Click here to switch to the map view.

The map label for this gene is dxr

Identifier: 124026297

GI number: 124026297

Start: 1301178

End: 1302416

Strand: Direct

Name: dxr

Synonym: NATL1_15911

Alternate gene names: 124026297

Gene position: 1301178-1302416 (Clockwise)

Preceding gene: 124026295

Following gene: 124026302

Centisome position: 69.78

GC content: 39.79

Gene sequence:

>1239_bases
GTGAAAGCCATAAGCGTTTTAGGCTCAACAGGATCTATTGGGACTCAAACCCTTCAAATTGCAGAAGAGTTTCCTGATCA
ATTCAAAATTGTTGCACTAACAGCAGGAAAGAATCTTGATTTAGTAACCAAACAAATTGAAACGCATCAACCTGAAGTCG
TTTCACTAGCCGATGAGTCTCTTTTGCCAGAACTGACTAGGCGAATAAATAGTCTCAATGAAGATTCAAAAATATTAAAG
AAGCCCTTATTGATGGCGGGAGCCGAAGGACTTAATACTGCGGCAGCTTGGGGAAGTGCAGATCTTGTTGTAACTGGAAT
AGTTGGCTGTGCAGGCCTCCTGCCAACACTTGCAGCTATTGAAGCAGGGAAGGACCTAGCTCTAGCAAATAAAGAAACTT
TGATTGCAGCAGGACCAGTTGTCATTCCTGCTTTAAAAAAAAGTGGCAGTAGACTCTTACCTGCAGATTCTGAACACTCA
GCGATATTTCAATGTCTCCAAGGAACGCCATGGGCTGACAATGCAAGACTCTCAACTGGAGTGCCTACTCCAGGATTTAA
ATCAATACAATTAACTGCATCAGGAGGAGCATTTAGAGATTGGAAAGCAGAAGATTTAGTCAAAGCCACTGTCGAGGATG
CGACTAGCCATCCTAATTGGAGCATGGGAAAGAAAATAACTGTAGATTCTGCAACCCTCATGAATAAGGGACTCGAAGTC
ATTGAAGCGCATTATCTTTTTGGTCTTTCATATGACCAAATCGAAATCATTATCCATCCACAAAGCATCATTCACTCGAT
GGTTGAATTGGATGATTCATCAGTTTTAGCTCAATTGGGATGGCCAGACATGAAGCTCCCTATTTTGTATTGCTTAAGTT
GGCCTAGTCGACTTAAAACACCATGGCCAAGATTAAAGCTTACTCAAATAGGCAATTTAACTTTTAAAGAACCAGATACT
AACAAATATCCATGTATGGAACTTGCTTACAGCGCAGGAAAATCAGGGGGGACAATGCCAGCAGTGCTTAATGCCGCTAA
TGAAAAAGCAGTAGAACTTTTTCTAGAAGAAAGGTTTAAATTTATTGATATTCCAAAAGTAATTGAGGCGATTTGCGAGA
AACATAAATGCGACCTAAATCTAAATCCAAGCCTCAGTGAAATTCTTGAAATTGACAACTGGGCAAGAGAAGAAGTCTTA
GATTATTCAGAAAAAAATATTAAAAAAATGCAGTTTTAG

Upstream 100 bases:

>100_bases
TCTTGCATAATAAATCTCTATTAAAATCCAGAAGAAACTGGTAAATATATAACTGGGTTATACCTTTAAATGGGAGACTG
GTCATACTTGACTTCACAAT

Downstream 100 bases:

>100_bases
ATTAAATAGTTTTCAAAGATAAAAACCACTTACAAACAACTTGATCCCCCCAGCATCCTTCATTGCCATGAAATCCATTG
TGTCCGCCTTTCTCCGTAAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKAISVLGSTGSIGTQTLQIAEEFPDQFKIVALTAGKNLDLVTKQIETHQPEVVSLADESLLPELTRRINSLNEDSKILK
KPLLMAGAEGLNTAAAWGSADLVVTGIVGCAGLLPTLAAIEAGKDLALANKETLIAAGPVVIPALKKSGSRLLPADSEHS
AIFQCLQGTPWADNARLSTGVPTPGFKSIQLTASGGAFRDWKAEDLVKATVEDATSHPNWSMGKKITVDSATLMNKGLEV
IEAHYLFGLSYDQIEIIIHPQSIIHSMVELDDSSVLAQLGWPDMKLPILYCLSWPSRLKTPWPRLKLTQIGNLTFKEPDT
NKYPCMELAYSAGKSGGTMPAVLNAANEKAVELFLEERFKFIDIPKVIEAICEKHKCDLNLNPSLSEILEIDNWAREEVL
DYSEKNIKKMQF

Sequences:

>Translated_412_residues
MKAISVLGSTGSIGTQTLQIAEEFPDQFKIVALTAGKNLDLVTKQIETHQPEVVSLADESLLPELTRRINSLNEDSKILK
KPLLMAGAEGLNTAAAWGSADLVVTGIVGCAGLLPTLAAIEAGKDLALANKETLIAAGPVVIPALKKSGSRLLPADSEHS
AIFQCLQGTPWADNARLSTGVPTPGFKSIQLTASGGAFRDWKAEDLVKATVEDATSHPNWSMGKKITVDSATLMNKGLEV
IEAHYLFGLSYDQIEIIIHPQSIIHSMVELDDSSVLAQLGWPDMKLPILYCLSWPSRLKTPWPRLKLTQIGNLTFKEPDT
NKYPCMELAYSAGKSGGTMPAVLNAANEKAVELFLEERFKFIDIPKVIEAICEKHKCDLNLNPSLSEILEIDNWAREEVL
DYSEKNIKKMQF
>Mature_412_residues
MKAISVLGSTGSIGTQTLQIAEEFPDQFKIVALTAGKNLDLVTKQIETHQPEVVSLADESLLPELTRRINSLNEDSKILK
KPLLMAGAEGLNTAAAWGSADLVVTGIVGCAGLLPTLAAIEAGKDLALANKETLIAAGPVVIPALKKSGSRLLPADSEHS
AIFQCLQGTPWADNARLSTGVPTPGFKSIQLTASGGAFRDWKAEDLVKATVEDATSHPNWSMGKKITVDSATLMNKGLEV
IEAHYLFGLSYDQIEIIIHPQSIIHSMVELDDSSVLAQLGWPDMKLPILYCLSWPSRLKTPWPRLKLTQIGNLTFKEPDT
NKYPCMELAYSAGKSGGTMPAVLNAANEKAVELFLEERFKFIDIPKVIEAICEKHKCDLNLNPSLSEILEIDNWAREEVL
DYSEKNIKKMQF

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=400, Percent_Identity=43.75, Blast_Score=307, Evalue=6e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_PROM1 (A2C3T8)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015413.1
- ProteinModelPortal:   A2C3T8
- SMR:   A2C3T8
- STRING:   A2C3T8
- GeneID:   4780265
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_15911
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   PMAR167555:NATL1_15911-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 44873; Mature: 44873

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: BINDING 131-131 BINDING 158-158 BINDING 194-194 BINDING 217-217 BINDING 239-239

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAISVLGSTGSIGTQTLQIAEEFPDQFKIVALTAGKNLDLVTKQIETHQPEVVSLADES
CCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEHHHHH
LLPELTRRINSLNEDSKILKKPLLMAGAEGLNTAAAWGSADLVVTGIVGCAGLLPTLAAI
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EAGKDLALANKETLIAAGPVVIPALKKSGSRLLPADSEHSAIFQCLQGTPWADNARLSTG
HCCCCEEECCCCEEEEECCEEEEHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECCC
VPTPGFKSIQLTASGGAFRDWKAEDLVKATVEDATSHPNWSMGKKITVDSATLMNKGLEV
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHCHHH
IEAHYLFGLSYDQIEIIIHPQSIIHSMVELDDSSVLAQLGWPDMKLPILYCLSWPSRLKT
HHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCHHHHHCCCCCCCCHHHEEECCHHHHCC
PWPRLKLTQIGNLTFKEPDTNKYPCMELAYSAGKSGGTMPAVLNAANEKAVELFLEERFK
CCCCEEEEEECCEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHC
FIDIPKVIEAICEKHKCDLNLNPSLSEILEIDNWAREEVLDYSEKNIKKMQF
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MKAISVLGSTGSIGTQTLQIAEEFPDQFKIVALTAGKNLDLVTKQIETHQPEVVSLADES
CCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEHHHHH
LLPELTRRINSLNEDSKILKKPLLMAGAEGLNTAAAWGSADLVVTGIVGCAGLLPTLAAI
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EAGKDLALANKETLIAAGPVVIPALKKSGSRLLPADSEHSAIFQCLQGTPWADNARLSTG
HCCCCEEECCCCEEEEECCEEEEHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECCC
VPTPGFKSIQLTASGGAFRDWKAEDLVKATVEDATSHPNWSMGKKITVDSATLMNKGLEV
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHCHHH
IEAHYLFGLSYDQIEIIIHPQSIIHSMVELDDSSVLAQLGWPDMKLPILYCLSWPSRLKT
HHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCHHHHHCCCCCCCCHHHEEECCHHHHCC
PWPRLKLTQIGNLTFKEPDTNKYPCMELAYSAGKSGGTMPAVLNAANEKAVELFLEERFK
CCCCEEEEEECCEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHC
FIDIPKVIEAICEKHKCDLNLNPSLSEILEIDNWAREEVLDYSEKNIKKMQF
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA