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The map label for this gene is 124028463

Identifier: 124028463

GI number: 124028463

Start: 1621395

End: 1623461

Strand: Direct

Name: 124028463

Synonym: Hbut_1623

Alternate gene names: NA

Gene position: 1621395-1623461 (Clockwise)

Preceding gene: 124028462

Following gene: 124028464

Centisome position: 97.25

GC content: 57.38

Gene sequence:

>2067_bases
TTGTTGCGTGTCGGTATCGATGTTGGGGGCACCTTTACCGACATTGTCGTGTTTGATGAGGAGTCGGGGAGGCTTGTTGC
TGGCAAGGTTTTGACGGTGCCTCGTGAACCTTGGCGTGGTGTTTTGGGGGCCTTTGATGCTCTTGGTGTTAGGGTTTCGG
ATGTCGGAGTGTTTGTTCACGCTACCACGCTTGGCACTAACATGTTTCTAGGCCAGGTTGGTATTGAGCCGCCTGTCGCT
GTGCTCATTACTAATGCTGGGTTCCGCGACGTTATCGAGATTGGCCGTCAGAATAGGGCTGAGCTTTACAACCTGTTCTT
CGAGAAGCCCCAGCCGTTGGTGCCGAGGTCTAGGAGGTTTGGTGTCAGGGGCAGGGTTAGCGCCCGGGGAGAGGAGCTGG
AGCCGCTGGATGTAGGGGCTGTTAGGCGTATTGCTCGCGAGTGGTGTGGCCGTGCGAAAGTGTTTATCATCTCCTTCCTA
CACTGCTACGCCAACGATGCGCATGAGAGGCTTGCGGCGAGGGTCGTCCGCGAAGAGTGTCCCGGCGCCGAAGTTGTTAC
CGGCTGTGAGGTTGACCCGGAGCCTGGCGAGTTCGAGCGCACTAGCACAGCTGTTGTCAATGGTCTTCTCCGCCCCATAT
TGTCTAGGTATCTTTCGAAGCTCGCGAGGGAGATGGAGCAGCGGGGGTTTCGGGGCAGGTTTCTAGTAATGCAGAGTAGC
GGAGGCGTAGCATCGCTAGAGTATGCTGTGAGGTTTCCGGCAGCATTTATCGAGAGTGGCCCTGCAGCAGGTGTTGTTGC
TACAGCATACTTTGCCGAGGCTATGGGTATAAGGTATGCGTTGAGCTTTGATATGGGTGGTACTACTGCTAAGGCTGCAG
CAATCGTTAACGGCGAGCCAATCGTAGCCGACATGTACGAGGTTGGCGGCAAGGTCCACATGGGCCGTGTACTGCGGGGA
TCCGGGTACCCTGTAAGGTACCCCTTCATAGACATCGCAGAGGTTAGCGCGGGAGGAGGCACTATAGCATGGGTGGATGC
CGGGGGCGCCCTCCGCGTCGGGCCGATTAGTGCTGGCGCTGACCCCGGCCCCGCATGTTACGGGCGTGGAGGCCGCGAGC
CAACAGTTACCGATGCCAACCTCGTGCTGGGCCGTCTACCCGAAGTGCTGGCAGGCGGCCGTGTACGTCTTCACCGCAAC
CTAGCCAAGGAAGCCCTAGAGAAGCTTGCCAAGGCTGTAGGAATGGATACCGTGGAAGCCGCCTTAGCCGTCATACGCAT
AGCTGACACCGTTATGGCACGCGCGCTCCGCCTTGTCAGCATAGAGAAAGGCTATGACCCTAGGATGTTCACACTATTCG
CCTTCGGGGGTGCTGGGCCCCTCCACGCTGTAAGCCTCGCTAGGGAGCTCGGCGTGCCACGGGTCGTTGTGCCGCCCTAT
ACAGGTGTGTTCTCCGCACTGGGGCTACTGCTTACCGACTACCGCCACGATCTACGGAGACCAGTTGTCCGCCGAGCCGA
CGAGCTCGAAGAGGAGCAACTAAATAAGGTTTTCGATGAGCTGGCAGATGAAGCTAAACGGATACTAGCATCGGAGGGCG
TGCCAGAGGAGCGAGTTAGGCTTACGAGGCTTCTCGAAGCACGCTACGAGGGACAGGCATACTCGCTAACCATCCCCTAC
CACGGCTCGCTCAGTGAGGCCGTAAACGAGTTCCACAAGCTACACGCTGCGAGGTATGGTTACAGCATGCCAGAACACCC
CGTGGTCATTGTCTCGGCTAGACTTGTAGCTATAGGAGTCACGCCAAAACCCCGCCTACCACGCAGTAAACCGCTACGAC
ATACACCGGAGCCCGTAGGGTACCGGGAGGTCTACTTCAAGGATGATGGGTGGACCCGTACCCCCATCTATCGCAGAGAC
AGGTTGAAGCCCGGAGCTGTGCTTAAGGGCCCTGCAGTTATAGAGTCTGATGATAGCACCATACTAATTCCACCAGACAG
TGTTGGCACAGTAGACGAGCACCATTCCATAGTTATTAGCGTTGGGGGTGGCAGTGTTGAAGCTTGA

Upstream 100 bases:

>100_bases
TGTAGGTTTTAGCACGTCTGCCTCTTGTGTGTTGCCTTGGCTGGATAGCACTCTTTATCCTGTTGCTGGTAGCTGCTGTG
GTGCTTGGGGTTGGGTTTTC

Downstream 100 bases:

>100_bases
CACTGCTACCGTTGAAGTTATTAGGAATGCTTCGATATACATTGCCGAGGAGATGGGTGTTGTGCTGAGGAATACAGCGC
TAAGCCCCAACATACGCGAC

Product: Hydantoin utilization protein A

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 688

Protein sequence:

>688_residues
MLRVGIDVGGTFTDIVVFDEESGRLVAGKVLTVPREPWRGVLGAFDALGVRVSDVGVFVHATTLGTNMFLGQVGIEPPVA
VLITNAGFRDVIEIGRQNRAELYNLFFEKPQPLVPRSRRFGVRGRVSARGEELEPLDVGAVRRIAREWCGRAKVFIISFL
HCYANDAHERLAARVVREECPGAEVVTGCEVDPEPGEFERTSTAVVNGLLRPILSRYLSKLAREMEQRGFRGRFLVMQSS
GGVASLEYAVRFPAAFIESGPAAGVVATAYFAEAMGIRYALSFDMGGTTAKAAAIVNGEPIVADMYEVGGKVHMGRVLRG
SGYPVRYPFIDIAEVSAGGGTIAWVDAGGALRVGPISAGADPGPACYGRGGREPTVTDANLVLGRLPEVLAGGRVRLHRN
LAKEALEKLAKAVGMDTVEAALAVIRIADTVMARALRLVSIEKGYDPRMFTLFAFGGAGPLHAVSLARELGVPRVVVPPY
TGVFSALGLLLTDYRHDLRRPVVRRADELEEEQLNKVFDELADEAKRILASEGVPEERVRLTRLLEARYEGQAYSLTIPY
HGSLSEAVNEFHKLHAARYGYSMPEHPVVIVSARLVAIGVTPKPRLPRSKPLRHTPEPVGYREVYFKDDGWTRTPIYRRD
RLKPGAVLKGPAVIESDDSTILIPPDSVGTVDEHHSIVISVGGGSVEA

Sequences:

>Translated_688_residues
MLRVGIDVGGTFTDIVVFDEESGRLVAGKVLTVPREPWRGVLGAFDALGVRVSDVGVFVHATTLGTNMFLGQVGIEPPVA
VLITNAGFRDVIEIGRQNRAELYNLFFEKPQPLVPRSRRFGVRGRVSARGEELEPLDVGAVRRIAREWCGRAKVFIISFL
HCYANDAHERLAARVVREECPGAEVVTGCEVDPEPGEFERTSTAVVNGLLRPILSRYLSKLAREMEQRGFRGRFLVMQSS
GGVASLEYAVRFPAAFIESGPAAGVVATAYFAEAMGIRYALSFDMGGTTAKAAAIVNGEPIVADMYEVGGKVHMGRVLRG
SGYPVRYPFIDIAEVSAGGGTIAWVDAGGALRVGPISAGADPGPACYGRGGREPTVTDANLVLGRLPEVLAGGRVRLHRN
LAKEALEKLAKAVGMDTVEAALAVIRIADTVMARALRLVSIEKGYDPRMFTLFAFGGAGPLHAVSLARELGVPRVVVPPY
TGVFSALGLLLTDYRHDLRRPVVRRADELEEEQLNKVFDELADEAKRILASEGVPEERVRLTRLLEARYEGQAYSLTIPY
HGSLSEAVNEFHKLHAARYGYSMPEHPVVIVSARLVAIGVTPKPRLPRSKPLRHTPEPVGYREVYFKDDGWTRTPIYRRD
RLKPGAVLKGPAVIESDDSTILIPPDSVGTVDEHHSIVISVGGGSVEA
>Mature_688_residues
MLRVGIDVGGTFTDIVVFDEESGRLVAGKVLTVPREPWRGVLGAFDALGVRVSDVGVFVHATTLGTNMFLGQVGIEPPVA
VLITNAGFRDVIEIGRQNRAELYNLFFEKPQPLVPRSRRFGVRGRVSARGEELEPLDVGAVRRIAREWCGRAKVFIISFL
HCYANDAHERLAARVVREECPGAEVVTGCEVDPEPGEFERTSTAVVNGLLRPILSRYLSKLAREMEQRGFRGRFLVMQSS
GGVASLEYAVRFPAAFIESGPAAGVVATAYFAEAMGIRYALSFDMGGTTAKAAAIVNGEPIVADMYEVGGKVHMGRVLRG
SGYPVRYPFIDIAEVSAGGGTIAWVDAGGALRVGPISAGADPGPACYGRGGREPTVTDANLVLGRLPEVLAGGRVRLHRN
LAKEALEKLAKAVGMDTVEAALAVIRIADTVMARALRLVSIEKGYDPRMFTLFAFGGAGPLHAVSLARELGVPRVVVPPY
TGVFSALGLLLTDYRHDLRRPVVRRADELEEEQLNKVFDELADEAKRILASEGVPEERVRLTRLLEARYEGQAYSLTIPY
HGSLSEAVNEFHKLHAARYGYSMPEHPVVIVSARLVAIGVTPKPRLPRSKPLRHTPEPVGYREVYFKDDGWTRTPIYRRD
RLKPGAVLKGPAVIESDDSTILIPPDSVGTVDEHHSIVISVGGGSVEA

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=741, Percent_Identity=29.9595141700405, Blast_Score=209, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI133901900, Length=737, Percent_Identity=24.6947082767978, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322634, Length=757, Percent_Identity=27.3447820343461, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI45550492, Length=750, Percent_Identity=29.8666666666667, Blast_Score=223, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 74581; Mature: 74581

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVGIDVGGTFTDIVVFDEESGRLVAGKVLTVPREPWRGVLGAFDALGVRVSDVGVFVH
CEEEEEECCCCEEEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHCEEEEEEEEEEE
ATTLGTNMFLGQVGIEPPVAVLITNAGFRDVIEIGRQNRAELYNLFFEKPQPLVPRSRRF
EEECCCEEEEECCCCCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
GVRGRVSARGEELEPLDVGAVRRIAREWCGRAKVFIISFLHCYANDAHERLAARVVREEC
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHC
PGAEVVTGCEVDPEPGEFERTSTAVVNGLLRPILSRYLSKLAREMEQRGFRGRFLVMQSS
CCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GGVASLEYAVRFPAAFIESGPAAGVVATAYFAEAMGIRYALSFDMGGTTAKAAAIVNGEP
CCEEEEHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCEEEEEEECCCCCCHHEEEEECCCC
IVADMYEVGGKVHMGRVLRGSGYPVRYPFIDIAEVSAGGGTIAWVDAGGALRVGPISAGA
CCHHHHHCCCEEEECEEEECCCCEEECCCEEEEEECCCCCEEEEEECCCEEEECCCCCCC
DPGPACYGRGGREPTVTDANLVLGRLPEVLAGGRVRLHRNLAKEALEKLAKAVGMDTVEA
CCCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHHH
ALAVIRIADTVMARALRLVSIEKGYDPRMFTLFAFGGAGPLHAVSLARELGVPRVVVPPY
HHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCC
TGVFSALGLLLTDYRHDLRRPVVRRADELEEEQLNKVFDELADEAKRILASEGVPEERVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LTRLLEARYEGQAYSLTIPYHGSLSEAVNEFHKLHAARYGYSMPEHPVVIVSARLVAIGV
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEC
TPKPRLPRSKPLRHTPEPVGYREVYFKDDGWTRTPIYRRDRLKPGAVLKGPAVIESDDST
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCCCHHCCCCCCCEEECCEEEECCCCE
ILIPPDSVGTVDEHHSIVISVGGGSVEA
EEECCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MLRVGIDVGGTFTDIVVFDEESGRLVAGKVLTVPREPWRGVLGAFDALGVRVSDVGVFVH
CEEEEEECCCCEEEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHCEEEEEEEEEEE
ATTLGTNMFLGQVGIEPPVAVLITNAGFRDVIEIGRQNRAELYNLFFEKPQPLVPRSRRF
EEECCCEEEEECCCCCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
GVRGRVSARGEELEPLDVGAVRRIAREWCGRAKVFIISFLHCYANDAHERLAARVVREEC
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHC
PGAEVVTGCEVDPEPGEFERTSTAVVNGLLRPILSRYLSKLAREMEQRGFRGRFLVMQSS
CCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GGVASLEYAVRFPAAFIESGPAAGVVATAYFAEAMGIRYALSFDMGGTTAKAAAIVNGEP
CCEEEEHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCEEEEEEECCCCCCHHEEEEECCCC
IVADMYEVGGKVHMGRVLRGSGYPVRYPFIDIAEVSAGGGTIAWVDAGGALRVGPISAGA
CCHHHHHCCCEEEECEEEECCCCEEECCCEEEEEECCCCCEEEEEECCCEEEECCCCCCC
DPGPACYGRGGREPTVTDANLVLGRLPEVLAGGRVRLHRNLAKEALEKLAKAVGMDTVEA
CCCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHHH
ALAVIRIADTVMARALRLVSIEKGYDPRMFTLFAFGGAGPLHAVSLARELGVPRVVVPPY
HHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCC
TGVFSALGLLLTDYRHDLRRPVVRRADELEEEQLNKVFDELADEAKRILASEGVPEERVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LTRLLEARYEGQAYSLTIPYHGSLSEAVNEFHKLHAARYGYSMPEHPVVIVSARLVAIGV
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEC
TPKPRLPRSKPLRHTPEPVGYREVYFKDDGWTRTPIYRRDRLKPGAVLKGPAVIESDDST
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCCCHHCCCCCCCEEECCEEEECCCCE
ILIPPDSVGTVDEHHSIVISVGGGSVEA
EEECCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]