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The map label for this gene is psmA [H]

Identifier: 124027453

GI number: 124027453

Start: 540786

End: 541517

Strand: Direct

Name: psmA [H]

Synonym: Hbut_0568

Alternate gene names: 124027453

Gene position: 540786-541517 (Clockwise)

Preceding gene: 124027451

Following gene: 124027454

Centisome position: 32.44

GC content: 52.32

Gene sequence:

>732_bases
GTGTCGTTCCCGGCTCCACCAGCGATGATGGGGTATGACCGTAGTACAGCGATGTTCTCTCCTGATGGCCGGCTATTCCA
GGTAGAGTATGCTATGGAGGCTGCTAAGCGTGGCTGGACGATGGTGGGTGTTAGGGCTCGCGACGGTGTGGTGATCGTTG
CTGAGAAGAAGAAGACAAGCCCGCTAATCGATATTGAGCAGCTGGAGAAGGTCTACATGGTTGACGAGCATATAGGAGCT
GGTTTTGTAGGGTTCGGCAGTGATGGTCGCGTGTTGATAGACTATGCTAGGCAGCTAGCGATACAGTACAAGTTCATCTA
TGGCGAGAAGATACCAGTTGAGTACCTTACCAGGCAGATCTGTGACCTAATGCAGCTCTACACCCAGCATGGTGGCGTGA
GACCCTTCGGTGTGACACTGCTGATAGTCGGTGTAGATGATAGTGGTCCCAAGCTATTCGTTGCAGAGCCGAGCGGCCAG
TACATGAGCTATAAGGCTCATGGTCTTGGCCAGGGTGGTGGCCAGGCTATAGAGATCCTGCAGCGCGAGTACAGGGACGA
CATAGATGTTGAGGGCGCAATACTCCTGGGCATAAGGGCTGTAGCATCTGTAATGGAGGGTAAGCCTACGCCGGAAACCC
TAGAGGTTGGTGTAGCGGATACTAGGACTGGGAGGTTTAGGAAACTGACTAAAGAGGAGCTATTAAAGTATATAGAAAAG
CTTGGTGCCTAG

Upstream 100 bases:

>100_bases
CACTAGGATGGTGGTTAGTGTAGCTATACGCTTTATAGCCTAGGTAAGGCTTTTTACGCGTAGGCCTGGGTTTACGGCTT
GATTGGAGGTGTAATGTGCA

Downstream 100 bases:

>100_bases
AGAATGCCGCGGAAGGGCAGGGGCGAGCACGAGCCTGTAGTTGCGAGGCTTGAGGTTGCAGGTAAGCGTTTCGAGGTTCT
CGTAAACCCGGACCTTGCTT

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSFPAPPAMMGYDRSTAMFSPDGRLFQVEYAMEAAKRGWTMVGVRARDGVVIVAEKKKTSPLIDIEQLEKVYMVDEHIGA
GFVGFGSDGRVLIDYARQLAIQYKFIYGEKIPVEYLTRQICDLMQLYTQHGGVRPFGVTLLIVGVDDSGPKLFVAEPSGQ
YMSYKAHGLGQGGGQAIEILQREYRDDIDVEGAILLGIRAVASVMEGKPTPETLEVGVADTRTGRFRKLTKEELLKYIEK
LGA

Sequences:

>Translated_243_residues
MSFPAPPAMMGYDRSTAMFSPDGRLFQVEYAMEAAKRGWTMVGVRARDGVVIVAEKKKTSPLIDIEQLEKVYMVDEHIGA
GFVGFGSDGRVLIDYARQLAIQYKFIYGEKIPVEYLTRQICDLMQLYTQHGGVRPFGVTLLIVGVDDSGPKLFVAEPSGQ
YMSYKAHGLGQGGGQAIEILQREYRDDIDVEGAILLGIRAVASVMEGKPTPETLEVGVADTRTGRFRKLTKEELLKYIEK
LGA
>Mature_242_residues
SFPAPPAMMGYDRSTAMFSPDGRLFQVEYAMEAAKRGWTMVGVRARDGVVIVAEKKKTSPLIDIEQLEKVYMVDEHIGAG
FVGFGSDGRVLIDYARQLAIQYKFIYGEKIPVEYLTRQICDLMQLYTQHGGVRPFGVTLLIVGVDDSGPKLFVAEPSGQY
MSYKAHGLGQGGGQAIEILQREYRDDIDVEGAILLGIRAVASVMEGKPTPETLEVGVADTRTGRFRKLTKEELLKYIEKL
GA

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation [H]

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family [H]

Homologues:

Organism=Homo sapiens, GI4506181, Length=231, Percent_Identity=41.1255411255411, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI4506189, Length=232, Percent_Identity=40.0862068965517, Blast_Score=166, Evalue=1e-41,
Organism=Homo sapiens, GI68303563, Length=200, Percent_Identity=42.5, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI156713442, Length=233, Percent_Identity=36.9098712446352, Blast_Score=158, Evalue=3e-39,
Organism=Homo sapiens, GI4506185, Length=233, Percent_Identity=36.9098712446352, Blast_Score=158, Evalue=3e-39,
Organism=Homo sapiens, GI68303561, Length=206, Percent_Identity=41.2621359223301, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI23110944, Length=236, Percent_Identity=33.4745762711864, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI23110942, Length=236, Percent_Identity=37.2881355932203, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI23110935, Length=211, Percent_Identity=33.6492890995261, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4506179, Length=211, Percent_Identity=33.6492890995261, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI68303565, Length=200, Percent_Identity=37, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI4506183, Length=176, Percent_Identity=37.5, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI23110939, Length=174, Percent_Identity=36.7816091954023, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI156713444, Length=166, Percent_Identity=33.1325301204819, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI221316716, Length=109, Percent_Identity=36.697247706422, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25143215, Length=227, Percent_Identity=38.3259911894273, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17508491, Length=231, Percent_Identity=39.8268398268398, Blast_Score=165, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17508493, Length=241, Percent_Identity=36.9294605809129, Blast_Score=159, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17562790, Length=232, Percent_Identity=37.5, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562788, Length=236, Percent_Identity=29.6610169491525, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562792, Length=204, Percent_Identity=32.843137254902, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71998965, Length=225, Percent_Identity=30.2222222222222, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323547, Length=246, Percent_Identity=39.4308943089431, Blast_Score=173, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321574, Length=198, Percent_Identity=41.4141414141414, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321692, Length=237, Percent_Identity=37.9746835443038, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324535, Length=239, Percent_Identity=38.0753138075314, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324938, Length=172, Percent_Identity=40.6976744186046, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323974, Length=233, Percent_Identity=35.1931330472103, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6321427, Length=232, Percent_Identity=30.1724137931034, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17737927, Length=230, Percent_Identity=38.2608695652174, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17136420, Length=239, Percent_Identity=39.3305439330544, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24651571, Length=238, Percent_Identity=38.2352941176471, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24654391, Length=238, Percent_Identity=35.7142857142857, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24654389, Length=238, Percent_Identity=35.7142857142857, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17933602, Length=213, Percent_Identity=38.0281690140845, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI281360341, Length=234, Percent_Identity=32.0512820512821, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24586406, Length=234, Percent_Identity=32.0512820512821, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24586400, Length=234, Percent_Identity=32.0512820512821, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24586402, Length=234, Percent_Identity=32.0512820512821, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21356137, Length=213, Percent_Identity=36.6197183098592, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922898, Length=216, Percent_Identity=36.1111111111111, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI19921232, Length=236, Percent_Identity=33.4745762711864, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737405, Length=203, Percent_Identity=36.9458128078818, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24652204, Length=187, Percent_Identity=35.2941176470588, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353 [H]

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N [H]

EC number: =3.4.25.1 [H]

Molecular weight: Translated: 26863; Mature: 26732

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPAPPAMMGYDRSTAMFSPDGRLFQVEYAMEAAKRGWTMVGVRARDGVVIVAEKKKTS
CCCCCCCCCCCCCCCCEEECCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEEEECCCCC
PLIDIEQLEKVYMVDEHIGAGFVGFGSDGRVLIDYARQLAIQYKFIYGEKIPVEYLTRQI
CCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHEEEEEEECCCCCHHHHHHHH
CDLMQLYTQHGGVRPFGVTLLIVGVDDSGPKLFVAEPSGQYMSYKAHGLGQGGGQAIEIL
HHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHH
QREYRDDIDVEGAILLGIRAVASVMEGKPTPETLEVGVADTRTGRFRKLTKEELLKYIEK
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHH
LGA
HCC
>Mature Secondary Structure 
SFPAPPAMMGYDRSTAMFSPDGRLFQVEYAMEAAKRGWTMVGVRARDGVVIVAEKKKTS
CCCCCCCCCCCCCCCEEECCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEEEECCCCC
PLIDIEQLEKVYMVDEHIGAGFVGFGSDGRVLIDYARQLAIQYKFIYGEKIPVEYLTRQI
CCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHEEEEEEECCCCCHHHHHHHH
CDLMQLYTQHGGVRPFGVTLLIVGVDDSGPKLFVAEPSGQYMSYKAHGLGQGGGQAIEIL
HHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHH
QREYRDDIDVEGAILLGIRAVASVMEGKPTPETLEVGVADTRTGRFRKLTKEELLKYIEK
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHH
LGA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA