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The map label for this gene is trxA [H]

Identifier: 124026231

GI number: 124026231

Start: 1242759

End: 1243082

Strand: Direct

Name: trxA [H]

Synonym: NATL1_15251

Alternate gene names: 124026231

Gene position: 1242759-1243082 (Clockwise)

Preceding gene: 124026230

Following gene: 124026232

Centisome position: 66.65

GC content: 42.9

Gene sequence:

>324_bases
ATGTCCACAGCTTCTGCAGTAACTGATTCTTCTTTCGAACAAGAAGTCCTCCAGAGCGATGTTCCTGTTTTGGTTGATTT
TTGGGCACCTTGGTGCGGACCATGCAGAATGGTTGCTCCAATTGTCGAAGAGATCTCAAAAGATTTTGAAGGCAAAATAA
AAGTTTACAAATTGAATACCGATGAGAATCCTAATGTTGCTAGCCAGTATGGGATCAGAAGCATCCCAACGCTGATGATA
TTCAAAGGAGGTCAGAAAGTAGATACCGTTGTGGGAGCAGTCCCTAAAGCCACCCTCTCAGGAACAATTTCCAAACATCT
CTAA

Upstream 100 bases:

>100_bases
AGGGGCCGAATGAATATTCAAACTTCGTTTAAAAATGGCAGAAAAACTTTTTATAGGCAAAATACAATTGTTATGATCAA
GTTCTTAAGACTTCTAAGGT

Downstream 100 bases:

>100_bases
TCCCAAAATTTAGAAGTTCTAGAGCCCAATTCAAATGATTCATAGGTAAATCTTTTGACAAAAATTGGATTAATAGATTA
TGGAATGGGTAATCTTTTTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSTASAVTDSSFEQEVLQSDVPVLVDFWAPWCGPCRMVAPIVEEISKDFEGKIKVYKLNTDENPNVASQYGIRSIPTLMI
FKGGQKVDTVVGAVPKATLSGTISKHL

Sequences:

>Translated_107_residues
MSTASAVTDSSFEQEVLQSDVPVLVDFWAPWCGPCRMVAPIVEEISKDFEGKIKVYKLNTDENPNVASQYGIRSIPTLMI
FKGGQKVDTVVGAVPKATLSGTISKHL
>Mature_106_residues
STASAVTDSSFEQEVLQSDVPVLVDFWAPWCGPCRMVAPIVEEISKDFEGKIKVYKLNTDENPNVASQYGIRSIPTLMIF
KGGQKVDTVVGAVPKATLSGTISKHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=34.0425531914894, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI5031973, Length=83, Percent_Identity=38.5542168674699, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI42794771, Length=88, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=8e-13,
Organism=Homo sapiens, GI224493972, Length=88, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI50592994, Length=94, Percent_Identity=38.2978723404255, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI21361657, Length=103, Percent_Identity=33.9805825242718, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=51.4851485148515, Blast_Score=123, Evalue=3e-30,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=50.5376344086022, Blast_Score=113, Evalue=3e-27,
Organism=Escherichia coli, GI87081747, Length=102, Percent_Identity=32.3529411764706, Blast_Score=70, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=92, Percent_Identity=39.1304347826087, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17507705, Length=84, Percent_Identity=38.0952380952381, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=37.2093023255814, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=39.1891891891892, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=74, Percent_Identity=39.1891891891892, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=35.8974358974359, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=74, Percent_Identity=39.1891891891892, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=72, Percent_Identity=38.8888888888889, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=75, Percent_Identity=40, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=86, Percent_Identity=33.7209302325581, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=86, Percent_Identity=33.7209302325581, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=81, Percent_Identity=35.8024691358025, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=44.4444444444444, Blast_Score=84, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=42.0454545454545, Blast_Score=84, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=92, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324862, Length=80, Percent_Identity=33.75, Blast_Score=63, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639826, Length=98, Percent_Identity=34.6938775510204, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28573567, Length=85, Percent_Identity=38.8235294117647, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664269, Length=82, Percent_Identity=41.4634146341463, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19921434, Length=83, Percent_Identity=37.3493975903614, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=41.8918918918919, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=41.8918918918919, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24658597, Length=108, Percent_Identity=32.4074074074074, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358065, Length=81, Percent_Identity=37.037037037037, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24639068, Length=92, Percent_Identity=28.2608695652174, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11615; Mature: 11484

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTASAVTDSSFEQEVLQSDVPVLVDFWAPWCGPCRMVAPIVEEISKDFEGKIKVYKLNT
CCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
DENPNVASQYGIRSIPTLMIFKGGQKVDTVVGAVPKATLSGTISKHL
CCCCCHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCHHHHCHHHCCC
>Mature Secondary Structure 
STASAVTDSSFEQEVLQSDVPVLVDFWAPWCGPCRMVAPIVEEISKDFEGKIKVYKLNT
CCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
DENPNVASQYGIRSIPTLMIFKGGQKVDTVVGAVPKATLSGTISKHL
CCCCCHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCHHHHCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]