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The map label for this gene is eif2g [H]

Identifier: 124027332

GI number: 124027332

Start: 425147

End: 426412

Strand: Reverse

Name: eif2g [H]

Synonym: Hbut_0441

Alternate gene names: 124027332

Gene position: 426412-425147 (Counterclockwise)

Preceding gene: 124027333

Following gene: 124027331

Centisome position: 25.58

GC content: 53.16

Gene sequence:

>1266_bases
ATGGCAAGGTTTGATAGGGAGGAGATAGAGGCGCAGCGTCGCCGTCAGCCAGAAGTAAACATTGGAACGGCAGGCCATGT
AGATCATGGCAAGACAACGCTGGTCCAAGCACTGACTGGCGTGTGGACGGCAAAGCATAGTGAGGAACTCAAGCGCGGCA
TGACAATAAAGCTGGGCTATGCAGAAGGCGAAGTATGGTATTGTGAAGGCGCGGAGGGTGTCGAGGCCTATCAGCCGTTC
CCAGAGCTATGTCCCGAGGGTACTGTGCCCAAGCTCCTACGCAAGGTATCCTACGTTGATGCACCGGGACACGAGATACT
AATGGCTACGATGCTCTCCGGTGCGGCGCTAATGGATGGGGCGCTACTGGTAATAGCTGCTAATGAGAGGTGTCCACAGC
CACAGACCTATGAGCACCTAATGGCGCTCGACATTGTTGGTGTGCATAACATAGTCATAGTCCAGAACAAAGTCGATGTA
GTCACTCCAGAGAGGGCGCGGGACAACTATAGGGAGATAAAAGAGTTCGTCAAGGGAACCTTCGCGGAGAATGCCCCGAT
TATACCCGTAAGTGCCCTCCACAAGGTAAACATAGATGCTGTGGCAATGGCCATTGAGAAGTTTATACCGACACCAAAGA
GGGATCCGTCAAAGCCACCACTAATGTTTATCGTGCGTAGCTTCGACGTAAACAAACCAGGCACAACAGTCGAGGAGCTG
AAGGGAGGGGTTGTTGGCGGCTCACTAATGCAGGGAGTGCTAAGGGTTGGAGACGAGGTAGAGATAGCACCTGGTGTTCG
TGTAGAGGAGCGCGGTAGGGTGCGTTACGAGCCAATAGTAACGGAGGTTGTAAGCCTAAGGTTTGGAGAGCTCGAGGTTG
AGGAGGCAAAGCCTGGAGGCCTAGTGGCGGTTGGTACAAAGCTTGATCCGGCAGTTGCTAAGGCTGACAACCTTGTGGGT
AATGTTCTCGGTAAGCCTGGTCATCTACCGCCAGTAAGGGATACGTTGAGACTTGAATACCACATGCTTGAAAGAGCTGT
AGGTACGAGAGAGTTTGTCAAGGTTCCACCTCCAAGGGCTAAGGAGATAGTAATGCTGACAGTCGGCACGGCAATAACAC
TCGGCGTAATCACGAGAGTTACCAGTGACGAGATGGAGGTCAGGCTTAGGAGGCCGGTAGTAGCGTGGGAGGGCGCAAGG
GTAGCGCTATCTCGGCAAATCTTTGGCCGCTGGAGGTTGGTTGGATGGGGTGTAGTACGAGACTGA

Upstream 100 bases:

>100_bases
TAAAACAGCTACCTCTTAGCAGCTAGTTTTCGGTAGTTTCTCCAGGAGGGGCGCACATTGTTTTAGGGGTTGTTAGGGGT
AGCTAGCGGGGGGAGCTGTA

Downstream 100 bases:

>100_bases
GAAGGGTTATTTTCGATACGAGCATGCTCATGCTCCTCTATGACGGTGTTGATGTTTTCGGCCAAGTTGAAGAACTTCTC
GACGCTAAGCCCGAATGCAT

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MARFDREEIEAQRRRQPEVNIGTAGHVDHGKTTLVQALTGVWTAKHSEELKRGMTIKLGYAEGEVWYCEGAEGVEAYQPF
PELCPEGTVPKLLRKVSYVDAPGHEILMATMLSGAALMDGALLVIAANERCPQPQTYEHLMALDIVGVHNIVIVQNKVDV
VTPERARDNYREIKEFVKGTFAENAPIIPVSALHKVNIDAVAMAIEKFIPTPKRDPSKPPLMFIVRSFDVNKPGTTVEEL
KGGVVGGSLMQGVLRVGDEVEIAPGVRVEERGRVRYEPIVTEVVSLRFGELEVEEAKPGGLVAVGTKLDPAVAKADNLVG
NVLGKPGHLPPVRDTLRLEYHMLERAVGTREFVKVPPPRAKEIVMLTVGTAITLGVITRVTSDEMEVRLRRPVVAWEGAR
VALSRQIFGRWRLVGWGVVRD

Sequences:

>Translated_421_residues
MARFDREEIEAQRRRQPEVNIGTAGHVDHGKTTLVQALTGVWTAKHSEELKRGMTIKLGYAEGEVWYCEGAEGVEAYQPF
PELCPEGTVPKLLRKVSYVDAPGHEILMATMLSGAALMDGALLVIAANERCPQPQTYEHLMALDIVGVHNIVIVQNKVDV
VTPERARDNYREIKEFVKGTFAENAPIIPVSALHKVNIDAVAMAIEKFIPTPKRDPSKPPLMFIVRSFDVNKPGTTVEEL
KGGVVGGSLMQGVLRVGDEVEIAPGVRVEERGRVRYEPIVTEVVSLRFGELEVEEAKPGGLVAVGTKLDPAVAKADNLVG
NVLGKPGHLPPVRDTLRLEYHMLERAVGTREFVKVPPPRAKEIVMLTVGTAITLGVITRVTSDEMEVRLRRPVVAWEGAR
VALSRQIFGRWRLVGWGVVRD
>Mature_420_residues
ARFDREEIEAQRRRQPEVNIGTAGHVDHGKTTLVQALTGVWTAKHSEELKRGMTIKLGYAEGEVWYCEGAEGVEAYQPFP
ELCPEGTVPKLLRKVSYVDAPGHEILMATMLSGAALMDGALLVIAANERCPQPQTYEHLMALDIVGVHNIVIVQNKVDVV
TPERARDNYREIKEFVKGTFAENAPIIPVSALHKVNIDAVAMAIEKFIPTPKRDPSKPPLMFIVRSFDVNKPGTTVEELK
GGVVGGSLMQGVLRVGDEVEIAPGVRVEERGRVRYEPIVTEVVSLRFGELEVEEAKPGGLVAVGTKLDPAVAKADNLVGN
VLGKPGHLPPVRDTLRLEYHMLERAVGTREFVKVPPPRAKEIVMLTVGTAITLGVITRVTSDEMEVRLRRPVVAWEGARV
ALSRQIFGRWRLVGWGVVRD

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasmic, and membrane-associated [C]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503507, Length=424, Percent_Identity=45.7547169811321, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI34147630, Length=270, Percent_Identity=32.962962962963, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI54607086, Length=331, Percent_Identity=26.8882175226586, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1789737, Length=439, Percent_Identity=29.3849658314351, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790412, Length=439, Percent_Identity=29.3849658314351, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI2367247, Length=242, Percent_Identity=34.297520661157, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17509919, Length=423, Percent_Identity=45.1536643026005, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17556456, Length=367, Percent_Identity=29.700272479564, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25141371, Length=265, Percent_Identity=33.2075471698113, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17506081, Length=271, Percent_Identity=26.1992619926199, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320863, Length=423, Percent_Identity=44.4444444444444, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324761, Length=343, Percent_Identity=33.2361516034985, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24647046, Length=423, Percent_Identity=45.3900709219858, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24647048, Length=423, Percent_Identity=45.3900709219858, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363316, Length=428, Percent_Identity=28.9719626168224, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17864358, Length=428, Percent_Identity=28.9719626168224, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19921738, Length=253, Percent_Identity=33.596837944664, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI19922690, Length=253, Percent_Identity=30.8300395256917, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 20568 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 46337; Mature: 46206

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARFDREEIEAQRRRQPEVNIGTAGHVDHGKTTLVQALTGVWTAKHSEELKRGMTIKLGY
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEEE
AEGEVWYCEGAEGVEAYQPFPELCPEGTVPKLLRKVSYVDAPGHEILMATMLSGAALMDG
CCCCEEEECCCCCCHHCCCCHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCC
ALLVIAANERCPQPQTYEHLMALDIVGVHNIVIVQNKVDVVTPERARDNYREIKEFVKGT
EEEEEECCCCCCCCHHHHHHHHHHEECCCEEEEEECCCCEECCHHHHHHHHHHHHHHHHH
FAENAPIIPVSALHKVNIDAVAMAIEKFIPTPKRDPSKPPLMFIVRSFDVNKPGTTVEEL
HCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
KGGVVGGSLMQGVLRVGDEVEIAPGVRVEERGRVRYEPIVTEVVSLRFGELEVEEAKPGG
CCCCCCHHHHHHHHHCCCCEEECCCCEECCCCCEEEHHHHHHHHHHHCCCEEEECCCCCC
LVAVGTKLDPAVAKADNLVGNVLGKPGHLPPVRDTLRLEYHMLERAVGTREFVKVPPPRA
EEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEEECCCCCC
KEIVMLTVGTAITLGVITRVTSDEMEVRLRRPVVAWEGARVALSRQIFGRWRLVGWGVVR
CEEEEEEECHHHHHHHHHHCCCHHHHHHHHCCEEEECCCHHHHHHHHHHCEEEEEEEEEC
D
C
>Mature Secondary Structure 
ARFDREEIEAQRRRQPEVNIGTAGHVDHGKTTLVQALTGVWTAKHSEELKRGMTIKLGY
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEEE
AEGEVWYCEGAEGVEAYQPFPELCPEGTVPKLLRKVSYVDAPGHEILMATMLSGAALMDG
CCCCEEEECCCCCCHHCCCCHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCC
ALLVIAANERCPQPQTYEHLMALDIVGVHNIVIVQNKVDVVTPERARDNYREIKEFVKGT
EEEEEECCCCCCCCHHHHHHHHHHEECCCEEEEEECCCCEECCHHHHHHHHHHHHHHHHH
FAENAPIIPVSALHKVNIDAVAMAIEKFIPTPKRDPSKPPLMFIVRSFDVNKPGTTVEEL
HCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
KGGVVGGSLMQGVLRVGDEVEIAPGVRVEERGRVRYEPIVTEVVSLRFGELEVEEAKPGG
CCCCCCHHHHHHHHHCCCCEEECCCCEECCCCCEEEHHHHHHHHHHHCCCEEEECCCCCC
LVAVGTKLDPAVAKADNLVGNVLGKPGHLPPVRDTLRLEYHMLERAVGTREFVKVPPPRA
EEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEEECCCCCC
KEIVMLTVGTAITLGVITRVTSDEMEVRLRRPVVAWEGARVALSRQIFGRWRLVGWGVVR
CEEEEEEECHHHHHHHHHHCCCHHHHHHHHCCEEEECCCHHHHHHHHHHCEEEEEEEEEC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]