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The map label for this gene is glcD [H]

Identifier: 124028309

GI number: 124028309

Start: 1468103

End: 1469527

Strand: Direct

Name: glcD [H]

Synonym: Hbut_1460

Alternate gene names: 124028309

Gene position: 1468103-1469527 (Clockwise)

Preceding gene: 124028308

Following gene: 124028310

Centisome position: 88.06

GC content: 60.0

Gene sequence:

>1425_bases
GTGGGGGTGCACCGGGTTACGGGTATCGTGCAGGAGCTTGAATCCATCCTTGGCAGGGGCAAGGTCTACGACGATCCAGC
AGTGGTGGCACTCTACTCGCGCGAGCCCAGCGGCCTCGAGGGTTTTGGACTCGCTGTAGTCTTTCCGGAGACCGCCGAGG
ATGTCTCTAGGCTTGCAGCATGGGCCTATCGTAGGATGGTGCCGCTCTACCCGCAGGGTAGCACTACGAGCCTCTCCGGC
TCTGCCGTGCCGGAGAATGGTGTGATAGTTAGCTTTGAGAGGATGAACCGTATCCTTGAGGTTAGCGTGCTTGACTCAGT
GGCTGTTGTCGAGCCGGGTGTGAGGATAGCCGAGCTTAACCTCGAGCTCGCCCGGTACCAGCACATGTTCCCCGTGGACC
CGGCTAGCCAGGCTGTAGCAACGGTGGGAGGCGCCATTAACAGCGGCGCTGGCGGCATGAAGGGGGCAAAGTATGGCACG
ATGAGGGACTGGGTTAACCAGCTCGAGATAGTGCTCGCCGACGAGAACGGTACGAGGATGACTATTGGCTGCCGGACCGT
GAAGTGCCGACAGGGCTACGACCTGGTAAGGCTTATCGTGGGTAGTGAGGGTACTCTTGCACTTGTAACGAGGGCTGTGC
TCCGGATAACACCGCTGCCCGAAGCTGCACCCACAGTACTAGGGTTCTTCGACAACCTGGGGGACCTTGTTGATGCCTTT
CTCGAGCTGCGTAGCGCTGGTGTACAACCGCTCCTAGCCGAGTTTCTCGACGCTAGAACAGTATCGATAGCTAGGCGTGG
ACTCCCCGGCTTCGAGAACGTGGAGGGCCACATGCTGCTGGTTAGCGTGGAGGCTAACCGGGAGGCTGTGGAGCGTATCC
AGGCCCAGCTGGTAAAGGTGTTCGAGTCCCACGGGGCTCACGGTATCCGGGTTGCAGGGGACCTAGGGGAGGCTGAGGAG
AAGGGGTTGCTAGCGCTACGCCGCAGGCTCCTCCCCGCACAGCTCGAGTACTCGCGGCGCTATTGGGGTGCACCAAGGGT
GCAGGTGTTCATAGAGGATATTGTGGTGCCCCCATCAAGGCTCGTGGAGGCCGTGGAAATGCTGAATCAGCTAACTGAGG
ACTACGGACTCCCCATGGTGCTCGGAGGCCATATAGGTGATGGAAACCTGCACCCCGCCGTAGGCTTCGACCCCGGAGAT
CCGGGAGCGGCAAGCCGGGTCCATGCATGGTTTACAGAGGTTATGAAGCTAGCCGTGAAGCTGGGCGGAAGCGTTAGCGC
CGAGCACGGGGTGGGGATGCTGAAGAGGGAGGGGTTGAGGATTGAGCTTGAGAGGCTTGGCTCGCTAAAAGCCCTCGAAC
TCATGAAGGCGATAAAGAGGCTATTCGACCCCCACAACGTGCTCAACCCCGGCAAGCTCTTCTAG

Upstream 100 bases:

>100_bases
AGAAGCTCTTGAGGATACTCGAAGCCCTGGAAGGGAGAGGAGGCATGGAGCAGGAAGAGGCATAGCCCCGGCCTTATAGG
AGCCCGTGGGTAGGGACTCT

Downstream 100 bases:

>100_bases
GCAGTGGAGGCGGCTGATATGGATGCTAGGGAGCGGCTAGCCAGCGAGGCTGGTAGATGCGCGTACTGCGGGTTCTGCGA
ACAGGCCTGCCCAACACTAC

Product: dehydrogenase

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MGVHRVTGIVQELESILGRGKVYDDPAVVALYSREPSGLEGFGLAVVFPETAEDVSRLAAWAYRRMVPLYPQGSTTSLSG
SAVPENGVIVSFERMNRILEVSVLDSVAVVEPGVRIAELNLELARYQHMFPVDPASQAVATVGGAINSGAGGMKGAKYGT
MRDWVNQLEIVLADENGTRMTIGCRTVKCRQGYDLVRLIVGSEGTLALVTRAVLRITPLPEAAPTVLGFFDNLGDLVDAF
LELRSAGVQPLLAEFLDARTVSIARRGLPGFENVEGHMLLVSVEANREAVERIQAQLVKVFESHGAHGIRVAGDLGEAEE
KGLLALRRRLLPAQLEYSRRYWGAPRVQVFIEDIVVPPSRLVEAVEMLNQLTEDYGLPMVLGGHIGDGNLHPAVGFDPGD
PGAASRVHAWFTEVMKLAVKLGGSVSAEHGVGMLKREGLRIELERLGSLKALELMKAIKRLFDPHNVLNPGKLF

Sequences:

>Translated_474_residues
MGVHRVTGIVQELESILGRGKVYDDPAVVALYSREPSGLEGFGLAVVFPETAEDVSRLAAWAYRRMVPLYPQGSTTSLSG
SAVPENGVIVSFERMNRILEVSVLDSVAVVEPGVRIAELNLELARYQHMFPVDPASQAVATVGGAINSGAGGMKGAKYGT
MRDWVNQLEIVLADENGTRMTIGCRTVKCRQGYDLVRLIVGSEGTLALVTRAVLRITPLPEAAPTVLGFFDNLGDLVDAF
LELRSAGVQPLLAEFLDARTVSIARRGLPGFENVEGHMLLVSVEANREAVERIQAQLVKVFESHGAHGIRVAGDLGEAEE
KGLLALRRRLLPAQLEYSRRYWGAPRVQVFIEDIVVPPSRLVEAVEMLNQLTEDYGLPMVLGGHIGDGNLHPAVGFDPGD
PGAASRVHAWFTEVMKLAVKLGGSVSAEHGVGMLKREGLRIELERLGSLKALELMKAIKRLFDPHNVLNPGKLF
>Mature_473_residues
GVHRVTGIVQELESILGRGKVYDDPAVVALYSREPSGLEGFGLAVVFPETAEDVSRLAAWAYRRMVPLYPQGSTTSLSGS
AVPENGVIVSFERMNRILEVSVLDSVAVVEPGVRIAELNLELARYQHMFPVDPASQAVATVGGAINSGAGGMKGAKYGTM
RDWVNQLEIVLADENGTRMTIGCRTVKCRQGYDLVRLIVGSEGTLALVTRAVLRITPLPEAAPTVLGFFDNLGDLVDAFL
ELRSAGVQPLLAEFLDARTVSIARRGLPGFENVEGHMLLVSVEANREAVERIQAQLVKVFESHGAHGIRVAGDLGEAEEK
GLLALRRRLLPAQLEYSRRYWGAPRVQVFIEDIVVPPSRLVEAVEMLNQLTEDYGLPMVLGGHIGDGNLHPAVGFDPGDP
GAASRVHAWFTEVMKLAVKLGGSVSAEHGVGMLKREGLRIELERLGSLKALELMKAIKRLFDPHNVLNPGKLF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=439, Percent_Identity=34.8519362186788, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI37595754, Length=460, Percent_Identity=33.695652173913, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI119964728, Length=467, Percent_Identity=29.9785867237687, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI4501993, Length=465, Percent_Identity=24.3010752688172, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1789351, Length=476, Percent_Identity=29.6218487394958, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1787977, Length=548, Percent_Identity=28.8321167883212, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI48994907, Length=507, Percent_Identity=22.6824457593688, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71992373, Length=474, Percent_Identity=27.0042194092827, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71992381, Length=473, Percent_Identity=26.4270613107822, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17534361, Length=473, Percent_Identity=25.5813953488372, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71992392, Length=379, Percent_Identity=28.2321899736148, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17556096, Length=299, Percent_Identity=23.4113712374582, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320027, Length=486, Percent_Identity=26.9547325102881, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320023, Length=441, Percent_Identity=27.6643990929705, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320764, Length=438, Percent_Identity=25.7990867579909, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI18921117, Length=436, Percent_Identity=25.9174311926606, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24639277, Length=436, Percent_Identity=25.9174311926606, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24639275, Length=436, Percent_Identity=25.9174311926606, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24653753, Length=180, Percent_Identity=31.1111111111111, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 51332; Mature: 51201

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVHRVTGIVQELESILGRGKVYDDPAVVALYSREPSGLEGFGLAVVFPETAEDVSRLAA
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHH
WAYRRMVPLYPQGSTTSLSGSAVPENGVIVSFERMNRILEVSVLDSVAVVEPGVRIAELN
HHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHEEHHHHCCHHHCCCCCEEEEEC
LELARYQHMFPVDPASQAVATVGGAINSGAGGMKGAKYGTMRDWVNQLEIVLADENGTRM
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCEE
TIGCRTVKCRQGYDLVRLIVGSEGTLALVTRAVLRITPLPEAAPTVLGFFDNLGDLVDAF
EEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LELRSAGVQPLLAEFLDARTVSIARRGLPGFENVEGHMLLVSVEANREAVERIQAQLVKV
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
FESHGAHGIRVAGDLGEAEEKGLLALRRRLLPAQLEYSRRYWGAPRVQVFIEDIVVPPSR
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCHHEEEHHHHCCCHHH
LVEAVEMLNQLTEDYGLPMVLGGHIGDGNLHPAVGFDPGDPGAASRVHAWFTEVMKLAVK
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGGSVSAEHGVGMLKREGLRIELERLGSLKALELMKAIKRLFDPHNVLNPGKLF
HCCCCCCHHCCCHHHHCCCEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GVHRVTGIVQELESILGRGKVYDDPAVVALYSREPSGLEGFGLAVVFPETAEDVSRLAA
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHH
WAYRRMVPLYPQGSTTSLSGSAVPENGVIVSFERMNRILEVSVLDSVAVVEPGVRIAELN
HHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHEEHHHHCCHHHCCCCCEEEEEC
LELARYQHMFPVDPASQAVATVGGAINSGAGGMKGAKYGTMRDWVNQLEIVLADENGTRM
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCEE
TIGCRTVKCRQGYDLVRLIVGSEGTLALVTRAVLRITPLPEAAPTVLGFFDNLGDLVDAF
EEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LELRSAGVQPLLAEFLDARTVSIARRGLPGFENVEGHMLLVSVEANREAVERIQAQLVKV
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
FESHGAHGIRVAGDLGEAEEKGLLALRRRLLPAQLEYSRRYWGAPRVQVFIEDIVVPPSR
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCHHEEEHHHHCCCHHH
LVEAVEMLNQLTEDYGLPMVLGGHIGDGNLHPAVGFDPGDPGAASRVHAWFTEVMKLAVK
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGGSVSAEHGVGMLKREGLRIELERLGSLKALELMKAIKRLFDPHNVLNPGKLF
HCCCCCCHHCCCHHHHCCCEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]