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The map label for this gene is lexA [H]

Identifier: 124026385

GI number: 124026385

Start: 1369052

End: 1369660

Strand: Reverse

Name: lexA [H]

Synonym: NATL1_16801

Alternate gene names: 124026385

Gene position: 1369660-1369052 (Counterclockwise)

Preceding gene: 124026386

Following gene: 124026383

Centisome position: 73.45

GC content: 40.89

Gene sequence:

>609_bases
ATGCCAGAAGAAACTCTAACTACTGCACAGCAAGAACTCTATGACTGGCTTGTAGATTTTATTGAAGATCATCATCACAG
CCCTTCGATCAGGCAAATGATGCAAGCTATGGGTCTAAGATCTCCGGCACCAATCCAAAGTCGTCTAAGACATTTACAAC
AAAAAGGGTGGATAAAATGGCAAGAAGGTCAGGCAAGAACGCTGCAATTAATAGAGGAGAGTATTTCTGGGGTACCTGTT
TTGGGAGCAATAGCTGCAGGTGGGTTGGTTGAAACTTTTGATGATGTACAGGAAACTCTAGACTTAAATTCAGTTCTTCA
ATTAAAGGGACTTTTTGCCTTGACGGTAAATGGAGATTCAATGATTGATTCTTTTATTGCAGACGGAGATATGGTTCTAA
TGGAACCTGTTAATGAGCCCGCTCGTCTGAGAAACGGAACGATTGTTAGCGCAATGGTTCCAGGATTAGGAACTACTTTG
AAACATTTTTTTCGTGATGGAAGTTTAGTCCGTTTAGAGGCCGCCAATACATCTTATGACCCTATAGAAATTGATGCTGA
ACAAGTTCATATTCAGGGAAAGTTAGCAGCTGTATGGAGGAAAACTTGA

Upstream 100 bases:

>100_bases
AAGCCTTGCTCGCCGTCCAGCTTGGAGGTATTTAGGGTTGCGATTTTTAGATATTTTAGGTACATATGTATTGAAGGACA
AATGTACTTAATCGATTCGA

Downstream 100 bases:

>100_bases
AGCTACTTCTAAAAACAATTAGAACTCTTAGTTCTTTTTGACTTCCAGGAGTTGAATAAAAATTTTCTATTTTTGTCTTC
ACTAAGAACTAAATTATCTG

Product: SOS function regulatory protein, LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MPEETLTTAQQELYDWLVDFIEDHHHSPSIRQMMQAMGLRSPAPIQSRLRHLQQKGWIKWQEGQARTLQLIEESISGVPV
LGAIAAGGLVETFDDVQETLDLNSVLQLKGLFALTVNGDSMIDSFIADGDMVLMEPVNEPARLRNGTIVSAMVPGLGTTL
KHFFRDGSLVRLEAANTSYDPIEIDAEQVHIQGKLAAVWRKT

Sequences:

>Translated_202_residues
MPEETLTTAQQELYDWLVDFIEDHHHSPSIRQMMQAMGLRSPAPIQSRLRHLQQKGWIKWQEGQARTLQLIEESISGVPV
LGAIAAGGLVETFDDVQETLDLNSVLQLKGLFALTVNGDSMIDSFIADGDMVLMEPVNEPARLRNGTIVSAMVPGLGTTL
KHFFRDGSLVRLEAANTSYDPIEIDAEQVHIQGKLAAVWRKT
>Mature_201_residues
PEETLTTAQQELYDWLVDFIEDHHHSPSIRQMMQAMGLRSPAPIQSRLRHLQQKGWIKWQEGQARTLQLIEESISGVPVL
GAIAAGGLVETFDDVQETLDLNSVLQLKGLFALTVNGDSMIDSFIADGDMVLMEPVNEPARLRNGTIVSAMVPGLGTTLK
HFFRDGSLVRLEAANTSYDPIEIDAEQVHIQGKLAAVWRKT

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=200, Percent_Identity=30.5, Blast_Score=86, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 22431; Mature: 22300

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEETLTTAQQELYDWLVDFIEDHHHSPSIRQMMQAMGLRSPAPIQSRLRHLQQKGWIKW
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEE
QEGQARTLQLIEESISGVPVLGAIAAGGLVETFDDVQETLDLNSVLQLKGLFALTVNGDS
CCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHH
MIDSFIADGDMVLMEPVNEPARLRNGTIVSAMVPGLGTTLKHFFRDGSLVRLEAANTSYD
HHHHHHCCCCEEEECCCCCHHHHCCCEEEEHHHCCCHHHHHHHHCCCCEEEEEECCCCCC
PIEIDAEQVHIQGKLAAVWRKT
CEEECHHHEEECHHHHHHCCCC
>Mature Secondary Structure 
PEETLTTAQQELYDWLVDFIEDHHHSPSIRQMMQAMGLRSPAPIQSRLRHLQQKGWIKW
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEE
QEGQARTLQLIEESISGVPVLGAIAAGGLVETFDDVQETLDLNSVLQLKGLFALTVNGDS
CCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHH
MIDSFIADGDMVLMEPVNEPARLRNGTIVSAMVPGLGTTLKHFFRDGSLVRLEAANTSYD
HHHHHHCCCCEEEECCCCCHHHHCCCEEEEHHHCCCHHHHHHHHCCCCEEEEEECCCCCC
PIEIDAEQVHIQGKLAAVWRKT
CEEECHHHEEECHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA