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The map label for this gene is maeB [H]

Identifier: 124265400

GI number: 124265400

Start: 222300

End: 224594

Strand: Reverse

Name: maeB [H]

Synonym: Mpe_A0207

Alternate gene names: 124265400

Gene position: 224594-222300 (Counterclockwise)

Preceding gene: 124265407

Following gene: 124265399

Centisome position: 5.55

GC content: 67.58

Gene sequence:

>2295_bases
ATGCTGACCAACGAAGAAAAGAGTGCGGAACTGCGCCAGGCCGCGCTCGAGTACCACGAGTTCCCGACGCCCGGCAAGGT
GGCCATCGCCGCCACCAAGCAGCTGGTCAATCAGCGCGACCTCGCGCTGGCGTATTCGCCCGGCGTGGCGGCCGCCTGCG
AAGAGATCGTGGCCGACCCGGCCAACGCCTACCGCTACACCTCGCGCGGCAACCTCGTGGCGGTGGTCACCAACGGCACT
GCGGTGCTGGGCCTGGGGGACATCGGTCCGCTGGCGGCCAAGCCGGTGATGGAAGGCAAGGGCGTGCTGTTCAAGAAGTT
CGCCGGCATCGACGTGTTCGACCTCGAGATCGCCGAGCGCAACCTCGACAAGCTGGTCGACTGCATCGCCGCGCTGGAAC
CCACCTTCGGCGGCATCAACCTCGAGGACATCAAGGCGCCGGACTGCTTCTACGTGGAGCGCAAGCTGCGCGAACGCATG
AAGATCCCGGTCTTCCACGACGACCAGCACGGCACGGCGATCGTGGTCGGTGCCGCGCTGATCAATGGCCTGAAGGTGGT
CGGCAAGGACATCACCAAGGTCAAGCTGGTCACGTCGGGCGCCGGTGCGGCTGCGCTGGCCTGCCTGAACCTGCTGGTGA
AGCTGGGGCTGCCGCGCGAGAACATCTGGGTCACCGATCTGGCCGGCGTGGTCTACAGCGGACGCACCGAGCTGATGGAC
CCCGACAAGGCCGAGTTTGCCCAGCCCACCAGCCAGCGCTCGCTGATGGACGCGATCGCTGGTGCCGACATCTTCCTGGG
CCTGTCAGCCGGCGGCGTGCTGAAGAAGGACATGGTCGCGAAGATGGCGGCCAATCCGGTGATCTTCGCACTGGCCAACC
CCAACCCCGAGATTTCACCGGAGGACGTGAAGGCGGTGCGTGACGACGCCATCATGGCCACCGGCCGCACCGACTACCCG
AACCAGGTCAACAACGTCCTGTGCTTCCCCTACATCTTCCGGGGCGCGCTGGACTCGGGGGCGACCACCATCACCGACGA
GATGGAAGTCGCCGCGGTCTACGCGATCGCCGACCTGGCCCAGGCCGAGCAGAGCGAGGTGGTGGCCGCCGCCTACGCCG
GCGCCACGCTGAGCTTCGGGCCGGAGTACCTGATCCCCAAGCCCTTCGACCCGCGCCTGATGATGAAGATCGCGCCGGCC
GTCGCGCTGGCGGCAGCGGCCTCGGGCGTGGCCACGAGGCCCGTCAAGGACATCGACGCCTACCGCGAGAAGCTGCAGGC
CTTCGTCTACGCCTCGGGCACGACGATGAAGCCGATCTTCAACGTCGCCAAGCGCGCCAAGGTCAAGCGCGTGGTGTTCT
GCGAGGGCGAGGAAGAGCGCGTGCTGCGCGCGGTGCAGGTCATCATCGACGAGGACCTGGCGCGGCCGACGCTGGTGGGC
CGCCCACCGGTCATCGAGCAGCGCTGCGAGCGCTTCGGGCTGCGGCTGCAAGCCGGTCGCGACTATGACGTGGTCAACCC
CGAGAACGACGAACGCTACCGCGACTACTGGCAGACCTACCACCGCATCATGGCGCGGCGCGGCGTGACCCAGCAGTTCG
CGAAGATCGAGATGCGGCGCCGGCTGACACTGATCGGCGGCATGCTGCTGCACAAGGGCGAGGTCGACGGCATGCTCTGC
GGCACCTGGGGCACGACAGCGATGCACCTCAAGCACATCGACGAGCTGATCGGCCTGCGCCCTGGCGCCAAGACCTACGC
CTGCATGAACGGGCTGATCCTGCCCGGCCGCCAGGTGATGCTGGTCGACACCCACGTCAACTACGACCCCACCGCGGCCC
AGCTGGCCGAGATCACGGTGATGGCGGCCGAGGAGATGAAGCGCTTCGGCCTGGTGCCCAAGGCGGCGCTGCTGAGCCAC
TCCAACTTCGGCTCCAGCAACCAGCCTTCGGCGCTGAAGATGCGCGAGGCGCTCGCGCTGGTGCGCGCGCAGGCGCCGTG
GCTGGAGGTCGACGGCGAGATGCACGGCGACACGGCACTCGATCCCTCGCAACGCAGTGCCCAGATCCCCGACAGCACAC
TGCAGGGAGAAGCGAACCTGCTGGTGTTGCCGAACATCGACGCCGCCAACATCTCGTACAACCTGCTCAAGACTGCAGCC
GGTGGCGGCATTGCGATCGGCCCGGTGCTGCTCGGCGCCGCCAAGCCGGTGCACATCCTGACGCCGTCCGCCACGGTGCG
GCGCATCGTGAACCTGACGGCGCTGACGGTCGCCGACATCAACGCCGTCCGCTGA

Upstream 100 bases:

>100_bases
TGCGCAAGCCGCTCTGGCCGCAAAAGGGGGTCTTCTTACAATCGTCGACCCGGCCCGCTGCCCCTCGTGCGGTGCGCCTC
CCAACACGGAAAGCCAGACC

Downstream 100 bases:

>100_bases
GCGCCGTCGACCCTTGCGCCGCCCTCCCCGGACCCACGGCGGCGGGCACCCCACAAGTCAGCGGCGAGAAAGTCGTCAAG
TTTTCCGATATTCAAGACCA

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 764; Mature: 764

Protein sequence:

>764_residues
MLTNEEKSAELRQAALEYHEFPTPGKVAIAATKQLVNQRDLALAYSPGVAAACEEIVADPANAYRYTSRGNLVAVVTNGT
AVLGLGDIGPLAAKPVMEGKGVLFKKFAGIDVFDLEIAERNLDKLVDCIAALEPTFGGINLEDIKAPDCFYVERKLRERM
KIPVFHDDQHGTAIVVGAALINGLKVVGKDITKVKLVTSGAGAAALACLNLLVKLGLPRENIWVTDLAGVVYSGRTELMD
PDKAEFAQPTSQRSLMDAIAGADIFLGLSAGGVLKKDMVAKMAANPVIFALANPNPEISPEDVKAVRDDAIMATGRTDYP
NQVNNVLCFPYIFRGALDSGATTITDEMEVAAVYAIADLAQAEQSEVVAAAYAGATLSFGPEYLIPKPFDPRLMMKIAPA
VALAAAASGVATRPVKDIDAYREKLQAFVYASGTTMKPIFNVAKRAKVKRVVFCEGEEERVLRAVQVIIDEDLARPTLVG
RPPVIEQRCERFGLRLQAGRDYDVVNPENDERYRDYWQTYHRIMARRGVTQQFAKIEMRRRLTLIGGMLLHKGEVDGMLC
GTWGTTAMHLKHIDELIGLRPGAKTYACMNGLILPGRQVMLVDTHVNYDPTAAQLAEITVMAAEEMKRFGLVPKAALLSH
SNFGSSNQPSALKMREALALVRAQAPWLEVDGEMHGDTALDPSQRSAQIPDSTLQGEANLLVLPNIDAANISYNLLKTAA
GGGIAIGPVLLGAAKPVHILTPSATVRRIVNLTALTVADINAVR

Sequences:

>Translated_764_residues
MLTNEEKSAELRQAALEYHEFPTPGKVAIAATKQLVNQRDLALAYSPGVAAACEEIVADPANAYRYTSRGNLVAVVTNGT
AVLGLGDIGPLAAKPVMEGKGVLFKKFAGIDVFDLEIAERNLDKLVDCIAALEPTFGGINLEDIKAPDCFYVERKLRERM
KIPVFHDDQHGTAIVVGAALINGLKVVGKDITKVKLVTSGAGAAALACLNLLVKLGLPRENIWVTDLAGVVYSGRTELMD
PDKAEFAQPTSQRSLMDAIAGADIFLGLSAGGVLKKDMVAKMAANPVIFALANPNPEISPEDVKAVRDDAIMATGRTDYP
NQVNNVLCFPYIFRGALDSGATTITDEMEVAAVYAIADLAQAEQSEVVAAAYAGATLSFGPEYLIPKPFDPRLMMKIAPA
VALAAAASGVATRPVKDIDAYREKLQAFVYASGTTMKPIFNVAKRAKVKRVVFCEGEEERVLRAVQVIIDEDLARPTLVG
RPPVIEQRCERFGLRLQAGRDYDVVNPENDERYRDYWQTYHRIMARRGVTQQFAKIEMRRRLTLIGGMLLHKGEVDGMLC
GTWGTTAMHLKHIDELIGLRPGAKTYACMNGLILPGRQVMLVDTHVNYDPTAAQLAEITVMAAEEMKRFGLVPKAALLSH
SNFGSSNQPSALKMREALALVRAQAPWLEVDGEMHGDTALDPSQRSAQIPDSTLQGEANLLVLPNIDAANISYNLLKTAA
GGGIAIGPVLLGAAKPVHILTPSATVRRIVNLTALTVADINAVR
>Mature_764_residues
MLTNEEKSAELRQAALEYHEFPTPGKVAIAATKQLVNQRDLALAYSPGVAAACEEIVADPANAYRYTSRGNLVAVVTNGT
AVLGLGDIGPLAAKPVMEGKGVLFKKFAGIDVFDLEIAERNLDKLVDCIAALEPTFGGINLEDIKAPDCFYVERKLRERM
KIPVFHDDQHGTAIVVGAALINGLKVVGKDITKVKLVTSGAGAAALACLNLLVKLGLPRENIWVTDLAGVVYSGRTELMD
PDKAEFAQPTSQRSLMDAIAGADIFLGLSAGGVLKKDMVAKMAANPVIFALANPNPEISPEDVKAVRDDAIMATGRTDYP
NQVNNVLCFPYIFRGALDSGATTITDEMEVAAVYAIADLAQAEQSEVVAAAYAGATLSFGPEYLIPKPFDPRLMMKIAPA
VALAAAASGVATRPVKDIDAYREKLQAFVYASGTTMKPIFNVAKRAKVKRVVFCEGEEERVLRAVQVIIDEDLARPTLVG
RPPVIEQRCERFGLRLQAGRDYDVVNPENDERYRDYWQTYHRIMARRGVTQQFAKIEMRRRLTLIGGMLLHKGEVDGMLC
GTWGTTAMHLKHIDELIGLRPGAKTYACMNGLILPGRQVMLVDTHVNYDPTAAQLAEITVMAAEEMKRFGLVPKAALLSH
SNFGSSNQPSALKMREALALVRAQAPWLEVDGEMHGDTALDPSQRSAQIPDSTLQGEANLLVLPNIDAANISYNLLKTAA
GGGIAIGPVLLGAAKPVHILTPSATVRRIVNLTALTVADINAVR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=396, Percent_Identity=26.7676767676768, Blast_Score=100, Evalue=9e-21,
Organism=Homo sapiens, GI62420882, Length=341, Percent_Identity=26.3929618768328, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI62420880, Length=341, Percent_Identity=26.3929618768328, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI239049447, Length=341, Percent_Identity=26.3929618768328, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI4505145, Length=402, Percent_Identity=26.1194029850746, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI270265879, Length=368, Percent_Identity=27.1739130434783, Blast_Score=82, Evalue=3e-15,
Organism=Escherichia coli, GI1788806, Length=751, Percent_Identity=60.7190412782956, Blast_Score=936, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=307, Percent_Identity=33.5504885993485, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788635, Length=312, Percent_Identity=31.4102564102564, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI87081919, Length=408, Percent_Identity=24.7549019607843, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17537199, Length=405, Percent_Identity=23.9506172839506, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=270, Percent_Identity=30.3703703703704, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281362672, Length=403, Percent_Identity=27.5434243176179, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281362674, Length=403, Percent_Identity=27.5434243176179, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356279, Length=403, Percent_Identity=27.5434243176179, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646388, Length=403, Percent_Identity=26.5508684863524, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646386, Length=403, Percent_Identity=26.5508684863524, Blast_Score=81, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82340; Mature: 82340

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNEEKSAELRQAALEYHEFPTPGKVAIAATKQLVNQRDLALAYSPGVAAACEEIVADP
CCCCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCC
ANAYRYTSRGNLVAVVTNGTAVLGLGDIGPLAAKPVMEGKGVLFKKFAGIDVFDLEIAER
CHHEEEECCCCEEEEEECCEEEEEECCCCCHHCCCCCCCCCEEEEHHCCCEEEEHHHHHH
NLDKLVDCIAALEPTFGGINLEDIKAPDCFYVERKLRERMKIPVFHDDQHGTAIVVGAAL
HHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHH
INGLKVVGKDITKVKLVTSGAGAAALACLNLLVKLGLPRENIWVTDLAGVVYSGRTELMD
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCCCCCC
PDKAEFAQPTSQRSLMDAIAGADIFLGLSAGGVLKKDMVAKMAANPVIFALANPNPEISP
CCHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCH
EDVKAVRDDAIMATGRTDYPNQVNNVLCFPYIFRGALDSGATTITDEMEVAAVYAIADLA
HHHHHHHCCEEEECCCCCCCHHHCCEEEHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
QAEQSEVVAAAYAGATLSFGPEYLIPKPFDPRLMMKIAPAVALAAAASGVATRPVKDIDA
HHHHHHEEEHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
YREKLQAFVYASGTTMKPIFNVAKRAKVKRVVFCEGEEERVLRAVQVIIDEDLARPTLVG
HHHHHHEEEEECCCCHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCC
RPPVIEQRCERFGLRLQAGRDYDVVNPENDERYRDYWQTYHRIMARRGVTQQFAKIEMRR
CCCHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RLTLIGGMLLHKGEVDGMLCGTWGTTAMHLKHIDELIGLRPGAKTYACMNGLILPGRQVM
HHHHHHHHHEECCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCEECCCCEEE
LVDTHVNYDPTAAQLAEITVMAAEEMKRFGLVPKAALLSHSNFGSSNQPSALKMREALAL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHH
VRAQAPWLEVDGEMHGDTALDPSQRSAQIPDSTLQGEANLLVLPNIDAANISYNLLKTAA
HHCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEECCCCCCCCCHHHHHHCC
GGGIAIGPVLLGAAKPVHILTPSATVRRIVNLTALTVADINAVR
CCCEEEHHHHHCCCCCEEEECCCHHHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure
MLTNEEKSAELRQAALEYHEFPTPGKVAIAATKQLVNQRDLALAYSPGVAAACEEIVADP
CCCCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCC
ANAYRYTSRGNLVAVVTNGTAVLGLGDIGPLAAKPVMEGKGVLFKKFAGIDVFDLEIAER
CHHEEEECCCCEEEEEECCEEEEEECCCCCHHCCCCCCCCCEEEEHHCCCEEEEHHHHHH
NLDKLVDCIAALEPTFGGINLEDIKAPDCFYVERKLRERMKIPVFHDDQHGTAIVVGAAL
HHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHH
INGLKVVGKDITKVKLVTSGAGAAALACLNLLVKLGLPRENIWVTDLAGVVYSGRTELMD
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCCCCCC
PDKAEFAQPTSQRSLMDAIAGADIFLGLSAGGVLKKDMVAKMAANPVIFALANPNPEISP
CCHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCH
EDVKAVRDDAIMATGRTDYPNQVNNVLCFPYIFRGALDSGATTITDEMEVAAVYAIADLA
HHHHHHHCCEEEECCCCCCCHHHCCEEEHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
QAEQSEVVAAAYAGATLSFGPEYLIPKPFDPRLMMKIAPAVALAAAASGVATRPVKDIDA
HHHHHHEEEHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
YREKLQAFVYASGTTMKPIFNVAKRAKVKRVVFCEGEEERVLRAVQVIIDEDLARPTLVG
HHHHHHEEEEECCCCHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCC
RPPVIEQRCERFGLRLQAGRDYDVVNPENDERYRDYWQTYHRIMARRGVTQQFAKIEMRR
CCCHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RLTLIGGMLLHKGEVDGMLCGTWGTTAMHLKHIDELIGLRPGAKTYACMNGLILPGRQVM
HHHHHHHHHEECCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCEECCCCEEE
LVDTHVNYDPTAAQLAEITVMAAEEMKRFGLVPKAALLSHSNFGSSNQPSALKMREALAL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHH
VRAQAPWLEVDGEMHGDTALDPSQRSAQIPDSTLQGEANLLVLPNIDAANISYNLLKTAA
HHCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEECCCCCCCCCHHHHHHCC
GGGIAIGPVLLGAAKPVHILTPSATVRRIVNLTALTVADINAVR
CCCEEEHHHHHCCCCCEEEECCCHHHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]