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The map label for this gene is mrdA [H]

Identifier: 124265273

GI number: 124265273

Start: 75419

End: 77530

Strand: Reverse

Name: mrdA [H]

Synonym: Mpe_A0080

Alternate gene names: 124265273

Gene position: 77530-75419 (Counterclockwise)

Preceding gene: 124265274

Following gene: 124265272

Centisome position: 1.92

GC content: 68.89

Gene sequence:

>2112_bases
GTGACCGAACTCAAGAACGTCGACCAGGAGCTGGGCCGCTTCCGGCTGCGCCTGATCGCCGCCGGCGCGCTGGTGCTGTT
CGGCTTCGGGCTGGTGACGGCGCGCCTGGTCACGCTGCAGGTGCTGCGGCACGACGAGCTGTCCACGCGCGCCGAGAGCA
ACCGCATCACGGTACTGCCGATCACGCCGAACCGCGGCCTGATCCTCGACCGCAACGGCGTCGTGCTGGCGAACAACTAC
TCGGCCTACACGCTGGAGCTCACGCCGTCGAAGATCGACGACCTGGAGGGCACCATCGATGCGCTGCAGGAAGTGATCGA
CATCACGACGCGCGACCGTCGCCGCTTCAAGCGCATGATGGACGACGCCAAGAGCTTCGAGTCCCTGCCGATCCGCACCA
AGCTCAGCGACGAGGAGGTGGCGCGTTTCACCGCGCAGCGTTTCCGCTTCCCCGGGGTCGACATCAAGGCGCGGCTGTTC
CGCAACTACCCCTATGGCGAGCTCGGCAGCCATGTGCTGGGCTACATCGGCCGCATCAACCAGGCCGAGAAGGACGCGAT
CGACGAGACCGACGATGCGGCCAACTACAAGGGCACCGACTACATCGGCAAGCTCGGCATCGAGCAGAAGTACGAGGCCG
AGCTGCACGGCATCACCGGCTTCGAGGAGGTCGAGACCAGCGCCTCGGGCCGCGCGGTGCGGCGCCTGCGGGCCAGCCCG
CCGACGCCGGGCAACACGGTGCGGCTGTCGATCGACATCAAGCTGCAGGCGATGGTCGAGCAGCTGTTCGGCGACCGGCG
CGGCGCGCTGGTCGCGATCGACCCGCGCTCCGGCGAGGTGCTGGCCTTCGTCAGCAAGCCGACCTTCGACCCCAACCTGT
TCGTCGACGGCATCGATTCGGAGAGCTGGAAGGAGCTCAACGAGTCGATCGACAAGCCCCTGCTGAACCGCGCCCTGCGC
GGCACCTACCCGCCCGGCTCGACCTTCAAGCCCTTCATGGCGATCGCCGCGCTGGAATCCGGCAAGCGCACGCCGCAGCA
GACCACCTACGACAACGGCGTCTTCATGTTCGGCAACCACCGCTTCCGCAGCCACGGTGACGGCGGGCTGGGCGTGGTGG
ACATGAACCGCTCGATCGTCAAGTCGAGCAACGTCTACTACTACCAGCTGGCCGCCGACATGGGCGTGGACCTGATCCAC
GAGCAGCTCGAGCCCTTCGGCTTCGGCCGCCGCACCGGCATCGACATCAACGGCGAGGTCACCGGCGTGCTGCCCTCGAC
CGAGTGGAAGCGCAAGTACTACAAGAAGCCGGAGCTGCAGAAGTGGTACGCCGGCGAGACCATCTCGCTCGGCATCGGCC
AGGGCTACAACAACTTCACGATGCTGCAGCTCGCCACCGCCACCGCCACGCTGGTATCGGGCGGGCAGCGCTATGTGCCG
CGGCTGGTGCGCGAGATCGAGGATGTGGCAACCCGGGAGACCCGACTGATGTCGGCCGAGGCGCTGAGTCCGCTGCCGTT
GCAGCCCGATCACGTGGAGGTGGTCCGCAAGGCGCTGCACGGCGTGACGCAGGAAGGCACCTCGACGCGCGTCTTCATGG
GGGCGAGCTACCCGAGTGGTGGGAAGACCGGGACGGCGCAGGCGGTCGGCATTCGCCAGGACCAGAAGTACGACAAGAGC
AAGATGGCCGACTACCTGCGCGACCATTCGCTCTACACCGCCTTCGCGCCGGTCGACAACCCGCAGGTCGCACTGGCCGT
CATCGTGGAGAACTCCGGTTTCGGCGCCGAGGCGGCCGCGCCGATCGCGCGGCGCGTGCTCGATTTCGTGCTGACGGGGC
GCTACCCGAACGCCGAGGACATCGCGCTGGTCCAGAAGGGCCAAGCCGGTCCGCCGGTCGGCACGCCGCGACTCGCCGCC
GAGGTGCCGCTGATGCCGTTCACGCCCGGCGCCGTCACGACCGCCGGCGGTGAGGCCGCCGCGGCGCCTGCCGCCCCCGC
CTCCCAACCCGCCCCGGCGGCTTCGGCGCCCGGGGGAGCGGCGGCAGCCCCGCCGGCGAAGATCGCCCAGGCGCCGGCGC
CGACAGCACCGGCCGAGGCCACGAATCGATGA

Upstream 100 bases:

>100_bases
CCGGTGGCCGCCGTGCTGCTGCTGGCGCCGCAGCGCCGTGCGCCGGACCGGGACGAGAATCGACCGCTGTGACCGCAGCG
CGGCAACGCCGGACAGGACC

Downstream 100 bases:

>100_bases
GCACCGTGTTCGACAAGCGTCCGTGGTGGCAACGTGCCGCCACCGTGTTCATGGGCTTCGACGGACCGCTGGCGCTGGCC
ATCGTGCTGCTGGCGGCCGC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MTELKNVDQELGRFRLRLIAAGALVLFGFGLVTARLVTLQVLRHDELSTRAESNRITVLPITPNRGLILDRNGVVLANNY
SAYTLELTPSKIDDLEGTIDALQEVIDITTRDRRRFKRMMDDAKSFESLPIRTKLSDEEVARFTAQRFRFPGVDIKARLF
RNYPYGELGSHVLGYIGRINQAEKDAIDETDDAANYKGTDYIGKLGIEQKYEAELHGITGFEEVETSASGRAVRRLRASP
PTPGNTVRLSIDIKLQAMVEQLFGDRRGALVAIDPRSGEVLAFVSKPTFDPNLFVDGIDSESWKELNESIDKPLLNRALR
GTYPPGSTFKPFMAIAALESGKRTPQQTTYDNGVFMFGNHRFRSHGDGGLGVVDMNRSIVKSSNVYYYQLAADMGVDLIH
EQLEPFGFGRRTGIDINGEVTGVLPSTEWKRKYYKKPELQKWYAGETISLGIGQGYNNFTMLQLATATATLVSGGQRYVP
RLVREIEDVATRETRLMSAEALSPLPLQPDHVEVVRKALHGVTQEGTSTRVFMGASYPSGGKTGTAQAVGIRQDQKYDKS
KMADYLRDHSLYTAFAPVDNPQVALAVIVENSGFGAEAAAPIARRVLDFVLTGRYPNAEDIALVQKGQAGPPVGTPRLAA
EVPLMPFTPGAVTTAGGEAAAAPAAPASQPAPAASAPGGAAAAPPAKIAQAPAPTAPAEATNR

Sequences:

>Translated_703_residues
MTELKNVDQELGRFRLRLIAAGALVLFGFGLVTARLVTLQVLRHDELSTRAESNRITVLPITPNRGLILDRNGVVLANNY
SAYTLELTPSKIDDLEGTIDALQEVIDITTRDRRRFKRMMDDAKSFESLPIRTKLSDEEVARFTAQRFRFPGVDIKARLF
RNYPYGELGSHVLGYIGRINQAEKDAIDETDDAANYKGTDYIGKLGIEQKYEAELHGITGFEEVETSASGRAVRRLRASP
PTPGNTVRLSIDIKLQAMVEQLFGDRRGALVAIDPRSGEVLAFVSKPTFDPNLFVDGIDSESWKELNESIDKPLLNRALR
GTYPPGSTFKPFMAIAALESGKRTPQQTTYDNGVFMFGNHRFRSHGDGGLGVVDMNRSIVKSSNVYYYQLAADMGVDLIH
EQLEPFGFGRRTGIDINGEVTGVLPSTEWKRKYYKKPELQKWYAGETISLGIGQGYNNFTMLQLATATATLVSGGQRYVP
RLVREIEDVATRETRLMSAEALSPLPLQPDHVEVVRKALHGVTQEGTSTRVFMGASYPSGGKTGTAQAVGIRQDQKYDKS
KMADYLRDHSLYTAFAPVDNPQVALAVIVENSGFGAEAAAPIARRVLDFVLTGRYPNAEDIALVQKGQAGPPVGTPRLAA
EVPLMPFTPGAVTTAGGEAAAAPAAPASQPAPAASAPGGAAAAPPAKIAQAPAPTAPAEATNR
>Mature_702_residues
TELKNVDQELGRFRLRLIAAGALVLFGFGLVTARLVTLQVLRHDELSTRAESNRITVLPITPNRGLILDRNGVVLANNYS
AYTLELTPSKIDDLEGTIDALQEVIDITTRDRRRFKRMMDDAKSFESLPIRTKLSDEEVARFTAQRFRFPGVDIKARLFR
NYPYGELGSHVLGYIGRINQAEKDAIDETDDAANYKGTDYIGKLGIEQKYEAELHGITGFEEVETSASGRAVRRLRASPP
TPGNTVRLSIDIKLQAMVEQLFGDRRGALVAIDPRSGEVLAFVSKPTFDPNLFVDGIDSESWKELNESIDKPLLNRALRG
TYPPGSTFKPFMAIAALESGKRTPQQTTYDNGVFMFGNHRFRSHGDGGLGVVDMNRSIVKSSNVYYYQLAADMGVDLIHE
QLEPFGFGRRTGIDINGEVTGVLPSTEWKRKYYKKPELQKWYAGETISLGIGQGYNNFTMLQLATATATLVSGGQRYVPR
LVREIEDVATRETRLMSAEALSPLPLQPDHVEVVRKALHGVTQEGTSTRVFMGASYPSGGKTGTAQAVGIRQDQKYDKSK
MADYLRDHSLYTAFAPVDNPQVALAVIVENSGFGAEAAAPIARRVLDFVLTGRYPNAEDIALVQKGQAGPPVGTPRLAAE
VPLMPFTPGAVTTAGGEAAAAPAAPASQPAPAASAPGGAAAAPPAKIAQAPAPTAPAEATNR

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=615, Percent_Identity=40, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1786272, Length=644, Percent_Identity=23.6024844720497, Blast_Score=119, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 76396; Mature: 76265

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKNVDQELGRFRLRLIAAGALVLFGFGLVTARLVTLQVLRHDELSTRAESNRITVLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEE
ITPNRGLILDRNGVVLANNYSAYTLELTPSKIDDLEGTIDALQEVIDITTRDRRRFKRMM
ECCCCCEEEECCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDAKSFESLPIRTKLSDEEVARFTAQRFRFPGVDIKARLFRNYPYGELGSHVLGYIGRIN
HHHHHHHCCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCC
QAEKDAIDETDDAANYKGTDYIGKLGIEQKYEAELHGITGFEEVETSASGRAVRRLRASP
CHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHCCCCCHHHHHCCCCCHHHHHHHCCC
PTPGNTVRLSIDIKLQAMVEQLFGDRRGALVAIDPRSGEVLAFVSKPTFDPNLFVDGIDS
CCCCCEEEEEEEEEHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCCCCEEECCCC
ESWKELNESIDKPLLNRALRGTYPPGSTFKPFMAIAALESGKRTPQQTTYDNGVFMFGNH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCC
RFRSHGDGGLGVVDMNRSIVKSSNVYYYQLAADMGVDLIHEQLEPFGFGRRTGIDINGEV
EECCCCCCCEEEEECCHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCEE
TGVLPSTEWKRKYYKKPELQKWYAGETISLGIGQGYNNFTMLQLATATATLVSGGQRYVP
EEECCCCHHHHHHCCCCCHHHHHCCCEEEEECCCCCCCEEEEEEHHHHHHHHCCCHHHHH
RLVREIEDVATRETRLMSAEALSPLPLQPDHVEVVRKALHGVTQEGTSTRVFMGASYPSG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
GKTGTAQAVGIRQDQKYDKSKMADYLRDHSLYTAFAPVDNPQVALAVIVENSGFGAEAAA
CCCCCEEEECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCCHHHH
PIARRVLDFVLTGRYPNAEDIALVQKGQAGPPVGTPRLAAEVPLMPFTPGAVTTAGGEAA
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCEEECCCCCC
AAPAAPASQPAPAASAPGGAAAAPPAKIAQAPAPTAPAEATNR
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TELKNVDQELGRFRLRLIAAGALVLFGFGLVTARLVTLQVLRHDELSTRAESNRITVLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEE
ITPNRGLILDRNGVVLANNYSAYTLELTPSKIDDLEGTIDALQEVIDITTRDRRRFKRMM
ECCCCCEEEECCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDAKSFESLPIRTKLSDEEVARFTAQRFRFPGVDIKARLFRNYPYGELGSHVLGYIGRIN
HHHHHHHCCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCC
QAEKDAIDETDDAANYKGTDYIGKLGIEQKYEAELHGITGFEEVETSASGRAVRRLRASP
CHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHCCCCCHHHHHCCCCCHHHHHHHCCC
PTPGNTVRLSIDIKLQAMVEQLFGDRRGALVAIDPRSGEVLAFVSKPTFDPNLFVDGIDS
CCCCCEEEEEEEEEHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCCCCEEECCCC
ESWKELNESIDKPLLNRALRGTYPPGSTFKPFMAIAALESGKRTPQQTTYDNGVFMFGNH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCC
RFRSHGDGGLGVVDMNRSIVKSSNVYYYQLAADMGVDLIHEQLEPFGFGRRTGIDINGEV
EECCCCCCCEEEEECCHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCEE
TGVLPSTEWKRKYYKKPELQKWYAGETISLGIGQGYNNFTMLQLATATATLVSGGQRYVP
EEECCCCHHHHHHCCCCCHHHHHCCCEEEEECCCCCCCEEEEEEHHHHHHHHCCCHHHHH
RLVREIEDVATRETRLMSAEALSPLPLQPDHVEVVRKALHGVTQEGTSTRVFMGASYPSG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
GKTGTAQAVGIRQDQKYDKSKMADYLRDHSLYTAFAPVDNPQVALAVIVENSGFGAEAAA
CCCCCEEEECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCCHHHH
PIARRVLDFVLTGRYPNAEDIALVQKGQAGPPVGTPRLAAEVPLMPFTPGAVTTAGGEAA
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCEEECCCCCC
AAPAAPASQPAPAASAPGGAAAAPPAKIAQAPAPTAPAEATNR
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]