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The map label for this gene is manC [H]

Identifier: 124026762

GI number: 124026762

Start: 1700713

End: 1702170

Strand: Direct

Name: manC [H]

Synonym: NATL1_20571

Alternate gene names: 124026762

Gene position: 1700713-1702170 (Clockwise)

Preceding gene: 124026761

Following gene: 124026765

Centisome position: 91.2

GC content: 32.78

Gene sequence:

>1458_bases
ATGAACATAACTGATAACTCCATAATTCCTGTAATTCTTAGTGGTGGATCAGGAACAAGACTTTGGCCACTTTCTCGAGA
AAGTTATCCTAAGCAATTTCTAGCATTAGATTCACGCACAAAAAAAACACTTTTGCAGAAAACTTATGAAAGGCTTCTAG
GTTTAGAGGGACTAGAAAATCCTATATTAATATGCAATGAAGATCACAGATTTATAGTTGCAGAGCAATTTAGAGAGATA
AATACTGATCCTCAAGCAATTATTTTAGAACCCGTCGGACGTAACACAGCTCCAGCAATAGCAGTTGCTGCTCTTCAAGC
GATTTCTCTAGGTAAAGACCCTTTGCTATTGATTTTGGCTTCTGATCACTTGATAGAGAATAACGTTGAATTTCAAAGAG
TAATTCAATCTGCAAAAATATATGCAAATCAAGGAAAGCTAGTAACTTTTGGTATAGTTCCAACAAGCGCAGAAACTGGT
TACGGTTATATTGAAACAAAAGAATTTCCTACCAAAGACAATCAAATAATTGGTTTAGAGATAAACAAATTTATAGAAAA
GCCTAATAAAGATATAGCTGAGAAATTAATCAAAGATTCTCGCTTCACATGGAATAGTGGTATGTTTCTTTTTAAAGCGA
GTACGATAATTAGTGAATTAAAAAAATTCTCTCCAGAGATACTCAATAATTGCAAAATTGCTCTCGAGAAAGATATAGAA
GATCTTGATTTTCTACGTTTAGAAACTGAATCCTTCAAGAAATGTCCAAAAATATCAATAGATATCGCAGTGATGGAAAA
AACGAATTTAGGAATCGTTCTTCCTTTAAATGTTGGATGGAATGATATAGGAAGTTGGAAATCTTTATGGGATATTAGCA
AAAAAAATAATGATGGAAACTATATCAACGGTAGAATAATAGCTGAAAAAAGTAAAAACTGTTATCTAAAAGGTGAACAA
CGTCTAATTGTAGGAATAGGGATAGAAAATCTAATAGTTGTTGATACAAATGATGCTATATTAGTAGCCAATAGAGATCA
ATCTCAAAATATTGGAAATATAGTCAAAAGTCTAAGTTCATCGGCATTTCCAGAAGGCAAAGTGCATAGAAAAATTTATC
GACCCTGGGGGAATTACACTACAATTGTCGAGGGAAATAGATGGTTAGTGAAACTCATCGAGGTAAAGCCAAATGCTTCT
CTTTCTTTACAAATGCATCATCATAGAGCAGAACACTGGGTAGTAGTTAATGGAACAGCATTGATAGAAAAAAATGGAGA
AAAAAAACTTTTAAGTGAAAATGAAAGTACATTTATCCCTTTAGGTTGCAAACATAGATTAAGTAATCCAGGAAAAATGA
GACTTGAACTTATTGAAGTTCAAAGCGGAACGTATTTAGGCGAAGAAGACATCATTCGTTTTGAAGATTCTTATGGCAGA
ATAAAAAATCAGAATTAA

Upstream 100 bases:

>100_bases
GAAAAATGGCTGCTAATCAACCCACCCCCTGGCTTATTGGAACTCTAATAATTATTCGAGTTTTTAATCAGAACTTCAAA
AATAGATTGCAAAGTTATTT

Downstream 100 bases:

>100_bases
TAAAAAAGCTTTATTTATTCAACGGTTACACTTTTAGCTAAATTCCTCGGCTGATCAACATCTAACCCTTTATGAGCTGC
TATGTGATAACTAAATAGCT

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MNITDNSIIPVILSGGSGTRLWPLSRESYPKQFLALDSRTKKTLLQKTYERLLGLEGLENPILICNEDHRFIVAEQFREI
NTDPQAIILEPVGRNTAPAIAVAALQAISLGKDPLLLILASDHLIENNVEFQRVIQSAKIYANQGKLVTFGIVPTSAETG
YGYIETKEFPTKDNQIIGLEINKFIEKPNKDIAEKLIKDSRFTWNSGMFLFKASTIISELKKFSPEILNNCKIALEKDIE
DLDFLRLETESFKKCPKISIDIAVMEKTNLGIVLPLNVGWNDIGSWKSLWDISKKNNDGNYINGRIIAEKSKNCYLKGEQ
RLIVGIGIENLIVVDTNDAILVANRDQSQNIGNIVKSLSSSAFPEGKVHRKIYRPWGNYTTIVEGNRWLVKLIEVKPNAS
LSLQMHHHRAEHWVVVNGTALIEKNGEKKLLSENESTFIPLGCKHRLSNPGKMRLELIEVQSGTYLGEEDIIRFEDSYGR
IKNQN

Sequences:

>Translated_485_residues
MNITDNSIIPVILSGGSGTRLWPLSRESYPKQFLALDSRTKKTLLQKTYERLLGLEGLENPILICNEDHRFIVAEQFREI
NTDPQAIILEPVGRNTAPAIAVAALQAISLGKDPLLLILASDHLIENNVEFQRVIQSAKIYANQGKLVTFGIVPTSAETG
YGYIETKEFPTKDNQIIGLEINKFIEKPNKDIAEKLIKDSRFTWNSGMFLFKASTIISELKKFSPEILNNCKIALEKDIE
DLDFLRLETESFKKCPKISIDIAVMEKTNLGIVLPLNVGWNDIGSWKSLWDISKKNNDGNYINGRIIAEKSKNCYLKGEQ
RLIVGIGIENLIVVDTNDAILVANRDQSQNIGNIVKSLSSSAFPEGKVHRKIYRPWGNYTTIVEGNRWLVKLIEVKPNAS
LSLQMHHHRAEHWVVVNGTALIEKNGEKKLLSENESTFIPLGCKHRLSNPGKMRLELIEVQSGTYLGEEDIIRFEDSYGR
IKNQN
>Mature_485_residues
MNITDNSIIPVILSGGSGTRLWPLSRESYPKQFLALDSRTKKTLLQKTYERLLGLEGLENPILICNEDHRFIVAEQFREI
NTDPQAIILEPVGRNTAPAIAVAALQAISLGKDPLLLILASDHLIENNVEFQRVIQSAKIYANQGKLVTFGIVPTSAETG
YGYIETKEFPTKDNQIIGLEINKFIEKPNKDIAEKLIKDSRFTWNSGMFLFKASTIISELKKFSPEILNNCKIALEKDIE
DLDFLRLETESFKKCPKISIDIAVMEKTNLGIVLPLNVGWNDIGSWKSLWDISKKNNDGNYINGRIIAEKSKNCYLKGEQ
RLIVGIGIENLIVVDTNDAILVANRDQSQNIGNIVKSLSSSAFPEGKVHRKIYRPWGNYTTIVEGNRWLVKLIEVKPNAS
LSLQMHHHRAEHWVVVNGTALIEKNGEKKLLSENESTFIPLGCKHRLSNPGKMRLELIEVQSGTYLGEEDIIRFEDSYGR
IKNQN

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=481, Percent_Identity=49.6881496881497, Blast_Score=499, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 54666; Mature: 54666

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITDNSIIPVILSGGSGTRLWPLSRESYPKQFLALDSRTKKTLLQKTYERLLGLEGLEN
CCCCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
PILICNEDHRFIVAEQFREINTDPQAIILEPVGRNTAPAIAVAALQAISLGKDPLLLILA
CEEEECCCCCEEEEHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEE
SDHLIENNVEFQRVIQSAKIYANQGKLVTFGIVPTSAETGYGYIETKEFPTKDNQIIGLE
CCCEECCCCHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCCEEECCCCCCCCCEEEEEE
INKFIEKPNKDIAEKLIKDSRFTWNSGMFLFKASTIISELKKFSPEILNNCKIALEKDIE
HHHHHCCCCHHHHHHHHHCCCEEECCCEEEEEHHHHHHHHHHCCHHHHCCCEEEEECCCC
DLDFLRLETESFKKCPKISIDIAVMEKTNLGIVLPLNVGWNDIGSWKSLWDISKKNNDGN
CCCEEEECCHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCC
YINGRIIAEKSKNCYLKGEQRLIVGIGIENLIVVDTNDAILVANRDQSQNIGNIVKSLSS
EEEEEEEEECCCCEEEECCCEEEEEECCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHH
SAFPEGKVHRKIYRPWGNYTTIVEGNRWLVKLIEVKPNASLSLQMHHHRAEHWVVVNGTA
CCCCCCCHHHHEECCCCCEEEEEECCCEEEEEEEECCCCEEEEEEECCCCCEEEEEECEE
LIEKNGEKKLLSENESTFIPLGCKHRLSNPGKMRLELIEVQSGTYLGEEDIIRFEDSYGR
EEECCCCHHHHCCCCCEEEEECCHHHCCCCCCEEEEEEEECCCCEECCCCEEEEECCCCC
IKNQN
CCCCC
>Mature Secondary Structure
MNITDNSIIPVILSGGSGTRLWPLSRESYPKQFLALDSRTKKTLLQKTYERLLGLEGLEN
CCCCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
PILICNEDHRFIVAEQFREINTDPQAIILEPVGRNTAPAIAVAALQAISLGKDPLLLILA
CEEEECCCCCEEEEHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEE
SDHLIENNVEFQRVIQSAKIYANQGKLVTFGIVPTSAETGYGYIETKEFPTKDNQIIGLE
CCCEECCCCHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCCEEECCCCCCCCCEEEEEE
INKFIEKPNKDIAEKLIKDSRFTWNSGMFLFKASTIISELKKFSPEILNNCKIALEKDIE
HHHHHCCCCHHHHHHHHHCCCEEECCCEEEEEHHHHHHHHHHCCHHHHCCCEEEEECCCC
DLDFLRLETESFKKCPKISIDIAVMEKTNLGIVLPLNVGWNDIGSWKSLWDISKKNNDGN
CCCEEEECCHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCC
YINGRIIAEKSKNCYLKGEQRLIVGIGIENLIVVDTNDAILVANRDQSQNIGNIVKSLSS
EEEEEEEEECCCCEEEECCCEEEEEECCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHH
SAFPEGKVHRKIYRPWGNYTTIVEGNRWLVKLIEVKPNASLSLQMHHHRAEHWVVVNGTA
CCCCCCCHHHHEECCCCCEEEEEECCCEEEEEEEECCCCEEEEEEECCCCCEEEEEECEE
LIEKNGEKKLLSENESTFIPLGCKHRLSNPGKMRLELIEVQSGTYLGEEDIIRFEDSYGR
EEECCCCHHHHCCCCCEEEEECCHHHCCCCCCEEEEEEEECCCCEECCCCEEEEECCCCC
IKNQN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]