Click here to switch to the map view.

The map label for this gene is uvrB

Identifier: 124026822

GI number: 124026822

Start: 1772477

End: 1774513

Strand: Reverse

Name: uvrB

Synonym: NATL1_21171

Alternate gene names: 124026822

Gene position: 1774513-1772477 (Counterclockwise)

Preceding gene: 124026823

Following gene: 124026819

Centisome position: 95.16

GC content: 34.56

Gene sequence:

>2037_bases
ATGCCTGAGTATAAACTTCAAGCTCCTTATACTCCGAAAGGGGATCAACCTGCAGCGATTAAAGGGCTTGTTGGAGGTGT
AAATGATGGGGAAAAATTTCAAACTTTATTAGGTGCAACTGGAACAGGGAAGACTTTTACAATAGCCAATTTGATCGCTC
AAACTGGAAGGCCTGCGTTAGTTTTAGCTCATAACAAAACACTTGCAGCTCAATTATGCAATGAACTAAGGGAATTTTTC
CCAGATAATGCGGTTGAATATTTTATCTCATATTATGATTATTATCAGCCAGAGGCTTATGTTCCAGTAAGTGATACTTA
CATAGCCAAGACTTCATCAATTAATGAAGAGATTGATATGTTACGCCACTCTGCGACTAGGTCTTTATTTGAACGAGATG
ATGTCATAGTTGTTGCCTCAATTAGTTGTATATATGGTTTAGGAATTCCAAGTGAATATCTAAAGGCTTCTGTAAAGTTT
CAAGTTGGTCAAAGTATTGATTTAAGATCTTGCCTTAGATCATTAGTTTCCAATCAATATACTCGTAACGATATCGAAAT
CAGTAGAGGTAGATTTAGAGTTAGAGGAGATGTATTAGAAATAGGGCCAGCATATGATGACAGACTTGTAAGGCTTGAAT
TATTTGGAGATGAAGTAGAAAGTATTAGCTATGTCGATCCTACAACTGGAGAAATCTTAAATAAACTTGACTCAATCAAC
ATATATCCAGCAAAACATTTTGTTACTCCAAAAGATCGCCTCGATTCTGCAATTAAAGCAATAAAAAAAGAGTTAAAAGA
TAGATTAGAATTTCTTAATCAAGAGGGTAAATTACTCGAGGCTCAAAGGTTAGAACAACGAACAATTTATGACCTAGAAA
TGTTAAAAGAAGTTGGATATTGTAATGGTGTTGAAAATTATGCTCGTCATCTTTCTGGAAGAGAACCAGGCTCTGCCCCA
GAATGTCTTATTGATTACTTCCCAAAAGACTGGTTATTACTTATTGATGAAAGTCATGTTACTTGTCCTCAATTAAGAGC
TATGTATAATGGTGATCAAGCAAGAAAGAAAGTCTTAATAGATCATGGATTTAGACTACCAAGTGCAGCTGATAATCGTC
CTTTAAAGGATATAGAATTTTGGAATAAGGCAAAACAAACTGTTTTTATAAGTGCTACTCCTGGTGATTGGGAATTGTCC
CAAAGTACAAAGAATATAGTTGAGCAAGTTATCAGACCTACCGGTGTTTTAGATCCTCTAGTTGAAGTACGTCCAACACA
TGGTCAAGTTGACGATTTGCTTTTTGAAATTAGAAAAAGAGCATCAAAAAATCAAAGAATACTTGTCACAACGCTCACGA
AAAGAATGGCTGAAGATCTTACAGATTATTTATCTGAAAATAAAATAAGAGTTCGCTATTTACATTCAGAGATTCATTCA
ATTGAGAGAATTGAAATCATTCAAGATTTACGATTGGGAGAATATGACGTATTAGTTGGAGTGAATCTTTTAAGAGAGGG
TTTGGATTTACCTGAGGTCTCTCTTGTCGTAATTCTTGATGCAGATAAAGAAGGATTTTTAAGAGCTCAAAGATCTTTGA
TACAAACAATAGGTCGAGCAGCAAGACATGTAGAAGGCTTAGCTTTACTCTATGCAGATAAGATGACTGATTCTATGGCA
AAGGCTATAAGTGAGACTGAAAGACGCAGAGAAATACAGAATATTTATAATATTGAGCATGGTATAACTCCTAAGCCAGC
AGGTAAGAAAGCAAGTAATTCTATTCTTTCTTTTTTAGAGATCTCCAGAAGATTAAATCAAGATGGAAGTACTGATGATT
TCGTTGATATCGCTGATAAGTTGATTGAACATAGTGCTAAAGATTCTGATAGCGGAGTATCTTTAGAATCTTTGCCTGAA
TTAATTGAAAAATTGGAATCTAAAATGAAAATAAAAGCTAAAGACCTAGATTTTGAAAAAGCAGCAATCCTTAGAGATCG
TATAAAGAAATTAAGGCATAGATTAGTCGGTAGATAA

Upstream 100 bases:

>100_bases
TAATCAATGAGTTTTATAAGGTAATTTAAGCTTTTTTATGTTCGAAATTGGAAGAATATGGAATTAATAAATCTATCTTT
TTTTAACCTTTAAAAAGAAG

Downstream 100 bases:

>100_bases
ATTATTTTTAGCTTTTATTTTTTCCTAATTTAAAGCAAGAATGAATTTCATTTAATGCTTTTTCACCATATTTTTCTGAG
ATAATACAAGTTGTTCTTAT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MPEYKLQAPYTPKGDQPAAIKGLVGGVNDGEKFQTLLGATGTGKTFTIANLIAQTGRPALVLAHNKTLAAQLCNELREFF
PDNAVEYFISYYDYYQPEAYVPVSDTYIAKTSSINEEIDMLRHSATRSLFERDDVIVVASISCIYGLGIPSEYLKASVKF
QVGQSIDLRSCLRSLVSNQYTRNDIEISRGRFRVRGDVLEIGPAYDDRLVRLELFGDEVESISYVDPTTGEILNKLDSIN
IYPAKHFVTPKDRLDSAIKAIKKELKDRLEFLNQEGKLLEAQRLEQRTIYDLEMLKEVGYCNGVENYARHLSGREPGSAP
ECLIDYFPKDWLLLIDESHVTCPQLRAMYNGDQARKKVLIDHGFRLPSAADNRPLKDIEFWNKAKQTVFISATPGDWELS
QSTKNIVEQVIRPTGVLDPLVEVRPTHGQVDDLLFEIRKRASKNQRILVTTLTKRMAEDLTDYLSENKIRVRYLHSEIHS
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAQRSLIQTIGRAARHVEGLALLYADKMTDSMA
KAISETERRREIQNIYNIEHGITPKPAGKKASNSILSFLEISRRLNQDGSTDDFVDIADKLIEHSAKDSDSGVSLESLPE
LIEKLESKMKIKAKDLDFEKAAILRDRIKKLRHRLVGR

Sequences:

>Translated_678_residues
MPEYKLQAPYTPKGDQPAAIKGLVGGVNDGEKFQTLLGATGTGKTFTIANLIAQTGRPALVLAHNKTLAAQLCNELREFF
PDNAVEYFISYYDYYQPEAYVPVSDTYIAKTSSINEEIDMLRHSATRSLFERDDVIVVASISCIYGLGIPSEYLKASVKF
QVGQSIDLRSCLRSLVSNQYTRNDIEISRGRFRVRGDVLEIGPAYDDRLVRLELFGDEVESISYVDPTTGEILNKLDSIN
IYPAKHFVTPKDRLDSAIKAIKKELKDRLEFLNQEGKLLEAQRLEQRTIYDLEMLKEVGYCNGVENYARHLSGREPGSAP
ECLIDYFPKDWLLLIDESHVTCPQLRAMYNGDQARKKVLIDHGFRLPSAADNRPLKDIEFWNKAKQTVFISATPGDWELS
QSTKNIVEQVIRPTGVLDPLVEVRPTHGQVDDLLFEIRKRASKNQRILVTTLTKRMAEDLTDYLSENKIRVRYLHSEIHS
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAQRSLIQTIGRAARHVEGLALLYADKMTDSMA
KAISETERRREIQNIYNIEHGITPKPAGKKASNSILSFLEISRRLNQDGSTDDFVDIADKLIEHSAKDSDSGVSLESLPE
LIEKLESKMKIKAKDLDFEKAAILRDRIKKLRHRLVGR
>Mature_677_residues
PEYKLQAPYTPKGDQPAAIKGLVGGVNDGEKFQTLLGATGTGKTFTIANLIAQTGRPALVLAHNKTLAAQLCNELREFFP
DNAVEYFISYYDYYQPEAYVPVSDTYIAKTSSINEEIDMLRHSATRSLFERDDVIVVASISCIYGLGIPSEYLKASVKFQ
VGQSIDLRSCLRSLVSNQYTRNDIEISRGRFRVRGDVLEIGPAYDDRLVRLELFGDEVESISYVDPTTGEILNKLDSINI
YPAKHFVTPKDRLDSAIKAIKKELKDRLEFLNQEGKLLEAQRLEQRTIYDLEMLKEVGYCNGVENYARHLSGREPGSAPE
CLIDYFPKDWLLLIDESHVTCPQLRAMYNGDQARKKVLIDHGFRLPSAADNRPLKDIEFWNKAKQTVFISATPGDWELSQ
STKNIVEQVIRPTGVLDPLVEVRPTHGQVDDLLFEIRKRASKNQRILVTTLTKRMAEDLTDYLSENKIRVRYLHSEIHSI
ERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAQRSLIQTIGRAARHVEGLALLYADKMTDSMAK
AISETERRREIQNIYNIEHGITPKPAGKKASNSILSFLEISRRLNQDGSTDDFVDIADKLIEHSAKDSDSGVSLESLPEL
IEKLESKMKIKAKDLDFEKAAILRDRIKKLRHRLVGR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=676, Percent_Identity=57.396449704142, Blast_Score=758, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_PROM1 (A2C5B3)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015937.1
- ProteinModelPortal:   A2C5B3
- STRING:   A2C5B3
- GeneID:   4780244
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_21171
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   PMAR167555:NATL1_21171-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76772; Mature: 76640

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEYKLQAPYTPKGDQPAAIKGLVGGVNDGEKFQTLLGATGTGKTFTIANLIAQTGRPAL
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNELREFFPDNAVEYFISYYDYYQPEAYVPVSDTYIAKTSSINEEIDM
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECCCCCCEEEECCCCHHHHHH
LRHSATRSLFERDDVIVVASISCIYGLGIPSEYLKASVKFQVGQSIDLRSCLRSLVSNQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHCCCC
TRNDIEISRGRFRVRGDVLEIGPAYDDRLVRLELFGDEVESISYVDPTTGEILNKLDSIN
CCCCCEECCCEEEEECCEEEECCCCCCCEEEEEEECCCHHHCCCCCCCHHHHHHHHHCCE
IYPAKHFVTPKDRLDSAIKAIKKELKDRLEFLNQEGKLLEAQRLEQRTIYDLEMLKEVGY
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
CNGVENYARHLSGREPGSAPECLIDYFPKDWLLLIDESHVTCPQLRAMYNGDQARKKVLI
CCCHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCHHHHHHHH
DHGFRLPSAADNRPLKDIEFWNKAKQTVFISATPGDWELSQSTKNIVEQVIRPTGVLDPL
HCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCH
VEVRPTHGQVDDLLFEIRKRASKNQRILVTTLTKRMAEDLTDYLSENKIRVRYLHSEIHS
HHCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAQRSLIQTIGRA
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGLALLYADKMTDSMAKAISETERRREIQNIYNIEHGITPKPAGKKASNSILSFLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ISRRLNQDGSTDDFVDIADKLIEHSAKDSDSGVSLESLPELIEKLESKMKIKAKDLDFEK
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEEHHCCCCHHH
AAILRDRIKKLRHRLVGR
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PEYKLQAPYTPKGDQPAAIKGLVGGVNDGEKFQTLLGATGTGKTFTIANLIAQTGRPAL
CCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNELREFFPDNAVEYFISYYDYYQPEAYVPVSDTYIAKTSSINEEIDM
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECCCCCCEEEECCCCHHHHHH
LRHSATRSLFERDDVIVVASISCIYGLGIPSEYLKASVKFQVGQSIDLRSCLRSLVSNQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHCCCC
TRNDIEISRGRFRVRGDVLEIGPAYDDRLVRLELFGDEVESISYVDPTTGEILNKLDSIN
CCCCCEECCCEEEEECCEEEECCCCCCCEEEEEEECCCHHHCCCCCCCHHHHHHHHHCCE
IYPAKHFVTPKDRLDSAIKAIKKELKDRLEFLNQEGKLLEAQRLEQRTIYDLEMLKEVGY
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
CNGVENYARHLSGREPGSAPECLIDYFPKDWLLLIDESHVTCPQLRAMYNGDQARKKVLI
CCCHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCHHHHHHHH
DHGFRLPSAADNRPLKDIEFWNKAKQTVFISATPGDWELSQSTKNIVEQVIRPTGVLDPL
HCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCH
VEVRPTHGQVDDLLFEIRKRASKNQRILVTTLTKRMAEDLTDYLSENKIRVRYLHSEIHS
HHCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAQRSLIQTIGRA
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGLALLYADKMTDSMAKAISETERRREIQNIYNIEHGITPKPAGKKASNSILSFLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ISRRLNQDGSTDDFVDIADKLIEHSAKDSDSGVSLESLPELIEKLESKMKIKAKDLDFEK
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEEHHCCCCHHH
AAILRDRIKKLRHRLVGR
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA