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The map label for this gene is ziaA [H]

Identifier: 124027102

GI number: 124027102

Start: 186124

End: 187503

Strand: Direct

Name: ziaA [H]

Synonym: Hbut_0205

Alternate gene names: 124027102

Gene position: 186124-187503 (Clockwise)

Preceding gene: 124027098

Following gene: 124027104

Centisome position: 11.16

GC content: 47.46

Gene sequence:

>1380_bases
TTGGTGAAGACGGTGGCAAAGCATGGTGTTGACGAGCAGCATGTGCATGATGCTGACGAGGTACCATTGTTCTGGATAGT
TGTTGGTGTTGTAAGTATAGCTATGTTAGTTGCATCCGCTGCTGGCTTACACTACCATATCATGGACTATGCGCTGCTAT
TGCTGTCCTTGGCTATACTGTCTAGGATGGCTAAGGTGTTGATAAGTAAACGTCGAATTACAGTAGATGTTCCAGTTGAC
GGTGTAATAGTTGATGGTGGATCAGTATTCGATACCTCCTATGTAACTGGTGAACCAGAACCAGTACCCCTAGGTAAGGG
CGACTACGTTGTAAGCGGCTACATCAATAAGGCTAGGCTCGTAAGGATAAGGGCTCTAAAGAGGCCTAGTGAATCGCTTC
TCCAGCTGCTCATAGTTGAAGCAGAGAAAGCGTTGGAGAGAAAAGCATCACTACAAAGATTTATTGAGAGGTTCTCACAG
CCATATACGCTTCTAGTGCTCGGGATATTTGGTTTAGCTCTCCTAGCACTATCTCCCTACAGAGCACTAGCTATACTGCT
CGCAGGGTGTCCCAGTGCGTTCATAATCTCGTCTAGTACAGCAACAGCTCTCTCAATAGCACTTCTCGCCAGGAAATCAA
CAGTGGTTAGGGGTGGTAGAGCCTTAGAAGAGCTAAGTAGGGTTAAAGTAATGGTATTTGATAAGACTGGCACAATAACG
CTAGGCGAAATGAGGATTACCAGGGTAGAGTCATTCAACGGTTTTAGTAGAGATGAGGTGCTGCTCTATGCTGGGGGTGC
AGCGAAGGCAAGTGACCACCCGGTAGCAAGGGTTCTAGCAAAGCACAGGCTTACACCATTGAGTGCTGAAGAGTATCCTG
GGAAGGGCGTAAAAGCAGTAGTGGATGGCGCACACGTATACTTGGGCTCGAGGAAGTTCTTAGAGGAACAAGGTGTTGAT
GTAAGCGCCTTGGATCAAAGTGTTTGCGGTGATGGGGAGAGGGAGGTATATGTAGCAGTAGACGGTGCTCTTGCTGGAAT
AGTGTGCATGGAGGAGGAGGTTTCCGAGAAAGTCAGGAGGGTATTAGACGCAATTAGGAGGGATGGGTTGAAGGTAGTTA
TAGCTAGTGGTGATAGAGTTGATAGAGTCAAGAGGATAGCCGAGTACCTAGGAGTAAACGAGTACTTCGGCGAGCTGAGC
CCAGGTGATAAGAGGAGGCTAGTTATAGATCTACGAGACAGGTATGGTAAGGTAGCCTTCGTAGGTGATGGTATTAATGA
TGTTGAAGCGTTAGCGGAAGCAGATGTAGGAATAGCTGTTGGGAGCCTATGTATAGTCTCAAACATAGGCGACGTAGTAC
TGCCTAGGGGTACTGCCTAG

Upstream 100 bases:

>100_bases
CATATAGTAGCATTGATGTTGCGGGTTAATAACCCTTATATAATAGCTCTAGCTCGCCTTAATAAGAGGACTTATTATAT
AAGCCTGGCTGTCGTTATGT

Downstream 100 bases:

>100_bases
GGGTATAGACACTATACCCCTACTCATAAAGCATGCTAGGAAATATATGAAGTCGATATACTTGTCAATAGCGTTGGCTG
TAACGATCAAGCTTCTAGCT

Product: cation transport ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MVKTVAKHGVDEQHVHDADEVPLFWIVVGVVSIAMLVASAAGLHYHIMDYALLLLSLAILSRMAKVLISKRRITVDVPVD
GVIVDGGSVFDTSYVTGEPEPVPLGKGDYVVSGYINKARLVRIRALKRPSESLLQLLIVEAEKALERKASLQRFIERFSQ
PYTLLVLGIFGLALLALSPYRALAILLAGCPSAFIISSSTATALSIALLARKSTVVRGGRALEELSRVKVMVFDKTGTIT
LGEMRITRVESFNGFSRDEVLLYAGGAAKASDHPVARVLAKHRLTPLSAEEYPGKGVKAVVDGAHVYLGSRKFLEEQGVD
VSALDQSVCGDGEREVYVAVDGALAGIVCMEEEVSEKVRRVLDAIRRDGLKVVIASGDRVDRVKRIAEYLGVNEYFGELS
PGDKRRLVIDLRDRYGKVAFVGDGINDVEALAEADVGIAVGSLCIVSNIGDVVLPRGTA

Sequences:

>Translated_459_residues
MVKTVAKHGVDEQHVHDADEVPLFWIVVGVVSIAMLVASAAGLHYHIMDYALLLLSLAILSRMAKVLISKRRITVDVPVD
GVIVDGGSVFDTSYVTGEPEPVPLGKGDYVVSGYINKARLVRIRALKRPSESLLQLLIVEAEKALERKASLQRFIERFSQ
PYTLLVLGIFGLALLALSPYRALAILLAGCPSAFIISSSTATALSIALLARKSTVVRGGRALEELSRVKVMVFDKTGTIT
LGEMRITRVESFNGFSRDEVLLYAGGAAKASDHPVARVLAKHRLTPLSAEEYPGKGVKAVVDGAHVYLGSRKFLEEQGVD
VSALDQSVCGDGEREVYVAVDGALAGIVCMEEEVSEKVRRVLDAIRRDGLKVVIASGDRVDRVKRIAEYLGVNEYFGELS
PGDKRRLVIDLRDRYGKVAFVGDGINDVEALAEADVGIAVGSLCIVSNIGDVVLPRGTA
>Mature_459_residues
MVKTVAKHGVDEQHVHDADEVPLFWIVVGVVSIAMLVASAAGLHYHIMDYALLLLSLAILSRMAKVLISKRRITVDVPVD
GVIVDGGSVFDTSYVTGEPEPVPLGKGDYVVSGYINKARLVRIRALKRPSESLLQLLIVEAEKALERKASLQRFIERFSQ
PYTLLVLGIFGLALLALSPYRALAILLAGCPSAFIISSSTATALSIALLARKSTVVRGGRALEELSRVKVMVFDKTGTIT
LGEMRITRVESFNGFSRDEVLLYAGGAAKASDHPVARVLAKHRLTPLSAEEYPGKGVKAVVDGAHVYLGSRKFLEEQGVD
VSALDQSVCGDGEREVYVAVDGALAGIVCMEEEVSEKVRRVLDAIRRDGLKVVIASGDRVDRVKRIAEYLGVNEYFGELS
PGDKRRLVIDLRDRYGKVAFVGDGINDVEALAEADVGIAVGSLCIVSNIGDVVLPRGTA

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=463, Percent_Identity=27.2138228941685, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI55743073, Length=437, Percent_Identity=28.1464530892449, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI115529486, Length=247, Percent_Identity=27.5303643724696, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1789879, Length=383, Percent_Identity=31.5926892950392, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1786691, Length=384, Percent_Identity=28.6458333333333, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786914, Length=409, Percent_Identity=26.8948655256724, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17556548, Length=446, Percent_Identity=23.3183856502242, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320475, Length=416, Percent_Identity=27.1634615384615, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319772, Length=403, Percent_Identity=21.3399503722084, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI221329854, Length=236, Percent_Identity=29.6610169491525, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 49461; Mature: 49461

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKTVAKHGVDEQHVHDADEVPLFWIVVGVVSIAMLVASAAGLHYHIMDYALLLLSLAIL
CCCCHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SRMAKVLISKRRITVDVPVDGVIVDGGSVFDTSYVTGEPEPVPLGKGDYVVSGYINKARL
HHHHHHHHHCCEEEEECCCCEEEECCCCEEECCEECCCCCCCCCCCCCEEEEECCCHHHE
VRIRALKRPSESLLQLLIVEAEKALERKASLQRFIERFSQPYTLLVLGIFGLALLALSPY
EEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHH
RALAILLAGCPSAFIISSSTATALSIALLARKSTVVRGGRALEELSRVKVMVFDKTGTIT
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEECCCCEE
LGEMRITRVESFNGFSRDEVLLYAGGAAKASDHPVARVLAKHRLTPLSAEEYPGKGVKAV
ECCEEEEEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEE
VDGAHVYLGSRKFLEEQGVDVSALDQSVCGDGEREVYVAVDGALAGIVCMEEEVSEKVRR
ECCCEEEECCHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHEEEHHHHHHHHHH
VLDAIRRDGLKVVIASGDRVDRVKRIAEYLGVNEYFGELSPGDKRRLVIDLRDRYGKVAF
HHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEECCCCCCEEE
VGDGINDVEALAEADVGIAVGSLCIVSNIGDVVLPRGTA
EECCCHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCC
>Mature Secondary Structure
MVKTVAKHGVDEQHVHDADEVPLFWIVVGVVSIAMLVASAAGLHYHIMDYALLLLSLAIL
CCCCHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SRMAKVLISKRRITVDVPVDGVIVDGGSVFDTSYVTGEPEPVPLGKGDYVVSGYINKARL
HHHHHHHHHCCEEEEECCCCEEEECCCCEEECCEECCCCCCCCCCCCCEEEEECCCHHHE
VRIRALKRPSESLLQLLIVEAEKALERKASLQRFIERFSQPYTLLVLGIFGLALLALSPY
EEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHH
RALAILLAGCPSAFIISSSTATALSIALLARKSTVVRGGRALEELSRVKVMVFDKTGTIT
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEECCCCEE
LGEMRITRVESFNGFSRDEVLLYAGGAAKASDHPVARVLAKHRLTPLSAEEYPGKGVKAV
ECCEEEEEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEE
VDGAHVYLGSRKFLEEQGVDVSALDQSVCGDGEREVYVAVDGALAGIVCMEEEVSEKVRR
ECCCEEEECCHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHEEEHHHHHHHHHH
VLDAIRRDGLKVVIASGDRVDRVKRIAEYLGVNEYFGELSPGDKRRLVIDLRDRYGKVAF
HHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEECCCCCCEEE
VGDGINDVEALAEADVGIAVGSLCIVSNIGDVVLPRGTA
EECCCHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]