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The map label for this gene is argF [H]

Identifier: 124026386

GI number: 124026386

Start: 1369726

End: 1370682

Strand: Reverse

Name: argF [H]

Synonym: NATL1_16811

Alternate gene names: 124026386

Gene position: 1370682-1369726 (Counterclockwise)

Preceding gene: 124026388

Following gene: 124026385

Centisome position: 73.51

GC content: 38.35

Gene sequence:

>957_bases
ATGGCTTCAGCATCTTCAAGCTTAGCTTCTAAATTATCTCCTTTAAGTAAAAGCAACTTCCTTTCTTCCTCTGATTTAAA
TAGCGATCAAATTTTATCTTTATTTGAATTAGCTAAACAGCTAAAAACAGGTAACAGAAGAATTGATCTAGGTAATAGAG
TTCTTGGATTGATATTCAAAAAAGCCTCTACTAGGACAAGAGTGAGTTTTCAAGTAGCGATGGCAAGACTGGGAGGTCAG
ACTGTTGATTTAAATCCTCAAATCACACAACTTGGTAGGGGTGAACCTATTAAAGACACAGCGAGGGTTTTGAGTCGTTA
TTGTGACGCACTAGCAATTAGGACTTTTTCTCAACAAGAACTTGAAGAATATGCAGAATGGTCCACTATTCCTGTCATTA
ATGCTTTAACTGACCTCGAACATCCTTGTCAGTCGCTTGCTGATTATTTAACAATTCAAGAAAAGTTTGGGGAGCTTAAA
GGGATAAATCTTTCTTACATCGGAGATGGAAATAATGTTGCCAACTCATTGATGATATGCGGCGCAATGCTGGGAGTTCA
TGTGAAAATTTGCTCGCCAAAAGGTTTTGAAGCAGATTCTAAAATTGTAGAGAAGGCAAAAACGCTCTCGGAATTTGGTT
CGAAAATATCTATTTCTAATGATCCTTTGAAGGCTATGAAGGACGCTCAAGTGATTTACACAGATGTCTGGGCTTCTATG
GGGCAAGAGGAAGAACATTTGAAGAGGAAAAAAATTTTTGAAAACTATAAAGTTGATCAAAAATTAATAGAACTTGCAGA
TGAGGGAGCAATCATTTTGCATTGCTTGCCTGCTCATAGAGGAGAAGAAATCACTGAAGAGGCTTTAGAGAGCAAAAGTA
GTCATGTCTTTGATCAGGCTGAGAACAGACTGCATGTTCAGCAAGCCTTGCTCGCCGTCCAGCTTGGAGGTATTTAG

Upstream 100 bases:

>100_bases
TTAAAATGCTATCAACCAGTGTTATGCCTGAAAAAGTTTCTAATTAAATCACTTGACTTTATATCCTTTATCCACGATAA
AGGATATTTGAGGCTTATTT

Downstream 100 bases:

>100_bases
GGTTGCGATTTTTAGATATTTTAGGTACATATGTATTGAAGGACAAATGTACTTAATCGATTCGAATGCCAGAAGAAACT
CTAACTACTGCACAGCAAGA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MASASSSLASKLSPLSKSNFLSSSDLNSDQILSLFELAKQLKTGNRRIDLGNRVLGLIFKKASTRTRVSFQVAMARLGGQ
TVDLNPQITQLGRGEPIKDTARVLSRYCDALAIRTFSQQELEEYAEWSTIPVINALTDLEHPCQSLADYLTIQEKFGELK
GINLSYIGDGNNVANSLMICGAMLGVHVKICSPKGFEADSKIVEKAKTLSEFGSKISISNDPLKAMKDAQVIYTDVWASM
GQEEEHLKRKKIFENYKVDQKLIELADEGAIILHCLPAHRGEEITEEALESKSSHVFDQAENRLHVQQALLAVQLGGI

Sequences:

>Translated_318_residues
MASASSSLASKLSPLSKSNFLSSSDLNSDQILSLFELAKQLKTGNRRIDLGNRVLGLIFKKASTRTRVSFQVAMARLGGQ
TVDLNPQITQLGRGEPIKDTARVLSRYCDALAIRTFSQQELEEYAEWSTIPVINALTDLEHPCQSLADYLTIQEKFGELK
GINLSYIGDGNNVANSLMICGAMLGVHVKICSPKGFEADSKIVEKAKTLSEFGSKISISNDPLKAMKDAQVIYTDVWASM
GQEEEHLKRKKIFENYKVDQKLIELADEGAIILHCLPAHRGEEITEEALESKSSHVFDQAENRLHVQQALLAVQLGGI
>Mature_317_residues
ASASSSLASKLSPLSKSNFLSSSDLNSDQILSLFELAKQLKTGNRRIDLGNRVLGLIFKKASTRTRVSFQVAMARLGGQT
VDLNPQITQLGRGEPIKDTARVLSRYCDALAIRTFSQQELEEYAEWSTIPVINALTDLEHPCQSLADYLTIQEKFGELKG
INLSYIGDGNNVANSLMICGAMLGVHVKICSPKGFEADSKIVEKAKTLSEFGSKISISNDPLKAMKDAQVIYTDVWASMG
QEEEHLKRKKIFENYKVDQKLIELADEGAIILHCLPAHRGEEITEEALESKSSHVFDQAENRLHVQQALLAVQLGGI

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=295, Percent_Identity=41.6949152542373, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI18105007, Length=323, Percent_Identity=29.1021671826625, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786469, Length=336, Percent_Identity=37.797619047619, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1790703, Length=335, Percent_Identity=36.1194029850746, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI2367364, Length=311, Percent_Identity=29.5819935691318, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI48994908, Length=356, Percent_Identity=24.438202247191, Blast_Score=94, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=325, Percent_Identity=26.7692307692308, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322373, Length=321, Percent_Identity=33.9563862928349, Blast_Score=182, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322331, Length=311, Percent_Identity=30.8681672025724, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24642586, Length=321, Percent_Identity=28.3489096573209, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 35024; Mature: 34893

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00018 EF_HAND_1 ; PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASASSSLASKLSPLSKSNFLSSSDLNSDQILSLFELAKQLKTGNRRIDLGNRVLGLIFK
CCCCHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHH
KASTRTRVSFQVAMARLGGQTVDLNPQITQLGRGEPIKDTARVLSRYCDALAIRTFSQQE
HCCCCHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
LEEYAEWSTIPVINALTDLEHPCQSLADYLTIQEKFGELKGINLSYIGDGNNVANSLMIC
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHH
GAMLGVHVKICSPKGFEADSKIVEKAKTLSEFGSKISISNDPLKAMKDAQVIYTDVWASM
HHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCHHHHHHHHHHHC
GQEEEHLKRKKIFENYKVDQKLIELADEGAIILHCLPAHRGEEITEEALESKSSHVFDQA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ENRLHVQQALLAVQLGGI
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASASSSLASKLSPLSKSNFLSSSDLNSDQILSLFELAKQLKTGNRRIDLGNRVLGLIFK
CCCHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHH
KASTRTRVSFQVAMARLGGQTVDLNPQITQLGRGEPIKDTARVLSRYCDALAIRTFSQQE
HCCCCHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
LEEYAEWSTIPVINALTDLEHPCQSLADYLTIQEKFGELKGINLSYIGDGNNVANSLMIC
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHH
GAMLGVHVKICSPKGFEADSKIVEKAKTLSEFGSKISISNDPLKAMKDAQVIYTDVWASM
HHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCHHHHHHHHHHHC
GQEEEHLKRKKIFENYKVDQKLIELADEGAIILHCLPAHRGEEITEEALESKSSHVFDQA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ENRLHVQQALLAVQLGGI
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917486 [H]