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The map label for this gene is gyrA [H]

Identifier: 124026229

GI number: 124026229

Start: 1238506

End: 1241124

Strand: Reverse

Name: gyrA [H]

Synonym: NATL1_15231

Alternate gene names: 124026229

Gene position: 1241124-1238506 (Counterclockwise)

Preceding gene: 124026234

Following gene: 124026228

Centisome position: 66.56

GC content: 37.23

Gene sequence:

>2619_bases
ATGGCTGATCCATTGGGACCTAATAGTACTGGTCCTGGGGAATCCGACGATCGGATCATTCAGACTGACTTAAGAAACGA
AATGTCGCGTTCCTATTTGGAATACGCGATGAGTGTGATTGTTGGGAGAGCTTTACCTGATTCGAGAGATGGACTTAAAC
CAGTTCACCGAAGGATCCTTTATGCAATGTATGAACTTGGACTGACTAGCGACAGACCTTACAGGAAATGCGCACGTGTG
GTTGGAGAGGTTTTAGGTAAATTCCATCCTCATGGTGATACCGCCGTTTATGACGCCTTGGTCCGAATGGCGCAAGATTT
TTCCATGCAGATGCCTTTAATAGATGGGCATGGGAATTTTGGATCTGTTGATAATGATCCTCCTGCCGCAATGAGATATA
CAGAATCCAGATTACAATCTTTGACTACAGACAGCTTGCTTGAAGATATTGAATCTGAAACAGTTGATTTCGCCGATAAC
TTTGATGGATCAGTACAAGAACCCACAGTATTACCGGCAAGAATTCCACAATTGCTTTTAAATGGTTCGTCTGGAATAGC
TGTAGGTATGGCAACCAACATACCTCCACATAATTTGGCCGAATTGATTGATGGATTGATGGCTTTAATTTCTAATCCTG
AGTTAGAAGAAATAGATTTGATGAATATAATTAAAGGTCCTGATTTTCCGACCGGTGGTCAGATCCTTGGCAGGAGTGGA
ATTAAGGAAACATATCTTTCTGGTAAAGGTTCAATCACCATGCGTGGAGTGGCTGAAATAGAAACAATTGAAAATCCAGG
GAGACCTGATAGGGACGCAGTGATAATTACTGAACTTCCTTATCAAACAAATAAAGCAGGATTAATTGAAAGAATCGCTG
ATATGGTGAACGATAAAAAACTTGAAGGTATTGCAGACATTAGAGATGAAAGTGATAGAGATGGTATGAGAATTGTTGTT
GAATTAAGAAGAGATTCATATCCTCAAGTTGTTTTAAATAATTTATTTAAACTTACTCCTTTACAGACTAATTTTAGTGC
AAATATGCTTGCATTAGTTAATGGTGAGCCTGTTATATTGTCACTTAGAAAGATGTTGCAAGTATTTTTAGATTTTAGAG
TAGAAACTATTGAGAAAAGAACTAAATATCTTTTAAAGAAGGCGGAGAGCAGAGATCATATATTATTAGGATTATTATTA
GCTTTAGATCAGCTAGATGAAATAATTAGTCTTATCAGATCAGCATCAGATTCGACTACGGCAAAAAATAAATTACAAGA
ACTGCATGGCTTAACAGATATTCAGTCTGATGCTATTTTGCAGATGCAGTTACGAAGACTGACCGCTTTAGAGGCAGATA
AGATAAGACTTGAACATGAGGATTTAGTTAAAAAAATAATAGATTTAAAAGATATCTTGAATAAGAAAGAAAGGGTATTT
GAAATAACAAAAATAGAATTAAATGAAATAAAAGAAAAATATAATACCCAAAGAAGAACAGAGATTCTTGATCTTGGCGG
AGGGCTTGAGGATATTGATTTAATTGCGAATGAAAGATCAGTTGTTTTGTTGACCGAGACAGGATATTTAAAGAGGATGC
CTGTTAATGAATTTGAAGCAACAAGTCGAGGTACTAGAGGTAAAGCAGGAACGCGAAGCCAAGGAGAGGAAGAGGTGAAA
AAATTTATTAGTTGTAATGACCATGACAGCCTTCTCCTTTTTAGTGATAGAGGTATTTCTTATGCTCTTCCTGCTTACAG
AGTTCCTCAATGTAGTAGAACTGCAAAAGGTACACCTATTGTTCAATTGCTTCCAATTCCGCGTGAAGAAGCTATTACTT
CATTGCTTTCTGTGAGTTCTTTTGATGATGAAAACTATTTATTGATGCTTACTAGAGGGGGGTATATAAAAAGGACACCT
CTTTCAGCTTTTAGCAAGATCAGAGCAAATGGGCTAATTGCAATAGGTTTAGAGGATGGTGATGCTTTGACTTGGGTTCG
ACTGGCTGAGTCTGGAGATAGTGTTTTGATTGGTTCCAAAAATGGAATGACAATCCATTTTAGATTAAATGATTCTGAAT
TACGCCCTTTAGGAAGATCAGCAAGAGGGGTCAAGTCAATGAATCTTAAGTCGGGTGATTCACTTGTAAGTATGGATGTT
TTGTCTACTGAGTTGGCTGATCATGTTGATAAAAGTGAAGAAGATGAACTACAGAGTGAATCATCAGAATCTGAAGGTCC
TTGGGTACTTGTTGCCTCTGGAAGCGGACTAGGTAAAAGAGTTCCTATGACACAATTTCGCTTGCAAAAAAGAGCTGGTA
TGGGTTTAAGAGCGATAAAATTCAGGAAAGATGGAGATGAACTTGTAGGTTTAAGGGTTCTGGGTAAAGGAGAAGAATTA
TTATTAGTTAGTGAAAGAGGAGTAATTGTTAGAACTAGTGCAGATAAAATCTCTCAACAATCCAGAGCTGCAACCGGCGT
AAGAATTCAAAAGCTTGATAATGGCGATAAGTTATCGGAGGTTGTTTTAGTTCCCCCAGAGCAAATTAATGATGATGATG
AGAATCAATCATCATTATCTAAAGAATCAATAAATACTGATACAACGTCAAAAAATTGA

Upstream 100 bases:

>100_bases
TTGATTTTGTTGGAGGTGATTTACTTTCAGATATCTGGTTATTCACTTTAAAAGGTTTATTAATGCTCAGATGTTCTTAT
AATTGGTAAAACCTTTATAT

Downstream 100 bases:

>100_bases
AATTGAATAATGTCGCTGATGTATTAGTCATGGGAGCAGGACCTGCTGCTCTTTGCATCGCTGCTGAGTTAGTTCAACAC
GGACTTGATGTTCAGGCGAT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 872; Mature: 871

Protein sequence:

>872_residues
MADPLGPNSTGPGESDDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDSRDGLKPVHRRILYAMYELGLTSDRPYRKCARV
VGEVLGKFHPHGDTAVYDALVRMAQDFSMQMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTTDSLLEDIESETVDFADN
FDGSVQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLAELIDGLMALISNPELEEIDLMNIIKGPDFPTGGQILGRSG
IKETYLSGKGSITMRGVAEIETIENPGRPDRDAVIITELPYQTNKAGLIERIADMVNDKKLEGIADIRDESDRDGMRIVV
ELRRDSYPQVVLNNLFKLTPLQTNFSANMLALVNGEPVILSLRKMLQVFLDFRVETIEKRTKYLLKKAESRDHILLGLLL
ALDQLDEIISLIRSASDSTTAKNKLQELHGLTDIQSDAILQMQLRRLTALEADKIRLEHEDLVKKIIDLKDILNKKERVF
EITKIELNEIKEKYNTQRRTEILDLGGGLEDIDLIANERSVVLLTETGYLKRMPVNEFEATSRGTRGKAGTRSQGEEEVK
KFISCNDHDSLLLFSDRGISYALPAYRVPQCSRTAKGTPIVQLLPIPREEAITSLLSVSSFDDENYLLMLTRGGYIKRTP
LSAFSKIRANGLIAIGLEDGDALTWVRLAESGDSVLIGSKNGMTIHFRLNDSELRPLGRSARGVKSMNLKSGDSLVSMDV
LSTELADHVDKSEEDELQSESSESEGPWVLVASGSGLGKRVPMTQFRLQKRAGMGLRAIKFRKDGDELVGLRVLGKGEEL
LLVSERGVIVRTSADKISQQSRAATGVRIQKLDNGDKLSEVVLVPPEQINDDDENQSSLSKESINTDTTSKN

Sequences:

>Translated_872_residues
MADPLGPNSTGPGESDDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDSRDGLKPVHRRILYAMYELGLTSDRPYRKCARV
VGEVLGKFHPHGDTAVYDALVRMAQDFSMQMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTTDSLLEDIESETVDFADN
FDGSVQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLAELIDGLMALISNPELEEIDLMNIIKGPDFPTGGQILGRSG
IKETYLSGKGSITMRGVAEIETIENPGRPDRDAVIITELPYQTNKAGLIERIADMVNDKKLEGIADIRDESDRDGMRIVV
ELRRDSYPQVVLNNLFKLTPLQTNFSANMLALVNGEPVILSLRKMLQVFLDFRVETIEKRTKYLLKKAESRDHILLGLLL
ALDQLDEIISLIRSASDSTTAKNKLQELHGLTDIQSDAILQMQLRRLTALEADKIRLEHEDLVKKIIDLKDILNKKERVF
EITKIELNEIKEKYNTQRRTEILDLGGGLEDIDLIANERSVVLLTETGYLKRMPVNEFEATSRGTRGKAGTRSQGEEEVK
KFISCNDHDSLLLFSDRGISYALPAYRVPQCSRTAKGTPIVQLLPIPREEAITSLLSVSSFDDENYLLMLTRGGYIKRTP
LSAFSKIRANGLIAIGLEDGDALTWVRLAESGDSVLIGSKNGMTIHFRLNDSELRPLGRSARGVKSMNLKSGDSLVSMDV
LSTELADHVDKSEEDELQSESSESEGPWVLVASGSGLGKRVPMTQFRLQKRAGMGLRAIKFRKDGDELVGLRVLGKGEEL
LLVSERGVIVRTSADKISQQSRAATGVRIQKLDNGDKLSEVVLVPPEQINDDDENQSSLSKESINTDTTSKN
>Mature_871_residues
ADPLGPNSTGPGESDDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDSRDGLKPVHRRILYAMYELGLTSDRPYRKCARVV
GEVLGKFHPHGDTAVYDALVRMAQDFSMQMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTTDSLLEDIESETVDFADNF
DGSVQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLAELIDGLMALISNPELEEIDLMNIIKGPDFPTGGQILGRSGI
KETYLSGKGSITMRGVAEIETIENPGRPDRDAVIITELPYQTNKAGLIERIADMVNDKKLEGIADIRDESDRDGMRIVVE
LRRDSYPQVVLNNLFKLTPLQTNFSANMLALVNGEPVILSLRKMLQVFLDFRVETIEKRTKYLLKKAESRDHILLGLLLA
LDQLDEIISLIRSASDSTTAKNKLQELHGLTDIQSDAILQMQLRRLTALEADKIRLEHEDLVKKIIDLKDILNKKERVFE
ITKIELNEIKEKYNTQRRTEILDLGGGLEDIDLIANERSVVLLTETGYLKRMPVNEFEATSRGTRGKAGTRSQGEEEVKK
FISCNDHDSLLLFSDRGISYALPAYRVPQCSRTAKGTPIVQLLPIPREEAITSLLSVSSFDDENYLLMLTRGGYIKRTPL
SAFSKIRANGLIAIGLEDGDALTWVRLAESGDSVLIGSKNGMTIHFRLNDSELRPLGRSARGVKSMNLKSGDSLVSMDVL
STELADHVDKSEEDELQSESSESEGPWVLVASGSGLGKRVPMTQFRLQKRAGMGLRAIKFRKDGDELVGLRVLGKGEELL
LVSERGVIVRTSADKISQQSRAATGVRIQKLDNGDKLSEVVLVPPEQINDDDENQSSLSKESINTDTTSKN

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=522, Percent_Identity=24.1379310344828, Blast_Score=86, Evalue=2e-16,
Organism=Escherichia coli, GI1788562, Length=843, Percent_Identity=41.8742586002372, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=735, Percent_Identity=36.3265306122449, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17535065, Length=356, Percent_Identity=23.876404494382, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=183, Percent_Identity=31.6939890710383, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=351, Percent_Identity=25.3561253561254, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96521; Mature: 96390

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPLGPNSTGPGESDDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDSRDGLKPVHRRIL
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
YAMYELGLTSDRPYRKCARVVGEVLGKFHPHGDTAVYDALVRMAQDFSMQMPLIDGHGNF
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTTDSLLEDIESETVDFADNFDGSVQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLAELIDGLMALISNPELEEIDLMNIIKGPDFPTGGQILGRSG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHCCCC
IKETYLSGKGSITMRGVAEIETIENPGRPDRDAVIITELPYQTNKAGLIERIADMVNDKK
CHHHHHCCCCCEEECCHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHH
LEGIADIRDESDRDGMRIVVELRRDSYPQVVLNNLFKLTPLQTNFSANMLALVNGEPVIL
HCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCHHHH
SLRKMLQVFLDFRVETIEKRTKYLLKKAESRDHILLGLLLALDQLDEIISLIRSASDSTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AKNKLQELHGLTDIQSDAILQMQLRRLTALEADKIRLEHEDLVKKIIDLKDILNKKERVF
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCHHHHHE
EITKIELNEIKEKYNTQRRTEILDLGGGLEDIDLIANERSVVLLTETGYLKRMPVNEFEA
EHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHEECCCEEEEEECCCCEECCCCCHHHH
TSRGTRGKAGTRSQGEEEVKKFISCNDHDSLLLFSDRGISYALPAYRVPQCSRTAKGTPI
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCE
VQLLPIPREEAITSLLSVSSFDDENYLLMLTRGGYIKRTPLSAFSKIRANGLIAIGLEDG
EEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECHHHHHHHHHCCCEEEEEECCC
DALTWVRLAESGDSVLIGSKNGMTIHFRLNDSELRPLGRSARGVKSMNLKSGDSLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEECCHHCCCCCCHHCCCCCCCCCCCCCEEEHHH
LSTELADHVDKSEEDELQSESSESEGPWVLVASGSGLGKRVPMTQFRLQKRAGMGLRAIK
HHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEE
FRKDGDELVGLRVLGKGEELLLVSERGVIVRTSADKISQQSRAATGVRIQKLDNGDKLSE
EECCCCCEEEEEEECCCCEEEEEECCCEEEEECHHHHHHHHHHHCCCEEEECCCCCCCCE
VVLVPPEQINDDDENQSSLSKESINTDTTSKN
EEEECCHHCCCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADPLGPNSTGPGESDDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDSRDGLKPVHRRIL
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
YAMYELGLTSDRPYRKCARVVGEVLGKFHPHGDTAVYDALVRMAQDFSMQMPLIDGHGNF
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTTDSLLEDIESETVDFADNFDGSVQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLAELIDGLMALISNPELEEIDLMNIIKGPDFPTGGQILGRSG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHCCCC
IKETYLSGKGSITMRGVAEIETIENPGRPDRDAVIITELPYQTNKAGLIERIADMVNDKK
CHHHHHCCCCCEEECCHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHH
LEGIADIRDESDRDGMRIVVELRRDSYPQVVLNNLFKLTPLQTNFSANMLALVNGEPVIL
HCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCHHHH
SLRKMLQVFLDFRVETIEKRTKYLLKKAESRDHILLGLLLALDQLDEIISLIRSASDSTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AKNKLQELHGLTDIQSDAILQMQLRRLTALEADKIRLEHEDLVKKIIDLKDILNKKERVF
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCHHHHHE
EITKIELNEIKEKYNTQRRTEILDLGGGLEDIDLIANERSVVLLTETGYLKRMPVNEFEA
EHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHEECCCEEEEEECCCCEECCCCCHHHH
TSRGTRGKAGTRSQGEEEVKKFISCNDHDSLLLFSDRGISYALPAYRVPQCSRTAKGTPI
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCE
VQLLPIPREEAITSLLSVSSFDDENYLLMLTRGGYIKRTPLSAFSKIRANGLIAIGLEDG
EEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECHHHHHHHHHCCCEEEEEECCC
DALTWVRLAESGDSVLIGSKNGMTIHFRLNDSELRPLGRSARGVKSMNLKSGDSLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEECCHHCCCCCCHHCCCCCCCCCCCCCEEEHHH
LSTELADHVDKSEEDELQSESSESEGPWVLVASGSGLGKRVPMTQFRLQKRAGMGLRAIK
HHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEE
FRKDGDELVGLRVLGKGEELLLVSERGVIVRTSADKISQQSRAATGVRIQKLDNGDKLSE
EECCCCCEEEEEEECCCCEEEEEECCCEEEEECHHHHHHHHHHHCCCEEEECCCCCCCCE
VVLVPPEQINDDDENQSSLSKESINTDTTSKN
EEEECCHHCCCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]