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The map label for this gene is secY [H]

Identifier: 124028178

GI number: 124028178

Start: 1320384

End: 1321778

Strand: Direct

Name: secY [H]

Synonym: Hbut_1323

Alternate gene names: 124028178

Gene position: 1320384-1321778 (Clockwise)

Preceding gene: 124028177

Following gene: 124028179

Centisome position: 79.2

GC content: 53.33

Gene sequence:

>1395_bases
ATGGGCGTCTTGGAGGTTTTGGCTGAGGTTTCGCGGTATATACCGGCGGCTGCCAAGCCTGCTAGGAGGCCAACACTACC
AACGAGGCTTATGTGGACTGGTCTCGTGGTGCTACTCTACCTTATCATGAGCGAGATACCACTAGTGGGCGTTTACGGGT
ATGGGCAGGCTACCCAGGCAACTCTAATGTCGATGCTTCTAGGCATGAATATTGGTACGTTGATGACGCTTGGTATAGGC
CCCATAGTAACTGCTGGCATCGTGCTAGAGGTGCTGGTTGGCGGCAAGCTGATAGAGCTAGACCTAACCAAGCCTAGGGA
CCGTAAGATATTCATGGGTGCCCAGCGCACCCTAGCGCTGCTCTTCGCGCTGCTCGAAGCGGCAGCTTATGTAATCGGGT
GCCGGTTCTGGATATCAGCCTTTGCTAGTAGCCCGGAGGTGTGTCCGCCAATATCAACAGCGGTGAAGATAATTGTTGTG
TTACAGTTAGTCTTTGCAACACTAGTACTAATGTGGTTCGACGAAATGATCCGCAACGGCTGGGGTATAGGCTCGGCGCT
CAGCCTGTTCATTGTGGCTAGCGTGGTTAAGGGATTGTTCTGGCAGCTGGCAGGGTCAACCAAGGTTGCTACGCCGGAGG
GACAGCCAGTATACTATGGTTGGCTAGCCCACGTGGTCTCAACCGGCGACCTCGGCGTGCTGAGGCGCGGCATGCCAGAC
ATGGTTGGGTTCCTGGCGACAATAGCGATCATAATGGTGCTGATATACTTCCAGCTTATGAGGGTCTACATACCGGTCAC
CAGCCCGAGGTATGGCAGCATAAAGACTAGGATACCGCTAAACTTCATCTACGTGACAAACATCCCTATACTATTCGTAG
CCATAGCAGTCTCAGACATCAAGGTATTCGAGATCGTAATAGCTAGCTTACTCGGCGCCGACAACCCCCTAGTGAGGGGC
ATGGATGTACTATACAACTATGTGAGCCCACCTCGTGGCCTCTTAGCGGCGGTTGCTGACCCGCTACGAACACTAACCTT
CGCCCTGGCATGGCTAGCACTAGGCCTTCTCTTCGGCTTTATCTGGGTTGAGATAGCAGGCCTCAGTCCGAGGCAGCAGG
CAGAAAACCTGATAAAATCTGGCATGGAGCTCCCCGGTATACGCAAGAATGTCAAGCTGCTTGAGCGCATACTAGCACGC
TACATCTACCCGCTAACAGTGATAAGCTCACTGCTAGTAACAACGATGGCCATACTAGCAGACGTGTTCGGCGCCTACGG
CACAGGCTCGGGCCTAGTACTACTCGTAGGTATAATCTACAACTTCTACCAGGCCCTGGTATACGAGCGTACGCTAGAGA
TGTACCCAACGCTACAGAGGCTACTAGGCCGCTGA

Upstream 100 bases:

>100_bases
TCCTCTCCTTAGGCCTGGTTGATGTGCTTGTGCTACTGTTTGGCTGTATGAGTAGGGTCTATATACTGGCTACTTCACTG
CTAGCGCGCGGGCTAGGCTT

Downstream 100 bases:

>100_bases
CGCAGCTCCTCCCCTTCCTGGGCTCAGGTTTTTATGAGCCCAGCTCCTCCGGCCCTGCTTGCCCGGGAAACTGGAGCCCA
ATACACCCATGCCCGGCGCT

Product: preprotein translocase subunit secY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MGVLEVLAEVSRYIPAAAKPARRPTLPTRLMWTGLVVLLYLIMSEIPLVGVYGYGQATQATLMSMLLGMNIGTLMTLGIG
PIVTAGIVLEVLVGGKLIELDLTKPRDRKIFMGAQRTLALLFALLEAAAYVIGCRFWISAFASSPEVCPPISTAVKIIVV
LQLVFATLVLMWFDEMIRNGWGIGSALSLFIVASVVKGLFWQLAGSTKVATPEGQPVYYGWLAHVVSTGDLGVLRRGMPD
MVGFLATIAIIMVLIYFQLMRVYIPVTSPRYGSIKTRIPLNFIYVTNIPILFVAIAVSDIKVFEIVIASLLGADNPLVRG
MDVLYNYVSPPRGLLAAVADPLRTLTFALAWLALGLLFGFIWVEIAGLSPRQQAENLIKSGMELPGIRKNVKLLERILAR
YIYPLTVISSLLVTTMAILADVFGAYGTGSGLVLLVGIIYNFYQALVYERTLEMYPTLQRLLGR

Sequences:

>Translated_464_residues
MGVLEVLAEVSRYIPAAAKPARRPTLPTRLMWTGLVVLLYLIMSEIPLVGVYGYGQATQATLMSMLLGMNIGTLMTLGIG
PIVTAGIVLEVLVGGKLIELDLTKPRDRKIFMGAQRTLALLFALLEAAAYVIGCRFWISAFASSPEVCPPISTAVKIIVV
LQLVFATLVLMWFDEMIRNGWGIGSALSLFIVASVVKGLFWQLAGSTKVATPEGQPVYYGWLAHVVSTGDLGVLRRGMPD
MVGFLATIAIIMVLIYFQLMRVYIPVTSPRYGSIKTRIPLNFIYVTNIPILFVAIAVSDIKVFEIVIASLLGADNPLVRG
MDVLYNYVSPPRGLLAAVADPLRTLTFALAWLALGLLFGFIWVEIAGLSPRQQAENLIKSGMELPGIRKNVKLLERILAR
YIYPLTVISSLLVTTMAILADVFGAYGTGSGLVLLVGIIYNFYQALVYERTLEMYPTLQRLLGR
>Mature_463_residues
GVLEVLAEVSRYIPAAAKPARRPTLPTRLMWTGLVVLLYLIMSEIPLVGVYGYGQATQATLMSMLLGMNIGTLMTLGIGP
IVTAGIVLEVLVGGKLIELDLTKPRDRKIFMGAQRTLALLFALLEAAAYVIGCRFWISAFASSPEVCPPISTAVKIIVVL
QLVFATLVLMWFDEMIRNGWGIGSALSLFIVASVVKGLFWQLAGSTKVATPEGQPVYYGWLAHVVSTGDLGVLRRGMPDM
VGFLATIAIIMVLIYFQLMRVYIPVTSPRYGSIKTRIPLNFIYVTNIPILFVAIAVSDIKVFEIVIASLLGADNPLVRGM
DVLYNYVSPPRGLLAAVADPLRTLTFALAWLALGLLFGFIWVEIAGLSPRQQAENLIKSGMELPGIRKNVKLLERILARY
IYPLTVISSLLVTTMAILADVFGAYGTGSGLVLLVGIIYNFYQALVYERTLEMYPTLQRLLGR

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel [H]

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family [H]

Homologues:

Organism=Homo sapiens, GI14589847, Length=477, Percent_Identity=29.1404612159329, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI7019415, Length=473, Percent_Identity=29.1754756871036, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI217330618, Length=477, Percent_Identity=28.5115303983228, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI217330616, Length=422, Percent_Identity=28.1990521327014, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17543770, Length=474, Percent_Identity=29.1139240506329, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323411, Length=475, Percent_Identity=25.6842105263158, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319760, Length=465, Percent_Identity=22.1505376344086, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19920826, Length=478, Percent_Identity=29.9163179916318, Blast_Score=215, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561 [H]

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY [H]

EC number: NA

Molecular weight: Translated: 50740; Mature: 50609

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00755 SECY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLEVLAEVSRYIPAAAKPARRPTLPTRLMWTGLVVLLYLIMSEIPLVGVYGYGQATQA
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHH
TLMSMLLGMNIGTLMTLGIGPIVTAGIVLEVLVGGKLIELDLTKPRDRKIFMGAQRTLAL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHHHHHHHH
LFALLEAAAYVIGCRFWISAFASSPEVCPPISTAVKIIVVLQLVFATLVLMWFDEMIRNG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WGIGSALSLFIVASVVKGLFWQLAGSTKVATPEGQPVYYGWLAHVVSTGDLGVLRRGMPD
CCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCCHHHHHCCCHH
MVGFLATIAIIMVLIYFQLMRVYIPVTSPRYGSIKTRIPLNFIYVTNIPILFVAIAVSDI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEECCHHHHHHHHHHHHH
KVFEIVIASLLGADNPLVRGMDVLYNYVSPPRGLLAAVADPLRTLTFALAWLALGLLFGF
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWVEIAGLSPRQQAENLIKSGMELPGIRKNVKLLERILARYIYPLTVISSLLVTTMAILA
HHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVFGAYGTGSGLVLLVGIIYNFYQALVYERTLEMYPTLQRLLGR
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVLEVLAEVSRYIPAAAKPARRPTLPTRLMWTGLVVLLYLIMSEIPLVGVYGYGQATQA
CHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHH
TLMSMLLGMNIGTLMTLGIGPIVTAGIVLEVLVGGKLIELDLTKPRDRKIFMGAQRTLAL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHHHHHHHH
LFALLEAAAYVIGCRFWISAFASSPEVCPPISTAVKIIVVLQLVFATLVLMWFDEMIRNG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WGIGSALSLFIVASVVKGLFWQLAGSTKVATPEGQPVYYGWLAHVVSTGDLGVLRRGMPD
CCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCCHHHHHCCCHH
MVGFLATIAIIMVLIYFQLMRVYIPVTSPRYGSIKTRIPLNFIYVTNIPILFVAIAVSDI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEECCHHHHHHHHHHHHH
KVFEIVIASLLGADNPLVRGMDVLYNYVSPPRGLLAAVADPLRTLTFALAWLALGLLFGF
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWVEIAGLSPRQQAENLIKSGMELPGIRKNVKLLERILARYIYPLTVISSLLVTTMAILA
HHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVFGAYGTGSGLVLLVGIIYNFYQALVYERTLEMYPTLQRLLGR
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]