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The map label for this gene is wecC [H]

Identifier: 124025571

GI number: 124025571

Start: 795754

End: 796965

Strand: Reverse

Name: wecC [H]

Synonym: NATL1_08641

Alternate gene names: 124025571

Gene position: 796965-795754 (Counterclockwise)

Preceding gene: 124025572

Following gene: 124025570

Centisome position: 42.74

GC content: 29.62

Gene sequence:

>1212_bases
ATGGCAAAAGTATGTGTCATTGGTCTAGGGTACATAGGTCTTCCGACTGCTGTTGTCTTAGCTAAAGCAGGTCACAGTAC
ATTAGGAATTGATATAGACCCACATGTCGTTAAAAATGTAAACAATGGAGTTACTCATTTTAGAGAGCCTAATTTAAACA
GTTCATTAATATCAGTTGTATCTAATGGAATGCTACGTGCTTCTGAAAAGATAAAGGATGCTGATATATTTATAATTGCT
GTTCCTACACCATTCAGAAAAACAAATAACAAAAATCCAGTTCCTAATCTAGATTATGTTATCTCTGCAATAAATTCTAT
TTTACCTTTTATTAGGAAAGGAAACAGTATAGTAATAGAGTCAACATGTCCAATAGGGACAACAGCTAAAGTAAAAAATA
TTATTATTGAGAATACTAAGTTAAAAGAAAATGATTTTAATCTTGCATACTGCCCAGAAAGAGTTATACCTGGAAATATT
ATGGTTGAACTAATAAATAATGATAGAGTTATTGGTAGTCATAATAATCAGTCAAAAGAAAAGATAATTAATTTTTATAA
AACTTTTTGTAAGGGTAATATTTTATCTACAACTGCTGAAACAGCTGAAATGGTTAAACTAACAGAAAACTCATTTAGAG
ATGTAAATATTGCTTTTGCTAATGAATTATCCATTATAAGTGATCATATAAATATTGACGTTATCGAACTGATTAAATTA
GCCAATTTTCACCCAAGAGTTAACATACTAAAACCTGGTTGTGGTGTAGGAGGACATTGCATTGCAGTAGACCCTTGGTT
TATCGCTTCAGAAGTCCCCGAAAAATCCCAATTAATACAAACCGCTAGAAAGATTAATGACTATAAGCCTCAATGGGTTA
TAGAAAAAATAACTAAAAAGGCTCGTGAACTTAAATCTACTCTTAGAAAAGATCCAATTATTGGCTGCTTAGGTATTACA
TTTAAACCAAATGTAGATGATTTAAGAGAATCCCCTGCACTAAAGATAGTTCAAGGTCTTGATAAAACTCAACTAAAATT
GATTGTAGCTGATCCTAATATTAAAAGTCATAATGAATTAAGTATATCTCCACTAAATAATTTAATTAATAATAGTGATC
TTTATGTTTTCTTAGTGGCTCATAATGAATTTAAATATATTTCATTAAAGAATAGAGAATATTTAGATTTTTGCGGAGTA
ATAAATAAATAA

Upstream 100 bases:

>100_bases
AAACATTATTCATTAACAATTTACCTATTAATGTTAAGGTCATAATCCCTGAGGCCTATAATTCTAGATATCTAGAATTA
TAGGCTTTTTTATAAAATTC

Downstream 100 bases:

>100_bases
CTTGAAAAGACTATTAATAACATTATATGATATTGGCCTGAAAAGGCTTTTTCAAAGATTATTATATGATTTCAAAAAAT
CTATAAATAAACTTTTACCA

Product: UDP-glucose 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAKVCVIGLGYIGLPTAVVLAKAGHSTLGIDIDPHVVKNVNNGVTHFREPNLNSSLISVVSNGMLRASEKIKDADIFIIA
VPTPFRKTNNKNPVPNLDYVISAINSILPFIRKGNSIVIESTCPIGTTAKVKNIIIENTKLKENDFNLAYCPERVIPGNI
MVELINNDRVIGSHNNQSKEKIINFYKTFCKGNILSTTAETAEMVKLTENSFRDVNIAFANELSIISDHINIDVIELIKL
ANFHPRVNILKPGCGVGGHCIAVDPWFIASEVPEKSQLIQTARKINDYKPQWVIEKITKKARELKSTLRKDPIIGCLGIT
FKPNVDDLRESPALKIVQGLDKTQLKLIVADPNIKSHNELSISPLNNLINNSDLYVFLVAHNEFKYISLKNREYLDFCGV
INK

Sequences:

>Translated_403_residues
MAKVCVIGLGYIGLPTAVVLAKAGHSTLGIDIDPHVVKNVNNGVTHFREPNLNSSLISVVSNGMLRASEKIKDADIFIIA
VPTPFRKTNNKNPVPNLDYVISAINSILPFIRKGNSIVIESTCPIGTTAKVKNIIIENTKLKENDFNLAYCPERVIPGNI
MVELINNDRVIGSHNNQSKEKIINFYKTFCKGNILSTTAETAEMVKLTENSFRDVNIAFANELSIISDHINIDVIELIKL
ANFHPRVNILKPGCGVGGHCIAVDPWFIASEVPEKSQLIQTARKINDYKPQWVIEKITKKARELKSTLRKDPIIGCLGIT
FKPNVDDLRESPALKIVQGLDKTQLKLIVADPNIKSHNELSISPLNNLINNSDLYVFLVAHNEFKYISLKNREYLDFCGV
INK
>Mature_402_residues
AKVCVIGLGYIGLPTAVVLAKAGHSTLGIDIDPHVVKNVNNGVTHFREPNLNSSLISVVSNGMLRASEKIKDADIFIIAV
PTPFRKTNNKNPVPNLDYVISAINSILPFIRKGNSIVIESTCPIGTTAKVKNIIIENTKLKENDFNLAYCPERVIPGNIM
VELINNDRVIGSHNNQSKEKIINFYKTFCKGNILSTTAETAEMVKLTENSFRDVNIAFANELSIISDHINIDVIELIKLA
NFHPRVNILKPGCGVGGHCIAVDPWFIASEVPEKSQLIQTARKINDYKPQWVIEKITKKARELKSTLRKDPIIGCLGITF
KPNVDDLRESPALKIVQGLDKTQLKLIVADPNIKSHNELSISPLNNLINNSDLYVFLVAHNEFKYISLKNREYLDFCGVI
NK

Specific function: Probably involved in the synthesis of sugar components of EPS I, by converting NDP-N-acetyl-D-galactosamine into NDP-N- acetyl-D-galactosaminuronic acid [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=372, Percent_Identity=26.6129032258064, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI296040438, Length=255, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI48994968, Length=416, Percent_Identity=45.6730769230769, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1788340, Length=361, Percent_Identity=23.5457063711911, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560350, Length=380, Percent_Identity=26.5789473684211, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136908, Length=374, Percent_Identity=29.4117647058824, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 44756; Mature: 44624

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVCVIGLGYIGLPTAVVLAKAGHSTLGIDIDPHVVKNVNNGVTHFREPNLNSSLISVV
CCEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCCCCCCCCCCCCHHHHHHH
SNGMLRASEKIKDADIFIIAVPTPFRKTNNKNPVPNLDYVISAINSILPFIRKGNSIVIE
HCCHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
STCPIGTTAKVKNIIIENTKLKENDFNLAYCPERVIPGNIMVELINNDRVIGSHNNQSKE
CCCCCCCCHHHHHEEEECCEECCCCCCEEECCCCCCCCCEEEEEECCCEEEECCCCHHHH
KIINFYKTFCKGNILSTTAETAEMVKLTENSFRDVNIAFANELSIISDHINIDVIELIKL
HHHHHHHHHHCCCEEECHHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCCHHHHHHHH
ANFHPRVNILKPGCGVGGHCIAVDPWFIASEVPEKSQLIQTARKINDYKPQWVIEKITKK
HCCCCCEEEECCCCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ARELKSTLRKDPIIGCLGITFKPNVDDLRESPALKIVQGLDKTQLKLIVADPNIKSHNEL
HHHHHHHHHCCCCEEEEEEEECCCHHHHHCCCHHHHHHCCCCCEEEEEEECCCCCCCCCE
SISPLNNLINNSDLYVFLVAHNEFKYISLKNREYLDFCGVINK
EECHHHHHCCCCCEEEEEEEECCEEEEEECCCCHHHHHCCCCC
>Mature Secondary Structure 
AKVCVIGLGYIGLPTAVVLAKAGHSTLGIDIDPHVVKNVNNGVTHFREPNLNSSLISVV
CEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCCCCCCCCCCCCHHHHHHH
SNGMLRASEKIKDADIFIIAVPTPFRKTNNKNPVPNLDYVISAINSILPFIRKGNSIVIE
HCCHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
STCPIGTTAKVKNIIIENTKLKENDFNLAYCPERVIPGNIMVELINNDRVIGSHNNQSKE
CCCCCCCCHHHHHEEEECCEECCCCCCEEECCCCCCCCCEEEEEECCCEEEECCCCHHHH
KIINFYKTFCKGNILSTTAETAEMVKLTENSFRDVNIAFANELSIISDHINIDVIELIKL
HHHHHHHHHHCCCEEECHHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCCHHHHHHHH
ANFHPRVNILKPGCGVGGHCIAVDPWFIASEVPEKSQLIQTARKINDYKPQWVIEKITKK
HCCCCCEEEECCCCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ARELKSTLRKDPIIGCLGITFKPNVDDLRESPALKIVQGLDKTQLKLIVADPNIKSHNEL
HHHHHHHHHCCCCEEEEEEEECCCHHHHHCCCHHHHHHCCCCCEEEEEEECCCCCCCCCE
SISPLNNLINNSDLYVFLVAHNEFKYISLKNREYLDFCGVINK
EECHHHHHCCCCCEEEEEEEECCEEEEEECCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]