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The map label for this gene is hemN [H]

Identifier: 124027245

GI number: 124027245

Start: 336220

End: 337527

Strand: Direct

Name: hemN [H]

Synonym: Hbut_0348

Alternate gene names: 124027245

Gene position: 336220-337527 (Clockwise)

Preceding gene: 124027242

Following gene: 124027248

Centisome position: 20.17

GC content: 57.65

Gene sequence:

>1308_bases
ATGAGGAGCATAGAGGTTCACGAGGTACATATACCCCGTAGGGCACGTCTACTAGCCAAGACAGCCTCTCGCATGGCACT
TTACGCTGCTGAGAGGTTCTTCAAAAGGCTCATAAAGAGGGGTGTTGATCCCGAGGAGCACGTGAAGACTATTCGCTCCG
CATCGGGACACTATGCCCTCTACATACACATGCCCTTCTGCCACAGGCCGCTCTGCACCTTTTGCTGCTTTGTCCGCTAC
CCCTTCCACGAGAAGAGGCACCGGGAATACATCGACGCACTACTCCAGGAGATATCGTGGCTAGCCTCGACCGCCGAGGG
AGCCCACATTGAGACACTCTATATTGGCGGGGGTACGCCCAGCATAGACGTCTACAGCCTTGCAAGGGTTATCGACGCTG
TACGCGAAGCCTTTGGCGGCAAGGTGCAAGTGTCTACCGAGGCTAATCCCAGGGACCTAACCGACGAAGCGGTCTCCGTG
CTGCGCAGCGCCGGCGTCTCAAGGCTGAGTATAGGGGTGCAAGCACTGGAGCAGAAGAGGCTCCTAGAGCTCGGCCGGCT
AAACAATACCGTCGAGGACGTCTACCGCGCCGTGGACCTGGTTAAGGGCAAGTTTGAGACGGTAAACATCGACATTATAT
GGGGGATTAGGAGCGACACCCCGGCAGTTGTTGCGAGGGAGGCTGCCAGAGCTCTAAGCCTCCCAGTGGACCAGGTAACA
TTCTACCCCCTCATGCCCGCACCGGGGCTCCGGGAGCTGGAGAAGAAGAGACGGGAGGGACCCTGGCACCCCCTCGAGCA
CCGGCTCTACGGTGTAATTCTCGGAGAGGCTCTCAGCAGGGGTTTCAGACCCGCTACGCCCTGGTGCATGGATAGGGGGT
CGAGACTTATAGACGAGTACGTGGTGGACTATGATAAGTTTCTGGCGCTGGGTATTAGCGGGATAGGCCGAGTCGGCAGC
TACGTCTACGTGAACACCTTTAGCCTCGAGAAGTACTCTCGACTAGTCCGCGAGAGGGGGTTCCCCACCGTTATCGGCTC
CATGGTCTCAACTAATAGCGACATGCTCTACTACTCGTTTACAGCCGCCTTCGGGCTCCGCTGGCCGCCGCCCAGGATAG
ACCTCTATGGGCTGCGTGGCTACCTCCTAGCATCCACCGGCTCCGCTGTGCTGAAGCTCCTTGGCGAGAGGAGGGGCAGC
AACAAGATTACACAGCCTGGCAGCCTCTACCTGCTACACAGCATACAGAGAAGCATATACATGGCCGTCAACATGCTAAG
AGAGTACGGCATGCAGGTACAGATCTAG

Upstream 100 bases:

>100_bases
GGTATTACCATATGTTCTTTGGAGGGGGCTCCAGGCTAAGAAATACGTAGGCTATACTCTAAACACTAGAATATCTAGGG
TGTGGGGCGACACGTGAGCT

Downstream 100 bases:

>100_bases
CTCTGCCTCGCCGCAGCCCACTTTACTAGTCTAACACCCCAGCTGCGCTCCACCATGTAGGGGCCGCCTCCCTGCGCCAC
AGCCCTCCTCACATAACTAC

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MRSIEVHEVHIPRRARLLAKTASRMALYAAERFFKRLIKRGVDPEEHVKTIRSASGHYALYIHMPFCHRPLCTFCCFVRY
PFHEKRHREYIDALLQEISWLASTAEGAHIETLYIGGGTPSIDVYSLARVIDAVREAFGGKVQVSTEANPRDLTDEAVSV
LRSAGVSRLSIGVQALEQKRLLELGRLNNTVEDVYRAVDLVKGKFETVNIDIIWGIRSDTPAVVAREAARALSLPVDQVT
FYPLMPAPGLRELEKKRREGPWHPLEHRLYGVILGEALSRGFRPATPWCMDRGSRLIDEYVVDYDKFLALGISGIGRVGS
YVYVNTFSLEKYSRLVRERGFPTVIGSMVSTNSDMLYYSFTAAFGLRWPPPRIDLYGLRGYLLASTGSAVLKLLGERRGS
NKITQPGSLYLLHSIQRSIYMAVNMLREYGMQVQI

Sequences:

>Translated_435_residues
MRSIEVHEVHIPRRARLLAKTASRMALYAAERFFKRLIKRGVDPEEHVKTIRSASGHYALYIHMPFCHRPLCTFCCFVRY
PFHEKRHREYIDALLQEISWLASTAEGAHIETLYIGGGTPSIDVYSLARVIDAVREAFGGKVQVSTEANPRDLTDEAVSV
LRSAGVSRLSIGVQALEQKRLLELGRLNNTVEDVYRAVDLVKGKFETVNIDIIWGIRSDTPAVVAREAARALSLPVDQVT
FYPLMPAPGLRELEKKRREGPWHPLEHRLYGVILGEALSRGFRPATPWCMDRGSRLIDEYVVDYDKFLALGISGIGRVGS
YVYVNTFSLEKYSRLVRERGFPTVIGSMVSTNSDMLYYSFTAAFGLRWPPPRIDLYGLRGYLLASTGSAVLKLLGERRGS
NKITQPGSLYLLHSIQRSIYMAVNMLREYGMQVQI
>Mature_435_residues
MRSIEVHEVHIPRRARLLAKTASRMALYAAERFFKRLIKRGVDPEEHVKTIRSASGHYALYIHMPFCHRPLCTFCCFVRY
PFHEKRHREYIDALLQEISWLASTAEGAHIETLYIGGGTPSIDVYSLARVIDAVREAFGGKVQVSTEANPRDLTDEAVSV
LRSAGVSRLSIGVQALEQKRLLELGRLNNTVEDVYRAVDLVKGKFETVNIDIIWGIRSDTPAVVAREAARALSLPVDQVT
FYPLMPAPGLRELEKKRREGPWHPLEHRLYGVILGEALSRGFRPATPWCMDRGSRLIDEYVVDYDKFLALGISGIGRVGS
YVYVNTFSLEKYSRLVRERGFPTVIGSMVSTNSDMLYYSFTAAFGLRWPPPRIDLYGLRGYLLASTGSAVLKLLGERRGS
NKITQPGSLYLLHSIQRSIYMAVNMLREYGMQVQI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=162, Percent_Identity=30.8641975308642, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87082341, Length=309, Percent_Identity=28.4789644012945, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789325, Length=195, Percent_Identity=29.2307692307692, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49187; Mature: 49187

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSIEVHEVHIPRRARLLAKTASRMALYAAERFFKRLIKRGVDPEEHVKTIRSASGHYAL
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEE
YIHMPFCHRPLCTFCCFVRYPFHEKRHREYIDALLQEISWLASTAEGAHIETLYIGGGTP
EEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
SIDVYSLARVIDAVREAFGGKVQVSTEANPRDLTDEAVSVLRSAGVSRLSIGVQALEQKR
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
LLELGRLNNTVEDVYRAVDLVKGKFETVNIDIIWGIRSDTPAVVAREAARALSLPVDQVT
HHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCCHHHEE
FYPLMPAPGLRELEKKRREGPWHPLEHRLYGVILGEALSRGFRPATPWCMDRGSRLIDEY
EEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHH
VVDYDKFLALGISGIGRVGSYVYVNTFSLEKYSRLVRERGFPTVIGSMVSTNSDMLYYSF
HHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEE
TAAFGLRWPPPRIDLYGLRGYLLASTGSAVLKLLGERRGSNKITQPGSLYLLHSIQRSIY
EHHCCCCCCCCCEEEEECCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MAVNMLREYGMQVQI
HHHHHHHHCCCEECC
>Mature Secondary Structure
MRSIEVHEVHIPRRARLLAKTASRMALYAAERFFKRLIKRGVDPEEHVKTIRSASGHYAL
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEE
YIHMPFCHRPLCTFCCFVRYPFHEKRHREYIDALLQEISWLASTAEGAHIETLYIGGGTP
EEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
SIDVYSLARVIDAVREAFGGKVQVSTEANPRDLTDEAVSVLRSAGVSRLSIGVQALEQKR
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
LLELGRLNNTVEDVYRAVDLVKGKFETVNIDIIWGIRSDTPAVVAREAARALSLPVDQVT
HHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCCHHHEE
FYPLMPAPGLRELEKKRREGPWHPLEHRLYGVILGEALSRGFRPATPWCMDRGSRLIDEY
EEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHH
VVDYDKFLALGISGIGRVGSYVYVNTFSLEKYSRLVRERGFPTVIGSMVSTNSDMLYYSF
HHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEE
TAAFGLRWPPPRIDLYGLRGYLLASTGSAVLKLLGERRGSNKITQPGSLYLLHSIQRSIY
EHHCCCCCCCCCEEEEECCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MAVNMLREYGMQVQI
HHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]