGCTGGCGCTGGAGGCGAGCGACGCCATCCGCGCCGCGGCGCGCGATGCCGGGCACACCGAGCGCGAGGTCCATCATG
TCGCCGGCGCGCACTTCGACTGGAGTTCGCTGCTCGGCGCGGCCAGCTCGATGAGCCTGTTCGCCGAGGCCAAGATCGTC
GAGATCCGCATCCCGTCGGGCAAGCCGGGCAAGGACGGGTCGCAGGCGCTCCAGCACTATTGCGAACACCTGCCCGAGGG
CGTGGTGACGCTGGTCACGCTGCCGCGGCTGGACCGCCAGCAGTCGGGCAGTGCCTGGTTCGGCGCGCTGGAATCGGCCG
GCGTGACGCTGCGCCTCGACCCGGTGGAACGTCAGGCGCTGCCGCAGTGGATCGCGCAGCGCCTCGCGGCGCAGAACCAG
CGCGTCGCCGCCGACGAGGAGGGGCAGCGCACGCTGGCTTTCTTTGCCGACCGGGTCGAGGGCAACCTGCTGGCGGCCCA
GCAGGAGCTCACCAAGCTCGGCCTGCTGTACCCGGCCGGCGAACTGAGCTTCGAACAGGTCGAGGCGGCGGTGCTGAATG
TGGCGCGCTACAGCGTCTTCAAGCTCGGTGAGGCGGTGCTGGCCGGCCAGGTCTCGCGCGTGCTGCGCATGCTCGACGGC
CTGCGCGCCGAGGGCGAAGCTGCCGTGCTGGTGCACTGGACGCTGGCCGAGGACATCCGTGCATTGCGGCGCTGCAAGGA
CGCCGTCGCGGCCGGCAAGCCGCTGCCGATGGCGCTGCGCGAGAACCGCATCTGGGGCCTCAAGGAGCGCCTCTTCGAGC
GCGCGCTGCCCCGGCTCGGCGACGGCACGATCGACCACCTGATCGAGGCCGCCCATGTCTGTGACGGCCTGGTCAAGGGT
CTGAAGCACCCGCAGTGGCCGCAGGACCCCTGGATCGGCCTGCAGCGGCTGGCGCTGCAGCTGGCGGGATCGATGCAGGC
GGCCCAGCTGCCGCGCGGCACCCCGTCGCAGCGGCTCGTGCTGCAGGCCTGA

Upstream 100 bases:

>100_bases
ACAGGAAGAGGCCATGCTCTACCGCGGCATGCAGAGCGACATCGTCGACCAGGTGATGCGCCAGCTCGCCGCCGTGCCGG
CCCCTTAGGCTCGCAAGCGC

Downstream 100 bases:

>100_bases
GGCGTCGGGTCGCCGCGCCTTCAGGACGTCCGCGCGCGGCCGATATCCCTGGCTGACACCCCATTGCTCGCGCTCGCGCA
TCATGCGCGCCGGCCGGCCC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MQIKPDQLDAHLKKGLRPLYTLHGDEPLLALEASDAIRAAARDAGHTEREVHHVAGAHFDWSSLLGAASSMSLFAEAKIV
EIRIPSGKPGKDGSQALQHYCEHLPEGVVTLVTLPRLDRQQSGSAWFGALESAGVTLRLDPVERQALPQWIAQRLAAQNQ
RVAADEEGQRTLAFFADRVEGNLLAAQQELTKLGLLYPAGELSFEQVEAAVLNVARYSVFKLGEAVLAGQVSRVLRMLDG
LRAEGEAAVLVHWTLAEDIRALRRCKDAVAAGKPLPMALRENRIWGLKERLFERALPRLGDGTIDHLIEAAHVCDGLVKG
LKHPQWPQDPWIGLQRLALQLAGSMQAAQLPRGTPSQRLVLQA

Sequences:

>Translated_363_residues
MQIKPDQLDAHLKKGLRPLYTLHGDEPLLALEASDAIRAAARDAGHTEREVHHVAGAHFDWSSLLGAASSMSLFAEAKIV
EIRIPSGKPGKDGSQALQHYCEHLPEGVVTLVTLPRLDRQQSGSAWFGALESAGVTLRLDPVERQALPQWIAQRLAAQNQ
RVAADEEGQRTLAFFADRVEGNLLAAQQELTKLGLLYPAGELSFEQVEAAVLNVARYSVFKLGEAVLAGQVSRVLRMLDG
LRAEGEAAVLVHWTLAEDIRALRRCKDAVAAGKPLPMALRENRIWGLKERLFERALPRLGDGTIDHLIEAAHVCDGLVKG
LKHPQWPQDPWIGLQRLALQLAGSMQAAQLPRGTPSQRLVLQA
>Mature_363_residues
MQIKPDQLDAHLKKGLRPLYTLHGDEPLLALEASDAIRAAARDAGHTEREVHHVAGAHFDWSSLLGAASSMSLFAEAKIV
EIRIPSGKPGKDGSQALQHYCEHLPEGVVTLVTLPRLDRQQSGSAWFGALESAGVTLRLDPVERQALPQWIAQRLAAQNQ
RVAADEEGQRTLAFFADRVEGNLLAAQQELTKLGLLYPAGELSFEQVEAAVLNVARYSVFKLGEAVLAGQVSRVLRMLDG
LRAEGEAAVLVHWTLAEDIRALRRCKDAVAAGKPLPMALRENRIWGLKERLFERALPRLGDGTIDHLIEAAHVCDGLVKG
LKHPQWPQDPWIGLQRLALQLAGSMQAAQLPRGTPSQRLVLQA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=309, Percent_Identity=30.42071197411, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39701; Mature: 39701

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKPDQLDAHLKKGLRPLYTLHGDEPLLALEASDAIRAAARDAGHTEREVHHVAGAHFD
CCCCHHHHHHHHHHCCCEEEEECCCCCEEEEECHHHHHHHHHCCCCHHHHHHHHHCCCCC
WSSLLGAASSMSLFAEAKIVEIRIPSGKPGKDGSQALQHYCEHLPEGVVTLVTLPRLDRQ
HHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHEEHHHCCCCCCC
QSGSAWFGALESAGVTLRLDPVERQALPQWIAQRLAAQNQRVAADEEGQRTLAFFADRVE
CCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC
GNLLAAQQELTKLGLLYPAGELSFEQVEAAVLNVARYSVFKLGEAVLAGQVSRVLRMLDG
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LRAEGEAAVLVHWTLAEDIRALRRCKDAVAAGKPLPMALRENRIWGLKERLFERALPRLG
CCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHCCCCC
DGTIDHLIEAAHVCDGLVKGLKHPQWPQDPWIGLQRLALQLAGSMQAAQLPRGTPSQRLV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEE
LQA
ECC
>Mature Secondary Structure
MQIKPDQLDAHLKKGLRPLYTLHGDEPLLALEASDAIRAAARDAGHTEREVHHVAGAHFD
CCCCHHHHHHHHHHCCCEEEEECCCCCEEEEECHHHHHHHHHCCCCHHHHHHHHHCCCCC
WSSLLGAASSMSLFAEAKIVEIRIPSGKPGKDGSQALQHYCEHLPEGVVTLVTLPRLDRQ
HHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHEEHHHCCCCCCC
QSGSAWFGALESAGVTLRLDPVERQALPQWIAQRLAAQNQRVAADEEGQRTLAFFADRVE
CCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC
GNLLAAQQELTKLGLLYPAGELSFEQVEAAVLNVARYSVFKLGEAVLAGQVSRVLRMLDG
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LRAEGEAAVLVHWTLAEDIRALRRCKDAVAAGKPLPMALRENRIWGLKERLFERALPRLG
CCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHCCCCC
DGTIDHLIEAAHVCDGLVKGLKHPQWPQDPWIGLQRLALQLAGSMQAAQLPRGTPSQRLV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEE
LQA
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]