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The map label for this gene is guaB [C]

Identifier: 124026230

GI number: 124026230

Start: 1241379

End: 1242542

Strand: Direct

Name: guaB [C]

Synonym: NATL1_15241

Alternate gene names: 124026230

Gene position: 1241379-1242542 (Clockwise)

Preceding gene: 124026227

Following gene: 124026231

Centisome position: 66.57

GC content: 41.24

Gene sequence:

>1164_bases
GTGAATATTCAACTAGGACGCACCAAAATTGTTCGAAGAGCCTACGGGATTGATGAGATTGCATTAGTTCCTGGAAGAAG
AACAGTTGACCCTGGCATCACAAAAACCAATTGGGAAATCGGTGGAATTGAAAGGGATATTCCCATAATCGCAAGCGCGA
TGGATGGTGTTGTAGATGTAAACATGGCCGTAGCCTTGTCAAAATTAGGAGCCCTAGGTGTTTTAAATCTAGAAGGAGTA
CAAACTAGATATGAAGATCCCAAAGAAGTTCTAACGAAAATCCAATCGATCGGGAAAGAGGAATTTGTTCCCCTAATGCA
AGAAATCTATAATAAGCCGATCAAAGAAAAGTTAATTTTAAAAAGAATTCAAGAAATCAAAGATAGTGGGGGTATTGCTG
CTGTAAGCGGGACACCATTAGCAGCAATTAAATATAAAAATCTAGTCAAAGACTCAGGTGCAGACTTATTTTTCCTTCAG
GCGACTGTAGTTTCAACAGAACATCTGGGTAAAGAGGGTAGTCAAAATCTTGATCTTTATGATCTTTGCGAAAACATTGG
CATACCGGTTGCTGTGGGTAATTGCGTTACTTATGAAGTGTCTTTAAAGCTTATGAAAGCAGGCGCTGCCGCAGTGATGG
TTGGTATTGGACCTGGAGCCGCATGCACCTCCAGAGGAGTATTAGGGGTTGGAATTCCTCAAGCAACTGCTATTTCTGAT
TGCGCTGCTGCAAGGGATGATTTTCAAAAAGAAAGTGGGAAATATGTCCCAATTATTGCTGATGGAGGAATTATCACTGG
TGGGGATATTTGCAAATGCATAGCATGTGGTGCTGATTCAGTGATGATTGGTTCCCCTATCGCAAGATCTCAGGAGGCTC
CAGGTAAAGGTTTCCATTGGGGTATGGCAACACCAAGTCCTGTTCTACCAAGAGGTACAAGGATTCAAGTTGGAACAACC
GGTAGTTTAAAAAGTATTCTTTGTGGACCAGCAATTCTTGATGATGGAACCCACAATTTATTAGGAGCAATAAAAACCTC
AATGGGAACTCTAGGCGCAACTAATATCAAGGAAATGCAAAATGTTGAGGTAGTTATCGCACCTTCTTTGTTAACAGAAG
GAAAGGTTTACCAAAAAGCGCAACAGCTTGGAATGGGAAAGTAA

Upstream 100 bases:

>100_bases
TAATCTGAAAAAATAAGCCAAATCTTGATTATCTATTCCCAACATTTGCTCAATTTGGCACTTCAGTTGGTAGTTTGACG
AGAACTTACAAAATTTAGGT

Downstream 100 bases:

>100_bases
AGCTACCGAAAGATTTCAGAATTAAATACACTGGCTACAATTGAGTAGTGAGAGCCCTTGCTCTCACACTCCTCACACTT
AAAAATGCCCGACTTGTTCG

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNIQLGRTKIVRRAYGIDEIALVPGRRTVDPGITKTNWEIGGIERDIPIIASAMDGVVDVNMAVALSKLGALGVLNLEGV
QTRYEDPKEVLTKIQSIGKEEFVPLMQEIYNKPIKEKLILKRIQEIKDSGGIAAVSGTPLAAIKYKNLVKDSGADLFFLQ
ATVVSTEHLGKEGSQNLDLYDLCENIGIPVAVGNCVTYEVSLKLMKAGAAAVMVGIGPGAACTSRGVLGVGIPQATAISD
CAAARDDFQKESGKYVPIIADGGIITGGDICKCIACGADSVMIGSPIARSQEAPGKGFHWGMATPSPVLPRGTRIQVGTT
GSLKSILCGPAILDDGTHNLLGAIKTSMGTLGATNIKEMQNVEVVIAPSLLTEGKVYQKAQQLGMGK

Sequences:

>Translated_387_residues
MNIQLGRTKIVRRAYGIDEIALVPGRRTVDPGITKTNWEIGGIERDIPIIASAMDGVVDVNMAVALSKLGALGVLNLEGV
QTRYEDPKEVLTKIQSIGKEEFVPLMQEIYNKPIKEKLILKRIQEIKDSGGIAAVSGTPLAAIKYKNLVKDSGADLFFLQ
ATVVSTEHLGKEGSQNLDLYDLCENIGIPVAVGNCVTYEVSLKLMKAGAAAVMVGIGPGAACTSRGVLGVGIPQATAISD
CAAARDDFQKESGKYVPIIADGGIITGGDICKCIACGADSVMIGSPIARSQEAPGKGFHWGMATPSPVLPRGTRIQVGTT
GSLKSILCGPAILDDGTHNLLGAIKTSMGTLGATNIKEMQNVEVVIAPSLLTEGKVYQKAQQLGMGK
>Mature_387_residues
MNIQLGRTKIVRRAYGIDEIALVPGRRTVDPGITKTNWEIGGIERDIPIIASAMDGVVDVNMAVALSKLGALGVLNLEGV
QTRYEDPKEVLTKIQSIGKEEFVPLMQEIYNKPIKEKLILKRIQEIKDSGGIAAVSGTPLAAIKYKNLVKDSGADLFFLQ
ATVVSTEHLGKEGSQNLDLYDLCENIGIPVAVGNCVTYEVSLKLMKAGAAAVMVGIGPGAACTSRGVLGVGIPQATAISD
CAAARDDFQKESGKYVPIIADGGIITGGDICKCIACGADSVMIGSPIARSQEAPGKGFHWGMATPSPVLPRGTRIQVGTT
GSLKSILCGPAILDDGTHNLLGAIKTSMGTLGATNIKEMQNVEVVIAPSLLTEGKVYQKAQQLGMGK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=106, Percent_Identity=43.3962264150943, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI217035150, Length=106, Percent_Identity=42.4528301886792, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI217035148, Length=106, Percent_Identity=42.4528301886792, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI217035146, Length=106, Percent_Identity=42.4528301886792, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI34328930, Length=106, Percent_Identity=42.4528301886792, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI217035152, Length=106, Percent_Identity=42.4528301886792, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI156104880, Length=197, Percent_Identity=28.4263959390863, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI34328928, Length=106, Percent_Identity=42.4528301886792, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI50541954, Length=197, Percent_Identity=28.4263959390863, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI50541952, Length=197, Percent_Identity=28.4263959390863, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI50541948, Length=197, Percent_Identity=28.4263959390863, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI156616279, Length=106, Percent_Identity=42.4528301886792, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI50541956, Length=197, Percent_Identity=28.4263959390863, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786293, Length=329, Percent_Identity=27.0516717325228, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788855, Length=196, Percent_Identity=34.1836734693878, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560440, Length=181, Percent_Identity=32.5966850828729, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994385, Length=129, Percent_Identity=37.2093023255814, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71994389, Length=129, Percent_Identity=37.2093023255814, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322012, Length=113, Percent_Identity=37.1681415929204, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323585, Length=112, Percent_Identity=33.9285714285714, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323464, Length=112, Percent_Identity=33.9285714285714, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641071, Length=165, Percent_Identity=34.5454545454545, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24641073, Length=165, Percent_Identity=34.5454545454545, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28571163, Length=165, Percent_Identity=34.5454545454545, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 40612; Mature: 40612

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQLGRTKIVRRAYGIDEIALVPGRRTVDPGITKTNWEIGGIERDIPIIASAMDGVVDV
CCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCEEH
NMAVALSKLGALGVLNLEGVQTRYEDPKEVLTKIQSIGKEEFVPLMQEIYNKPIKEKLIL
HHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHH
KRIQEIKDSGGIAAVSGTPLAAIKYKNLVKDSGADLFFLQATVVSTEHLGKEGSQNLDLY
HHHHHHHCCCCEEEECCCCEEEHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCCCCCCCHH
DLCENIGIPVAVGNCVTYEVSLKLMKAGAAAVMVGIGPGAACTSRGVLGVGIPQATAISD
HHHHHCCCCEEECCEEEEEEEEEEECCCCEEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CAAARDDFQKESGKYVPIIADGGIITGGDICKCIACGADSVMIGSPIARSQEAPGKGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECCHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEC
GMATPSPVLPRGTRIQVGTTGSLKSILCGPAILDDGTHNLLGAIKTSMGTLGATNIKEMQ
CCCCCCCCCCCCCEEEEECCCCHHHHHHCCHHCCCCCHHHHHHHHHHHCCCCCCCHHHHC
NVEVVIAPSLLTEGKVYQKAQQLGMGK
CCEEEEECCHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNIQLGRTKIVRRAYGIDEIALVPGRRTVDPGITKTNWEIGGIERDIPIIASAMDGVVDV
CCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCEEH
NMAVALSKLGALGVLNLEGVQTRYEDPKEVLTKIQSIGKEEFVPLMQEIYNKPIKEKLIL
HHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHH
KRIQEIKDSGGIAAVSGTPLAAIKYKNLVKDSGADLFFLQATVVSTEHLGKEGSQNLDLY
HHHHHHHCCCCEEEECCCCEEEHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCCCCCCCHH
DLCENIGIPVAVGNCVTYEVSLKLMKAGAAAVMVGIGPGAACTSRGVLGVGIPQATAISD
HHHHHCCCCEEECCEEEEEEEEEEECCCCEEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CAAARDDFQKESGKYVPIIADGGIITGGDICKCIACGADSVMIGSPIARSQEAPGKGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECCHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEC
GMATPSPVLPRGTRIQVGTTGSLKSILCGPAILDDGTHNLLGAIKTSMGTLGATNIKEMQ
CCCCCCCCCCCCCEEEEECCCCHHHHHHCCHHCCCCCHHHHHHHHHHHCCCCCCCHHHHC
NVEVVIAPSLLTEGKVYQKAQQLGMGK
CCEEEEECCHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA