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The map label for this gene is degP [C]

Identifier: 124026596

GI number: 124026596

Start: 1553275

End: 1554420

Strand: Reverse

Name: degP [C]

Synonym: NATL1_18911

Alternate gene names: 124026596

Gene position: 1554420-1553275 (Counterclockwise)

Preceding gene: 124026601

Following gene: 124026595

Centisome position: 83.36

GC content: 38.74

Gene sequence:

>1146_bases
ATGCAGAGCCTTAGAAAGTTAGAAATTATGCGGCGATTCATTGGTATATTTTCCCTTTTCTCAATCCTTTTTTGTTTTTT
GTTTGAGCCAATATCTGTATTCGCGCTAGCAGATTTTCAAGAAAGCGAATCACACAGTTTTGTTGCCAATGTAGCTAGCA
AAGTTTCACCTTCGGTCGTAAGGATTGATATTGAAAGAGAGTTTCAAACAGATGAATTTGAATCTGATTTGTTAGATCCC
TTACTAAAAGATCTTTTAGGGGATTTGGGAACTTTTCCCAAAAAAGAGAGAGGGCAAGGCTCTGGGGTCATAATCGATAG
CTCTGGATTAGTTCTCACCAATGCTCATGTAGTGGAAAGAGTTGATCGTGTGATAGTTACTCTTCAAAATGGAAATCAAG
TGGATGGAACAGTTGTTGGAACCGATCAAGTTACTGACTTAGCTTTGGTGAAAATTAAAGAATTTCCTGATTTAGAAAGT
GCAAAATTGGGTGATTCAGAAGATATCCAAGTTGGGGACTGGGCAATTGCTCTTGGAACACCTTATGGCCTTGAAAGCAC
TGTCACGCTGGGTATAGTCAGCAGTCTTCATAGAGACATTAATTCTCTTGGCTTTTCTGATAAGAGATTGGATTTAATTC
AAACTGACGCAGCAATAAATCCTGGGAATTCCGGCGGACCATTGATAAATGCAAATGGAGAAGTTATTGGAATTAATACT
TTAGTCAGATCAGGTCCAGGGGCTGGACTTGGATTCGCAATCCCAATAAATCTTGCTTCAAAAGTTACCAATCAACTGCT
CACTAACGGTGAGGTTATTCATCCTTACTTGGGTGCTCAGTTGGTTTTATTGAATGAAAGAATAGCTAAAGAACATAATC
AAGATCCAAATGCATTGATTTTTTTGCCTGAAAGGTCAGGAGCCCTAGTTCAATCAGTTATCCCTCAAAGTCCAGCAGAG
GAAGGAGGTTTAAGACGGGGTGATCTTGTAATTAATGCAGGGGGTAATGCAATTAATGATCCTAGGTCTTTACTCATGCA
AGTTGAAAATGCTCAAATAGGAAAGCCATTTGAATTGGAAGTGGTTCGAAATAATAAAGAGATTAATCTTTCTATTAAGC
CAGCTGCTTTACCAGGAATTAGCTAG

Upstream 100 bases:

>100_bases
AACTAAATATTACTAGATAAAGGTTTCGGTTACCTCTAAAATCAAATTCTCTTTATTTTGGATTGTTCTACTTTATTGTT
TTTAGAAGTCTAGACTAGTT

Downstream 100 bases:

>100_bases
AAATCTTGCTACTGTCTTTCGAAAAGGTATGACTAAATGGATCTCCAAAACCAGATGAAAAAAGCAGTTGCTCAAGCTGC
TGTAGATCAAATTCAAAACG

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MQSLRKLEIMRRFIGIFSLFSILFCFLFEPISVFALADFQESESHSFVANVASKVSPSVVRIDIEREFQTDEFESDLLDP
LLKDLLGDLGTFPKKERGQGSGVIIDSSGLVLTNAHVVERVDRVIVTLQNGNQVDGTVVGTDQVTDLALVKIKEFPDLES
AKLGDSEDIQVGDWAIALGTPYGLESTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINANGEVIGINT
LVRSGPGAGLGFAIPINLASKVTNQLLTNGEVIHPYLGAQLVLLNERIAKEHNQDPNALIFLPERSGALVQSVIPQSPAE
EGGLRRGDLVINAGGNAINDPRSLLMQVENAQIGKPFELEVVRNNKEINLSIKPAALPGIS

Sequences:

>Translated_381_residues
MQSLRKLEIMRRFIGIFSLFSILFCFLFEPISVFALADFQESESHSFVANVASKVSPSVVRIDIEREFQTDEFESDLLDP
LLKDLLGDLGTFPKKERGQGSGVIIDSSGLVLTNAHVVERVDRVIVTLQNGNQVDGTVVGTDQVTDLALVKIKEFPDLES
AKLGDSEDIQVGDWAIALGTPYGLESTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINANGEVIGINT
LVRSGPGAGLGFAIPINLASKVTNQLLTNGEVIHPYLGAQLVLLNERIAKEHNQDPNALIFLPERSGALVQSVIPQSPAE
EGGLRRGDLVINAGGNAINDPRSLLMQVENAQIGKPFELEVVRNNKEINLSIKPAALPGIS
>Mature_381_residues
MQSLRKLEIMRRFIGIFSLFSILFCFLFEPISVFALADFQESESHSFVANVASKVSPSVVRIDIEREFQTDEFESDLLDP
LLKDLLGDLGTFPKKERGQGSGVIIDSSGLVLTNAHVVERVDRVIVTLQNGNQVDGTVVGTDQVTDLALVKIKEFPDLES
AKLGDSEDIQVGDWAIALGTPYGLESTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINANGEVIGINT
LVRSGPGAGLGFAIPINLASKVTNQLLTNGEVIHPYLGAQLVLLNERIAKEHNQDPNALIFLPERSGALVQSVIPQSPAE
EGGLRRGDLVINAGGNAINDPRSLLMQVENAQIGKPFELEVVRNNKEINLSIKPAALPGIS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=346, Percent_Identity=34.393063583815, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI22129776, Length=339, Percent_Identity=34.2182890855457, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI24308541, Length=340, Percent_Identity=32.0588235294118, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI7019477, Length=343, Percent_Identity=32.0699708454811, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1786356, Length=278, Percent_Identity=39.568345323741, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789629, Length=329, Percent_Identity=35.5623100303951, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789630, Length=288, Percent_Identity=35.7638888888889, Blast_Score=155, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24646839, Length=349, Percent_Identity=32.0916905444126, Blast_Score=154, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40973; Mature: 40973

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLRKLEIMRRFIGIFSLFSILFCFLFEPISVFALADFQESESHSFVANVASKVSPSVV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCCEEE
RIDIEREFQTDEFESDLLDPLLKDLLGDLGTFPKKERGQGSGVIIDSSGLVLTNAHVVER
EEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEECHHHHHH
VDRVIVTLQNGNQVDGTVVGTDQVTDLALVKIKEFPDLESAKLGDSEDIQVGDWAIALGT
HCCEEEEECCCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCEEEEECC
PYGLESTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINANGEVIGINT
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCEEEEEH
LVRSGPGAGLGFAIPINLASKVTNQLLTNGEVIHPYLGAQLVLLNERIAKEHNQDPNALI
HHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCEEECCCCCEEEEECHHHHHHCCCCCCEEE
FLPERSGALVQSVIPQSPAEEGGLRRGDLVINAGGNAINDPRSLLMQVENAQIGKPFELE
EEECCCCHHHHHHCCCCCCHHCCCEECCEEEECCCCCCCCHHHHHEECCCCCCCCCEEEE
VVRNNKEINLSIKPAALPGIS
EEECCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MQSLRKLEIMRRFIGIFSLFSILFCFLFEPISVFALADFQESESHSFVANVASKVSPSVV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCCEEE
RIDIEREFQTDEFESDLLDPLLKDLLGDLGTFPKKERGQGSGVIIDSSGLVLTNAHVVER
EEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEECHHHHHH
VDRVIVTLQNGNQVDGTVVGTDQVTDLALVKIKEFPDLESAKLGDSEDIQVGDWAIALGT
HCCEEEEECCCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCEEEEECC
PYGLESTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINANGEVIGINT
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCEEEEEH
LVRSGPGAGLGFAIPINLASKVTNQLLTNGEVIHPYLGAQLVLLNERIAKEHNQDPNALI
HHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCEEECCCCCEEEEECHHHHHHCCCCCCEEE
FLPERSGALVQSVIPQSPAEEGGLRRGDLVINAGGNAINDPRSLLMQVENAQIGKPFELE
EEECCCCHHHHHHCCCCCCHHCCCEECCEEEECCCCCCCCHHHHHEECCCCCCCCCEEEE
VVRNNKEINLSIKPAALPGIS
EEECCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA