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The map label for this gene is focA [H]

Identifier: 124265211

GI number: 124265211

Start: 21070

End: 21867

Strand: Direct

Name: focA [H]

Synonym: Mpe_A0018

Alternate gene names: 124265211

Gene position: 21070-21867 (Clockwise)

Preceding gene: 124265210

Following gene: 124265226

Centisome position: 0.52

GC content: 70.93

Gene sequence:

>798_bases
ATGAGCGACCTGTTCGGACTCGACGCCTACGCGCCGAAGGAGATCGCCGCGCGCGTGAGCGAGATCGGCGTCGCCAAGAC
GCGGCTGCCGCGGCTGACGCTTGCGCTGCTGGGCGTGCTGGCCGGGGCCTACATCGGCCTGGGCGCCATGCTGTCCACGC
TGGTGGCGAGCGATGCCACGCTGGGCTTCGCGGTGTCGCGTTTGCTGGGTGGGCTGGTGTTCTCGCTCGGCCTGATGCTG
GTGGTGGTGGCCGGTGCCGAACTGTTCACCGGCAACAACCTGCTCGTGATGGCCTGGGCCGGTGGGCGCATCGGCAGCGC
CGAGCTGCTGCGCCACTGGGCGCTGGTGGGCGCGGCCAATGCGGTGGGTGCGGCCGGTCTGGCGTTGCTGGTGTGGCTGT
CGGGGCACGGTGCGCTGCAGCAGGGCGAGGTGGGCCGCAGCGTGGTCCGCATCGCGACCGCGAAGGCTCAGCTGCCGCTG
GCCGAGGCCTTCTTCCGCGGGGTGTTGTGCAACGTGCTGGTCTGCATGGCGGTGTGGATGGCGCTGGCCGGGCGCAGCGT
GACCGACAAGCTGCTGGCCATCGCGTTCCCGGTCACCGCCTTCGTCGCCGCCGGCTTCGAGCACTCGATCGCCAACCTCT
ACTTCTTCCCGCTGGCGCTGCTGCTCGGTGCGCCGCTGGCTGCCGGCGACATCGCGGGCAACCTGCTGGCGGTGATCGCC
GGCAATCTGGTCGGCGGTGGCGTGCTGGTCGCGCTGGTCTACTGGGTGATCTACCTGCGGCCGGCATCGCGCGACTGA

Upstream 100 bases:

>100_bases
GTGCTGGGCGGCGTGACGCGCACCGTGCTGCGCTCGATGACGCTGCCGGTGCTGATGGTGCACTGAGCGTGCGCATCCGC
GCGCCCCGTCGGCACCGCGC

Downstream 100 bases:

>100_bases
GCCGCCCGCTCCAGCAGCAGCTCGCGCTCGCGCCCATTGCGCGTCAGCGCCGCGGCGCGCTCGAACTCCGCGCGCGCCTC
GTCATGGCGGCCCAGCTTGG

Product: formate/nitrate transporter

Products: formate [Periplasm]; formate [Cytoplasm] [C]

Alternate protein names: Formate channel 1 [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSDLFGLDAYAPKEIAARVSEIGVAKTRLPRLTLALLGVLAGAYIGLGAMLSTLVASDATLGFAVSRLLGGLVFSLGLML
VVVAGAELFTGNNLLVMAWAGGRIGSAELLRHWALVGAANAVGAAGLALLVWLSGHGALQQGEVGRSVVRIATAKAQLPL
AEAFFRGVLCNVLVCMAVWMALAGRSVTDKLLAIAFPVTAFVAAGFEHSIANLYFFPLALLLGAPLAAGDIAGNLLAVIA
GNLVGGGVLVALVYWVIYLRPASRD

Sequences:

>Translated_265_residues
MSDLFGLDAYAPKEIAARVSEIGVAKTRLPRLTLALLGVLAGAYIGLGAMLSTLVASDATLGFAVSRLLGGLVFSLGLML
VVVAGAELFTGNNLLVMAWAGGRIGSAELLRHWALVGAANAVGAAGLALLVWLSGHGALQQGEVGRSVVRIATAKAQLPL
AEAFFRGVLCNVLVCMAVWMALAGRSVTDKLLAIAFPVTAFVAAGFEHSIANLYFFPLALLLGAPLAAGDIAGNLLAVIA
GNLVGGGVLVALVYWVIYLRPASRD
>Mature_264_residues
SDLFGLDAYAPKEIAARVSEIGVAKTRLPRLTLALLGVLAGAYIGLGAMLSTLVASDATLGFAVSRLLGGLVFSLGLMLV
VVAGAELFTGNNLLVMAWAGGRIGSAELLRHWALVGAANAVGAAGLALLVWLSGHGALQQGEVGRSVVRIATAKAQLPLA
EAFFRGVLCNVLVCMAVWMALAGRSVTDKLLAIAFPVTAFVAAGFEHSIANLYFFPLALLLGAPLAAGDIAGNLLAVIAG
NLVGGGVLVALVYWVIYLRPASRD

Specific function: Involved in the bidirectional transport of formate [H]

COG id: COG2116

COG function: function code P; Formate/nitrite family of transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FNT transporter (TC 2.A.44) family [H]

Homologues:

Organism=Escherichia coli, GI1787132, Length=279, Percent_Identity=38.3512544802867, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI1788837, Length=276, Percent_Identity=35.8695652173913, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI87082249, Length=233, Percent_Identity=38.6266094420601, Blast_Score=107, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321779, Length=265, Percent_Identity=27.5471698113208, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000292 [H]

Pfam domain/function: PF01226 Form_Nir_trans [H]

EC number: NA

Molecular weight: Translated: 27163; Mature: 27031

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS01005 FORMATE_NITRITE_TP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDLFGLDAYAPKEIAARVSEIGVAKTRLPRLTLALLGVLAGAYIGLGAMLSTLVASDAT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LGFAVSRLLGGLVFSLGLMLVVVAGAELFTGNNLLVMAWAGGRIGSAELLRHWALVGAAN
HHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHH
AVGAAGLALLVWLSGHGALQQGEVGRSVVRIATAKAQLPLAEAFFRGVLCNVLVCMAVWM
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ALAGRSVTDKLLAIAFPVTAFVAAGFEHSIANLYFFPLALLLGAPLAAGDIAGNLLAVIA
HHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GNLVGGGVLVALVYWVIYLRPASRD
HHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate [Cytoplasm]; formate [Periplasm] [C]

Specific reaction: formate [Cytoplasm] = formate [Periplasm] formate [Periplasm] = formate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]