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The map label for this gene is hmgA [H]

Identifier: 124028378

GI number: 124028378

Start: 1537507

End: 1538793

Strand: Direct

Name: hmgA [H]

Synonym: Hbut_1531

Alternate gene names: 124028378

Gene position: 1537507-1538793 (Clockwise)

Preceding gene: 124028376

Following gene: 124028379

Centisome position: 92.22

GC content: 56.33

Gene sequence:

>1287_bases
TTGCAGGAGAGTGAACGCTCAAAGCTTGAAGAGGTTGTACGGGGGATTATCGAGGGCCGCATAAAGCTTCATGAAGCCGA
CAAGATTCTCGGCAATGCCAATGCAGGTGCTCTTGCTCGGAGGCTTGCGCTTGAAAAGATGCTTGGCGTTAGCCTTTCAA
GTATTGGGAGCACCATACTGGACTTCGAGGAGCTTGTTGGCAGGAACATCGAGAACCCGATTGGCGCGGTTCAGATCCCG
GTCGGCATTGTTGGCCCGTTGAGGGTTAGGGGCGACTATGCTAACGGCGATTACTACGTGCCAATGGCTACTACCGAGGG
GGCCCTTGTTGCAAGCGTGAATCGTGGCGCTAAGGCGATAACTCTTAGCGGTGGTGCTAGGGCCAAGGTGCTCCGGGACG
GCATGGCGAGGGCTCCCGTGTTCTGGACGCCCGGCATTGAGGAGGCTGCACGCTTCGTTGAATGGGTACGCGAGCACATG
GACGAGGTTAGGAGGGAGGCAGAATCCACAACAAGGCATGGCAAGCTGTTGGAGGTTCAGCCCTTCATTACGGGTAACCT
TGTCTGGCTGCGTTTCGTCTATGAGACCGGTGACGCCATGGGAATGAACATGGCTACTATAGCTACTGACAAGGCTGCTG
AATGGATACTGGCAAACTATCCGGGCACTGTCCGGCTCATAGCGCTCAGCGGTAACATGTGTACGGACAAGAAGCCAGCA
CTGCTAAACATGCTCTTCGGTAGGGGGAAGACAGTTGTAGCCGAGGCGGTTATCAAAAGGGATGTCGCGCTAAAGGTTTT
GAAGGCTCGGCCAGAGGAGATAGACTTCGTAAACCGTGTCAAGAACTTGCTTGGCACAGCCAGGGCTGGATCGTTCAGCC
TCAACGCTCACTTCGCAAACATCATAGCAGCAATATTCATCGCGACCGGGCAGGACGTAGCACAGGTCGTCGAGAGCAGC
ATGGGCTACACGTGGACAGAGGTGCGTAACGGAGACCTCTACATCTCGGTAACACTTCCAAGCCTAGAGGTGGGCACCGT
CGGGGGAGGCACCCGGCTCCCCACACAGCGGGAAGCACTAGCCCTCATGGGTGTAGCAGGCGGCGGAGACCCGCCAGGGA
GCAACGCCAGGAAGTTCGCCGAGATAGTAGCAGCAACAGTGCTTGCAGGCGAGCTAAACCTGCTAGCCGCGCTAGCCGCA
AACGAGCTAGCCAGAGCTCACAAGCTACTAGGCAGGGGCGAAGCCAGAAAAGAGAAAAACACGGCAAACAGCAAACCCAC
CAATTAG

Upstream 100 bases:

>100_bases
GTCGGGGCTGCTCGTTCTGCATATCATTGTGCTGCGGGCCGGGGTACTGAATAACGCGGCCCGGGACTACGTTGCTGTCT
GCGGGAGGTGTCTCGGGGGC

Downstream 100 bases:

>100_bases
CAAACAACACCACACACAAGCAACAAGACACCAACAACAAGAAAAACCTACTAGCAGGCTCCTTTCTTAGTTCCATTCGC
TCACTTATATATTTTGGTTA

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MQESERSKLEEVVRGIIEGRIKLHEADKILGNANAGALARRLALEKMLGVSLSSIGSTILDFEELVGRNIENPIGAVQIP
VGIVGPLRVRGDYANGDYYVPMATTEGALVASVNRGAKAITLSGGARAKVLRDGMARAPVFWTPGIEEAARFVEWVREHM
DEVRREAESTTRHGKLLEVQPFITGNLVWLRFVYETGDAMGMNMATIATDKAAEWILANYPGTVRLIALSGNMCTDKKPA
LLNMLFGRGKTVVAEAVIKRDVALKVLKARPEEIDFVNRVKNLLGTARAGSFSLNAHFANIIAAIFIATGQDVAQVVESS
MGYTWTEVRNGDLYISVTLPSLEVGTVGGGTRLPTQREALALMGVAGGGDPPGSNARKFAEIVAATVLAGELNLLAALAA
NELARAHKLLGRGEARKEKNTANSKPTN

Sequences:

>Translated_428_residues
MQESERSKLEEVVRGIIEGRIKLHEADKILGNANAGALARRLALEKMLGVSLSSIGSTILDFEELVGRNIENPIGAVQIP
VGIVGPLRVRGDYANGDYYVPMATTEGALVASVNRGAKAITLSGGARAKVLRDGMARAPVFWTPGIEEAARFVEWVREHM
DEVRREAESTTRHGKLLEVQPFITGNLVWLRFVYETGDAMGMNMATIATDKAAEWILANYPGTVRLIALSGNMCTDKKPA
LLNMLFGRGKTVVAEAVIKRDVALKVLKARPEEIDFVNRVKNLLGTARAGSFSLNAHFANIIAAIFIATGQDVAQVVESS
MGYTWTEVRNGDLYISVTLPSLEVGTVGGGTRLPTQREALALMGVAGGGDPPGSNARKFAEIVAATVLAGELNLLAALAA
NELARAHKLLGRGEARKEKNTANSKPTN
>Mature_428_residues
MQESERSKLEEVVRGIIEGRIKLHEADKILGNANAGALARRLALEKMLGVSLSSIGSTILDFEELVGRNIENPIGAVQIP
VGIVGPLRVRGDYANGDYYVPMATTEGALVASVNRGAKAITLSGGARAKVLRDGMARAPVFWTPGIEEAARFVEWVREHM
DEVRREAESTTRHGKLLEVQPFITGNLVWLRFVYETGDAMGMNMATIATDKAAEWILANYPGTVRLIALSGNMCTDKKPA
LLNMLFGRGKTVVAEAVIKRDVALKVLKARPEEIDFVNRVKNLLGTARAGSFSLNAHFANIIAAIFIATGQDVAQVVESS
MGYTWTEVRNGDLYISVTLPSLEVGTVGGGTRLPTQREALALMGVAGGGDPPGSNARKFAEIVAATVLAGELNLLAALAA
NELARAHKLLGRGEARKEKNTANSKPTN

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=413, Percent_Identity=43.3414043583535, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI196049380, Length=300, Percent_Identity=46.6666666666667, Blast_Score=241, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25144592, Length=429, Percent_Identity=43.1235431235431, Blast_Score=314, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6323565, Length=424, Percent_Identity=41.7452830188679, Blast_Score=296, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6323483, Length=425, Percent_Identity=41.8823529411765, Blast_Score=289, Evalue=5e-79,
Organism=Drosophila melanogaster, GI281362379, Length=411, Percent_Identity=43.0656934306569, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI45553469, Length=411, Percent_Identity=43.0656934306569, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24649399, Length=411, Percent_Identity=43.0656934306569, Blast_Score=268, Evalue=7e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 45865; Mature: 45865

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQESERSKLEEVVRGIIEGRIKLHEADKILGNANAGALARRLALEKMLGVSLSSIGSTIL
CCCHHHHHHHHHHHHHHHCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
DFEELVGRNIENPIGAVQIPVGIVGPLRVRGDYANGDYYVPMATTEGALVASVNRGAKAI
HHHHHHCCCCCCCCCEEEECCEEECCEEEEEEECCCCEEEEEECCCCCEEEEECCCCEEE
TLSGGARAKVLRDGMARAPVFWTPGIEEAARFVEWVREHMDEVRREAESTTRHGKLLEVQ
EECCCCHHHHHHCCHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
PFITGNLVWLRFVYETGDAMGMNMATIATDKAAEWILANYPGTVRLIALSGNMCTDKKPA
CCEECCEEEEEEEECCCCCCCCCEEEEECCHHHCEEEECCCCEEEEEEEECCCCCCCCCH
LLNMLFGRGKTVVAEAVIKRDVALKVLKARPEEIDFVNRVKNLLGTARAGSFSLNAHFAN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHH
IIAAIFIATGQDVAQVVESSMGYTWTEVRNGDLYISVTLPSLEVGTVGGGTRLPTQREAL
HHHHHHHHCCHHHHHHHHHHCCCEEEEECCCEEEEEEEECCEEEECCCCCCCCCCHHHHE
ALMGVAGGGDPPGSNARKFAEIVAATVLAGELNLLAALAANELARAHKLLGRGEARKEKN
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
TANSKPTN
CCCCCCCC
>Mature Secondary Structure
MQESERSKLEEVVRGIIEGRIKLHEADKILGNANAGALARRLALEKMLGVSLSSIGSTIL
CCCHHHHHHHHHHHHHHHCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
DFEELVGRNIENPIGAVQIPVGIVGPLRVRGDYANGDYYVPMATTEGALVASVNRGAKAI
HHHHHHCCCCCCCCCEEEECCEEECCEEEEEEECCCCEEEEEECCCCCEEEEECCCCEEE
TLSGGARAKVLRDGMARAPVFWTPGIEEAARFVEWVREHMDEVRREAESTTRHGKLLEVQ
EECCCCHHHHHHCCHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
PFITGNLVWLRFVYETGDAMGMNMATIATDKAAEWILANYPGTVRLIALSGNMCTDKKPA
CCEECCEEEEEEEECCCCCCCCCEEEEECCHHHCEEEECCCCEEEEEEEECCCCCCCCCH
LLNMLFGRGKTVVAEAVIKRDVALKVLKARPEEIDFVNRVKNLLGTARAGSFSLNAHFAN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHH
IIAAIFIATGQDVAQVVESSMGYTWTEVRNGDLYISVTLPSLEVGTVGGGTRLPTQREAL
HHHHHHHHCCHHHHHHHHHHCCCEEEEECCCEEEEEEEECCEEEECCCCCCCCCCHHHHE
ALMGVAGGGDPPGSNARKFAEIVAATVLAGELNLLAALAANELARAHKLLGRGEARKEKN
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
TANSKPTN
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]