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The map label for this gene is thiD [H]

Identifier: 124028308

GI number: 124028308

Start: 1466640

End: 1468067

Strand: Direct

Name: thiD [H]

Synonym: Hbut_1459

Alternate gene names: 124028308

Gene position: 1466640-1468067 (Clockwise)

Preceding gene: 124028306

Following gene: 124028309

Centisome position: 87.97

GC content: 59.03

Gene sequence:

>1428_bases
TTGGTTAGCGGGGGTGTTCTCCTCGTGGACAACCATGGAGTTCAAGTCATCTACCCGGTTGCAGTTACTGTTGCTGGTGT
TGATCCTAGTGGTGGTGCAGGCATTGCTGCCGACTTGAAGGCTTTCGCAGCCATGGGTGTTCATGGGGCTGTAGTTGTTG
CCGTTGTCACTGTACAGGATACCCGTGGTGTTCGCCGTGTCCATGTGCTGCCCAGCTGGCTTGTAGAGGAGCAGTTGCAG
GCCGTGCTCGAGGACTATCGTGTTGGGGCTGTTAAGACCGGGGTGCTGGGCTCCCGCGAGAATGTTGAAGCTATAGCTAG
GCTCCTCCGCGGGCGAGACATCGCCCTTGTCGTGGACCCTGTGTATCGTGCTTCGGCGGGCCAGCTACTTAACAGTGATG
ATGCATTCAAGGCTATTGTGGAGGAGCTATTTCCACTGGCTAGCCTCGTTGCCCCGAACGTGCCTGAGGCCGAGAGGATT
ACGGGTACACGTATACGCAGTATCGAGGATGCGAAGAGGGCTGCCAGGATACTCGTGGAGGACTATGGTGCTAGGGCCGC
CCTAATCAAGGGGGGACACTTGCCCGGCGAGCCTGTTGACGTGCTCTACTACGAGGATGTTTTCTGGGAGTTTAGGGGCG
AAAGGAGAAGCGGCTGCAGCCACGGCACTGGCTGCACCTTCACTGCCGCGTTAGCTGCTGGGCTTGCAAAGGGCTTGGAC
CTGGTCGAAGCCGTTGTGAGGGCTCGAAAGCTAGTCGAGGAGGCTATAGAGTACGGGTTCCGTGTTGGTCGCGGCGATTG
TCCCGTAAACCCTCTAGCTGGGCTTGAGAGGGATGCTGAGAGGTACCGAGCCATAGCCGCCGTCGAGGATGCTCTTAGAC
TCCTCCTCGAGAATGCTAGCCGGGTAGCCCGCTACGCTCCCGAGGTAGGCATGAACATCGCCTATGCTATCGAGCCTCGC
CTCGCCCGGAGCATCGGGGACGTCGCAGGTGTCATGGGGAGGATCGTGAGGTACGGCGATACATTGAAGCCCGTTGGTCC
AGTGAGGATGGGTGCTTCCAGCCACATGGCCCGCCTGGTCCTAGCAGCAATGGAGCGCGACCCCTCGCTAAGGGCTGCAC
TAAACATTCGCTACGCCCCCGAGCTGATAGAGGCTGCTAGGCGAACCGGCTTGCGGGTCGTCTATGTTGATCGCCGAGCT
GAGCCGGAGGAGGTGCGCAGAGTTGAGGGCGCCAGTATGAGGTGGCTAGTGGAGAGAGCCTTCGCTGTTGCCGGTGCTAC
GCCAGATGTAGTCTATGATACAGGGGATGTGGGAAAGGAGGCCATGATACGCATCCTAGCTCGCACACCGAGGGAGGCCA
TTGAGAAGCTCTTGAGGATACTCGAAGCCCTGGAAGGGAGAGGAGGCATGGAGCAGGAAGAGGCATAG

Upstream 100 bases:

>100_bases
GTTCATGGCAAGGTGTGCTATCACGTTATTTAAGGCATATACACTTGGTTAGTACCCCGTTCGCCACCTAGGCCTAAGCT
AATTAGGTTAATTATGCATA

Downstream 100 bases:

>100_bases
CCCCGGCCTTATAGGAGCCCGTGGGTAGGGACTCTGTGGGGGTGCACCGGGTTACGGGTATCGTGCAGGAGCTTGAATCC
ATCCTTGGCAGGGGCAAGGT

Product: hypothetical protein

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MVSGGVLLVDNHGVQVIYPVAVTVAGVDPSGGAGIAADLKAFAAMGVHGAVVVAVVTVQDTRGVRRVHVLPSWLVEEQLQ
AVLEDYRVGAVKTGVLGSRENVEAIARLLRGRDIALVVDPVYRASAGQLLNSDDAFKAIVEELFPLASLVAPNVPEAERI
TGTRIRSIEDAKRAARILVEDYGARAALIKGGHLPGEPVDVLYYEDVFWEFRGERRSGCSHGTGCTFTAALAAGLAKGLD
LVEAVVRARKLVEEAIEYGFRVGRGDCPVNPLAGLERDAERYRAIAAVEDALRLLLENASRVARYAPEVGMNIAYAIEPR
LARSIGDVAGVMGRIVRYGDTLKPVGPVRMGASSHMARLVLAAMERDPSLRAALNIRYAPELIEAARRTGLRVVYVDRRA
EPEEVRRVEGASMRWLVERAFAVAGATPDVVYDTGDVGKEAMIRILARTPREAIEKLLRILEALEGRGGMEQEEA

Sequences:

>Translated_475_residues
MVSGGVLLVDNHGVQVIYPVAVTVAGVDPSGGAGIAADLKAFAAMGVHGAVVVAVVTVQDTRGVRRVHVLPSWLVEEQLQ
AVLEDYRVGAVKTGVLGSRENVEAIARLLRGRDIALVVDPVYRASAGQLLNSDDAFKAIVEELFPLASLVAPNVPEAERI
TGTRIRSIEDAKRAARILVEDYGARAALIKGGHLPGEPVDVLYYEDVFWEFRGERRSGCSHGTGCTFTAALAAGLAKGLD
LVEAVVRARKLVEEAIEYGFRVGRGDCPVNPLAGLERDAERYRAIAAVEDALRLLLENASRVARYAPEVGMNIAYAIEPR
LARSIGDVAGVMGRIVRYGDTLKPVGPVRMGASSHMARLVLAAMERDPSLRAALNIRYAPELIEAARRTGLRVVYVDRRA
EPEEVRRVEGASMRWLVERAFAVAGATPDVVYDTGDVGKEAMIRILARTPREAIEKLLRILEALEGRGGMEQEEA
>Mature_475_residues
MVSGGVLLVDNHGVQVIYPVAVTVAGVDPSGGAGIAADLKAFAAMGVHGAVVVAVVTVQDTRGVRRVHVLPSWLVEEQLQ
AVLEDYRVGAVKTGVLGSRENVEAIARLLRGRDIALVVDPVYRASAGQLLNSDDAFKAIVEELFPLASLVAPNVPEAERI
TGTRIRSIEDAKRAARILVEDYGARAALIKGGHLPGEPVDVLYYEDVFWEFRGERRSGCSHGTGCTFTAALAAGLAKGLD
LVEAVVRARKLVEEAIEYGFRVGRGDCPVNPLAGLERDAERYRAIAAVEDALRLLLENASRVARYAPEVGMNIAYAIEPR
LARSIGDVAGVMGRIVRYGDTLKPVGPVRMGASSHMARLVLAAMERDPSLRAALNIRYAPELIEAARRTGLRVVYVDRRA
EPEEVRRVEGASMRWLVERAFAVAGATPDVVYDTGDVGKEAMIRILARTPREAIEKLLRILEALEGRGGMEQEEA

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=256, Percent_Identity=37.109375, Blast_Score=138, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6325378, Length=271, Percent_Identity=30.9963099630996, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6324517, Length=280, Percent_Identity=30.3571428571429, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324997, Length=280, Percent_Identity=31.0714285714286, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 51221; Mature: 51221

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSGGVLLVDNHGVQVIYPVAVTVAGVDPSGGAGIAADLKAFAAMGVHGAVVVAVVTVQD
CCCCCEEEEECCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEC
TRGVRRVHVLPSWLVEEQLQAVLEDYRVGAVKTGVLGSRENVEAIARLLRGRDIALVVDP
CCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEEECC
VYRASAGQLLNSDDAFKAIVEELFPLASLVAPNVPEAERITGTRIRSIEDAKRAARILVE
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHH
DYGARAALIKGGHLPGEPVDVLYYEDVFWEFRGERRSGCSHGTGCTFTAALAAGLAKGLD
HCCCCEEEEECCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVEAVVRARKLVEEAIEYGFRVGRGDCPVNPLAGLERDAERYRAIAAVEDALRLLLENAS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVARYAPEVGMNIAYAIEPRLARSIGDVAGVMGRIVRYGDTLKPVGPVRMGASSHMARLV
HHHHHCHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LAAMERDPSLRAALNIRYAPELIEAARRTGLRVVYVDRRAEPEEVRRVEGASMRWLVERA
HHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHH
FAVAGATPDVVYDTGDVGKEAMIRILARTPREAIEKLLRILEALEGRGGMEQEEA
HHHCCCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVSGGVLLVDNHGVQVIYPVAVTVAGVDPSGGAGIAADLKAFAAMGVHGAVVVAVVTVQD
CCCCCEEEEECCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEC
TRGVRRVHVLPSWLVEEQLQAVLEDYRVGAVKTGVLGSRENVEAIARLLRGRDIALVVDP
CCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEEECC
VYRASAGQLLNSDDAFKAIVEELFPLASLVAPNVPEAERITGTRIRSIEDAKRAARILVE
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHH
DYGARAALIKGGHLPGEPVDVLYYEDVFWEFRGERRSGCSHGTGCTFTAALAAGLAKGLD
HCCCCEEEEECCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVEAVVRARKLVEEAIEYGFRVGRGDCPVNPLAGLERDAERYRAIAAVEDALRLLLENAS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVARYAPEVGMNIAYAIEPRLARSIGDVAGVMGRIVRYGDTLKPVGPVRMGASSHMARLV
HHHHHCHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LAAMERDPSLRAALNIRYAPELIEAARRTGLRVVYVDRRAEPEEVRRVEGASMRWLVERA
HHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHH
FAVAGATPDVVYDTGDVGKEAMIRILARTPREAIEKLLRILEALEGRGGMEQEEA
HHHCCCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]