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The map label for this gene is coaBC [H]

Identifier: 124028284

GI number: 124028284

Start: 1441592

End: 1442881

Strand: Direct

Name: coaBC [H]

Synonym: Hbut_1435

Alternate gene names: 124028284

Gene position: 1441592-1442881 (Clockwise)

Preceding gene: 124028282

Following gene: 124028290

Centisome position: 86.47

GC content: 57.13

Gene sequence:

>1290_bases
GTGGGTGCTCCAGGCGTGGAGGCTGGCGAATGGTTATGGGGTTATCATCCTAGCAGGGAGATCGTAGGCGAGTATGGGGG
CGACCTTTCCGGCCGCTGTATAGCCCTCGGCGTTACTGGTAGTGTCGCGCTGTACCGCAGCATCGACCTTGCAAGACTGC
TTATGAGGATGGGTGCTCGTGTCCGGGTTGTGATGACTCCAGCTGCTGCCGAGATGGTCTCCCCCGCTGTCTTCGAGTGG
GCTACCGGCGAGCCCGTCGTATCCAGGCTCACCGGCCTCGTGGAGCATGTTACCCTTGCAAAGGTGTGCGATGCTGTACT
CATTGCCCCGGCAACACTGGACATCATAGCCGAGATTGCAGGGTTTAGAGCATCGAAGCCCGTCTCGGCTCTTGCACAGG
AAGCTGCCGGTCTCGGGAAGCCCGTGCTCATAGTGCCTGCTATGCATGGCGGTATGTGGAAGCGTGCATCCAAGCTTGCC
GACGAGCTCGAGAAGCAGGGCTTTCACGTGCTTCGACCGATTGTTGAGGAGGAGCGGGCAAAGTATCCACCAGTCGAGCT
CATAGCATGGTGGGCTGAAGCGATTATCTCCCGTGGCCGCGACCTTGAGGGGCTAAGGTTCCTAGTTACTGCTGGGCCTA
CAAGGGAGCACATAGATCCTGTAAGAGTCATCACGAACCCCTCCACGGGCCTCATGGGCGTCTCTATAGCGCTTGAAGCG
GCTTTCCGCGGTGCAAGGGTAAAACTCGTACATGGCCCCCTGTCTGTCTATGTCCCGGAGGGGTGGAGGAACTATCTCGA
AGAGGTAGTAGGTGTTGAAACTGCCGAAGAGATGATGGAGTCTGTCCTAGCACGCGTCGGTAGTGTTGACGTGGCTATAT
ATGCTGCAGCTGTTAGCGACTACCAGCCCGTGGAGACTAGCAGGGTGAAGATCCCAAGCAGGAAGGGAGAGTTAACACTA
AGGCTCAAGCCCACGCCGAAGATAGTTGCTAGGGCTGTAGAGGCTGCACCAGGAGTAGTACATGTGGGCTTTGCAGCAGA
AACCACGTCAAGCCTCGAGGAGCTAGTCAAGAAGGCTAGAGAGAAGCTTGAGGAGTACATGCTTGACGCTGTTGCCGCCA
ATAACGTGCTGGAGCCGGGAGCAGGGTTCGCCTCAGAGACCAACCACGTGATAGTGCTTACCTGGAGGGGCGAAAAACTA
GAGATACCACATATGCATAAGAGGCTTGTGGCACGGCGCCTTCTAGACATTGTTGCTAGGCTTGCTAGGAGCGGTGCTAG
GCCCCGCTAG

Upstream 100 bases:

>100_bases
TATGTGGTTCTATATGTGCGTGGTGGGTACTTGCTGCGACTGCTACGTGTTATCTTCTGTGGGGGAGGCTATAGGGGCTG
GATATGGCTTGTCTTTATGA

Downstream 100 bases:

>100_bases
TTTTGCGGCTGCTGGTAGTGATCTGCGTAGGATGTATACGCCGAGGTAGACGAATGGCGTATCAAGCACTGCTACTAAGA
CCTTCCACATCCACTGACCG

Product: coenzyme A biosynthesis bifunctional protein CoaBC

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MGAPGVEAGEWLWGYHPSREIVGEYGGDLSGRCIALGVTGSVALYRSIDLARLLMRMGARVRVVMTPAAAEMVSPAVFEW
ATGEPVVSRLTGLVEHVTLAKVCDAVLIAPATLDIIAEIAGFRASKPVSALAQEAAGLGKPVLIVPAMHGGMWKRASKLA
DELEKQGFHVLRPIVEEERAKYPPVELIAWWAEAIISRGRDLEGLRFLVTAGPTREHIDPVRVITNPSTGLMGVSIALEA
AFRGARVKLVHGPLSVYVPEGWRNYLEEVVGVETAEEMMESVLARVGSVDVAIYAAAVSDYQPVETSRVKIPSRKGELTL
RLKPTPKIVARAVEAAPGVVHVGFAAETTSSLEELVKKAREKLEEYMLDAVAANNVLEPGAGFASETNHVIVLTWRGEKL
EIPHMHKRLVARRLLDIVARLARSGARPR

Sequences:

>Translated_429_residues
MGAPGVEAGEWLWGYHPSREIVGEYGGDLSGRCIALGVTGSVALYRSIDLARLLMRMGARVRVVMTPAAAEMVSPAVFEW
ATGEPVVSRLTGLVEHVTLAKVCDAVLIAPATLDIIAEIAGFRASKPVSALAQEAAGLGKPVLIVPAMHGGMWKRASKLA
DELEKQGFHVLRPIVEEERAKYPPVELIAWWAEAIISRGRDLEGLRFLVTAGPTREHIDPVRVITNPSTGLMGVSIALEA
AFRGARVKLVHGPLSVYVPEGWRNYLEEVVGVETAEEMMESVLARVGSVDVAIYAAAVSDYQPVETSRVKIPSRKGELTL
RLKPTPKIVARAVEAAPGVVHVGFAAETTSSLEELVKKAREKLEEYMLDAVAANNVLEPGAGFASETNHVIVLTWRGEKL
EIPHMHKRLVARRLLDIVARLARSGARPR
>Mature_428_residues
GAPGVEAGEWLWGYHPSREIVGEYGGDLSGRCIALGVTGSVALYRSIDLARLLMRMGARVRVVMTPAAAEMVSPAVFEWA
TGEPVVSRLTGLVEHVTLAKVCDAVLIAPATLDIIAEIAGFRASKPVSALAQEAAGLGKPVLIVPAMHGGMWKRASKLAD
ELEKQGFHVLRPIVEEERAKYPPVELIAWWAEAIISRGRDLEGLRFLVTAGPTREHIDPVRVITNPSTGLMGVSIALEAA
FRGARVKLVHGPLSVYVPEGWRNYLEEVVGVETAEEMMESVLARVGSVDVAIYAAAVSDYQPVETSRVKIPSRKGELTLR
LKPTPKIVARAVEAAPGVVHVGFAAETTSSLEELVKKAREKLEEYMLDAVAANNVLEPGAGFASETNHVIVLTWRGEKLE
IPHMHKRLVARRLLDIVARLARSGARPR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=421, Percent_Identity=36.3420427553444, Blast_Score=169, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 46417; Mature: 46285

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPGVEAGEWLWGYHPSREIVGEYGGDLSGRCIALGVTGSVALYRSIDLARLLMRMGAR
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
VRVVMTPAAAEMVSPAVFEWATGEPVVSRLTGLVEHVTLAKVCDAVLIAPATLDIIAEIA
EEEEECCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
GFRASKPVSALAQEAAGLGKPVLIVPAMHGGMWKRASKLADELEKQGFHVLRPIVEEERA
CCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
KYPPVELIAWWAEAIISRGRDLEGLRFLVTAGPTREHIDPVRVITNPSTGLMGVSIALEA
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHCCCCEEEEECCCCCHHHHHHHHHH
AFRGARVKLVHGPLSVYVPEGWRNYLEEVVGVETAEEMMESVLARVGSVDVAIYAAAVSD
HHCCCEEEEEECCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHEEEEEHHCC
YQPVETSRVKIPSRKGELTLRLKPTPKIVARAVEAAPGVVHVGFAAETTSSLEELVKKAR
CCCCCCCEEECCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHH
EKLEEYMLDAVAANNVLEPGAGFASETNHVIVLTWRGEKLEIPHMHKRLVARRLLDIVAR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHH
LARSGARPR
HHHCCCCCC
>Mature Secondary Structure 
GAPGVEAGEWLWGYHPSREIVGEYGGDLSGRCIALGVTGSVALYRSIDLARLLMRMGAR
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
VRVVMTPAAAEMVSPAVFEWATGEPVVSRLTGLVEHVTLAKVCDAVLIAPATLDIIAEIA
EEEEECCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
GFRASKPVSALAQEAAGLGKPVLIVPAMHGGMWKRASKLADELEKQGFHVLRPIVEEERA
CCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
KYPPVELIAWWAEAIISRGRDLEGLRFLVTAGPTREHIDPVRVITNPSTGLMGVSIALEA
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHCCCCEEEEECCCCCHHHHHHHHHH
AFRGARVKLVHGPLSVYVPEGWRNYLEEVVGVETAEEMMESVLARVGSVDVAIYAAAVSD
HHCCCEEEEEECCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHEEEEEHHCC
YQPVETSRVKIPSRKGELTLRLKPTPKIVARAVEAAPGVVHVGFAAETTSSLEELVKKAR
CCCCCCCEEECCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHH
EKLEEYMLDAVAANNVLEPGAGFASETNHVIVLTWRGEKLEIPHMHKRLVARRLLDIVAR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHH
LARSGARPR
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA