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The map label for this gene is mrdB [H]

Identifier: 124265272

GI number: 124265272

Start: 74265

End: 75422

Strand: Reverse

Name: mrdB [H]

Synonym: Mpe_A0079

Alternate gene names: 124265272

Gene position: 75422-74265 (Counterclockwise)

Preceding gene: 124265273

Following gene: 124265268

Centisome position: 1.86

GC content: 67.01

Gene sequence:

>1158_bases
ATGAGCACCGTGTTCGACAAGCGTCCGTGGTGGCAACGTGCCGCCACCGTGTTCATGGGCTTCGACGGACCGCTGGCGCT
GGCCATCGTGCTGCTGGCGGCCGCGGGCCTGCTGACCATGTATTCGGCCGGCTACGACCATGGCACGCGCTTCGTCGATC
ACGGCCGCAACATGCTGCTGGCCGCCGGCGTGATGTTCATCGTGGCGCAGCTCTCGCCGCAGCGCCTGGCGCAGCTGGCG
GTGCCGCTGTACGTGCTGGGTGTGGCGCTGCTGATCGCCGTCGAGCTGTTCGGCGTGACGAAGAAGGGCGCCACGCGCTG
GCTCGACCTGCAGGTGCTGGTGATCCAGCCCAGCGAACTGCTGAAGATCGCCACGCCCCTGATGCTGGCCTGGTGGTTCC
AGCGCCGGGAAGGCCAGCTGCAGGCGCCGGACTTCGTGGTGGCCTTCGTGCTGCTGGCGGTGCCGGTCGCACTGATCGTG
AAGCAGCCGGACCTGGGCACTGCCATCCTGGTGCTGTCGGGCGGGCTGTACGTGATGTTCTTCGCCGGCCTGAGCTGGGC
GCTGATCCTGCCGGTGCTGGGGCTGGGCGCGGTCGGCATCGGCGGGTTGATCTGGTTCCAGACGCAGATCTGCGAGCCCG
GCGTCGACTGGGTGTTGCTGCACGAGTATCAGAAGCACCGCGTCTGCACCCTGCTCGACCCGACCACCGATCCCTTGGGG
AAGGGCTTCCACATCATCCAGGGCATGATCGCCATCGGCTCGGGCGGGGTCACCGGCAAGGGGTTCATGAACGGCACCCA
GACCCATCTGGAGTTCATCCCCGAGCGCACCACCGACTTCATCTTCGCGGCCTTCTCGGAGGAGTTCGGACTGGCGGGCT
GCGTGGCGCTGCTGCTGGGCTTCACCTTCCTGATCTTCCGCGGTCTGATGATCGCGTCGGACGCGCCGACGCTGTTCTCG
CGGCTGCTGGCCGGCGCGATCACGCTCAGCTTCTTCACCTACAGCATGGTGAACATGGGCATGGTGACCGGCATCCTGCC
GGTGGTGGGCATCCCGTTGCCCTTCATCAGCTACGGCGGCACGGCGATGGTCACGCTGGGTCTCGCGCTCGGCATCCTGA
TGTCGGTGGCGCGCAGCAAGCGGCTGATGCAGAGCTGA

Upstream 100 bases:

>100_bases
CCGCCCCGGCGGCTTCGGCGCCCGGGGGAGCGGCGGCAGCCCCGCCGGCGAAGATCGCCCAGGCGCCGGCGCCGACAGCA
CCGGCCGAGGCCACGAATCG

Downstream 100 bases:

>100_bases
ACGGCCGGCGACGGACTCAGCGCGGCGGCTTGCGTGGACGCTTGATCCAGCGCGACAGGAGGGAAGGCAGGCGCGGCCGC
GCCACGGCTGGCCGCGCCGC

Product: putative rod shape-determining transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSTVFDKRPWWQRAATVFMGFDGPLALAIVLLAAAGLLTMYSAGYDHGTRFVDHGRNMLLAAGVMFIVAQLSPQRLAQLA
VPLYVLGVALLIAVELFGVTKKGATRWLDLQVLVIQPSELLKIATPLMLAWWFQRREGQLQAPDFVVAFVLLAVPVALIV
KQPDLGTAILVLSGGLYVMFFAGLSWALILPVLGLGAVGIGGLIWFQTQICEPGVDWVLLHEYQKHRVCTLLDPTTDPLG
KGFHIIQGMIAIGSGGVTGKGFMNGTQTHLEFIPERTTDFIFAAFSEEFGLAGCVALLLGFTFLIFRGLMIASDAPTLFS
RLLAGAITLSFFTYSMVNMGMVTGILPVVGIPLPFISYGGTAMVTLGLALGILMSVARSKRLMQS

Sequences:

>Translated_385_residues
MSTVFDKRPWWQRAATVFMGFDGPLALAIVLLAAAGLLTMYSAGYDHGTRFVDHGRNMLLAAGVMFIVAQLSPQRLAQLA
VPLYVLGVALLIAVELFGVTKKGATRWLDLQVLVIQPSELLKIATPLMLAWWFQRREGQLQAPDFVVAFVLLAVPVALIV
KQPDLGTAILVLSGGLYVMFFAGLSWALILPVLGLGAVGIGGLIWFQTQICEPGVDWVLLHEYQKHRVCTLLDPTTDPLG
KGFHIIQGMIAIGSGGVTGKGFMNGTQTHLEFIPERTTDFIFAAFSEEFGLAGCVALLLGFTFLIFRGLMIASDAPTLFS
RLLAGAITLSFFTYSMVNMGMVTGILPVVGIPLPFISYGGTAMVTLGLALGILMSVARSKRLMQS
>Mature_384_residues
STVFDKRPWWQRAATVFMGFDGPLALAIVLLAAAGLLTMYSAGYDHGTRFVDHGRNMLLAAGVMFIVAQLSPQRLAQLAV
PLYVLGVALLIAVELFGVTKKGATRWLDLQVLVIQPSELLKIATPLMLAWWFQRREGQLQAPDFVVAFVLLAVPVALIVK
QPDLGTAILVLSGGLYVMFFAGLSWALILPVLGLGAVGIGGLIWFQTQICEPGVDWVLLHEYQKHRVCTLLDPTTDPLGK
GFHIIQGMIAIGSGGVTGKGFMNGTQTHLEFIPERTTDFIFAAFSEEFGLAGCVALLLGFTFLIFRGLMIASDAPTLFSR
LLAGAITLSFFTYSMVNMGMVTGILPVVGIPLPFISYGGTAMVTLGLALGILMSVARSKRLMQS

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=322, Percent_Identity=47.5155279503106, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1786277, Length=367, Percent_Identity=31.8801089918256, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 41525; Mature: 41394

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVFDKRPWWQRAATVFMGFDGPLALAIVLLAAAGLLTMYSAGYDHGTRFVDHGRNMLL
CCCCCCCCCHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHH
AAGVMFIVAQLSPQRLAQLAVPLYVLGVALLIAVELFGVTKKGATRWLDLQVLVIQPSEL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCHHH
LKIATPLMLAWWFQRREGQLQAPDFVVAFVLLAVPVALIVKQPDLGTAILVLSGGLYVMF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHHH
FAGLSWALILPVLGLGAVGIGGLIWFQTQICEPGVDWVLLHEYQKHRVCTLLDPTTDPLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCEEEEECCCCCCCC
KGFHIIQGMIAIGSGGVTGKGFMNGTQTHLEFIPERTTDFIFAAFSEEFGLAGCVALLLG
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
FTFLIFRGLMIASDAPTLFSRLLAGAITLSFFTYSMVNMGMVTGILPVVGIPLPFISYGG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
TAMVTLGLALGILMSVARSKRLMQS
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STVFDKRPWWQRAATVFMGFDGPLALAIVLLAAAGLLTMYSAGYDHGTRFVDHGRNMLL
CCCCCCCCHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHH
AAGVMFIVAQLSPQRLAQLAVPLYVLGVALLIAVELFGVTKKGATRWLDLQVLVIQPSEL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCHHH
LKIATPLMLAWWFQRREGQLQAPDFVVAFVLLAVPVALIVKQPDLGTAILVLSGGLYVMF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHHH
FAGLSWALILPVLGLGAVGIGGLIWFQTQICEPGVDWVLLHEYQKHRVCTLLDPTTDPLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCEEEEECCCCCCCC
KGFHIIQGMIAIGSGGVTGKGFMNGTQTHLEFIPERTTDFIFAAFSEEFGLAGCVALLLG
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
FTFLIFRGLMIASDAPTLFSRLLAGAITLSFFTYSMVNMGMVTGILPVVGIPLPFISYGG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
TAMVTLGLALGILMSVARSKRLMQS
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]