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The map label for this gene is pyrH

Identifier: 124027906

GI number: 124027906

Start: 1051162

End: 1051842

Strand: Reverse

Name: pyrH

Synonym: Hbut_1037

Alternate gene names: 124027906

Gene position: 1051842-1051162 (Counterclockwise)

Preceding gene: 124027910

Following gene: 124027900

Centisome position: 63.09

GC content: 59.18

Gene sequence:

>681_bases
GTGCCGAAGGGCCCCGTAGTCATCAAGGTTAGCGGAAAGTATGTCAACCCGGAGAAGCCCGGGCTCGTTAAACGCTACGC
CCAGGTCCTCCATGAGCTACATAGCGTGGGCTACCGGCTCGTAGTAGTCGTCGGCGGTGGTCCCGAGGCTAGACGCTACA
TTGAAGCTGCCCGGGAGCTGGGGCTGGGGAAGAGCTTCCAGGACATCCTCGGCATAGAGGCCTCCAGGCTCAACGCTCGG
CTCCTAATCTACGCGCTGCACCCCAACGCCTACCCGGAGCCCCCGAGGAGCATCTGGGAGCTGCTCGAAGCATACTCCAC
CGGGCTCATAGTGGTGGCTGGCGGGTTCCAACCTGGCCAGAGCACCTCCGGCGTAGCAGCCCTCGTTGCTGAAGCCATCG
GGGCAGAGCTTCTCGTACTTGCAACCACGGTTGACGGCGTATACACGGCGGACCCCGCCGTGGATAAGTCTGCACAGCTG
ATACCGAGGCTAAGCTATGAAGAGTTTCGCAGGGTTGTAAGGCAGAGCATGAGCCCCGGCCGCTACGAGCTACTAGACCC
GGTAGCAATATCGATTGTTGAGAGGAGCAATATACCGGTAAGAGTAGTTAATGGTTCGGATCCGGAGAACGTGAAAAGGG
TAGTGCTTGGAGAAGAGCTTGGCAGCCTAATAACAGGCTAG

Upstream 100 bases:

>100_bases
CCGCCTATACTACCGGACGGGGCTGGTCACTTTACGCCCGCTGTTTGCTGTAAGGGTTTTAGGGCCCTATCCAGGTAGAG
CCAACACGTCTGGGTGGCCG

Downstream 100 bases:

>100_bases
TACCTACGGCTACGCCGCAGGTGTTCTGGACAGCCAACACGCTCTGCTATATCAACATACTCTACTCCGCCGCCAGGCTT
AGGCCTTGCTAGCACACAGT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MPKGPVVIKVSGKYVNPEKPGLVKRYAQVLHELHSVGYRLVVVVGGGPEARRYIEAARELGLGKSFQDILGIEASRLNAR
LLIYALHPNAYPEPPRSIWELLEAYSTGLIVVAGGFQPGQSTSGVAALVAEAIGAELLVLATTVDGVYTADPAVDKSAQL
IPRLSYEEFRRVVRQSMSPGRYELLDPVAISIVERSNIPVRVVNGSDPENVKRVVLGEELGSLITG

Sequences:

>Translated_226_residues
MPKGPVVIKVSGKYVNPEKPGLVKRYAQVLHELHSVGYRLVVVVGGGPEARRYIEAARELGLGKSFQDILGIEASRLNAR
LLIYALHPNAYPEPPRSIWELLEAYSTGLIVVAGGFQPGQSTSGVAALVAEAIGAELLVLATTVDGVYTADPAVDKSAQL
IPRLSYEEFRRVVRQSMSPGRYELLDPVAISIVERSNIPVRVVNGSDPENVKRVVLGEELGSLITG
>Mature_225_residues
PKGPVVIKVSGKYVNPEKPGLVKRYAQVLHELHSVGYRLVVVVGGGPEARRYIEAARELGLGKSFQDILGIEASRLNARL
LIYALHPNAYPEPPRSIWELLEAYSTGLIVVAGGFQPGQSTSGVAALVAEAIGAELLVLATTVDGVYTADPAVDKSAQLI
PRLSYEEFRRVVRQSMSPGRYELLDPVAISIVERSNIPVRVVNGSDPENVKRVVLGEELGSLITG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=239, Percent_Identity=28.8702928870293, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_HYPBU (A2BLM0)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001013226.1
- ProteinModelPortal:   A2BLM0
- SMR:   A2BLM0
- STRING:   A2BLM0
- GeneID:   4782769
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_1037
- eggNOG:   arNOG05927
- HOGENOM:   HBG497552
- OMA:   TRANAML
- BioCyc:   HBUT415426:HBUT_1037-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_A
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR011818
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02076

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 24349; Mature: 24218

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: BINDING 46-46 BINDING 47-47 BINDING 51-51 BINDING 68-68 BINDING 142-142 BINDING 148-148 BINDING 151-151

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKGPVVIKVSGKYVNPEKPGLVKRYAQVLHELHSVGYRLVVVVGGGPEARRYIEAAREL
CCCCCEEEEECCEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHH
GLGKSFQDILGIEASRLNARLLIYALHPNAYPEPPRSIWELLEAYSTGLIVVAGGFQPGQ
CCCCCHHHHHCCCHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCC
STSGVAALVAEAIGAELLVLATTVDGVYTADPAVDKSAQLIPRLSYEEFRRVVRQSMSPG
CCCHHHHHHHHHHCCEEEEEEEECCCEEECCCCCCCCHHHHCCCCHHHHHHHHHHHCCCC
RYELLDPVAISIVERSNIPVRVVNGSDPENVKRVVLGEELGSLITG
CEEHHHHHHHEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKGPVVIKVSGKYVNPEKPGLVKRYAQVLHELHSVGYRLVVVVGGGPEARRYIEAAREL
CCCCEEEEECCEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHH
GLGKSFQDILGIEASRLNARLLIYALHPNAYPEPPRSIWELLEAYSTGLIVVAGGFQPGQ
CCCCCHHHHHCCCHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCC
STSGVAALVAEAIGAELLVLATTVDGVYTADPAVDKSAQLIPRLSYEEFRRVVRQSMSPG
CCCHHHHHHHHHHCCEEEEEEEECCCEEECCCCCCCCHHHHCCCCHHHHHHHHHHHCCCC
RYELLDPVAISIVERSNIPVRVVNGSDPENVKRVVLGEELGSLITG
CEEHHHHHHHEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA