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The map label for this gene is adk

Identifier: 124026689

GI number: 124026689

Start: 1636933

End: 1637481

Strand: Reverse

Name: adk

Synonym: NATL1_19841

Alternate gene names: 124026689

Gene position: 1637481-1636933 (Counterclockwise)

Preceding gene: 124026690

Following gene: 124026688

Centisome position: 87.81

GC content: 34.43

Gene sequence:

>549_bases
ATGAAAAAAAAATTACTATTTCTTGGCCCCCCTGGCGCGGGGAAAGGGACGCAAGCAAATCTTTTTTGCAAAAAATACGG
ACTAATTCATCTTTCAACTGGAGATTTACTTAGAGATGAGGTCTCCTCTGGATCTGTTTTAGGGATCAAAGCTGCTGAGA
TTATGAATAAAGGAGAATTAGTGAGTGATGAATTAGTTCTCTCAATTGTTGAAGGGAGATTATTAAATATTAATGAGGGT
TGGTTGCTGGATGGTTTCCCTAGAAATGTCAATCAAGCTAATTCTTTAAAAGATCTTTTAGAAAAAATTAATCAACCTTT
AGAAGGGGTCATCTTAATAAAAGTTGCTGACGATTATTTAATTAAAAGGCTTGTAGAAAGAGGAAGACAGGATGACAATG
AGCAAGTAATAACTAACAGGCTAAAAATATACAGAGAAAAAACCTCTCCACTAATTGATTTGTATAAGAAGCAAGGTATT
CTTGAAGAGATAGAAGGTAATGCTGACATTGATGTTGTTTTTTCATGCATTGAGAAATCTTTAGGCTGA

Upstream 100 bases:

>100_bases
GAGTGGCAATTGATACCTCTAAACAGATTCAGACTTATGTCATTTCTCAAAGATATGAAGGATTAGTACGTCAATAAAGT
TTTACTATGATTTTATTTAA

Downstream 100 bases:

>100_bases
CGATGTAGTAAGCTTATAGTTTGGAAATAGGAGAGTCTCACCAAATGAAGGTTAGATCCTCAGTCAAAAAAATTAGTCCT
GACGATCAGATCGTGAGGCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKKKLLFLGPPGAGKGTQANLFCKKYGLIHLSTGDLLRDEVSSGSVLGIKAAEIMNKGELVSDELVLSIVEGRLLNINEG
WLLDGFPRNVNQANSLKDLLEKINQPLEGVILIKVADDYLIKRLVERGRQDDNEQVITNRLKIYREKTSPLIDLYKKQGI
LEEIEGNADIDVVFSCIEKSLG

Sequences:

>Translated_182_residues
MKKKLLFLGPPGAGKGTQANLFCKKYGLIHLSTGDLLRDEVSSGSVLGIKAAEIMNKGELVSDELVLSIVEGRLLNINEG
WLLDGFPRNVNQANSLKDLLEKINQPLEGVILIKVADDYLIKRLVERGRQDDNEQVITNRLKIYREKTSPLIDLYKKQGI
LEEIEGNADIDVVFSCIEKSLG
>Mature_182_residues
MKKKLLFLGPPGAGKGTQANLFCKKYGLIHLSTGDLLRDEVSSGSVLGIKAAEIMNKGELVSDELVLSIVEGRLLNINEG
WLLDGFPRNVNQANSLKDLLEKINQPLEGVILIKVADDYLIKRLVERGRQDDNEQVITNRLKIYREKTSPLIDLYKKQGI
LEEIEGNADIDVVFSCIEKSLG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=207, Percent_Identity=39.6135265700483, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI4502013, Length=207, Percent_Identity=39.6135265700483, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=41.8478260869565, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI19923437, Length=196, Percent_Identity=29.0816326530612, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI28144899, Length=181, Percent_Identity=34.8066298342541, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7706497, Length=192, Percent_Identity=33.8541666666667, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28144897, Length=181, Percent_Identity=34.8066298342541, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI22749187, Length=130, Percent_Identity=32.3076923076923, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=34.5622119815668, Blast_Score=121, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17552384, Length=212, Percent_Identity=37.7358490566038, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=38.9189189189189, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17533833, Length=190, Percent_Identity=32.6315789473684, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=180, Percent_Identity=32.2222222222222, Blast_Score=93, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17537943, Length=209, Percent_Identity=26.3157894736842, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25147457, Length=180, Percent_Identity=26.1111111111111, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321018, Length=203, Percent_Identity=31.5270935960591, Blast_Score=99, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322828, Length=187, Percent_Identity=29.9465240641711, Blast_Score=95, Evalue=7e-21,
Organism=Drosophila melanogaster, GI22026816, Length=206, Percent_Identity=36.8932038834951, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=34.6368715083799, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=34.6368715083799, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI221459597, Length=187, Percent_Identity=32.620320855615, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356893, Length=187, Percent_Identity=32.620320855615, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PROM1 (A2C4Y0)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015804.1
- ProteinModelPortal:   A2C4Y0
- SMR:   A2C4Y0
- STRING:   A2C4Y0
- GeneID:   4780675
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_19841
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   CLSK645602
- BioCyc:   PMAR167555:NATL1_19841-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20219; Mature: 20219

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKLLFLGPPGAGKGTQANLFCKKYGLIHLSTGDLLRDEVSSGSVLGIKAAEIMNKGEL
CCCCEEEECCCCCCCCCCCCEEEEHHCEEEECCCHHHHHHCCCCCEEEEHHHHHHCCCCC
VSDELVLSIVEGRLLNINEGWLLDGFPRNVNQANSLKDLLEKINQPLEGVILIKVADDYL
HHHHHHHHHHCCEEEECCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHH
IKRLVERGRQDDNEQVITNRLKIYREKTSPLIDLYKKQGILEEIEGNADIDVVFSCIEKS
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHH
LG
CC
>Mature Secondary Structure
MKKKLLFLGPPGAGKGTQANLFCKKYGLIHLSTGDLLRDEVSSGSVLGIKAAEIMNKGEL
CCCCEEEECCCCCCCCCCCCEEEEHHCEEEECCCHHHHHHCCCCCEEEEHHHHHHCCCCC
VSDELVLSIVEGRLLNINEGWLLDGFPRNVNQANSLKDLLEKINQPLEGVILIKVADDYL
HHHHHHHHHHCCEEEECCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHH
IKRLVERGRQDDNEQVITNRLKIYREKTSPLIDLYKKQGILEEIEGNADIDVVFSCIEKS
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHH
LG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA