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The map label for this gene is prs [H]

Identifier: 124027543

GI number: 124027543

Start: 645362

End: 646030

Strand: Reverse

Name: prs [H]

Synonym: Hbut_0662

Alternate gene names: 124027543

Gene position: 646030-645362 (Counterclockwise)

Preceding gene: 124027547

Following gene: 124027542

Centisome position: 38.75

GC content: 60.39

Gene sequence:

>669_bases
GTGGCTGCTTATACTCCGTATGCGAGGCAGGACCGCAGGTTTCTCCGCGGAGAGCCTGTTAGCGTGAGGGCGCTCTTCTA
CTCCCTCGCCGCTAGCGGGGCAGAGGCCTTTGTTACTGTTGATATTCACAAGACTGTTAGCCTCCAGTGGTTCCCTGGCC
CAGCCGTAAACGTTGATCCCGCGCCAGCATTTGCGGAGAAGCTGCGTCCGCTGCTTGAGGGCCGGGAGAAGGTCTACGTT
ATCGCGCCGGATCAGGGCGCGGTGGGCAGGGCTAAGAGCCTAGCTGAGAGGCTTGGCGCGCCGTTCGACTACCTGGAGAA
GGTGAGGGACCGGGTTACGGGAGAGATAGTGCTGAGGCCCAAGCTGGTGGATGTGAGTGGCGCAGCTGTAGTCCTCATAG
ACGATATCGTCAGCACCGGCGGCACCATGGCTAAGGCTGCTAGGATGCTCTACGAGCAGGGAGCCGAGGTTGTGATAGCT
GCTGCTACACACGGCCTCTTCGCGGGTGAGGCGCTGGAGAAGATGAGGAAGGCCGGTATAGTGCATATACTCGTTGCGGA
TACTGTAAAGGCGCCAGAGGACGTTGACGTAGCCAGTGTCGGCAGGCTGGCAGCCGACGCGGTGAAAAGCGTTCTTGAGG
CTGTGGCTGGCTACGAGTCTGAGGGCTGA

Upstream 100 bases:

>100_bases
CATAGTGTTTACGGGCTACCCGGAGCCCACGCAGCGTCTATGGGAGGCTGTCCTGGCGGTCGAGGCTGCTCGTGGGCTCG
GTGCGGAGCATGTTGTTGTC

Downstream 100 bases:

>100_bases
ACCGGGGCCTTGGAGCTGGGCATAGTCTTTCTCGGCACGAGCGCGGCTGTGCCAACCCGGTACCGGGGGCTCCCAAGCAT
AGCCGTGGTACACCGTGGCA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MAAYTPYARQDRRFLRGEPVSVRALFYSLAASGAEAFVTVDIHKTVSLQWFPGPAVNVDPAPAFAEKLRPLLEGREKVYV
IAPDQGAVGRAKSLAERLGAPFDYLEKVRDRVTGEIVLRPKLVDVSGAAVVLIDDIVSTGGTMAKAARMLYEQGAEVVIA
AATHGLFAGEALEKMRKAGIVHILVADTVKAPEDVDVASVGRLAADAVKSVLEAVAGYESEG

Sequences:

>Translated_222_residues
MAAYTPYARQDRRFLRGEPVSVRALFYSLAASGAEAFVTVDIHKTVSLQWFPGPAVNVDPAPAFAEKLRPLLEGREKVYV
IAPDQGAVGRAKSLAERLGAPFDYLEKVRDRVTGEIVLRPKLVDVSGAAVVLIDDIVSTGGTMAKAARMLYEQGAEVVIA
AATHGLFAGEALEKMRKAGIVHILVADTVKAPEDVDVASVGRLAADAVKSVLEAVAGYESEG
>Mature_221_residues
AAYTPYARQDRRFLRGEPVSVRALFYSLAASGAEAFVTVDIHKTVSLQWFPGPAVNVDPAPAFAEKLRPLLEGREKVYVI
APDQGAVGRAKSLAERLGAPFDYLEKVRDRVTGEIVLRPKLVDVSGAAVVLIDDIVSTGGTMAKAARMLYEQGAEVVIAA
ATHGLFAGEALEKMRKAGIVHILVADTVKAPEDVDVASVGRLAADAVKSVLEAVAGYESEG

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=211, Percent_Identity=29.8578199052133, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI84875539, Length=214, Percent_Identity=30.3738317757009, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4506127, Length=211, Percent_Identity=29.8578199052133, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI28557709, Length=189, Percent_Identity=29.1005291005291, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI1787458, Length=194, Percent_Identity=34.020618556701, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25149168, Length=207, Percent_Identity=28.0193236714976, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17554704, Length=207, Percent_Identity=28.0193236714976, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17554702, Length=207, Percent_Identity=28.0193236714976, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71989924, Length=207, Percent_Identity=28.0193236714976, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17570245, Length=239, Percent_Identity=23.0125523012552, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319403, Length=192, Percent_Identity=31.7708333333333, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320946, Length=193, Percent_Identity=32.6424870466321, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321776, Length=208, Percent_Identity=31.7307692307692, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324511, Length=85, Percent_Identity=34.1176470588235, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355239, Length=189, Percent_Identity=30.6878306878307, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI45551540, Length=212, Percent_Identity=27.8301886792453, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 23589; Mature: 23458

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYTPYARQDRRFLRGEPVSVRALFYSLAASGAEAFVTVDIHKTVSLQWFPGPAVNVDP
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEEEEECCCCCCCCCC
APAFAEKLRPLLEGREKVYVIAPDQGAVGRAKSLAERLGAPFDYLEKVRDRVTGEIVLRP
CHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEE
KLVDVSGAAVVLIDDIVSTGGTMAKAARMLYEQGAEVVIAAATHGLFAGEALEKMRKAGI
EEEECCCCEEEEEEHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCE
VHILVADTVKAPEDVDVASVGRLAADAVKSVLEAVAGYESEG
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AAYTPYARQDRRFLRGEPVSVRALFYSLAASGAEAFVTVDIHKTVSLQWFPGPAVNVDP
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEEEEECCCCCCCCCC
APAFAEKLRPLLEGREKVYVIAPDQGAVGRAKSLAERLGAPFDYLEKVRDRVTGEIVLRP
CHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEE
KLVDVSGAAVVLIDDIVSTGGTMAKAARMLYEQGAEVVIAAATHGLFAGEALEKMRKAGI
EEEECCCCEEEEEEHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCE
VHILVADTVKAPEDVDVASVGRLAADAVKSVLEAVAGYESEG
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]