Click here to switch to the map view.

The map label for this gene is rpiA

Identifier: 124026595

GI number: 124026595

Start: 1552528

End: 1553238

Strand: Reverse

Name: rpiA

Synonym: NATL1_18901

Alternate gene names: 124026595

Gene position: 1553238-1552528 (Counterclockwise)

Preceding gene: 124026596

Following gene: 124026593

Centisome position: 83.3

GC content: 36.43

Gene sequence:

>711_bases
ATGGATCTCCAAAACCAGATGAAAAAAGCAGTTGCTCAAGCTGCTGTAGATCAAATTCAAAACGGTATGATTCTAGGCCT
TGGCTCTGGTTCTACAGCAGCTTTGATGATTGAAGCTCTTGCTATAAAAATAAAATCAGGAGAAATTAAAGATGTTGTTG
GAGTGACTACATCTTTTCAGGGTGAAGTTCTTGCTTCTGAATTAGGCATACCACTTAAATCTCTTTCATCTGTTTCAGAA
ATTGATCTTGCAATTGATGGTGCTGATGAAGTTGATCCCAAATTTCAATTAATCAAAGGAGGAGGAGCTTGCCATGTGCA
GGAAAAACTTGTTGCTGCTTTAGCTAAAAAATTTATAGTTGTTGTTGACTCAACTAAACTTGTTGAAAAATTGAACCTTG
ATTTCAAATTACCTGTAGAGGTTCTTCCTTCTGCTTGGAAACAAGTACAAAAAACATTAATAAATCTTGGAGGAGAAGGG
AATCTAAGGATGGCTCAGAAAAAGGCCGGACCTATAGTTACTGATCAGGGAAACTTGATACTGGATTTAACCTTTAGGAA
CGGTATTGATCAACCTGAACTATTGGAAACTCAAATCAATAATATTCCAGGTGTCCTTGAAAATGGACTTTTTGTAAACC
TGACTGATGAAGTATTGGTTGGGAAAGTAGAAAGTGATGTTGTGGGTGTTGAATCACTTAAAAAGATTTAG

Upstream 100 bases:

>100_bases
GGTTCGAAATAATAAAGAGATTAATCTTTCTATTAAGCCAGCTGCTTTACCAGGAATTAGCTAGAAATCTTGCTACTGTC
TTTCGAAAAGGTATGACTAA

Downstream 100 bases:

>100_bases
AGTCTCTAATTCTTATTGATTCTGCATGACTATGTAGTCCCTCGCTATTGGCTAATTGTACAACTGCATTTTTATTTTCA
TTAAATGCTTCTTTTGAAAA

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MDLQNQMKKAVAQAAVDQIQNGMILGLGSGSTAALMIEALAIKIKSGEIKDVVGVTTSFQGEVLASELGIPLKSLSSVSE
IDLAIDGADEVDPKFQLIKGGGACHVQEKLVAALAKKFIVVVDSTKLVEKLNLDFKLPVEVLPSAWKQVQKTLINLGGEG
NLRMAQKKAGPIVTDQGNLILDLTFRNGIDQPELLETQINNIPGVLENGLFVNLTDEVLVGKVESDVVGVESLKKI

Sequences:

>Translated_236_residues
MDLQNQMKKAVAQAAVDQIQNGMILGLGSGSTAALMIEALAIKIKSGEIKDVVGVTTSFQGEVLASELGIPLKSLSSVSE
IDLAIDGADEVDPKFQLIKGGGACHVQEKLVAALAKKFIVVVDSTKLVEKLNLDFKLPVEVLPSAWKQVQKTLINLGGEG
NLRMAQKKAGPIVTDQGNLILDLTFRNGIDQPELLETQINNIPGVLENGLFVNLTDEVLVGKVESDVVGVESLKKI
>Mature_236_residues
MDLQNQMKKAVAQAAVDQIQNGMILGLGSGSTAALMIEALAIKIKSGEIKDVVGVTTSFQGEVLASELGIPLKSLSSVSE
IDLAIDGADEVDPKFQLIKGGGACHVQEKLVAALAKKFIVVVDSTKLVEKLNLDFKLPVEVLPSAWKQVQKTLINLGGEG
NLRMAQKKAGPIVTDQGNLILDLTFRNGIDQPELLETQINNIPGVLENGLFVNLTDEVLVGKVESDVVGVESLKKI

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=231, Percent_Identity=41.5584415584416, Blast_Score=161, Evalue=4e-40,
Organism=Escherichia coli, GI1789280, Length=219, Percent_Identity=42.0091324200913, Blast_Score=141, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17551758, Length=235, Percent_Identity=39.5744680851064, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324669, Length=233, Percent_Identity=37.7682403433476, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281364072, Length=222, Percent_Identity=43.6936936936937, Blast_Score=155, Evalue=2e-38,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA_PROM1 (A2C4N6)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015710.1
- ProteinModelPortal:   A2C4N6
- SMR:   A2C4N6
- STRING:   A2C4N6
- GeneID:   4779199
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_18901
- eggNOG:   COG0120
- HOGENOM:   HBG515603
- OMA:   VFDLNSV
- ProtClustDB:   PRK00702
- BioCyc:   PMAR167555:NATL1_18901-MONOMER
- HAMAP:   MF_00170
- InterPro:   IPR014036
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF00455 DeoR; PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 25093; Mature: 25093

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQNQMKKAVAQAAVDQIQNGMILGLGSGSTAALMIEALAIKIKSGEIKDVVGVTTSFQ
CCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHEEECCCCCCHHHCCCCCCC
GEVLASELGIPLKSLSSVSEIDLAIDGADEVDPKFQLIKGGGACHVQEKLVAALAKKFIV
CHHHHHHHCCCHHHHCCHHHEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEEE
VVDSTKLVEKLNLDFKLPVEVLPSAWKQVQKTLINLGGEGNLRMAQKKAGPIVTDQGNLI
EECCHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCEEECCCCEE
LDLTFRNGIDQPELLETQINNIPGVLENGLFVNLTDEVLVGKVESDVVGVESLKKI
EEEEECCCCCCHHHHHHHHHCCCCHHHCCEEEEEEHHHHEECHHHCCCCHHHHHCC
>Mature Secondary Structure
MDLQNQMKKAVAQAAVDQIQNGMILGLGSGSTAALMIEALAIKIKSGEIKDVVGVTTSFQ
CCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHEEECCCCCCHHHCCCCCCC
GEVLASELGIPLKSLSSVSEIDLAIDGADEVDPKFQLIKGGGACHVQEKLVAALAKKFIV
CHHHHHHHCCCHHHHCCHHHEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEEE
VVDSTKLVEKLNLDFKLPVEVLPSAWKQVQKTLINLGGEGNLRMAQKKAGPIVTDQGNLI
EECCHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCEEECCCCEE
LDLTFRNGIDQPELLETQINNIPGVLENGLFVNLTDEVLVGKVESDVVGVESLKKI
EEEEECCCCCCHHHHHHHHHCCCCHHHCCEEEEEEHHHHEECHHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA