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The map label for this gene is nblS [H]

Identifier: 124026473

GI number: 124026473

Start: 1449698

End: 1451767

Strand: Direct

Name: nblS [H]

Synonym: NATL1_17681

Alternate gene names: 124026473

Gene position: 1449698-1451767 (Clockwise)

Preceding gene: 124026472

Following gene: 124026476

Centisome position: 77.74

GC content: 36.04

Gene sequence:

>2070_bases
ATGAATAATACTAATTTAAATCAGAATAAAAACTTTATAGCATCAAAACATGATGTAATATTAGATGATTTAACCTTTTT
AGAAAAAATAAATTTATGGTGGTCTAGATTTAATTTAAGATCTAAACTACTAGCTTTTGGAACGTTAGTAGTTAGTTTCA
TAATGACACTTATTACGTTTTTTGCTTTAAGTAGTATTCAAAAGGATGCTGGCATGAATGATACAAGATACGCCAGAGAT
TTAGGGTTGTTATTGTCAGGGAACGTTACGGAATTAGTAGCGAAGAATCAAACAAGAGAACTTTTCAACGTTGCTGAGAA
GTTTTGGCGTTCCAGTAGGAACTTAAGATACATTTTCTTCACTGACCCAGATGGGTTTGTAAAATTGGGTATCCCAGTTA
GTGCAACGGCTTCAGAATCTGATGCTGAAGGTGCTTTGCAACTAACCAGAAAACTTAAATTACCAAGTGAACTAAAAAAA
CAACCTCAATTCCCATTAGTCAGACAACATTCAACTCCACAAGGCCAGGTAACTGATGTTTTTGTTCCCATGCTTTGGAA
AGGTGAATATCTAGGCACCTTGGCTCTGGGAGTAACACCGAACAAAAAAGCTCTTGCTACAGCCGCTTTAACCAGAGAAA
TTACTGTTGCAGTATTTATTTCTATTTGGGTATTAGTAATAATAGGAGCTGTATTTAATGCGCTAACAATCACTCGTCCA
ATAAGAGAATTAGTTATTGGAGTCAGAGAAATTGCTAAAGGTAATTTCAAATCAAGAGTAGATCTTCCTATGAGTGGAGA
ACTTGGGGAACTCTTAACTGGGTTTAATGCAATGGCATCCAGATTAGAAGACTACGATGCTGCAAATATTGAGGAACTTA
AAGCTGCTCAAGTCAAACAGCAATCCTTAATAGCCACAATGGCAGATGGAGCCCTTCTTCTTGACGAACAAGGAAATATT
GTCTTAGTCAATCCAACTGCTAGAAGACTCTTCCGATGGGAAGGGAGAAATCTTGAAGGTCAAAATTTATTGAATCAACT
TCCTGACTCTCTTGTAAAAGAACTTGAAACTCCAATAACCTCTCTACTAAACAATTTCGGAGACAGCGATGATTTGCGTT
GCAATCTTGAAGAACCACCAAGAACACTTCGTATAGTTTTAAAGTCTGTCAGAGACACTACTGGAGAGAATATAAAAGGT
ATTGCTGTTACTGTTCAAGATCTCACTAGGGAAGTGCAATTAAACGCAGCACAAAAAAGATTCATCAGCAATGTTTCTCA
CGAACTGAGAACGCCATTATTCAACATTAAAAGCTATGTTGAAACTCTATATGACCTAGGAGAACAGCTTACAAAAGACG
AGCAAAAAGAATTTCTAGGTGTTGCGAATTCAGAAACAGATAGACTCACTCGCTTGGTCAATGATGTTCTTGACTTATCC
AAGTTGGAGTCTGGAAGAACAATCCAATTAGAAGCACTAAGTATAAAAGAAGCTATGGAACAAACCCTAAGAAACTATAA
ACTTAATGCCGAGGAAAAAAATGTTAAATTAATATTAACTGTTGAAAATAATTTGACATTTGTTTTAGGTAATTGGGATA
TGCTTCTTCAAGTTTTTGACAATCTTGTTGGTAATGCACTTAAATTCAGTCAAGAGGGAGGAATAATAAATTTAAAGGCT
TATACATGGCCCGATATATGCGTTGCTTCGCCAGTTGATTTAGATAATAAAGCTCCACATTGTGAAATTTTGTCCCCGAT
GCCAAAAATCAGAGTTGAGGTCTCCGATACAGGATATGGAATTTCTGAAATTGATCAACAAAGAATATTTGAACGTTTTT
ACAGAGTTGAAGATTCAGTGCATACTGAAGTGGGCACTGGACTTGGCCTGTCAATCGTTAAAGGGATAGTTGATAAACAC
GGAAGTGAGATAAGAATGGCAAGTGAACCAAATACTGGAACAACTTTTTGGTTTGAACTTCCTCTTGAAGACTCTGACGC
TGATGAGTTGTTACTAAAATCTGCTAGGAAAAATTGGGAACTTGAAAATGATAAGACATTAATTAAATAG

Upstream 100 bases:

>100_bases
TTTAGCCTATTCTAACCTTAAAAAAATTAACTTTAATGGTATGCATTTTCGCGAAGATATAGGTTACCAAGTTAGGAATA
TTTGAATTAATTTATCTTAT

Downstream 100 bases:

>100_bases
AGTTACTAGTTACCGTTCTTTTGGATTAATGCTTTTAAAAACGCCAGGTATCTGTTCTTCAGGATTAATTCGATGAGGGG
CACCACTAAATATCTGTTCA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MNNTNLNQNKNFIASKHDVILDDLTFLEKINLWWSRFNLRSKLLAFGTLVVSFIMTLITFFALSSIQKDAGMNDTRYARD
LGLLLSGNVTELVAKNQTRELFNVAEKFWRSSRNLRYIFFTDPDGFVKLGIPVSATASESDAEGALQLTRKLKLPSELKK
QPQFPLVRQHSTPQGQVTDVFVPMLWKGEYLGTLALGVTPNKKALATAALTREITVAVFISIWVLVIIGAVFNALTITRP
IRELVIGVREIAKGNFKSRVDLPMSGELGELLTGFNAMASRLEDYDAANIEELKAAQVKQQSLIATMADGALLLDEQGNI
VLVNPTARRLFRWEGRNLEGQNLLNQLPDSLVKELETPITSLLNNFGDSDDLRCNLEEPPRTLRIVLKSVRDTTGENIKG
IAVTVQDLTREVQLNAAQKRFISNVSHELRTPLFNIKSYVETLYDLGEQLTKDEQKEFLGVANSETDRLTRLVNDVLDLS
KLESGRTIQLEALSIKEAMEQTLRNYKLNAEEKNVKLILTVENNLTFVLGNWDMLLQVFDNLVGNALKFSQEGGIINLKA
YTWPDICVASPVDLDNKAPHCEILSPMPKIRVEVSDTGYGISEIDQQRIFERFYRVEDSVHTEVGTGLGLSIVKGIVDKH
GSEIRMASEPNTGTTFWFELPLEDSDADELLLKSARKNWELENDKTLIK

Sequences:

>Translated_689_residues
MNNTNLNQNKNFIASKHDVILDDLTFLEKINLWWSRFNLRSKLLAFGTLVVSFIMTLITFFALSSIQKDAGMNDTRYARD
LGLLLSGNVTELVAKNQTRELFNVAEKFWRSSRNLRYIFFTDPDGFVKLGIPVSATASESDAEGALQLTRKLKLPSELKK
QPQFPLVRQHSTPQGQVTDVFVPMLWKGEYLGTLALGVTPNKKALATAALTREITVAVFISIWVLVIIGAVFNALTITRP
IRELVIGVREIAKGNFKSRVDLPMSGELGELLTGFNAMASRLEDYDAANIEELKAAQVKQQSLIATMADGALLLDEQGNI
VLVNPTARRLFRWEGRNLEGQNLLNQLPDSLVKELETPITSLLNNFGDSDDLRCNLEEPPRTLRIVLKSVRDTTGENIKG
IAVTVQDLTREVQLNAAQKRFISNVSHELRTPLFNIKSYVETLYDLGEQLTKDEQKEFLGVANSETDRLTRLVNDVLDLS
KLESGRTIQLEALSIKEAMEQTLRNYKLNAEEKNVKLILTVENNLTFVLGNWDMLLQVFDNLVGNALKFSQEGGIINLKA
YTWPDICVASPVDLDNKAPHCEILSPMPKIRVEVSDTGYGISEIDQQRIFERFYRVEDSVHTEVGTGLGLSIVKGIVDKH
GSEIRMASEPNTGTTFWFELPLEDSDADELLLKSARKNWELENDKTLIK
>Mature_689_residues
MNNTNLNQNKNFIASKHDVILDDLTFLEKINLWWSRFNLRSKLLAFGTLVVSFIMTLITFFALSSIQKDAGMNDTRYARD
LGLLLSGNVTELVAKNQTRELFNVAEKFWRSSRNLRYIFFTDPDGFVKLGIPVSATASESDAEGALQLTRKLKLPSELKK
QPQFPLVRQHSTPQGQVTDVFVPMLWKGEYLGTLALGVTPNKKALATAALTREITVAVFISIWVLVIIGAVFNALTITRP
IRELVIGVREIAKGNFKSRVDLPMSGELGELLTGFNAMASRLEDYDAANIEELKAAQVKQQSLIATMADGALLLDEQGNI
VLVNPTARRLFRWEGRNLEGQNLLNQLPDSLVKELETPITSLLNNFGDSDDLRCNLEEPPRTLRIVLKSVRDTTGENIKG
IAVTVQDLTREVQLNAAQKRFISNVSHELRTPLFNIKSYVETLYDLGEQLTKDEQKEFLGVANSETDRLTRLVNDVLDLS
KLESGRTIQLEALSIKEAMEQTLRNYKLNAEEKNVKLILTVENNLTFVLGNWDMLLQVFDNLVGNALKFSQEGGIINLKA
YTWPDICVASPVDLDNKAPHCEILSPMPKIRVEVSDTGYGISEIDQQRIFERFYRVEDSVHTEVGTGLGLSIVKGIVDKH
GSEIRMASEPNTGTTFWFELPLEDSDADELLLKSARKNWELENDKTLIK

Specific function: Member Of The Two-Component Regulatory System Uvry/Bara Involved In The Regulation Of Carbon Metabolism Via The Csra/Csrb Regulatory System. Phosphorylates Uvry, Probably Via A Four-Step Phosphorelay. [C]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=268, Percent_Identity=33.2089552238806, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788549, Length=416, Percent_Identity=25.9615384615385, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1786600, Length=414, Percent_Identity=28.5024154589372, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=27.7978339350181, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1788713, Length=258, Percent_Identity=27.5193798449612, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI145693157, Length=253, Percent_Identity=29.2490118577075, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081816, Length=320, Percent_Identity=26.875, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87082128, Length=249, Percent_Identity=25.7028112449799, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790346, Length=254, Percent_Identity=28.3464566929134, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=29.8755186721992, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=246, Percent_Identity=26.0162601626016, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=27.2, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=224, Percent_Identity=25.8928571428571, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 77362; Mature: 77362

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTNLNQNKNFIASKHDVILDDLTFLEKINLWWSRFNLRSKLLAFGTLVVSFIMTLITF
CCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FALSSIQKDAGMNDTRYARDLGLLLSGNVTELVAKNQTRELFNVAEKFWRSSRNLRYIFF
HHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEE
TDPDGFVKLGIPVSATASESDAEGALQLTRKLKLPSELKKQPQFPLVRQHSTPQGQVTDV
ECCCCEEEECCCEECCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCEECCCCCCCCCCEE
FVPMLWKGEYLGTLALGVTPNKKALATAALTREITVAVFISIWVLVIIGAVFNALTITRP
EEHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRELVIGVREIAKGNFKSRVDLPMSGELGELLTGFNAMASRLEDYDAANIEELKAAQVKQ
HHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QSLIATMADGALLLDEQGNIVLVNPTARRLFRWEGRNLEGQNLLNQLPDSLVKELETPIT
HHHHHHHCCCEEEEECCCCEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SLLNNFGDSDDLRCNLEEPPRTLRIVLKSVRDTTGENIKGIAVTVQDLTREVQLNAAQKR
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHH
FISNVSHELRTPLFNIKSYVETLYDLGEQLTKDEQKEFLGVANSETDRLTRLVNDVLDLS
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KLESGRTIQLEALSIKEAMEQTLRNYKLNAEEKNVKLILTVENNLTFVLGNWDMLLQVFD
HCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEECHHHHHHHHH
NLVGNALKFSQEGGIINLKAYTWPDICVASPVDLDNKAPHCEILSPMPKIRVEVSDTGYG
HHHHHHHEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEEECCCCCC
ISEIDQQRIFERFYRVEDSVHTEVGTGLGLSIVKGIVDKHGSEIRMASEPNTGTTFWFEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEE
PLEDSDADELLLKSARKNWELENDKTLIK
CCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNNTNLNQNKNFIASKHDVILDDLTFLEKINLWWSRFNLRSKLLAFGTLVVSFIMTLITF
CCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FALSSIQKDAGMNDTRYARDLGLLLSGNVTELVAKNQTRELFNVAEKFWRSSRNLRYIFF
HHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEE
TDPDGFVKLGIPVSATASESDAEGALQLTRKLKLPSELKKQPQFPLVRQHSTPQGQVTDV
ECCCCEEEECCCEECCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCEECCCCCCCCCCEE
FVPMLWKGEYLGTLALGVTPNKKALATAALTREITVAVFISIWVLVIIGAVFNALTITRP
EEHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRELVIGVREIAKGNFKSRVDLPMSGELGELLTGFNAMASRLEDYDAANIEELKAAQVKQ
HHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QSLIATMADGALLLDEQGNIVLVNPTARRLFRWEGRNLEGQNLLNQLPDSLVKELETPIT
HHHHHHHCCCEEEEECCCCEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SLLNNFGDSDDLRCNLEEPPRTLRIVLKSVRDTTGENIKGIAVTVQDLTREVQLNAAQKR
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHH
FISNVSHELRTPLFNIKSYVETLYDLGEQLTKDEQKEFLGVANSETDRLTRLVNDVLDLS
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KLESGRTIQLEALSIKEAMEQTLRNYKLNAEEKNVKLILTVENNLTFVLGNWDMLLQVFD
HCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEECHHHHHHHHH
NLVGNALKFSQEGGIINLKAYTWPDICVASPVDLDNKAPHCEILSPMPKIRVEVSDTGYG
HHHHHHHEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEEECCCCCC
ISEIDQQRIFERFYRVEDSVHTEVGTGLGLSIVKGIVDKHGSEIRMASEPNTGTTFWFEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEE
PLEDSDADELLLKSARKNWELENDKTLIK
CCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8535519; 8905231; 3141423 [H]