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The map label for this gene is lysC [H]

Identifier: 124026821

GI number: 124026821

Start: 1770703

End: 1772469

Strand: Direct

Name: lysC [H]

Synonym: NATL1_21161

Alternate gene names: 124026821

Gene position: 1770703-1772469 (Clockwise)

Preceding gene: 124026820

Following gene: 124026824

Centisome position: 94.96

GC content: 37.58

Gene sequence:

>1767_bases
ATGGCATTGCTGGTTCAAAAATTTGGCGGCACCTCTCTAGGAAGTATTGAGCGCATAAAAGCTGTCGCGCAAAGAATCAA
ATCAAGTAAAGAAAAAGGTGCTGATCTAGTAGTTGTTGTGTCGGCCATGGGACATCAAACTGATGAGTTAACACGGCTAG
CGTCAGAAATAACTGTTGATCCTCCTCATAGAGAAATGGATATGCTCCTCTCAACTGGGGAGCAAGTTTCAATATCATTA
TTAACAATGGCCCTGAACGAATTGGGCACACCAGCAATCTCTTTGACTGGAACTCAAGCTGGAATTATCACAGAATCAGC
TCATGGAAGAGCCAGAATCCTCGAGATAAGGACAGAACGAATAAAAAATCTCTTAGACCAAGGTCAAACCATAGTTATTG
CTGGATTCCAAGGAACAACTCTTGGCATAGGAGGAATTGCTGAAATTACAACTTTAGGTAGAGGAGGTTCAGATACTTCT
GCAGTAGCTCTAGCGGCATCGCTTGAAGCTGCTACATGTGAAATTTATACCGATGTTCCTGGCGTACTTACAACTGACCC
AAGAATTGTGAAAAATGCAAAATTAATGAAAAGTATTAGTTGTGATGAAATGTTAGAACTTGCCAGCCTTGGCGCAGCTG
TTTTACATCCTCGAGCAGTTGAAATAGCAAGAAATTTCGGCGTAACTCTCGTCGTTAAATCCAGTTGGGACAACCTTGAT
GGAACCACTCTAACTAGTAATAAGAAGCCTGACTTTTCTCAAGGTGGAATAGAACATCAAAGTCCTGTCGATGGATTAGA
ACTTCTTGAGAATCAAGCAGTCGTAGCTTTATCTAATATTCCAGATCGTCCAGGAATTGCTGCGGAACTTTTTGAATCTT
TATCAGAGGGTGGGGTGAATGTCGATCTCATTATTCAAGCGACACATCAAATTGACTCTAACGACATCACTTTTACTATT
GCTGAAAATGAATTACATAATGCACTAACTCAATGTAAAAAACTCGTTAATACTATTGGAGGTGATATCTCTTTTCAAAA
AGATCTGACTAAACTAAGTATTTATGGAGCTGGGATAATGGGAAGGCCTGGAATAGCGTCATCGCTATTCCAAATTCTAT
CTGACTCTGGTATTAATATAAGACTAATCGCAACTAGTGAAGTCAAAGTCAGTTGTGTTATTGATGCAGAATTAGGGAAA
AAAGCACTACGTAATGTAAGCGAAGTTTTCAAGCTCACTGATAAACAAATTACCGTGAATCCTACGATTGAAAATAATAA
CGAGCCAGAAGTAAGGGGAATAGCTTTAGATAAAGATCAAATACAAATTAGCGTGAAGAATGTGCCAGATAAACCAGGGA
CTGCCTCATCAATATGTTCCACTTTAGCTGAGAAAAATATCAGCTTAGATACTATAGTTCAATCTGAAAGAAAGCATAAA
GATAAAACCAAAGATATCAGCTTCACTTTAAAGAAAAATGATAGAAGCGATGCTAAATATGCATTAAAAGAATTGATTGA
AAATTGGAAAGGAGCAAAACTCGAAGAAGGAGAGTCAATAGTACGAATTAGCGCAGTAGGTTCTGGAATGCCTTTTACAA
AAGGAACAGCCGGTAAAATTTTTAGAGCACTAGCAAATCAAAAAATCAACATAGAAATGATCGCCACAAGTGAAATAAGA
ACAACTTGTATTATCTCAGAAAAATATGGTGAAAAAGCATTAAATGAAATTCATTCTTGCTTTAAATTAGGAAAAAATAA
AAGCTAA

Upstream 100 bases:

>100_bases
ATCAGGAATCAAGCCAATCGATTCTTTTAAAGATAATCTGCTAACACACAGTAAATTTTTGGCTAAGAACTGAAATAATC
AATAAGTTAACGTAAGTTCA

Downstream 100 bases:

>100_bases
AAATAATTTATCTACCGACTAATCTATGCCTTAATTTCTTTATACGATCTCTAAGGATTGCTGCTTTTTCAAAATCTAGG
TCTTTAGCTTTTATTTTCAT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MALLVQKFGGTSLGSIERIKAVAQRIKSSKEKGADLVVVVSAMGHQTDELTRLASEITVDPPHREMDMLLSTGEQVSISL
LTMALNELGTPAISLTGTQAGIITESAHGRARILEIRTERIKNLLDQGQTIVIAGFQGTTLGIGGIAEITTLGRGGSDTS
AVALAASLEAATCEIYTDVPGVLTTDPRIVKNAKLMKSISCDEMLELASLGAAVLHPRAVEIARNFGVTLVVKSSWDNLD
GTTLTSNKKPDFSQGGIEHQSPVDGLELLENQAVVALSNIPDRPGIAAELFESLSEGGVNVDLIIQATHQIDSNDITFTI
AENELHNALTQCKKLVNTIGGDISFQKDLTKLSIYGAGIMGRPGIASSLFQILSDSGINIRLIATSEVKVSCVIDAELGK
KALRNVSEVFKLTDKQITVNPTIENNNEPEVRGIALDKDQIQISVKNVPDKPGTASSICSTLAEKNISLDTIVQSERKHK
DKTKDISFTLKKNDRSDAKYALKELIENWKGAKLEEGESIVRISAVGSGMPFTKGTAGKIFRALANQKINIEMIATSEIR
TTCIISEKYGEKALNEIHSCFKLGKNKS

Sequences:

>Translated_588_residues
MALLVQKFGGTSLGSIERIKAVAQRIKSSKEKGADLVVVVSAMGHQTDELTRLASEITVDPPHREMDMLLSTGEQVSISL
LTMALNELGTPAISLTGTQAGIITESAHGRARILEIRTERIKNLLDQGQTIVIAGFQGTTLGIGGIAEITTLGRGGSDTS
AVALAASLEAATCEIYTDVPGVLTTDPRIVKNAKLMKSISCDEMLELASLGAAVLHPRAVEIARNFGVTLVVKSSWDNLD
GTTLTSNKKPDFSQGGIEHQSPVDGLELLENQAVVALSNIPDRPGIAAELFESLSEGGVNVDLIIQATHQIDSNDITFTI
AENELHNALTQCKKLVNTIGGDISFQKDLTKLSIYGAGIMGRPGIASSLFQILSDSGINIRLIATSEVKVSCVIDAELGK
KALRNVSEVFKLTDKQITVNPTIENNNEPEVRGIALDKDQIQISVKNVPDKPGTASSICSTLAEKNISLDTIVQSERKHK
DKTKDISFTLKKNDRSDAKYALKELIENWKGAKLEEGESIVRISAVGSGMPFTKGTAGKIFRALANQKINIEMIATSEIR
TTCIISEKYGEKALNEIHSCFKLGKNKS
>Mature_587_residues
ALLVQKFGGTSLGSIERIKAVAQRIKSSKEKGADLVVVVSAMGHQTDELTRLASEITVDPPHREMDMLLSTGEQVSISLL
TMALNELGTPAISLTGTQAGIITESAHGRARILEIRTERIKNLLDQGQTIVIAGFQGTTLGIGGIAEITTLGRGGSDTSA
VALAASLEAATCEIYTDVPGVLTTDPRIVKNAKLMKSISCDEMLELASLGAAVLHPRAVEIARNFGVTLVVKSSWDNLDG
TTLTSNKKPDFSQGGIEHQSPVDGLELLENQAVVALSNIPDRPGIAAELFESLSEGGVNVDLIIQATHQIDSNDITFTIA
ENELHNALTQCKKLVNTIGGDISFQKDLTKLSIYGAGIMGRPGIASSLFQILSDSGINIRLIATSEVKVSCVIDAELGKK
ALRNVSEVFKLTDKQITVNPTIENNNEPEVRGIALDKDQIQISVKNVPDKPGTASSICSTLAEKNISLDTIVQSERKHKD
KTKDISFTLKKNDRSDAKYALKELIENWKGAKLEEGESIVRISAVGSGMPFTKGTAGKIFRALANQKINIEMIATSEIRT
TCIISEKYGEKALNEIHSCFKLGKNKS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=300, Percent_Identity=31, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790455, Length=157, Percent_Identity=40.7643312101911, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790376, Length=174, Percent_Identity=31.6091954022989, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=378, Percent_Identity=23.2804232804233, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 63024; Mature: 62893

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLVQKFGGTSLGSIERIKAVAQRIKSSKEKGADLVVVVSAMGHQTDELTRLASEITVD
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCC
PPHREMDMLLSTGEQVSISLLTMALNELGTPAISLTGTQAGIITESAHGRARILEIRTER
CCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCEEEHHHHHHH
IKNLLDQGQTIVIAGFQGTTLGIGGIAEITTLGRGGSDTSAVALAASLEAATCEIYTDVP
HHHHHHCCCEEEEECCCCCEECCCCHHHHHCCCCCCCCCHHEEEEEECCCCEEEEEECCC
GVLTTDPRIVKNAKLMKSISCDEMLELASLGAAVLHPRAVEIARNFGVTLVVKSSWDNLD
CCEECCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHCCHHHHHHHCCCEEEEEECCCCCCC
GTTLTSNKKPDFSQGGIEHQSPVDGLELLENQAVVALSNIPDRPGIAAELFESLSEGGVN
CCEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCE
VDLIIQATHQIDSNDITFTIAENELHNALTQCKKLVNTIGGDISFQKDLTKLSIYGAGIM
EEEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEEHHCCCEEEEECCCCC
GRPGIASSLFQILSDSGINIRLIATSEVKVSCVIDAELGKKALRNVSEVFKLTDKQITVN
CCCCHHHHHHHHHCCCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEE
PTIENNNEPEVRGIALDKDQIQISVKNVPDKPGTASSICSTLAEKNISLDTIVQSERKHK
CCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCC
DKTKDISFTLKKNDRSDAKYALKELIENWKGAKLEEGESIVRISAVGSGMPFTKGTAGKI
CCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHH
FRALANQKINIEMIATSEIRTTCIISEKYGEKALNEIHSCFKLGKNKS
HHHHCCCCEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALLVQKFGGTSLGSIERIKAVAQRIKSSKEKGADLVVVVSAMGHQTDELTRLASEITVD
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCC
PPHREMDMLLSTGEQVSISLLTMALNELGTPAISLTGTQAGIITESAHGRARILEIRTER
CCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCEEEHHHHHHH
IKNLLDQGQTIVIAGFQGTTLGIGGIAEITTLGRGGSDTSAVALAASLEAATCEIYTDVP
HHHHHHCCCEEEEECCCCCEECCCCHHHHHCCCCCCCCCHHEEEEEECCCCEEEEEECCC
GVLTTDPRIVKNAKLMKSISCDEMLELASLGAAVLHPRAVEIARNFGVTLVVKSSWDNLD
CCEECCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHCCHHHHHHHCCCEEEEEECCCCCCC
GTTLTSNKKPDFSQGGIEHQSPVDGLELLENQAVVALSNIPDRPGIAAELFESLSEGGVN
CCEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCE
VDLIIQATHQIDSNDITFTIAENELHNALTQCKKLVNTIGGDISFQKDLTKLSIYGAGIM
EEEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEEHHCCCEEEEECCCCC
GRPGIASSLFQILSDSGINIRLIATSEVKVSCVIDAELGKKALRNVSEVFKLTDKQITVN
CCCCHHHHHHHHHCCCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEE
PTIENNNEPEVRGIALDKDQIQISVKNVPDKPGTASSICSTLAEKNISLDTIVQSERKHK
CCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCC
DKTKDISFTLKKNDRSDAKYALKELIENWKGAKLEEGESIVRISAVGSGMPFTKGTAGKI
CCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHH
FRALANQKINIEMIATSEIRTTCIISEKYGEKALNEIHSCFKLGKNKS
HHHHCCCCEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8635739 [H]