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The map label for this gene is mutY [H]

Identifier: 124026785

GI number: 124026785

Start: 1722891

End: 1724045

Strand: Reverse

Name: mutY [H]

Synonym: NATL1_20801

Alternate gene names: 124026785

Gene position: 1724045-1722891 (Counterclockwise)

Preceding gene: 124026787

Following gene: 124026784

Centisome position: 92.46

GC content: 36.88

Gene sequence:

>1155_bases
ATGGGCATTTTTGATTCTCCTCAAGATATCCAAAATTCACTTCTGGCATGGTTTAGGGAAAATGGTAGATACTGGATACC
ATGGAAATTAAAGAAAGATGGTTCCGTTCCTCGATCAGGAGAAAGTATATCTCCTTATGGAATTTGGATTGCAGAGGTCA
TGCTTCAGCAGACACAGTTGAAGGTCGTTATTCCTTATTGGAAAAAATGGATGAAGTTTTTTCCTACCTTGTCGTCTTTA
GCAGAGGCTGATTTGGAGAATCTTCTAATGATTTGGCAAGGTCTTGGTTATTATTCACGTGCGAAACGAATACATCAATC
CTCTAAAATATTAGTTGAATTTGTTGGCAAAAATAGAGATCAAGATCCAGATTCTTGGCCTAATCAAATAGATAAGTGGA
TGTCTCTTCCTGGTATCGGTAGAAGTACTGCAGGTAGTATTATCTCATCTGCCTTTGACCTGCCAACCCCAATATTGGAT
GGGAATGTAAAAAGAATTTTGTCAAGATTGCTAGCCATTGAACGAAAATCTATTAAAGATGAAAGAAAATTATGGGAATT
CAGCTCGTTATTGATTGAAAGGCTAAGTCCAAGGGATTTCAATCAGGCTTTGATGGATTTAGGGGCAATTATTTGTACTC
CCACAAAACCAAGTTGTTCTTCGTGCCCACTACAAAATTTTTGTGTTGCTTATACAAAGTACGATCCTGAAGATTTTCCT
AAAAAAGAAATGACCAAAATAAAGCCTCTGCAAGAAATTGGAATTGGGCTTGTTTTTAATCAAAAAGGTGAATTGCTTAT
CGATCAGCGATTAGAAAGCTCAAGTATGGGCGGAATGTGGGAATTTCCAGGAGGAAAAAAAATTCCCAACGAATCGATTG
AGACAACTATCGAGCGAGAATTAAAAGAAGAGCTTGGGATTGTTGTCAACGTTGGAGAAAAGCTTTTATCTTTTGAACAC
GCTTATACCCACAAGAGGCTGAATTTTACTGTTCATATTTGCGCATGGATATCAGGTCAGCCCAAACCTTTAGCTAGTCA
AAAATTACTTTGGGTGTCTCCGGACAAACTTTTTGATTTTCCTTTTCCTGCTGCTAACACTAAAATTATTTCTGAATTAC
ATAAACATCTTTGTATTGGAAATAAAAATCTGTAA

Upstream 100 bases:

>100_bases
GTCGATGTATTACCTATTCAAAAAGTATTAATTTGAGTCGATAAAATTATCAAAAAAATGATATTATGAAACAACATTTT
TTAAATTTTGATTTATTTTG

Downstream 100 bases:

>100_bases
ATCACCAATAATAAATCTATTAATAATTAATTAGACATGCGTGCTGGAAGTGTCATTGCGATTGGAGAAGCTTTAATAGA
TCGGCTTGGACCTCTTGGTG

Product: adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MGIFDSPQDIQNSLLAWFRENGRYWIPWKLKKDGSVPRSGESISPYGIWIAEVMLQQTQLKVVIPYWKKWMKFFPTLSSL
AEADLENLLMIWQGLGYYSRAKRIHQSSKILVEFVGKNRDQDPDSWPNQIDKWMSLPGIGRSTAGSIISSAFDLPTPILD
GNVKRILSRLLAIERKSIKDERKLWEFSSLLIERLSPRDFNQALMDLGAIICTPTKPSCSSCPLQNFCVAYTKYDPEDFP
KKEMTKIKPLQEIGIGLVFNQKGELLIDQRLESSSMGGMWEFPGGKKIPNESIETTIERELKEELGIVVNVGEKLLSFEH
AYTHKRLNFTVHICAWISGQPKPLASQKLLWVSPDKLFDFPFPAANTKIISELHKHLCIGNKNL

Sequences:

>Translated_384_residues
MGIFDSPQDIQNSLLAWFRENGRYWIPWKLKKDGSVPRSGESISPYGIWIAEVMLQQTQLKVVIPYWKKWMKFFPTLSSL
AEADLENLLMIWQGLGYYSRAKRIHQSSKILVEFVGKNRDQDPDSWPNQIDKWMSLPGIGRSTAGSIISSAFDLPTPILD
GNVKRILSRLLAIERKSIKDERKLWEFSSLLIERLSPRDFNQALMDLGAIICTPTKPSCSSCPLQNFCVAYTKYDPEDFP
KKEMTKIKPLQEIGIGLVFNQKGELLIDQRLESSSMGGMWEFPGGKKIPNESIETTIERELKEELGIVVNVGEKLLSFEH
AYTHKRLNFTVHICAWISGQPKPLASQKLLWVSPDKLFDFPFPAANTKIISELHKHLCIGNKNL
>Mature_383_residues
GIFDSPQDIQNSLLAWFRENGRYWIPWKLKKDGSVPRSGESISPYGIWIAEVMLQQTQLKVVIPYWKKWMKFFPTLSSLA
EADLENLLMIWQGLGYYSRAKRIHQSSKILVEFVGKNRDQDPDSWPNQIDKWMSLPGIGRSTAGSIISSAFDLPTPILDG
NVKRILSRLLAIERKSIKDERKLWEFSSLLIERLSPRDFNQALMDLGAIICTPTKPSCSSCPLQNFCVAYTKYDPEDFPK
KEMTKIKPLQEIGIGLVFNQKGELLIDQRLESSSMGGMWEFPGGKKIPNESIETTIERELKEELGIVVNVGEKLLSFEHA
YTHKRLNFTVHICAWISGQPKPLASQKLLWVSPDKLFDFPFPAANTKIISELHKHLCIGNKNL

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=426, Percent_Identity=29.5774647887324, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI190358497, Length=426, Percent_Identity=29.81220657277, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI115298650, Length=426, Percent_Identity=29.5774647887324, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI6912520, Length=426, Percent_Identity=29.5774647887324, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI115298654, Length=426, Percent_Identity=29.5774647887324, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI115298652, Length=426, Percent_Identity=29.5774647887324, Blast_Score=192, Evalue=4e-49,
Organism=Escherichia coli, GI1789331, Length=319, Percent_Identity=36.6771159874608, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1788056, Length=120, Percent_Identity=31.6666666666667, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 43856; Mature: 43725

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIFDSPQDIQNSLLAWFRENGRYWIPWKLKKDGSVPRSGESISPYGIWIAEVMLQQTQL
CCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KVVIPYWKKWMKFFPTLSSLAEADLENLLMIWQGLGYYSRAKRIHQSSKILVEFVGKNRD
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
QDPDSWPNQIDKWMSLPGIGRSTAGSIISSAFDLPTPILDGNVKRILSRLLAIERKSIKD
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ERKLWEFSSLLIERLSPRDFNQALMDLGAIICTPTKPSCSSCPLQNFCVAYTKYDPEDFP
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHEEEEECCCCCCCC
KKEMTKIKPLQEIGIGLVFNQKGELLIDQRLESSSMGGMWEFPGGKKIPNESIETTIERE
HHHHHHHCCHHHCCCEEEECCCCCEEHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHH
LKEELGIVVNVGEKLLSFEHAYTHKRLNFTVHICAWISGQPKPLASQKLLWVSPDKLFDF
HHHHCCEEEECHHHHHHHHHHHHHCEEEEEEEEEEEECCCCCCCCCCEEEEECCCHHCCC
PFPAANTKIISELHKHLCIGNKNL
CCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GIFDSPQDIQNSLLAWFRENGRYWIPWKLKKDGSVPRSGESISPYGIWIAEVMLQQTQL
CCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KVVIPYWKKWMKFFPTLSSLAEADLENLLMIWQGLGYYSRAKRIHQSSKILVEFVGKNRD
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
QDPDSWPNQIDKWMSLPGIGRSTAGSIISSAFDLPTPILDGNVKRILSRLLAIERKSIKD
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ERKLWEFSSLLIERLSPRDFNQALMDLGAIICTPTKPSCSSCPLQNFCVAYTKYDPEDFP
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHEEEEECCCCCCCC
KKEMTKIKPLQEIGIGLVFNQKGELLIDQRLESSSMGGMWEFPGGKKIPNESIETTIERE
HHHHHHHCCHHHCCCEEEECCCCCEEHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHH
LKEELGIVVNVGEKLLSFEHAYTHKRLNFTVHICAWISGQPKPLASQKLLWVSPDKLFDF
HHHHCCEEEECHHHHHHHHHHHHHCEEEEEEEEEEEECCCCCCCCCCEEEEECCCHHCCC
PFPAANTKIISELHKHLCIGNKNL
CCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]