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The map label for this gene is cobH [H]

Identifier: 124026819

GI number: 124026819

Start: 1768943

End: 1769587

Strand: Reverse

Name: cobH [H]

Synonym: NATL1_21141

Alternate gene names: 124026819

Gene position: 1769587-1768943 (Counterclockwise)

Preceding gene: 124026822

Following gene: 124026817

Centisome position: 94.9

GC content: 36.74

Gene sequence:

>645_bases
GTGAAAACATCAGAACATCCAATTTTTCTAGAAAGCATCAAATACATTAGATCTAAACTAGGCAATACCGGACTTGATCA
CATTCAGCAATCAATTTTAGAACGCATTATTCATTCAAGTGGAGACTTTAGTTTGCAGTCATGTCTCAAGTTTAGTCCCA
CTGCTTGTAAGGATGCTATTAGGGCATTGAAAAATGGTGCAACGATTTTGACTGATACTTATATGGCAGAGGCAGCAATA
TCGCCTATGGCTAAAAGAACCTTGAATTCAAATATTGAATGCATTTTGGATATGGCTCCAGCTTCTATATCCATAAATAC
AAGTTTGACTACAAGAAGTGCAATTGGTATGAAAAATAAGTGGTTAAATTTTGAGGATAATGACGCCATAAAAAAAACAA
CTGCTCCAGTGGTTGTAATTGGGAGCGCTCCAACAGCTTTAATTTCTTTGTTAGATCTTGTTGAAGCTGGCTATAAGCTC
CCAAGTTTAATTATTGGAATGCCAGTGGGCTTTATTGGGGTTAATGAGAGTAAAACTCGATTATTAAATAGTGATTGTGC
ATATATTGTTCTTGAAGGTTCTAAAGGAGGCGCATCTTTAGCGGCAGCTGCTACAAATGCTTTATTGAGAGCGGCTGAGA
ATTAA

Upstream 100 bases:

>100_bases
CAGGCTTCATAATCATTCCCCCAGATTAAATGTATTGGCATTACTTAGAGATATTTTATTAATAAGAGTTTGATCTTAAA
TTAGCCAAAGAAATTTAACA

Downstream 100 bases:

>100_bases
ATTGCAACGATTGTTCTTTATTTTATTTGCAACTTTCAATTGGCTTAGTGATTTGAATGGTGTTGGAGTTATTTTTTTCT
AGATTTTTTAATATCAATCT

Product: putative precorrin-8X methylmutase CobH

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKTSEHPIFLESIKYIRSKLGNTGLDHIQQSILERIIHSSGDFSLQSCLKFSPTACKDAIRALKNGATILTDTYMAEAAI
SPMAKRTLNSNIECILDMAPASISINTSLTTRSAIGMKNKWLNFEDNDAIKKTTAPVVVIGSAPTALISLLDLVEAGYKL
PSLIIGMPVGFIGVNESKTRLLNSDCAYIVLEGSKGGASLAAAATNALLRAAEN

Sequences:

>Translated_214_residues
MKTSEHPIFLESIKYIRSKLGNTGLDHIQQSILERIIHSSGDFSLQSCLKFSPTACKDAIRALKNGATILTDTYMAEAAI
SPMAKRTLNSNIECILDMAPASISINTSLTTRSAIGMKNKWLNFEDNDAIKKTTAPVVVIGSAPTALISLLDLVEAGYKL
PSLIIGMPVGFIGVNESKTRLLNSDCAYIVLEGSKGGASLAAAATNALLRAAEN
>Mature_214_residues
MKTSEHPIFLESIKYIRSKLGNTGLDHIQQSILERIIHSSGDFSLQSCLKFSPTACKDAIRALKNGATILTDTYMAEAAI
SPMAKRTLNSNIECILDMAPASISINTSLTTRSAIGMKNKWLNFEDNDAIKKTTAPVVVIGSAPTALISLLDLVEAGYKL
PSLIIGMPVGFIGVNESKTRLLNSDCAYIVLEGSKGGASLAAAATNALLRAAEN

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 22800; Mature: 22800

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSEHPIFLESIKYIRSKLGNTGLDHIQQSILERIIHSSGDFSLQSCLKFSPTACKDAI
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHH
RALKNGATILTDTYMAEAAISPMAKRTLNSNIECILDMAPASISINTSLTTRSAIGMKNK
HHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCHHHHCCCCCC
WLNFEDNDAIKKTTAPVVVIGSAPTALISLLDLVEAGYKLPSLIIGMPVGFIGVNESKTR
CCCCCCCCCHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHCCCCEEECCCHHHH
LLNSDCAYIVLEGSKGGASLAAAATNALLRAAEN
HCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTSEHPIFLESIKYIRSKLGNTGLDHIQQSILERIIHSSGDFSLQSCLKFSPTACKDAI
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHH
RALKNGATILTDTYMAEAAISPMAKRTLNSNIECILDMAPASISINTSLTTRSAIGMKNK
HHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCHHHHCCCCCC
WLNFEDNDAIKKTTAPVVVIGSAPTALISLLDLVEAGYKLPSLIIGMPVGFIGVNESKTR
CCCCCCCCCHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHCCCCEEECCCHHHH
LLNSDCAYIVLEGSKGGASLAAAATNALLRAAEN
HCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]