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The map label for this gene is rnc [H]

Identifier: 124026759

GI number: 124026759

Start: 1699128

End: 1699871

Strand: Direct

Name: rnc [H]

Synonym: NATL1_20541

Alternate gene names: 124026759

Gene position: 1699128-1699871 (Clockwise)

Preceding gene: 124026756

Following gene: 124026761

Centisome position: 91.12

GC content: 30.24

Gene sequence:

>744_bases
ATGAAAATTTCAAATCACAGAGTAGAAGAAATAATTAATTTTATTAAAGGTCTAAAGTTAGATCAAAAATTTCAAAAGGA
GTTTACTAAAGAAAAAATAAAAAATATTTTATATATTAATGAATCACTAACTCATAGTTCAGCAAATAGTGAAATTAATT
ATGAAAATCTTGAATTTCTTGGAGACGCGGTTCTAAGACTCATTGCATCAGATTTCATAAAAAATAAATATCCATATATG
CAAGTAGGAGAAAGATCTGAACTTCGTTCACATCTTGTAAGTGATCAATGGCTAGAAGAAGTTGGTAAAAAGATAGAAAT
CAAAAATGTATTAGTAATTGGGAATAAAGCCCTTAGAGATAAATCAGCAAGCGCAACTATTCAAGCAGAAGCCACTGAAG
CATTAATAGGAGCTTTGTATGAAAGTCTTACTGTTCTAGAACCTATAAAAGATTGGCTTATTCCATTCTGGGAAGAAAAA
AGTAAAGAAGTTCTAGCTGATCCTCATAAGAAGAATTACAAATCAGCACTTCAAGAATTGACTCAAAGTAAAGGCCTATC
AATTCCCATATATAAAACAACTGAAATTGACAAAAAGCATGACAATCCAGAACGATTTTTTTGTAATGTTTATGTCAAAA
ACCGATCGATAGCTGAAGGAAGTGGAAAGTCAATGAAACAAGCAGAAAAAAATGCTGCAAGTAAAGCATTGAAGTATTTC
GAGAACAATGTAATTGATCAGTAA

Upstream 100 bases:

>100_bases
AGAACCCGGCTTATGACCTGCTTTCACTTTATTCATTTTACAAAAAAATTACAGTCAAAGTCCTATTTTTTATCACTCAA
ATTATATGCTTTAAATCATT

Downstream 100 bases:

>100_bases
TTAGTTTCTTTGGAAAAATAAATAATCAGCTTTTCGTAAGATCTTTCAAAGGCAGTGTCAACAATTTATCCCAATTGCCA
CCTTCAAAAAGTACTGCCGC

Product: putative ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III 2; RNase III 2 [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKISNHRVEEIINFIKGLKLDQKFQKEFTKEKIKNILYINESLTHSSANSEINYENLEFLGDAVLRLIASDFIKNKYPYM
QVGERSELRSHLVSDQWLEEVGKKIEIKNVLVIGNKALRDKSASATIQAEATEALIGALYESLTVLEPIKDWLIPFWEEK
SKEVLADPHKKNYKSALQELTQSKGLSIPIYKTTEIDKKHDNPERFFCNVYVKNRSIAEGSGKSMKQAEKNAASKALKYF
ENNVIDQ

Sequences:

>Translated_247_residues
MKISNHRVEEIINFIKGLKLDQKFQKEFTKEKIKNILYINESLTHSSANSEINYENLEFLGDAVLRLIASDFIKNKYPYM
QVGERSELRSHLVSDQWLEEVGKKIEIKNVLVIGNKALRDKSASATIQAEATEALIGALYESLTVLEPIKDWLIPFWEEK
SKEVLADPHKKNYKSALQELTQSKGLSIPIYKTTEIDKKHDNPERFFCNVYVKNRSIAEGSGKSMKQAEKNAASKALKYF
ENNVIDQ
>Mature_247_residues
MKISNHRVEEIINFIKGLKLDQKFQKEFTKEKIKNILYINESLTHSSANSEINYENLEFLGDAVLRLIASDFIKNKYPYM
QVGERSELRSHLVSDQWLEEVGKKIEIKNVLVIGNKALRDKSASATIQAEATEALIGALYESLTVLEPIKDWLIPFWEEK
SKEVLADPHKKNYKSALQELTQSKGLSIPIYKTTEIDKKHDNPERFFCNVYVKNRSIAEGSGKSMKQAEKNAASKALKYF
ENNVIDQ

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=192, Percent_Identity=27.6041666666667, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI155030236, Length=192, Percent_Identity=27.6041666666667, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788920, Length=225, Percent_Identity=27.5555555555556, Blast_Score=85, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28357; Mature: 28357

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISNHRVEEIINFIKGLKLDQKFQKEFTKEKIKNILYINESLTHSSANSEINYENLEFL
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCHHHHHHH
GDAVLRLIASDFIKNKYPYMQVGERSELRSHLVSDQWLEEVGKKIEIKNVLVIGNKALRD
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEHHHEEEECCHHHHC
KSASATIQAEATEALIGALYESLTVLEPIKDWLIPFWEEKSKEVLADPHKKNYKSALQEL
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCCHHHHHHHHHHH
TQSKGLSIPIYKTTEIDKKHDNPERFFCNVYVKNRSIAEGSGKSMKQAEKNAASKALKYF
HHHCCCCCEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
ENNVIDQ
HHHCCCC
>Mature Secondary Structure
MKISNHRVEEIINFIKGLKLDQKFQKEFTKEKIKNILYINESLTHSSANSEINYENLEFL
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCHHHHHHH
GDAVLRLIASDFIKNKYPYMQVGERSELRSHLVSDQWLEEVGKKIEIKNVLVIGNKALRD
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEHHHEEEECCHHHHC
KSASATIQAEATEALIGALYESLTVLEPIKDWLIPFWEEKSKEVLADPHKKNYKSALQEL
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCCHHHHHHHHHHH
TQSKGLSIPIYKTTEIDKKHDNPERFFCNVYVKNRSIAEGSGKSMKQAEKNAASKALKYF
HHHCCCCCEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
ENNVIDQ
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]