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The map label for this gene is rnz [H]

Identifier: 124027542

GI number: 124027542

Start: 644444

End: 645352

Strand: Reverse

Name: rnz [H]

Synonym: Hbut_0661

Alternate gene names: 124027542

Gene position: 645352-644444 (Counterclockwise)

Preceding gene: 124027543

Following gene: 124027540

Centisome position: 38.71

GC content: 63.37

Gene sequence:

>909_bases
TTGGAGCTGGGCATAGTCTTTCTCGGCACGAGCGCGGCTGTGCCAACCCGGTACCGGGGGCTCCCAAGCATAGCCGTGGT
ACACCGTGGCAGCATAGTGCTGCTAGATGCGGGGGAGGGGACACAAGCCGCTCTTACCCGGGCTGGGCTGAGCCCGCTCC
GCGTCGAGGCGATCTTCATCACCCACCTGCACGGCGACCACTTCTTCGGGCTTCCCGGCCTACTACAGTCCATGGGGATG
CTCGGCAGGAAGACGCCGCTCCTCGTAGCAGGGCCACGGGGGCTCTACGGCTTTCTCCGCGAAGCCTTTAGGGCCAGCAG
GTGGCTCCCCGGCTTCCCGCTCTACGTGGCGGAGCTGGAGCCCGGCGAGAAGCTGGTGCTGCCCAGCGGCTTGGAGGTCG
AGTCGTTCCCTGTCTCCCACACAATCCCCGCTATGGGGTATAGACTCGTTGAGCCCCGGAGGAAGCCAAGGATAAACATC
GAGAAGGCTAGGAGGCTCGGCATAGAGCCCGGCCCGCTGCTCGCGAAGCTTCAGCGGGGCGAGCCGGTCACCGTCGCCGG
AAGGATTGTGAGGCCGGAGGAGGTCGTGGAGGAGCAGCCCCGCGCAGTGATAGTCTATACGGGCGATACCAGGCCCTGCC
CAACAGTGGTAGAGGCTGCCCGCAACGCCACAGTGCTAATACACGACGCCACATTCACCAGTAGCATGGCCCGAGAAGCC
TACGAGCAGGGCCACAGCACAGCCAGAGACGCAGCCAGAGCCGCCAGCACTGCAGATGCACGCCTCCTAGTACTATTCCA
TATAAGTGCACGCTACGAAACACCCGACCCCCTCCTAGCCGAGGCAAGAATACACCACGACAACGTGGTTGCAGCAGAGG
ACTACCTCAAGATACCAATCCGACCCTAG

Upstream 100 bases:

>100_bases
GGACGTTGACGTAGCCAGTGTCGGCAGGCTGGCAGCCGACGCGGTGAAAAGCGTTCTTGAGGCTGTGGCTGGCTACGAGT
CTGAGGGCTGAACCGGGGCC

Downstream 100 bases:

>100_bases
ATGCTACCAGCCCATAACAACACGGGCCCCACTGCAAACGGGAATACAAATAGTGTAACATACAGGTAAAACCCATGCAA
CTCCACATGTACACAGCCTC

Product: metal-dependent hydrolase of beta lactamase, ElaC

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MELGIVFLGTSAAVPTRYRGLPSIAVVHRGSIVLLDAGEGTQAALTRAGLSPLRVEAIFITHLHGDHFFGLPGLLQSMGM
LGRKTPLLVAGPRGLYGFLREAFRASRWLPGFPLYVAELEPGEKLVLPSGLEVESFPVSHTIPAMGYRLVEPRRKPRINI
EKARRLGIEPGPLLAKLQRGEPVTVAGRIVRPEEVVEEQPRAVIVYTGDTRPCPTVVEAARNATVLIHDATFTSSMAREA
YEQGHSTARDAARAASTADARLLVLFHISARYETPDPLLAEARIHHDNVVAAEDYLKIPIRP

Sequences:

>Translated_302_residues
MELGIVFLGTSAAVPTRYRGLPSIAVVHRGSIVLLDAGEGTQAALTRAGLSPLRVEAIFITHLHGDHFFGLPGLLQSMGM
LGRKTPLLVAGPRGLYGFLREAFRASRWLPGFPLYVAELEPGEKLVLPSGLEVESFPVSHTIPAMGYRLVEPRRKPRINI
EKARRLGIEPGPLLAKLQRGEPVTVAGRIVRPEEVVEEQPRAVIVYTGDTRPCPTVVEAARNATVLIHDATFTSSMAREA
YEQGHSTARDAARAASTADARLLVLFHISARYETPDPLLAEARIHHDNVVAAEDYLKIPIRP
>Mature_302_residues
MELGIVFLGTSAAVPTRYRGLPSIAVVHRGSIVLLDAGEGTQAALTRAGLSPLRVEAIFITHLHGDHFFGLPGLLQSMGM
LGRKTPLLVAGPRGLYGFLREAFRASRWLPGFPLYVAELEPGEKLVLPSGLEVESFPVSHTIPAMGYRLVEPRRKPRINI
EKARRLGIEPGPLLAKLQRGEPVTVAGRIVRPEEVVEEQPRAVIVYTGDTRPCPTVVEAARNATVLIHDATFTSSMAREA
YEQGHSTARDAARAASTADARLLVLFHISARYETPDPLLAEARIHHDNVVAAEDYLKIPIRP

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=362, Percent_Identity=32.3204419889503, Blast_Score=154, Evalue=9e-38,
Organism=Escherichia coli, GI87082078, Length=292, Percent_Identity=36.986301369863, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71985814, Length=95, Percent_Identity=35.7894736842105, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71985808, Length=95, Percent_Identity=35.7894736842105, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24652403, Length=306, Percent_Identity=30.0653594771242, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 32929; Mature: 32929

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGIVFLGTSAAVPTRYRGLPSIAVVHRGSIVLLDAGEGTQAALTRAGLSPLRVEAIFI
CCEEEEEEECCCCCCHHHCCCCCEEEEECCCEEEEECCCCCHHHHHHCCCCCEEEEEEEE
THLHGDHFFGLPGLLQSMGMLGRKTPLLVAGPRGLYGFLREAFRASRWLPGFPLYVAELE
EEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEC
PGEKLVLPSGLEVESFPVSHTIPAMGYRLVEPRRKPRINIEKARRLGIEPGPLLAKLQRG
CCCEEECCCCCCEECCCCCCCCHHHCEEECCCCCCCCCCHHHHHHCCCCCCHHHHHCCCC
EPVTVAGRIVRPEEVVEEQPRAVIVYTGDTRPCPTVVEAARNATVLIHDATFTSSMAREA
CCEEEEEEEECHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHH
YEQGHSTARDAARAASTADARLLVLFHISARYETPDPLLAEARIHHDNVVAAEDYLKIPI
HHHCCHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHEEECCCCEEEECCEEEECC
RP
CC
>Mature Secondary Structure
MELGIVFLGTSAAVPTRYRGLPSIAVVHRGSIVLLDAGEGTQAALTRAGLSPLRVEAIFI
CCEEEEEEECCCCCCHHHCCCCCEEEEECCCEEEEECCCCCHHHHHHCCCCCEEEEEEEE
THLHGDHFFGLPGLLQSMGMLGRKTPLLVAGPRGLYGFLREAFRASRWLPGFPLYVAELE
EEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEC
PGEKLVLPSGLEVESFPVSHTIPAMGYRLVEPRRKPRINIEKARRLGIEPGPLLAKLQRG
CCCEEECCCCCCEECCCCCCCCHHHCEEECCCCCCCCCCHHHHHHCCCCCCHHHHHCCCC
EPVTVAGRIVRPEEVVEEQPRAVIVYTGDTRPCPTVVEAARNATVLIHDATFTSSMAREA
CCEEEEEEEECHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHH
YEQGHSTARDAARAASTADARLLVLFHISARYETPDPLLAEARIHHDNVVAAEDYLKIPI
HHHCCHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHEEECCCCEEEECCEEEECC
RP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]