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The map label for this gene is hemB [H]

Identifier: 124028236

GI number: 124028236

Start: 1381787

End: 1382803

Strand: Reverse

Name: hemB [H]

Synonym: Hbut_1386

Alternate gene names: 124028236

Gene position: 1382803-1381787 (Counterclockwise)

Preceding gene: 124028245

Following gene: 124028234

Centisome position: 82.94

GC content: 58.7

Gene sequence:

>1017_bases
GTGCCCGGGTTCCCTGAGCTCCGGCCTCGGAGGCTAAGGCTCACCAAGGCGATCCGCGACCTTGTCGCCGAGACCCTGGT
TTCGCCCAGCCAGCTCATGATGCCGATATTCGTTAAGGAGGGGATAAAGGAGCCCGAGCCCATCCCCAGCATGCCGGGCC
AGTACCGCTATCCCCCGGAGAGGGTCGTGGACGTTATACGCGAGGCACTAGACCTCGGCATCAAGTCATTCCTATTGTTC
GGCGTTGTCCCGGACGAGAAGAAGGACCTCCGCGGCACCTACGCCTACGACCCACGGGGCCCCGTGCCCACTGCGATAAG
GCTGATACGCCGCGAGCTCGGCTGGGAGCCAGCCATCTTCACCGACGTCTGCATATGCGGCTACACCACCCATGGGCATT
GCGGCATACCCGTTGAAAGGCACGGGAGACAGCTCATAGACAACGACTCAACCCTAGAGGTCATCGCCCGCATAGCTGTC
ACCCACGCTGAGGCTGGAGCAGACTTCGTAGCTCCCTCAGGAATGATGGATGGTATGGTGTCAGCGATAAGGGAGGCGCT
AGACGACGCTGGCTACACCGAGGTCGGGATTATGAGCTATGCTGTAAAGTATGCCAGCGGCTTCTACGGCCCATTCAGAG
AGGCTGCTGGATCAGCACCACGGTTTGGCGACCGGAGAAGCTACCAGATGGACCCGAGGAATGCGATGGAGGCGATTAAG
GAGGCGATGCTGGATATCGAGGAGGGAGCGGATATCCTCATGGTGAAGCCGGCCCTGGCATACCTTGACGTTATAAGACT
GGTTAAGGAGGCGTTTCCCCAGTACCCCCTAGCAGCCTACAACGTGAGCGCAGAATACTCCATGGTCAAGGCTGCTGCTG
AGAAGGGCTGGATAGATGAGAAGCTCGTAACAATGGAGATAATAACTGCTATAAGGAGGGCGGGTGCAGACATAGTGATA
ACTTATCATGCGCTTGACGTGGCTCGGTGGCTCCGGGAGGGCTACAGCCCGTTCTAG

Upstream 100 bases:

>100_bases
CTTCCCCGCGCTGCGTCTCTTGCTAGGCGGGGCTGCTGGAAGGCTCGGGGTAAAGTTCCTAATCGCCTGCTAGGCCTATG
CTAACAGTGGTGGATGCTGG

Downstream 100 bases:

>100_bases
GCTAGCCCGTGCTCCTCAAGTATCCTCCAGTAGTTTTCATCTTCCATAACCTCCTGGTACTCTCTCTCAATCCTCCTAAG
CAGGCCAGCTGCACCCCTCC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MPGFPELRPRRLRLTKAIRDLVAETLVSPSQLMMPIFVKEGIKEPEPIPSMPGQYRYPPERVVDVIREALDLGIKSFLLF
GVVPDEKKDLRGTYAYDPRGPVPTAIRLIRRELGWEPAIFTDVCICGYTTHGHCGIPVERHGRQLIDNDSTLEVIARIAV
THAEAGADFVAPSGMMDGMVSAIREALDDAGYTEVGIMSYAVKYASGFYGPFREAAGSAPRFGDRRSYQMDPRNAMEAIK
EAMLDIEEGADILMVKPALAYLDVIRLVKEAFPQYPLAAYNVSAEYSMVKAAAEKGWIDEKLVTMEIITAIRRAGADIVI
TYHALDVARWLREGYSPF

Sequences:

>Translated_338_residues
MPGFPELRPRRLRLTKAIRDLVAETLVSPSQLMMPIFVKEGIKEPEPIPSMPGQYRYPPERVVDVIREALDLGIKSFLLF
GVVPDEKKDLRGTYAYDPRGPVPTAIRLIRRELGWEPAIFTDVCICGYTTHGHCGIPVERHGRQLIDNDSTLEVIARIAV
THAEAGADFVAPSGMMDGMVSAIREALDDAGYTEVGIMSYAVKYASGFYGPFREAAGSAPRFGDRRSYQMDPRNAMEAIK
EAMLDIEEGADILMVKPALAYLDVIRLVKEAFPQYPLAAYNVSAEYSMVKAAAEKGWIDEKLVTMEIITAIRRAGADIVI
TYHALDVARWLREGYSPF
>Mature_337_residues
PGFPELRPRRLRLTKAIRDLVAETLVSPSQLMMPIFVKEGIKEPEPIPSMPGQYRYPPERVVDVIREALDLGIKSFLLFG
VVPDEKKDLRGTYAYDPRGPVPTAIRLIRRELGWEPAIFTDVCICGYTTHGHCGIPVERHGRQLIDNDSTLEVIARIAVT
HAEAGADFVAPSGMMDGMVSAIREALDDAGYTEVGIMSYAVKYASGFYGPFREAAGSAPRFGDRRSYQMDPRNAMEAIKE
AMLDIEEGADILMVKPALAYLDVIRLVKEAFPQYPLAAYNVSAEYSMVKAAAEKGWIDEKLVTMEIITAIRRAGADIVIT
YHALDVARWLREGYSPF

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=315, Percent_Identity=43.1746031746032, Blast_Score=252, Evalue=4e-67,
Organism=Escherichia coli, GI87081728, Length=321, Percent_Identity=48.2866043613707, Blast_Score=282, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=39.1849529780564, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21358291, Length=299, Percent_Identity=42.4749163879599, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37617; Mature: 37486

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGFPELRPRRLRLTKAIRDLVAETLVSPSQLMMPIFVKEGIKEPEPIPSMPGQYRYPPE
CCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
RVVDVIREALDLGIKSFLLFGVVPDEKKDLRGTYAYDPRGPVPTAIRLIRRELGWEPAIF
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
TDVCICGYTTHGHCGIPVERHGRQLIDNDSTLEVIARIAVTHAEAGADFVAPSGMMDGMV
HHHHHHCCCCCCCCCCCHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SAIREALDDAGYTEVGIMSYAVKYASGFYGPFREAAGSAPRFGDRRSYQMDPRNAMEAIK
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
EAMLDIEEGADILMVKPALAYLDVIRLVKEAFPQYPLAAYNVSAEYSMVKAAAEKGWIDE
HHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCHH
KLVTMEIITAIRRAGADIVITYHALDVARWLREGYSPF
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PGFPELRPRRLRLTKAIRDLVAETLVSPSQLMMPIFVKEGIKEPEPIPSMPGQYRYPPE
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
RVVDVIREALDLGIKSFLLFGVVPDEKKDLRGTYAYDPRGPVPTAIRLIRRELGWEPAIF
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
TDVCICGYTTHGHCGIPVERHGRQLIDNDSTLEVIARIAVTHAEAGADFVAPSGMMDGMV
HHHHHHCCCCCCCCCCCHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SAIREALDDAGYTEVGIMSYAVKYASGFYGPFREAAGSAPRFGDRRSYQMDPRNAMEAIK
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
EAMLDIEEGADILMVKPALAYLDVIRLVKEAFPQYPLAAYNVSAEYSMVKAAAEKGWIDE
HHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCHH
KLVTMEIITAIRRAGADIVITYHALDVARWLREGYSPF
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377 [H]